CD155 – Wikipedia
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From Wikipedia, Liberade Libera.
The CD155 (acronym for Differentiation cluster 155 ), also called Poliovirus receptor It is a human protein, coded by the gene PVR . [first] [2]
The CD155 is a transmembrane glycoprotein of the surface of the immunoglobulins [3] Commonly known as Poliovirus receptor (PVR) due to its role in the infection of poliovirus in primates, although its physiological function is the formation of joint joints between epithelial cells. [4] The role of the CD155 in the immune system is not clear, although it seems to be involved in the humoral immune response in the intestine. [4]
The extracellular domain averages the cell adhesion to the vitronectin present in the extracellular matrix, while the intracellular domain interacts with the light chain of Dinein.
The CD155 is a transmembrane protein with 3 extracellular domains Ig-like , D1-D3, where the D1 is the one linked by the poliovirus. [5]
The low resolution of the complex CD155 with Poliovirus was obtained under the electronic microscope [5] While the high resolution structure of the D1 and D2 ectodini has been obtained by X -ray crystallography.
- ^ Entrez Gene: poliovirus receptor . are ncbi.nlm.nih.gov . URL consulted on July 18, 2012 .
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- ^ a b Michael K. Maier, Sebastian Seth, Niklas Czeloth, Quan Qiu, Inga Ravens, Elisabeth Kremmer, The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens , in European Journal of Immunology , vol. 37, n. 8, 2007, pp. 2214–2225, DOI: 10.1002 / used.200737072 . URL consulted on July 18, 2012 .
- ^ a b P. Zhang, S. Mueller, M. C. Morais, C. M. Bator, V. D. Bowman, S. Hafenstein, Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses , in Proceedings of the National Academy of Sciences , vol. 105, n. 47, 2008, pp. 18284–18289, DOI: 10.1073/pnas.0807848105 . URL consulted on July 18, 2012 .
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- D. Pende, Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112) , in Blood , vol. 105, n. 5, 2005, pp. 2066–2073, DOI: 10.1182/blood-2004-09-3548 . URL consulted on July 18, 2012 .
- Furio Pezzetti, Annalisa Palmieri, Marcella Martinelli, Luca Scapoli, Marzia Arlotti, Ugo Baciliero, Linkage disequilibrium analysis of two genes mapping on OFC3: PVR and PVRL2 , in European Journal of Human Genetics , vol. 15, n. 9, 2007, pp. 992–994, DOI: 10.1038/sj.ejhg.5201868 . URL consulted on July 18, 2012 .
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- Daniela Pende, Cristina Bottino, Roberta Castriconi, Claudia Cantoni, Stefania Marcenaro, Paola Rivera, PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis , in Molecular Immunology , vol. 42, n. 4, 2005, pp. 463–469, DOI: 10.1016/j.molimm.2004.07.028 . URL consulted on July 18, 2012 .
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- P. Zhang, S. Mueller; Mc. Morais; CM. Bator; Vd. Bowman; S. Hafenstein; E. Wimmer; Mg. Rossmann, Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. , in Proc Natl Acad Sci U S A , vol. 105, n. 47, November 2008, pp. 18284-9, doi: 10.1073/pnas.0807848105 , PMID 19011098 .
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- D. Meyer, S. Seth; J. Albrecht; MK. Maier; L. Du Pasquier; I. Ravens; L. Dreyer; R. Burger; M. Gramatzki; R. Schwinzer; E. Kremmer, CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains. , in J Biol Chem , vol. 284, n. 4, January 2009, pp. 2235-44, doi: 10.1074/jbc.M807698200 , PMID 19056733 .
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