[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/all2en\/wiki32\/topiramate-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/all2en\/wiki32\/topiramate-wikipedia\/","headline":"Topiramate \u2014 Wikipedia","name":"Topiramate \u2014 Wikipedia","description":"before-content-x4 A wikipedia article, free l’encyclop\u00e9i. Topiramate Identification UICPA name Sulfamate de ((3AS, 5AR, 8AR, 8BS) -2,2,7-7-T\u00e9tm\u00e9thylt\u00e9trahydro-3AH-Bis [1,3] Dioxolo [4,5-b:","datePublished":"2019-10-28","dateModified":"2019-10-28","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/all2en\/wiki32\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/all2en\/wiki32\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/3\/3a\/Topiramate.svg\/langfr-172px-Topiramate.svg.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/3\/3a\/Topiramate.svg\/langfr-172px-Topiramate.svg.png","height":"152","width":"172"},"url":"https:\/\/wiki.edu.vn\/all2en\/wiki32\/topiramate-wikipedia\/","wordCount":3144,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4A wikipedia article, free l’encyclop\u00e9i. Topiramate  Identification UICPA name Sulfamate de ((3AS, 5AR, 8AR, 8BS) -2,2,7-7-T\u00e9tm\u00e9thylt\u00e9trahydro-3AH-Bis [1,3] Dioxolo [4,5-b: 4 ‘, 5’-D] pyran-3a -Yl] M\u00e9thyle  Synonyms        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Sulifamate 2, 4,5-besydy (1-Maryism)-Malimy-aretante). N O CAS 97240-79-4  N O Echa 100.129.713 Code ATC N03 AX11  DrugBank AprD00237  Pubchem 5284627  SMILES O1[C@]2([C@H]([C@H]3[C@H](OC(O3)(C)C)CO2)OC1(C)C)COS(N)(=O)=O Pubchem , 3D view Inches Inches:  3D view  Inchi = 1\/C12h21no8s\/C1-10 (2) 18-7-5-16-12 (6-17-22 (13,14) 15) 9 (8 (7) 19-10) 20-11 (3, 4) 21-12\/h7-9h, 5-6h2,1-4h3, (H2,13,14,15)\/T7-, 8-, 9+, 12+\/m1\/s1 Chemicals Formula C twelfth H 21 NO 8 S\u00a0\u00a0 [Isomers] Molar mass [ first ] 339,362 \u00b1 0.019 G\/MOL C\u00a042,47\u00a0%,  H\u00a06,24\u00a0%,  N\u00a04,13\u00a0%,  O\u00a037,72\u00a0%,  S\u00a09,45\u00a0%,  Pharmacokinetic data Bio -supplood 80% Metabolism 30% liver, 70% is excreted unchanged Half-life of \u00e9lim.  19 to 11 p.m. Excretion 70% renal (the form unchanged)        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Therapeutic considerations Administration oral IS units and CNTP , unless otherwise stated. modifier  The topiramate is an antiepileptic drug used for generalized or partial type epilepsies. It is found, in France, under the name of Epitomax and in the United States, Canada, the United Kingdom, Australia and certain other countries under the name of Topamax.It can also be used as a preventive treatment for migraine attacks. Studies have also been carried out on its usefulness in the treatment of the effects induced by ketamine, then used as a model of schizophrenia.   Il Casiit a Durriv\u00e9 du Frucstose [ 2 ] .        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The bioavailability is more than 80%, without significant modification by food intake. Its half-life is around 24 hours and the excretion is renal. Phenytoin and carbamazepine halved its half-life, imposing an increase in doses [ 3 ] . Epilepsy Epilepsy of the child and adolescent. This is its first use. In children, it is indicated for the treatment of Lennox-Gastaut syndrome [Ref. necessary] . Migraines Furthermore, it significantly decreases the number of migraine crises when given in basic treatment [ 4 ] . Borderline personality disorder Borderline personality disorder including mood instability. This indication is recommended by a review of the 2010 Cochrane collaboration [ 5 ] . Bipolar disorder However, this indication is criticized by a Cochrane review which concludes in insufficient efficiency [ 6 ] . Studies have also been carried out on its usefulness in treating the effects brought about by ketamine, then used as a model of schizophrenia [ 7 ] , [ 8 ] . The most frequent are the tingling sensations (paraesthesia present in half of the cases and leading to stopping treatment in just less than one in 10) and a fairly significant loss of weight during treatment [ 9 ] . The ANSM warns against the teratogenicity of the topiramate: pregnant women are exposed to a risk 3 times greater of fetus malformations, including Bacs-de-de-de-livre or hypospadias. In addition, cases of neurodevelopmental disorders are reported [ ten ] . The study Jama Neurology of May 31, 2022 brings new elements. The ANSM then modifies the prescription conditions mentioning that the observed risk of major malformations amounts to 8.2%, as well as the risk of the occurrence of autistic spectrum disorders which is between 2 and 6%, finally a risk of an intellectual impairment which located between 1 and 8%. \u2191 Molar mass calculated after ‘ Atomic weights of the elements 2007 \u00bb , on www.chem.qmul.ac.uk .  \u2191 (in) Shank RP, Maryanoff BE, \u00ab\u00a0Molecular pharmacodynamics, clinical therapeutics, and pharmacokinetics of topiramate\u00a0\u00bb  CNS Neurosci Ther . 2008; 14: 120-42.  \u2191 (in) Bialer M, Doose DR,  Murthy B. et al.  \u00ab\u00a0Pharmacokinetic interactions of topiramate\u00a0\u00bb  Clin Pharmacokinet . 2004; 43: 763-80.  \u2191 (in) Brandes JL, Saper JR, Diamond M. et al.  \u00ab\u00a0Topiramate for migraine prevention: a randomized controlled trial\u00a0\u00bb  PEOPLE . 2004; 291: 965-73.  \u2191 (in) Klaus body , Birgit V\u00f6llm , Happen Back , Antje Timber And Jutta M Drugs , ‘ Pharmacotherapy for borderline personality disorder: Cochrane systematic review of randomised trials \u00bb , British Journal of Psychiatry , vol. 196, n O 1, 2010 , p. 4\u201312 (DOI\u00a0 10.1192\/bjp.bp.108.062984)  \u2191 (in) Fireplaces Vasudev , Karine MacRitchie , John Geddes , Stuart Watson , Allan H Young and allan h Young , ‘ Topiramate for acute affective episodes in bipolar disorder \u00bb , Cochrane database of systematic reviews (Online) , n O 1, 2006 , p. \u00a0CD003384 (PMID\u00a0 16437453, DOI\u00a0 10.1002\/14651858.CD003384.pub2)  \u2191 (in) Deutsch Si, Rosse Rb, Billingslea EN, Bellack MP, Mastropaolo J, ‘ Topiramate antagonizes MK-801 in an animal model of schizophrenia \u00bb , EUR J PHARMACOL , vol. 449, n you 1-2, 2002 , p. 121-5. (PMID\u00a0 12163115 ) \u00a0modifier  \u2191 (in) Micallef J, Gavadan G, Burle B, Blin O, Hasbroucq T, ‘ A study of a topiramate pre-treatment on the effects induced by a subanaesthetic dose of ketamine on human reaction time \u00bb , Neurosci Lett , vol. 369, n O 2, 2004 , p. 99-103. (PMID\u00a0 15450676 ) \u00a0modifier  \u2191 (in) Edvinsson L, Linde M, \u00ab\u00a0New drugs in migraine treatment and prophylaxis: telcagepant and topiramate\u00a0\u00bb  Lancet . 2010; 376: 645-55.  \u2191 ANSM – Antiepileptics during pregnancy: current state of knowledge on the risks of malformations and neur -developmental disorders – Information point  On other Wikimedia projects:        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/all2en\/wiki32\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/all2en\/wiki32\/topiramate-wikipedia\/#breadcrumbitem","name":"Topiramate \u2014 Wikipedia"}}]}]