[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/all2en\/wiki14\/food-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/all2en\/wiki14\/food-wikipedia\/","headline":"Food \u2013 Wikipedia","name":"Food \u2013 Wikipedia","description":"before-content-x4 Structural formula Simplified structural formula without stereochemistry General Freiname Alfuzosin other names ( RS )-Tetrahydro-2-furancarbons\u00e4ure-3-[(4-amino-6,7-dimethoxy-2-chinazolinyl)-methyl-amino]propylamid ( RS )- N","datePublished":"2021-12-26","dateModified":"2021-12-26","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/all2en\/wiki14\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/all2en\/wiki14\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/e\/ee\/%28RS%29-Alfuzosin_Structural_Formula_V2.svg\/300px-%28RS%29-Alfuzosin_Structural_Formula_V2.svg.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/e\/ee\/%28RS%29-Alfuzosin_Structural_Formula_V2.svg\/300px-%28RS%29-Alfuzosin_Structural_Formula_V2.svg.png","height":"108","width":"300"},"url":"https:\/\/wiki.edu.vn\/all2en\/wiki14\/food-wikipedia\/","wordCount":1502,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4Structural formula  Simplified structural formula without stereochemistry General Freiname Alfuzosin other names ( RS )-Tetrahydro-2-furancarbons\u00e4ure-3-[(4-amino-6,7-dimethoxy-2-chinazolinyl)-methyl-amino]propylamid ( RS )- N -[3-[(4-Amino-6,7-dimethoxychinazolin-2-yl)(methyl)amino]tetrahydrofuran-2-carboxamid Mash formula  External identifiers\/databases  Drug ATC-Code G04 CA01  Active ingredient class        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Alphablocker Mechanism a first -Adrenoreceptor antagonist Characteristics Molar masses 389.45 g \u00b7 mol \u22121 (Alfuzosin) 425.9 g \u00b7 mol \u22121 (Alfuzosin\u00b7HCl) Aggregate state fest        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Melting point 225 \u00b0 C (hydrochloride) [first] p K S -Value 8.13 [first] safety instructions  Toxicological data  As far as possible and common, SI units are used. Unless otherwise noted, the data provided applies to standard conditions. Alfuzosin Is a drug from the group of \u03b1 first -Adrenoreceptor antagonist (alphablocker), which is used in the treatment of a benign prostate hyperplasia (BPH). The chiral connection is derived from the Chinese. It was patented in 1979 and 1982 as an antihypertonic by Synth\u00e9labo (today Sanofi). [first] application areas [ Edit | Edit the source text ] The drug is used to treat the symptoms of benign prostate hyperplasia. It has no influence on the size of the prostate.        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Contraindications (contraindications) [ Edit | Edit the source text ] In the presence of severe liver sufficiency or orthostatic hypotension (low blood pressure), the administration is contraindicated, as well as treatment with other alpha blockers. [3] Unwanted effects (side effects) [ Edit | Edit the source text ] Possible side effects include fatigue, dizziness, headache, flu symptoms and hypotone dysregulation. [3] As an antagonist, alfuzosin selectively binds to postsynaptic \u03b1 first -Drenoreceptors and thus relaxes the smooth muscles of prostate and urethra. This increases urinary flow and makes micturition easier. The bioavailability is 64% and the plasmhale dumpling time is 4 to 6 hours. The maximum plasma concentration is reached after 90 minutes. [3] Alfuzosin contains a stereo center and is therefore a chiral. There are two enantiomeric shapes ( R )-form and ( S )-Shape. However, only the racemat [(( RS ) -Alfuzosin], i.e. a 1: 1 mixture from the ( R ) -Enantiomer and the ( S )-Enantiomer: [4] Enantiomeres from Alfuzosin ( R )-Alfuzosin  ( S )-Alfuzosin  Alfunar (d), [5] Fuzocim (CH), Urion (D), UroXatral (D), Xatral (CH) \u2191 a b c  Entry to Alfuzosin . In: R\u00f6mpp Online. Georg Thieme Verlag, accessed on September 9, 2014.  \u2191 a b c d  data sheet Alfuzosin hydrochloride at Sigma-Aldrich, accessed on May 31, 2022 ( PDF ).  \u2191 a b c  Michael C. Tru\u00df, Christian G. Stief, Stefan Machtens, Till Wagner, Udo Jonas: Pharmacotherapy in urology. 2nd, completely revised edition. Springer, Heidelberg 2005, ISBN 3-540-23449-7, p. 302 ff.  \u2191  Red List Service GmbH (ed.): Red List 2017 – Drugs for Germany (including EU registrations and certain medical devices) . Rote List Service GmbH, Frankfurt\/Main, 2017, ed. 57, p. 159, ISBN 978-3-946057-10-9.  \u2191  Red List 2017, Verlag Rote List Service GmbH, Frankfurt am Main, ISBN 978-3-946057-10-9, p. 159.  This article deals with a health issue. He serves not the self -diagnosis and replaced not A diagnosis by a doctor. Please note the note on health issues!       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