[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/15140#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/15140","headline":"\u30a2\u30c7\u30ce\u95a2\u9023\u30a6\u30a4\u30eb\u30b9\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2","name":"\u30a2\u30c7\u30ce\u95a2\u9023\u30a6\u30a4\u30eb\u30b9\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2","description":"before-content-x4 \u30a2\u30c7\u30ce\u95a2\u9023\u30a6\u30a4\u30eb\u30b9 \uff08 AAV \uff09\u3001\u6b63\u5f0f\u306b \u30a2\u30c7\u30ce\u95a2\u9023\u4f9d\u5b58\u75c7\u4f9d\u5b58\u75c7 \u3001compendoviruses\u306b\u5c5e\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u540c\u3058\u7d30\u80de\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u30d8\u30eb\u30d1\u30fc\u30a6\u30a4\u30eb\u30b9\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\uff08lat\u3002\u4f9d\u5b58\u8005\uff09\u3002 AAV\u306f1\u3064\u3067\u3059 \u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9 \u4f9d\u5b58\uff08\u3057\u305f\u304c\u3063\u3066\u3001\u300c\u30a2\u30c7\u30ce\u300d\u306b\u95a2\u9023\u3059\u308b\u30a6\u30a4\u30eb\u30b9\uff09\u3002\u30d8\u30eb\u30d1\u30fc\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u7d30\u80de\u5185\u306e\u8907\u88fd\u306bAAV\u304c\u5fc5\u8981\u3068\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30bf\u30f3\u30d1\u30af\u8ceaE1A\u3001E2A\u3001E4\u3001\u304a\u3088\u3073Va-RNA\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30d8\u30eb\u30d1\u30fc\u30a6\u30a4\u30eb\u30b9\u3068\u3057\u3066\u3001\u305d\u308c\u306f \u30d8\u30eb\u30da\u30b9 – \u30b7\u30f3\u30d7\u30eb\u306a\u30a6\u30a4\u30eb\u30b91 \u307e\u305f\u306f\u305d\u306e \u4eba\u9053\u7684\u30b5\u30a4\u30c8\u30e1\u30ac\u30ea\u30a6\u30a4\u30eb\u30b9 \u4ed5\u3048\u308b\u3002 [2] after-content-x4 \u30d8\u30eb\u30d1\u30fc\u30a6\u30a4\u30eb\u30b9\u306e\u5b58\u5728\u304c\u306a\u3051\u308c\u3070\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u907a\u4f1d\u7269\u8cea\u306f\u30d2\u30c8\u306e\u67d3\u8272\u4f5319\u306b\u7d71\u5408\u3067\u304d\u307e\u3059\u304c\u3001\u901a\u5e38\u306f\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u96a3\u306e\u30a8\u30d4\u30bd\u30fc\u30de\u3067\u3059\u3002 [3]","datePublished":"2023-05-06","dateModified":"2023-05-06","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/de.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/de.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/15140","wordCount":1128,"articleBody":" (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4\u30a2\u30c7\u30ce\u95a2\u9023\u30a6\u30a4\u30eb\u30b9 \uff08 AAV \uff09\u3001\u6b63\u5f0f\u306b \u30a2\u30c7\u30ce\u95a2\u9023\u4f9d\u5b58\u75c7\u4f9d\u5b58\u75c7 \u3001compendoviruses\u306b\u5c5e\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u540c\u3058\u7d30\u80de\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u30d8\u30eb\u30d1\u30fc\u30a6\u30a4\u30eb\u30b9\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\uff08lat\u3002\u4f9d\u5b58\u8005\uff09\u3002 AAV\u306f1\u3064\u3067\u3059 \u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9 \u4f9d\u5b58\uff08\u3057\u305f\u304c\u3063\u3066\u3001\u300c\u30a2\u30c7\u30ce\u300d\u306b\u95a2\u9023\u3059\u308b\u30a6\u30a4\u30eb\u30b9\uff09\u3002\u30d8\u30eb\u30d1\u30fc\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u7d30\u80de\u5185\u306e\u8907\u88fd\u306bAAV\u304c\u5fc5\u8981\u3068\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30bf\u30f3\u30d1\u30af\u8ceaE1A\u3001E2A\u3001E4\u3001\u304a\u3088\u3073Va-RNA\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30d8\u30eb\u30d1\u30fc\u30a6\u30a4\u30eb\u30b9\u3068\u3057\u3066\u3001\u305d\u308c\u306f \u30d8\u30eb\u30da\u30b9 – \u30b7\u30f3\u30d7\u30eb\u306a\u30a6\u30a4\u30eb\u30b91 \u307e\u305f\u306f\u305d\u306e \u4eba\u9053\u7684\u30b5\u30a4\u30c8\u30e1\u30ac\u30ea\u30a6\u30a4\u30eb\u30b9 \u4ed5\u3048\u308b\u3002 [2] (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4\u30d8\u30eb\u30d1\u30fc\u30a6\u30a4\u30eb\u30b9\u306e\u5b58\u5728\u304c\u306a\u3051\u308c\u3070\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u907a\u4f1d\u7269\u8cea\u306f\u30d2\u30c8\u306e\u67d3\u8272\u4f5319\u306b\u7d71\u5408\u3067\u304d\u307e\u3059\u304c\u3001\u901a\u5e38\u306f\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u96a3\u306e\u30a8\u30d4\u30bd\u30fc\u30de\u3067\u3059\u3002 [3] \u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u304c\u5b58\u5728\u3059\u308b\u3068\u3059\u3050\u306b\u3001\u7d30\u80de\u306f\u6eb6\u89e3\u30b5\u30a4\u30af\u30eb\u306b\u901a\u904e\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u7c92\u5b50\u304c\u5897\u6b96\u3057\u3001\u7d30\u80de\u304c\u7206\u767a\u3057\u3066AAV\u304c\u5e83\u304c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002 AAV\u306f\u3001\u75be\u60a3\u306b\u95a2\u9023\u3057\u3066\u304a\u3089\u305a\u3001\u30a6\u30a4\u30eb\u30b9\u907a\u4f1d\u7269\u8cea\u304c\u5bbf\u4e3b\u7d30\u80de\u306e\u30b2\u30ce\u30e0\u306b\u7d71\u5408\u3055\u308c\u306a\u3044\u305f\u3081\u3001\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u7642\u6cd5\u306e\u767a\u764c\u6027\u306e\u53ef\u80fd\u6027\u304c\u6e1b\u5c11\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7c92\u5b50\u306f\u975e\u5e38\u306b\u5b89\u5b9a\u3057\u3066\u304a\u308a\u3001\u9759\u6b62\u7d44\u7e54\uff08\u30cb\u30e5\u30fc\u30ed\u30f3\u306a\u3069\uff09\u3082\u611f\u67d3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 AAV\u306e\u6df1\u523b\u306a\u6b20\u70b9\u306f\u3001\u5f7c\u5973\u306e\u5c0f\u3055\u306a\u30b2\u30ce\u30e0\u3067\u3042\u308a\u30012\u3064\u306eITR\uff08\u9006\u672b\u7aef\u7e70\u308a\u8fd4\u3057\uff09\u304c\u96a3\u63a5\u3057\u3066\u3044\u307e\u3059\u3002 ITR\u306e\u9593\u306b\u306f4.7kb\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u308c\u306f\u3001\u7d44\u63db\u3048\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u5229\u7528\u53ef\u80fd\u306a\u306e\u306f2.5kb\u672a\u6e80\u3067\u3059\u3002 (adsbygoogle = window.adsbygoogle || []).push({});after-content-x42018\u5e7411\u6708\u73fe\u5728\u3001\u56fd\u969b\u30a6\u30a4\u30eb\u30b9\u306e\u5206\u985e\u59d4\u54e1\u4f1a\u306f\u3001\u4ee5\u524d\u306f\u7570\u306a\u308b\u8840\u6e05\u578b\u3068\u3057\u3066\u306e\u307f\u5c0e\u304b\u308c\u3066\u3044\u305f2\u3064\u306e\u7a2e\u3092\u533a\u5225\u3057\u3066\u3044\u307e\u3059\uff1aAAV-A\u3068AAV-B\u3002 NCBI\u306b\u3088\u308b\u3068\u30012\u3064\u306e\u7a2e\u3068a\u3002\u6b21\u306e\u30a6\u30a4\u30eb\u30b9\uff1a \u7a2e\u65cf\uff1a \u30a2\u30c7\u30ce\u95a2\u9023\u4f9d\u5b58\u75c7\u4f9d\u5b58\u75c7a \uff08AAV-A\uff09 \u30a2\u30c9\u30bd\u30bd\u30b8\u30a8\u30c9\u30a6\u30a4\u30eb\u30b91\uff08AAV-1\uff09 \u30a2\u30c9\u30bd\u30bd\u306f\u30a6\u30a4\u30eb\u30b96\uff08AAV-6\uff09 \u30a2\u30c9\u30bd\u30bd\u30b8\u30a8\u30c9\u30a6\u30a4\u30eb\u30b92\uff08AAV-2\uff09 adenoassoziierereereereeres Virus 2H\uff08AAV-2H\uff09 Adsoassoizieed First 3\uff08AAV-3\uff09 adenoassoziiererereereeres Virus 3a\uff08AAV-3A\uff09 Adenoassoziiertes\u30a6\u30a4\u30eb\u30b93b\uff08AAV-3B\uff09 \u30a2\u30c9\u30bd\u30bd\u30b8\u30a8\u30c9\u30a6\u30a4\u30eb\u30b94\uff08AAV-4\uff09 \u30a6\u30a4\u30eb\u30b97\u306badsoassoizieeded\uff08AAV-7\uff09 Adsoassoizieieed\u30a6\u30a4\u30eb\u30b98\uff08AAV-8\uff09 \u30a2\u30c9\u30bd\u30bd\u306f\u30a6\u30a4\u30eb\u30b99\uff08AAV-9\uff09 \u30a2\u30c9\u30bd\u30bd\u30b8\u30a8\u30c9\u30a6\u30a4\u30eb\u30b910\uff08AAV-10\uff09 \u30a2\u30c9\u30bd\u30bd\u306f\u30a6\u30a4\u30eb\u30b911\uff08AAV-11\uff09 \u30a2\u30c9\u30bd\u30bd\u306f\u30a6\u30a4\u30eb\u30b912\uff08AAV-12\uff09 Adsoassoiziedes\u30a6\u30a4\u30eb\u30b913\uff08AVA-13\uff09 \u7a2e\u65cf\uff1a \u30a2\u30c7\u30ce\u95a2\u9023\u4f9d\u5b58\u75c7\u4f9d\u5b58\u75c7b \uff08AAV-B\uff09 Adsoassoizieed First 5\uff08AAV-5\uff09 uwe haberkorn\uff1a \u81ea\u6bba\u907a\u4f1d\u5b50\u306b\u3088\u308bGen\u6cbb\u7642 \u3001\u30cf\u30a4\u30c7\u30eb\u30d9\u30eb\u30af\u5927\u5b66\u3001\u30eb\u30d1\u30c8\u30ab\u30ed\u30e93\/1999 \u30ad\u30e3\u30b5\u30ea\u30fc\u30ca\u30fb\u30b7\u30a7\u30fc\u30d3\uff1a AAV2\u306e\u4e88\u671f\u3057\u306a\u3044\u30b9\u30ad\u30eb \u3001\u79d1\u5b66\u306e\u30a4\u30e1\u30fc\u30b8\u30012005\u5e746\u670823\u65e5 \u30c7\u30d3\u30c3\u30c9\u30fb\u30cb\u30fc\u30eb\u30c9\uff1a \u7247\u65b9\u306e\u76ee\u306b\u6ce8\u5165\u3055\u308c\u305f\u5b9f\u9a13\u7642\u6cd5\u306f\u3001\u3082\u3046\u4e00\u65b9\u306e\u76ee\u306e\u8996\u529b\u3092\u6539\u5584\u3057\u307e\u3059 \u3001on\uff1a\u79d1\u5b66 \u30a2\u30e9\u30fc\u30c8 VOM 2020\u5e7412\u670815\u65e5-VERAL VECTOR RAV2 \/ 2-ND4\u304b\u3089\u5b9f\u9a13\u7642\u6cd5\u3078\u306eVon Lhon \u30de\u30eb\u30b3\u30fb\u30e9\u30a4\u30d3\u30f3\u30ac\u30fc\u3001\u30b7\u30e3\u30fc\u30ed\u30c3\u30c8\u30fb\u30b6\u30a4\u30c8\u30e9\u30fc\u3001\u30d5\u30a3\u30ea\u30c3\u30d7\u30fb\u30b4\u30d6\u30ec\u30d2\u30c8\u3001\u30a2\u30ca\u30b9\u30bf\u30b7\u30a2\u30fb\u30a2\u30f3\u30c7\u30a2\u30c0\u30ad\u3001\u30ae\u30e5\u30f3\u30bf\u30fc\u30fb\u30ae\u30bb\u30eb\u30de\u30f3\u3001\u30c7\u30a3\u30fc\u30c8\u30de\u30fc\u30eb\u30fb\u30d5\u30a3\u30c3\u30b7\u30e3\u30fc\uff1a \u30de\u30a6\u30b9\u306e\u91cd\u5ea6\u306e\u810a\u9ac4\u640d\u50b7\u5f8c\u306e\u30cf\u30a4\u30d1\u30fc\u30a4\u30f3\u30bf\u30fc\u30eb\u30a4\u30f3-6\u306e\u7d4c\u8178\u5185\u9001\u9054\u306b\u3088\u308a\u3001\u6a5f\u80fd\u7684\u306a\u56de\u5fa9\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059 \u3001In\uff1aNature Communications\u3001nr\u3002 391\u300115\u3002Januar2021\u3001 2\uff1a10.1038\/S41467-020-20112-4 \u3002 hyper-il-6\u306b\u3088\u308bgen\u6cbb\u7642 [\u306e] \uff09AAV\u3054\u3068\u3002\u30c0\u30ba\uff1a \u7db2\u819c\u75be\u60a3\uff08\u809d\u81d3\u5148\u5929\u6027\u30a2\u30de\u30ed\u30fc\u30b9\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059RPE65\u306e\u5909\u7570\u306f\u30012017\u5e74\u306b\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30d9\u30fc\u30b9\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\uff08\u30d9\u30af\u30bf\u30fcAAV2-HRPE65V2\u3092\u4f7f\u7528\uff09\u306b\u3088\u308a\u6210\u529f\u88cf\u306b\u6cbb\u7642\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002 [4] \u30d7\u30e9\u30c6\u30a3\u30de\u30fb\u30c1\u30e3\u30a6\u30c0\u30ea\u30fc\u3001\u30b9\u30fc\u30b6\u30f3\u30fb\u30b7\u30e3\u30d4\u30ed\u3001\u30de\u30a4\u30af\u30fb\u30de\u30af\u30ea\u30b9\u3001\u30b8\u30ea\u30a2\u30f3\u30fb\u30a8\u30f4\u30a1\u30f3\u30b9\u3001\u30b5\u30e9\u30fb\u30dc\u30a4\u30b9\u3001\u30b1\u30a4\u30c8\u30fb\u30c8\u30fc\u30af\u30b9\u3001\u30b8\u30a7\u30e9\u30eb\u30c9\u30fb\u30c9\u30fc\u30e9\u30f3\u3001\u30a6\u30eb\u30ea\u30b1\u30fb\u30e9\u30a4\u30b9\u3001\u30de\u30fc\u30af\u30fb\u30d5\u30a3\u30ea\u30c3\u30d7\u30b9\u3001\u30a2\u30f3\u30fb\u30ea\u30c7\u30eb\u3001\u30de\u30ea\u30a2\u30fbR\u30fb\u30da\u30e9\u30eb\u30bf\u3001\u30df\u30b7\u30a7\u30eb\u30fb\u30ad\u30fc\u30a4\u3001\u30c7\u30d3\u30c3\u30c9W. 3\u8840\u53cb\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b3\u907a\u4f1d\u5b50\u6cbb\u7642B. In\uff1aNew England Journal of Medicine\uff08NEJM\uff09\u3001Band 387\u3001Nr\u3002 3\u300121\u3002Juli2022\u3001S\u3002237; doi\uff1a10.1056\/nejmoa2119913 \u3001 \u7814\u7a76\u306e\u6982\u8981 \u3002\u8840\u53cb\u75c5B\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u8a66\u9a13\u6bb5\u968e\uff1a\u4fee\u6b63\u3055\u308c\u305fAAV FLT180A\u3092\u4ecb\u3057\u305f\u56e0\u5b50IX\u3002\u52a0\u3048\u3066\uff1a \u30c6\u30e5\u30fc\u30d3\u30f3\u30b2\u30f3\u5927\u5b66\u75c5\u9662\u3067\u306f\u30012020\u5e74\u4ee5\u6765\u3001\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u3092\u5b8c\u5168\u306a\u8272\u899a\u7570\u5e38\uff08\u30a2\u30af\u30e9\u30fc\u30de\u30c8\u30d7\u30b7\u30fc\uff09\u306e\u305f\u3081\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\u306b\u3069\u306e\u3088\u3046\u306b\u4f7f\u7528\u3067\u304d\u308b\u304b\uff08\u6b20\u9665\u907a\u4f1d\u5b50CNGA3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\uff09\u304c\u30c6\u30b9\u30c8\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30c1\u30fc\u30e0\u306f\u3001\u958b\u767a\u3057\u305f\u30d9\u30af\u30c8\u30eb\u3092AAV8.CNGA3\uff08GNGA3\u907a\u4f1d\u5b50\u3092\u4f7f\u7528\u3057\u305f\u30a2\u30c7\u30ce\u95a2\u9023\u30a6\u30a4\u30eb\u30b9\uff09\u3068\u547c\u3073\u307e\u3059\u3002\u7279\u306b\u82e5\u3044\u60a3\u8005\u306e\u5834\u5408\u3001\u6210\u529f\u306e\u53ef\u80fd\u6027\u306f\u9069\u5207\u306a\u6761\u4ef6\u4e0b\u3067\u8a08\u7b97\u3055\u308c\u307e\u3059\u3002 [5] \u30df\u30e5\u30f3\u30d8\u30f3\u306eLudwig Maximilians University\u3067\u306f\u3001\u624b\u9806\u306e\u6539\u5584\uff082021\uff09\u3082AAV\u306e\u52a9\u3051\u3092\u501f\u308a\u3066\u81ea\u7136\u306e\u907a\u4f1d\u7684\u6b20\u9665\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u76f2\u76ee\u306e\u3086\u3063\u304f\u308a\u3068\u3057\u3066\u3044\u307e\u3059\u3002 [6] (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4\u30c6\u30eb\u30a2\u30d3\u30d6\u5927\u5b66\u3067\u306f\u3001AAV\u3068\u907a\u4f1d\u5b50\u306f\u3055\u307f\u306eCRISPR B\u30ea\u30f3\u30d1\u7403\u306e\u52a9\u3051\u3092\u501f\u308a\u3066\u624b\u9806\uff082022\uff09\u306b\u53d6\u308a\u7d44\u3080\u3053\u3068\u306f\u3001\u30a8\u30a4\u30ba\u75c5\u539f\u4f53HIV\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3092\u5f62\u6210\u3059\u308b\u3088\u3046\u306b\u8ffd\u52a0\u3055\u308c\u308b\u3079\u304d\u3067\u3059\u3002\u305d\u306e\u5f8c\u3001HIV\u30a6\u30a4\u30eb\u30b9\u306e\u65b0\u3057\u3044\u30d0\u30ea\u30a8\u30fc\u30b7\u30e7\u30f3\u306b\u9069\u5fdc\u3067\u304d\u308b\u306f\u305a\u3067\u3059\u3002 [7] \u2191 a b c d \u305d\u3046\u3067\u3059 ICTV\uff1a ICTV\u5206\u985e\u5c65\u6b74\uff1a\u970a\u9577\u985e\u30a8\u30ea\u30b9\u30ed\u30d1\u30eb\u30dc\u30a6\u30a4\u30eb\u30b91 \u3001EC 51\u3001\u30d9\u30eb\u30ea\u30f3\u3001\u30c9\u30a4\u30c4\u30012019\u5e747\u6708\u3002 2020\u5e743\u67083\u6708\uff08MSL\uff0335\uff09\u306e\u96fb\u5b50\u30e1\u30fc\u30eb\u6279\u51c6 \u2191 H.B\u00fcning\u3001L\u3002Perabou\u3002 a\u3002\uff1a \u30a2\u30c7\u30ce\u95a2\u9023\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u6700\u8fd1\u306e\u958b\u767a\u3002 \u306e\uff1a \u30b8\u30e3\u30fc\u30ca\u30eb\u30aa\u30d6\u30b8\u30fc\u30f3\u30e1\u30c7\u30a3\u30b7\u30f3\u3002 \u30d0\u30f3\u30c910\u3001\u756a\u53f77\u30012008\u5e747\u6708\u3001S\u3002717\u2013733\u3002 doi\uff1a10.1002 \/ jgm.1205 \u3002 PMID 18452237 \u3002 \uff08\u30ec\u30d3\u30e5\u30fc\uff09\u3002 \u2191 D. R. Deyle\u3001D\u3002W\u3002Russell\uff1a \u30a2\u30c7\u30ce\u95a2\u9023\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u306e\u7d71\u5408\u3002 \u306e\uff1a \u5206\u5b50\u6cbb\u7642\u306b\u304a\u3051\u308b\u73fe\u5728\u306e\u610f\u898b\u3002 \u30d0\u30f3\u30c911\u3001\u30ca\u30f3\u30d0\u30fc4\u30012009\u5e748\u6708\u3001pp\u3002442\u2013447\u3001 PMID 19649989 \u3001 PMC 2929125 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\uff08\u30ec\u30d3\u30e5\u30fc\uff09\u3002 \u2191 Stephen Russell et al\u3002\uff1a RPE65\u3092\u4ecb\u3057\u305f\u907a\u4f1d\u6027\u7db2\u819c\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\u60a3\u8005\u306b\u304a\u3051\u308b\u30dc\u30ec\u30c1\u30b2\u30f3NeParvovec\uff08AAV2-HRPE65V2\uff09\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\uff1a\u7121\u4f5c\u70ba\u5316\u3001\u5236\u5fa1\u3055\u308c\u305f\u3001\u975e\u76f2\u691c\u3001\u7b2c3\u76f8\u8a66\u9a13 \u3002\u306e\uff1a \u30e9\u30f3\u30bb\u30c3\u30c8\uff08\u30a4\u30ae\u30ea\u30b9\u3001\u30ed\u30f3\u30c9\u30f3\uff09 \u3002 \u30d0\u30f3\u30c9 390 \u3001 \u3044\u3044\u3048\u3002 10097 \u300126\u30022017\u5e748\u6708\u3001 S. 849\u2013860 \u3001doi\uff1a 10.1016\/S0140-6736\uff0817\uff0931868-8 \u3001 PMID 28712537 \u3001 PMC 5726391 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\u3002 \u2191 M.\u30c9\u30df\u30cb\u30af\u30d5\u30a3\u30c3\u30b7\u30e3\u30fc et al\u3002 \uff1a \u30a2\u30b0\u30ed\u30de\u30c8\u30d7\u30b7\u30a2\u306e\u30b3\u30fc\u30f3\u5149\u53d7\u5bb9\u4f53\u3092\u6a19\u7684\u3068\u3059\u308b\u7db2\u819c\u4e0b\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u5b89\u5168\u6027\u3068\u8996\u529b\u8ee2\u5e30\uff1a\u975e\u30e9\u30f3\u30c0\u30e0\u5316\u5bfe\u7167\u8a66\u9a13 \u3002\u306e\uff1a \u30b8\u30e3\u30de\u773c\u79d1 \u3002 30. 2020\u5e744\u6708\u30012\uff1a 10.1001\/Jamaophthalmol.2020.1032 \u3001 PMID 32352493 \u3001 PMC 7193523 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\u3002 \u52a0\u3048\u3066\uff1a\u8a18\u4e8b\u306f\u8aa4\u3063\u3066\u3044\u307e\u3059 \u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9 \u6b63\u3057\u3044\u4ee3\u308f\u308a\u306b \u30a2\u30c7\u30ce\u95a2\u9023\u30a6\u30a4\u30eb\u30b9 \uff08AAV\uff09\u3002 AAV\u306f\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001i\u304c\u767a\u751f\u3057\u307e\u3059\u3002 d\u3002 R.\u5f7c\u3089\u3068\u4e00\u7dd2\u306b\u306e\u307f\uff08\u6383\u9664\u9b5a\u306e\u3088\u3046\u306b\u30b5\u30e1\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff09\u3002 \u2191 \u30de\u30ea\u30fc\u30ca\u30fb\u30d1\u30d6\u30e9\u3001\u30af\u30ea\u30b9\u30c1\u30e3\u30f3\u30fb\u30b7\u30a7\u30fc\u30f3 et al\u3002 \uff1a\u5149\u53d7\u5bb9\u4f53\u969c\u5bb3\u306e\u785d\u5b50\u4f53\u5185\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u305f\u3081\u306e\u65b0\u3057\u3044AAV Capsids\u3002 In\uff1aEMBO Molecular Medicine\u300122\u3002Februar2021; doi\uff1a10.15252\/emmm.202013392 \u3002\u52a0\u3048\u3066\uff1a \u2191 \u30a8\u30a4\u30ba\u306e\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6cd5\uff1a1\u56de\u306e\u6ce8\u5c04\u3067HIV\u3092\u5012\u3059 \u3002 ON\uff1a2022\u5e747\u67085\u65e5\u304b\u3089ScitechDaily\u3002\u51fa\u5178\uff1aTel-Aviv University\u3002 (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/15140#breadcrumbitem","name":"\u30a2\u30c7\u30ce\u95a2\u9023\u30a6\u30a4\u30eb\u30b9\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2"}}]}]