[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/2660#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/2660","headline":"\u591a\u62b5\u6297\u6027 – \u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2","name":"\u591a\u62b5\u6297\u6027 – \u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2","description":"before-content-x4 \u3044\u3064 \u591a\u62b5\u6297 \u533b\u5b66\u306e\uff08\u30e9\u30c6\u30f3\u8907\u5408\u6750\uff09\u306f\u3001\u7d30\u83cc\uff08\u7d30\u83cc\u307e\u305f\u306f\u30a6\u30a4\u30eb\u30b9\uff09\u306e\u6297\u751f\u7269\u8cea\u307e\u305f\u306f\u30a6\u30a4\u30eb\u30b9\u75c7\u306e\u8010\u6027\u306e\u4e00\u7a2e\u3067\u3059\uff09 SuperKeime \u3044\u304f\u3064\u304b\u306e\u7570\u306a\u308b\u6297\u751f\u7269\u8cea\u307e\u305f\u306f\u30a6\u30a4\u30eb\u30b9\u75c7\u306b\u920d\u611f\u3067\u3059\u3002\u3042\u306a\u305f\u306f\u307e\u305f\u3001mre\u7d30\u83cc\u3067\u3059\uff08 m ulti r \u65e2\u5b58 \u3068 rreger\uff09\u3002\u5c5e\u306e\u5358\u7d30\u80de\u5bc4\u751f\u866b\u306b\u3082\u540c\u3058\u3053\u3068\u304c\u5f53\u3066\u306f\u307e\u308a\u307e\u3059 \u30d7\u30e9\u30b9\u30e2\u30c7\u30a3\u30a6\u30e0 \u30de\u30e9\u30ea\u30a2\u306e\u75c5\u539f\u4f53\u306f\u5c5e\u3057\u307e\u3059\u3002 after-content-x4 Den Letzten Jahrzehnten Vor Allem","datePublished":"2019-02-03","dateModified":"2019-02-03","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/b\/b7\/Qsicon_Quelle.svg\/24px-Qsicon_Quelle.svg.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/b\/b7\/Qsicon_Quelle.svg\/24px-Qsicon_Quelle.svg.png","height":"24","width":"24"},"url":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/2660","wordCount":4221,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4\u3044\u3064 \u591a\u62b5\u6297 \u533b\u5b66\u306e\uff08\u30e9\u30c6\u30f3\u8907\u5408\u6750\uff09\u306f\u3001\u7d30\u83cc\uff08\u7d30\u83cc\u307e\u305f\u306f\u30a6\u30a4\u30eb\u30b9\uff09\u306e\u6297\u751f\u7269\u8cea\u307e\u305f\u306f\u30a6\u30a4\u30eb\u30b9\u75c7\u306e\u8010\u6027\u306e\u4e00\u7a2e\u3067\u3059\uff09 SuperKeime \u3044\u304f\u3064\u304b\u306e\u7570\u306a\u308b\u6297\u751f\u7269\u8cea\u307e\u305f\u306f\u30a6\u30a4\u30eb\u30b9\u75c7\u306b\u920d\u611f\u3067\u3059\u3002\u3042\u306a\u305f\u306f\u307e\u305f\u3001mre\u7d30\u83cc\u3067\u3059\uff08 m ulti r \u65e2\u5b58  \u3068 rreger\uff09\u3002\u5c5e\u306e\u5358\u7d30\u80de\u5bc4\u751f\u866b\u306b\u3082\u540c\u3058\u3053\u3068\u304c\u5f53\u3066\u306f\u307e\u308a\u307e\u3059 \u30d7\u30e9\u30b9\u30e2\u30c7\u30a3\u30a6\u30e0 \u30de\u30e9\u30ea\u30a2\u306e\u75c5\u539f\u4f53\u306f\u5c5e\u3057\u307e\u3059\u3002        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Den Letzten Jahrzehnten Vor Allem Multirestente Grampositive Bakterien\uff08Stichworte Mrsa\u3001Glykopeptid-Resistente Enterokokken Bzw. Vancomycin-Resistente Enterokokken\uff09als ausausl\u00f6servonnosokomianen didektionen\uff08 Standen\u3001Trifft Dies Dies Des 20.\u305d\u308c\u3089\u306e\u8010\u6027\u306f\u4e3b\u306b\u03b2-\u30e9\u30af\u30bf\u30de\uff08\u30d9\u30fc\u30bf\u30e9\u30af\u30bf\u30de\uff09\u306e\u7523\u751f\u306b\u57fa\u3065\u3044\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306f\u03b2-\u30e9\u30af\u30bf\u30e0\u6297\u751f\u7269\u8cea\u306e\u30b0\u30eb\u30fc\u30d7\u5185\u3067\u7279\u5b9a\u306e\u6709\u52b9\u6210\u5206\u3092\u5206\u89e3\u307e\u305f\u306f\u5909\u5316\u3055\u305b\u308b\u9175\u7d20\u3067\u3042\u308a\u3001\u3057\u305f\u304c\u3063\u3066\u52b9\u679c\u7684\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7279\u5225\u306a\u6ce8\u610f\u304c\u6255\u308f\u308c\u307e\u3059 \u62e1\u5f35\u30b9\u30da\u30af\u30bf\u30fc\u03b2-\u30e9\u30af\u30bf\u30de\u30bb\u30f3 \uff08ESBL\uff09\u306f\u3001\u30e9\u30af\u30bf\u30de\u30fc\u30bc\u306e\u3053\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u3001\u7279\u5b9a\u306e\u30da\u30cb\u30b7\u30ea\u30f3\uff08\u30d4\u30da\u30e9\u30b7\u30ea\u30f3\u306a\u3069\uff09\u3084\u30bb\u30d5\u30a1\u30ed\u30b9\u30dd\u30ea\u30f3\u306a\u3069\u306e\u3055\u3089\u306a\u308b\u6297\u751f\u7269\u8cea\u57fa\u3092\u8a31\u53ef\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u9175\u7d20\u306e\u907a\u4f1d\u60c5\u5831\u3092\u30b3\u30fc\u30c9\u5316\u3057\u305f\u907a\u4f1d\u5b50\u306f\u3001\u30d7\u30e9\u30b9\u30df\u30c9\u3092\u4ecb\u3057\u3066\u3001\u305d\u308c\u3089\u3092\u4ecb\u3057\u305f\u3053\u306e\u5f62\u614b\u306e\u6297\u751f\u7269\u8cea\u8010\u6027\u3092\u4ecb\u3057\u3066\u3001\u7570\u306a\u308b\u30b0\u30e9\u30e0\u9670\u6027\u7d30\u83cc\u7a2e\u9593\u3067\u4ea4\u63db\u3067\u304d\u307e\u3059\u3002 [\u521d\u3081] Robert Koch Institute\uff08RKI\uff09\u306e\u79d1\u5b66\u8005\u306f\u30012003\u5e74\u306bESBL\u306b\u95a2\u3059\u308b\u57fa\u790e\u7814\u7a76\u3068\u4e88\u9632\u306e\u7d50\u8ad6\u3001\u4f8b\u3048\u3070\u75c5\u9662\u306e\u885b\u751f\u4e0a\u306e\u51fa\u7248\u7269\u3092\u6307\u6458\u3057\u307e\u3057\u305f\u3002 [2] 2007\u5e74\u306e\u30b7\u30ea\u30fc\u30ba\u306eRKI \u75ab\u5b66\u901f\u5831 \u8178\u5185\u7d30\u83cc\u306b\u304a\u3051\u308b\u30bb\u30d5\u30a1\u30ed\u30b9\u30dd\u30ea\u30f3\u62b5\u6297\u6027\u306e\u5206\u5b50\u751f\u7269\u5b66\u7684\u57fa\u790e\u306e\u6982\u8981\u3002\u3059\u3067\u306b\u3053\u306e\u6587\u66f8\u3067\u306f\u3001\u03b2-\u30e9\u30af\u30bf\u30e0\u3068\u30d5\u30eb\u30aa\u30eb\u30ad\u30ce\u30ed\u30f3\u62b5\u6297\u6027\u306e\u7d50\u5408\u306b\u63cf\u304b\u308c\u3066\u3044\u307e\u3059\u3002 [3] \u30d5\u30eb\u30aa\u30eb\u30ad\u30ce\u30ed\u30f3\u306e\u6297\u751f\u7269\u8cea\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u03b2-\u30e9\u30af\u30bf\u30e0\u6297\u751f\u7269\u8cea\u3068\u306f\u7570\u306a\u308b\u5316\u5b66\u69cb\u9020\u3068\u7570\u306a\u308b\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u3044\u308f\u3086\u308b\u30b8\u30e3\u30a4\u30e9\u30fc\u30bc\u963b\u5bb3\u5264\u3067\u3059\u3002 21\u4e16\u7d00\u306e\u521d\u3081\u306b\u3001\u4e00\u90e8\u306e\u30e8\u30fc\u30ed\u30c3\u30d1\u8af8\u56fd\u306f\u3001\u30ab\u30eb\u30d0\u30da\u30fc\u30f3\u306b\u5bfe\u3059\u308b\u5225\u306e\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u6297\u751f\u7269\u8cea\u30b0\u30eb\u30fc\u30d7\u306b\u5bfe\u3059\u308b\u5e83\u7bc4\u306a\u62b5\u6297\u6027\u306b\u6c17\u3065\u304d\u307e\u3057\u305f\u3002\u305d\u308c\u3089\u306f\u3001\u30ab\u30eb\u30d0\u30da\u30cd\u30de\u30bb\u30f3\u3068\u547c\u3070\u308c\u308b\u7d30\u83cc\u9175\u7d20\u306b\u3088\u3063\u3066\u4e0d\u6d3b\u6027\u5316\u3055\u308c\u3066\u304a\u308a\u3001\u30b0\u30e9\u30e0\u9670\u6027\u306e\u7d30\u83cc\u3067\u518d\u3073\u767a\u751f\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u9175\u7d20\u306e\u91cd\u8981\u306a\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306f\u3001VIM\uff08Verona Integron Metallo-\u03b2-Lactamas\uff09\u304a\u3088\u3073NDM\uff08\u30cb\u30e5\u30fc\u30c7\u30ea\u30fc\u30e1\u30bf\u30ed-\u03b2-\u03b2-\u30e9\u30af\u30bf\u30de\uff09\u3068\u547c\u3070\u308c\u307e\u3059\u3002 [4] \u3057\u304b\u3057\u3001\u7d30\u83cc\u306e\u5f8c\u3067\u3082\u3001\u540d\u524d\u306e\u9175\u7d20\u306f\u3053\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u3002 B. Klebsiella pneumoniae Carbapenemase\uff08KPC\uff09\u3067\u3059\u304c\u3001\u305d\u306e\u767a\u751f\u306f\u305d\u3046\u3067\u306f\u3042\u308a\u307e\u305b\u3093 Klebsiella pneumoniae \u9650\u3089\u308c\u305f\u307e\u307e\u3067\u3057\u305f\u3002 [\u521d\u3081] \u30b0\u30e9\u30e0\u9670\u6027\u7d30\u83cc\u306e\u591a\u62b5\u6297\u306f\u3001\u975e\u5e38\u306b\u591a\u304f\u306e\u7570\u306a\u308b\u8010\u6027\u907a\u4f1d\u5b50\u307e\u305f\u306f\u9175\u7d20\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u305f\u3081\u3001\u8010\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u306f\u306a\u304f\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u6297\u751f\u7269\u8cea\u30b0\u30eb\u30fc\u30d7\u304c\u8010\u6027\u306b\u7126\u70b9\u3092\u5f53\u3066\u308b\u65b0\u3057\u3044\u5b9a\u7fa9\u304c\u5fc5\u8981\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u306e\u5b9a\u7fa9\u306b\u3064\u306a\u304c\u308a\u307e\u3057\u305f m ulti r esistenten g RAM n 2012\u5e74\u306b\u516c\u958b\u3055\u308c\u305fRKI\u306b\u8a2d\u7f6e\u3055\u308c\u305f\u75c5\u9662\u306e\u885b\u751f\u304a\u3088\u3073\u611f\u67d3\u4e88\u9632\u59d4\u54e1\u4f1a\uff08Krinko\uff09\u306b\u3088\u308b\u30a8\u30b0\u30c6\u30a3\u30d6\u30ed\u30c3\u30c9\u30d0\u30af\u30c6\u30ea\u30a2\uff08MRGN\uff09\u3002 4\u3064\u306e\u6297\u751f\u7269\u8cea\u30b0\u30eb\u30fc\u30d7\u304c\u5b9a\u7fa9\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u30b0\u30e9\u30e0\u9670\u6027\u83cc\uff08\u8178\u5185\u83cc\u306e\u30e1\u30f3\u30d0\u30fc\u3068\u305d\u306e\u305f\u3081\u3001\u975e\u767a\u9175\u5264\u306e\u4e21\u65b9\uff09\u306b\u91cd\u5ea6\u306e\u611f\u67d3\u75c7\u304c\u767a\u751f\u3057\u305f\u5834\u5408\u306b\u81e8\u5e8a\u7684\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002 [\u521d\u3081]        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4\u4e16\u754c\u4e2d\u3067\u8a00\u53ca\u3055\u308c\u3066\u3044\u308b\u3053\u308c\u3089\u306e\u591a\u62b5\u6297\u6027\u75c5\u539f\u4f53\u306b\u52a0\u3048\u3066\u3001\u6df1\u523b\u306a\u611f\u67d3\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u75c5\u539f\u4f53\u306e\u591a\u8010\u6027\u3082\u5927\u304d\u306a\u554f\u984c\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u75c5\u6c17\u306f\u30c9\u30a4\u30c4\u3084\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u306f\u307e\u308c\u3067\u3042\u308b\u305f\u3081\u3001\u5831\u544a\u306e\u7126\u70b9\u3067\u306f\u200b\u200b\u3042\u308a\u307e\u305b\u3093\u3002\u4f8b\u306f\u591a\u62b5\u6297\u304c\u3042\u308a\u307e\u3059 Mycobacterium\u7d50\u6838  – \u30c8\u30e9\u30f3\u30af\uff08\u7d50\u6838\u306e\u75c5\u539f\u4f53\uff09\u307e\u305f\u306f\u5c5e\u304b\u3089\u306e\u500b\u3005\u306e\u75c5\u539f\u4f53 \u30d7\u30e9\u30b9\u30e2\u30c7\u30a3\u30a6\u30e0 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       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4SARI\u30d7\u30ed\u30b0\u30e9\u30e0\uff08\u4ee5\u4e0b\u3092\u53c2\u7167\uff09\u3067\u306f\u300113\u306e\u983b\u7e41\u306a\u75c5\u539f\u4f53\u3068\u305d\u306e\u6297\u751f\u7269\u8cea\u8010\u6027\u306b\u3064\u3044\u3066\u30b5\u30f3\u30d7\u30eb\u304c\u8abf\u3079\u3089\u308c\u307e\u3059\u3002 \u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc \u3001 \u80ba\u708e\u9023\u9396\u7403\u83cc \u3001\u30b3\u30a2\u30b0\u30e9\u30fc\u30bc\u9670\u6027\u30d6\u30c9\u30a6\u7403\u83cc\u3001 \u8178\u7403\u83cc\u7cde\u4fbf \u3001 Enterococcus faecalis \u3001 \u5927\u8178\u83cc \u3001 Klebsiella pneumoniae \u3001 Enterobacter cloacae \u3001 Serratia Marcescens \u3001 Citrobacter spp\u3002\u3001 Pseudomonas aeruginosa \u3001 acinetobacter baumannii \u3068 \u30b9\u30c6\u30ce\u30c8\u30ed\u30d5\u30a9\u30e2\u30ca\u30b9\u30de\u30eb\u30c8\u30d5\u30a3\u30ea\u30a2 \uff08\u30b9\u30bf\u30f3\u30c92015\uff09\u3002 [5] 2008\u5e74\u306bCharit\u00e9Berlin\u306f\u3001\u885b\u751f\u74b0\u5883\u533b\u5b66\u7814\u7a76\u6240\u3067\u306e\u56fd\u7acb\u53c2\u7167\u9662\u5185\u611f\u67d3\u30bb\u30f3\u30bf\u30fc\u306e\u76e3\u8996\u30bb\u30f3\u30bf\u30fc\u306b\u3088\u3063\u3066\u8abf\u6574\u3055\u308c\u305fKISS\u30b7\u30b9\u30c6\u30e0\uff08\u75c5\u9662\u611f\u67d3\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\uff09\u3092\u8abf\u6574\u3057\u307e\u3057\u305f\u3002 [6] \u75c5\u539f\u4f53\u7fa4\u306e\u9078\u629e\u306f\u3001\u591a\u8010\u6027\u30b0\u30e9\u30e0\u9670\u6027\u83cc\u3092\u4ecb\u3057\u3066\u65b0\u3057\u3044\u6240\u898b\u306b\u9069\u5fdc\u3057\u3001\u73fe\u5728\u306f\u30d0\u30f3\u30b3\u30de\u30a4\u30b7\u30f3\u8010\u6027\u8178\u7403\u83cc\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\uff08 Enterococcus faecalis \u3068 \u8178\u7403\u83cc\u7cde\u4fbf \uff09\u30013MRGN\u304a\u3088\u30734MRGN; MRSA\u306f\u3001\u5225\u306e\u30e2\u30b8\u30e5\u30fc\u30ebMRSA Kiss\uff082015\u5e74\u73fe\u5728\uff09\u306b\u8a18\u9332\u3055\u308c\u3066\u3044\u307e\u3059\u3002 [5] Table of Contents\u30e1\u30c1\u30b7\u30ea\u30f3 – \u8010\u6027 \u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc \uff08MRSA\uff09\u30b9\u30bf\u30f3\u30d7 [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] Vancyycin-intermediored-sensible \u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc \uff08\u30d3\u30b6\uff09 – \u30c6\u30fc\u30de [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30d0\u30f3\u30b3\u30de\u30a4\u30b7\u30f3\u8010\u6027 \u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc \uff08VRSA\uff09\u30c8\u30e9\u30f3\u30af [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30d0\u30f3\u30b3\u30de\u30a4\u30b7\u30f3\u8010\u6027\u8178\u7403\u83cc\uff08VRE\uff09\u90e8\u65cf [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u62e1\u5f35\u3055\u308c\u305f\u30b9\u30da\u30af\u30c8\u30eb\u03b2-\u30e9\u30af\u30bf\u30de\u30fc\u30bc\uff08ESBL\uff09\u751f\u6210\u75c5\u539f\u4f53 [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] Carbapenem-Resistant Klebsiella pneumoniae \uff08KPC\uff09\u30c8\u30e9\u30f3\u30af [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30cb\u30e5\u30fc\u30c7\u30ea\u30fc\u30e1\u30bf\u30ed-\u03b2-\u30e9\u30af\u30bf\u30de\u30fc\u30bc1\uff08NDM-1\uff09\u30c8\u30e9\u30f3\u30af [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u591a\u62b5\u6297\u6027\u30b0\u30e9\u30e0\u9670\u6027\u7d30\u83cc\uff08MRGN\uff09 [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u3088\u308a\u591a\u304f\u306e\u554f\u984c\u306e\u7d30\u83cc [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u5065\u5eb7\u653f\u7b56\u5bfe\u7b56 [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u65b0\u3057\u3044\u6297\u751f\u7269\u8cea\u306e\u958b\u767a [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30e1\u30c1\u30b7\u30ea\u30f3 – \u8010\u6027 \u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc \uff08MRSA\uff09\u30b9\u30bf\u30f3\u30d7 [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] 1963\u5e74\u4ee5\u6765 \u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc  – \u30da\u30cb\u30b7\u30ea\u30f3\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8ceaII\uff08PBP IIA\uff09\u306b\u7a81\u7136\u5909\u7570\u304c\u3042\u308a\u3001\u3057\u305f\u304c\u3063\u3066\u3059\u3079\u3066\u306e\u30d9\u30fc\u30bf\u30e9\u30af\u30bf\u30e0\u6297\u751f\u7269\u8cea\uff08\u3044\u308f\u3086\u308b\u30d9\u30fc\u30bf\u30e9\u30af\u30bf\u30de\u30fc\u30bc\u30d5\u30a7\u30b9\u30c6\u30a3\u30d0\u30eb\u306b\u53cd\u5bfe\u3059\u308b\u3053\u3068\u3092\u542b\u3080\uff09\u304c\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4ed6\u306e\u30af\u30e9\u30b9\u306e\u6709\u52b9\u6210\u5206\u306b\u3082\u8010\u6027\u304c\u3042\u308b\u5834\u5408\u3001\u6cbb\u7642\u306e\u305f\u3081\u306e\u6e96\u5099\u306f\u308f\u305a\u304b\u3057\u304b\u3042\u308a\u307e\u305b\u3093\uff08\u305f\u3068\u3048\u3070\u3001\u30b0\u30ea\u30b3\u30da\u30d7\u30c1\u30c9\u306a\u3069\u306e\u30b0\u30ea\u30b3\u30da\u30d7\u30c1\u30c9\u3001\u307e\u305f\u306f\u30b0\u30ea\u30b7\u30eb\u30b7\u30af\u30ea\u30f3\u306e\u30af\u30e9\u30b9\u304b\u3089\u306e\u30aa\u30ad\u30b5\u30be\u30ea\u30b8\u30ce\u30f3\u3084\u30c1\u30b2\u30b7\u30af\u30ea\u30f3\u306e\u30af\u30e9\u30b9\u306e\u30af\u30e9\u30b9\u304b\u3089\u306e\u30ea\u30cd\u30be\u30ea\u30c9\u306a\u3069\uff09\u3002MRSA\u306f\u73fe\u5728\u3001\u4e16\u754c\u4e2d\u3067\u767a\u898b\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u96c6\u4e2d\u6cbb\u7642\u85ac\u3067\u306f\u3053\u308c\u307e\u3067\u4ee5\u4e0a\u306b\u5927\u304d\u306a\u554f\u984c\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7c73\u56fd\u306e\u96c6\u4e2d\u6cbb\u7642\u5ba4\u3067\u306e\u75c5\u6c17\u306e\u983b\u5ea6\uff08\u767a\u751f\u7387\uff09\u306f\u3001\u3059\u3067\u306b\u5357\u30e8\u30fc\u30ed\u30c3\u30d1\u3068\u30d5\u30e9\u30f3\u30b9\u3067\u306f30\uff05\u4ee5\u4e0a\u306750\uff05\u3092\u8d85\u3048\u3066\u3044\u307e\u3059\u3002\u30c9\u30a4\u30c4\u3067\u306f\u3001\u75c5\u9662\u3067\u306e\u767a\u751f\u7387\u306f\u7d0415\u301c20\uff05\u3067\u3059\u304c\u3001\u5730\u57df\u7684\u306b\u5927\u304d\u306a\u5909\u52d5\u306e\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002 MRSA\u306f\u3001\u9ad8\u9f62\u8005\u304a\u3088\u3073\u990a\u8b77\u65bd\u8a2d\u306e\u3059\u3079\u3066\u306e\u5c45\u4f4f\u8005\u306e\u7d042.5\uff05\u3067\u65ad\u71b1\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002 MRSA\u306f\u3001\u76ae\u819a\u611f\u67d3\u75c7\u3001\u8edf\u90e8\u7d44\u7e54\u3001\u304a\u3088\u3073\u533b\u5b66\u7684\u4ecb\u5165\u306b\u3088\u308b\u611f\u67d3\u75c7\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u7406\u7531\u3067\u3059\u3002 [7] \u4ed6\u306e\u4eba\u306e\u3088\u3046\u306b S. aureus  –  MRSA\u306f\u3001\u60a3\u8005\u304c\u75c5\u6c17\u306b\u306a\u308b\u3053\u3068\u306a\u304f\u3001\u9f3b\u3068\u5589\u306e\u7c98\u819c\u306e\u6c88\u964d\u80da\u306e\u3088\u3046\u306b\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4ed6\u306e\u514d\u75ab\u4e0d\u5168\u60a3\u8005\u304c\u611f\u67d3\u3067\u304d\u308b\u751f\u6b96\u8caf\u7559\u5c64\u304c\u751f\u6210\u3055\u308c\u307e\u3059\u3002\u75c5\u9662\u306e\u30b9\u30bf\u30c3\u30d5\u306e\u751f\u6b96\u548c\u89e3\u306f\u7279\u306b\u5371\u967a\u3067\u3059\u3002\u306a\u305c\u306a\u3089\u3001\u3053\u308c\u306f\u514d\u75ab\u4e0d\u8db3\u306e\u60a3\u8005\u306e\u611f\u67d3\u306e\u7d99\u7d9a\u7684\u306a\u30ea\u30b9\u30af\u3067\u3042\u308b\u305f\u3081\uff08\u305f\u3068\u3048\u3070\u3001\u958b\u3044\u305f\u5275\u50b7\u3001\u8840\u7ba1\u5185\u30ab\u30c6\u30fc\u30c6\u30eb\u3001\u900f\u6790\u307e\u305f\u306f\u63db\u6c17\u306e\u5834\u5408\uff09\u3002MRSA\u90e8\u65cf\u306b\u5bfe\u3059\u308b\u6297\u751f\u7269\u8cea\u306e\u3055\u3089\u306a\u308b\u958b\u767a\u306f\u8003\u3048\u3089\u308c\u307e\u3059\u3002 [8] [9] Vancyycin-intermediored-sensible \u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc \uff08\u30d3\u30b6\uff09 – \u30c6\u30fc\u30de [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u6570\u5e74\u524d\u304b\u3089\u65e5\u672c\u3067MRSA\u90e8\u65cf\u304c\u767a\u751f\u3057\u3066\u304a\u308a\u3001\u30b0\u30ea\u30b3\u30da\u30d7\u30c1\u30c9\u306b\u5bfe\u3059\u308b\u4ef2\u4ecb\u8005\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u7c73\u56fd\u3001\u30d5\u30e9\u30f3\u30b9\u3001\u9999\u6e2f\u3001\u30bf\u30a4\u3067\u3082\u500b\u3005\u306e\u75c7\u4f8b\u304c\u767a\u751f\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30c8\u30e9\u30f3\u30af\u304c\u3055\u3089\u306b\u5e83\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u30d0\u30f3\u30b3\u30de\u30a4\u30b7\u30f3\u8010\u6027 \u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc \uff08VRSA\uff09\u30c8\u30e9\u30f3\u30af [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u5b9f\u969b\u306b\u30d0\u30f3\u30b3\u30de\u30a4\u30b7\u30f3\u8010\u6027\u306e S. aureus -Traces\uff08VRSA\uff09\u306f\u3001\u7c73\u56fd\u3067\u3057\u304b\u8a18\u8ff0\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u30d3\u30b6\u90e8\u65cf\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u305d\u308c\u3089\u306f\u30d0\u30f3\u30b3\u30de\u30a4\u30b7\u30f3\/\u30b0\u30ea\u30b3\u30da\u30d7\u30c1\u30c9\u8010\u6027\u8178\u7403\u83cc\uff08VRE\/GRE\uff09\u306b\u7531\u6765\u3059\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u306b\u3088\u3063\u3066\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u307e\u3059\u3002 \u5e74 -Gen Own\u3002 \u30d0\u30f3\u30b3\u30de\u30a4\u30b7\u30f3\u8010\u6027\u8178\u7403\u83cc\uff08VRE\uff09\u90e8\u65cf [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u3053\u306e\u8010\u6027\u7d30\u83cc\u57fa\u306f\u3001\u30b0\u30ea\u30b3\u30da\u30d7\u30c1\u30c9\u8010\u6027\u8178\u7403\u83cc\uff08GRE\uff09\u3068\u3082\u547c\u3070\u308c\u3001\u30d0\u30f3\u30b3\u30de\u30a4\u30b7\u30f3\u306f\u7cd6\u30da\u30d7\u30c1\u30c9\u6297\u751f\u7269\u8cea\u306e\u6709\u52b9\u6210\u5206\u7fa4\u306e\u6709\u540d\u306a\u4ee3\u8868\u3067\u3059\u3002\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u7a2e\u985e\u306f\u3001\u30b0\u30e9\u30e0\u967d\u6027\u5c5e\u8178\u7403\u83cc\u306e\u4ee3\u8868\u8005\u3067\u3059\u3002 Enterococcus faecalis \u3068 \u8178\u7403\u83cc\u7cde\u4fbf \u3002 2011\u5e74\u3001\u5f7c\u3089\u306f\u96c6\u4e2d\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u6d41\u306e\u611f\u67d3\u306e2\u756a\u76ee\u306b\u4e00\u822c\u7684\u306a\u75c5\u539f\u4f53\u3067\u3057\u305f\u3002\u4e88\u9632\u63a5\u7a2e\u3084\u91cd\u75c5\u60a3\u8005\u306f\u3057\u3070\u3057\u3070\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002\u75c5\u9662\u306b\u56fa\u6709\u306e\u3044\u308f\u3086\u308b\u75c5\u9662\u95a2\u9023\u306e\u30c8\u30e9\u30f3\u30af\u304c\u3042\u308a\u307e\u3059\u3002\u4eba\u9593\u306e\u8178\u5185\u7d30\u83cc\u53e2\u307e\u305f\u306f\u76ae\u819a\u690d\u7269\u306e\u4e00\u90e8\u306b\u306a\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u548c\u89e3\u90e8\u65cf\u3068\u6bd4\u8f03\u3057\u3066\u3001\u5f7c\u3089\u306f\u3088\u308a\u9ad8\u3044\u6297\u751f\u7269\u8cea\u8010\u6027\u7387\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u30b0\u30ea\u30b3\u30da\u30d7\u30c1\u30c9\u6297\u751f\u7269\u8cea\u306b\u52a0\u3048\u3066\u3001\u305d\u308c\u3089\u306f\u30a2\u30df\u30ce\u30b0\u30ea\u30b3\u30b7\u30c9\u3068\u30d9\u30fc\u30bf\u30e9\u30af\u30bf\u30e0\u6297\u751f\u7269\u8cea\u306b\u8010\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30c9\u30a4\u30c4\u306e\u76e3\u8996\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u9662\u5185\u611f\u67d3\u75c7\u3067\u5b64\u7acb\u3057\u305f11\u301c13\uff05\u306f E. FAEC \u30d0\u30f3\u30b3\u30de\u30a4\u30b7\u30f3\u306b\u8010\u6027\u304c\u3042\u308bSTAMMS\uff082008\u5e74\u73fe\u5728\uff09\u3002 [6] \u62e1\u5f35\u3055\u308c\u305f\u30b9\u30da\u30af\u30c8\u30eb\u03b2-\u30e9\u30af\u30bf\u30de\u30fc\u30bc\uff08ESBL\uff09\u751f\u6210\u75c5\u539f\u4f53 [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u62e1\u5f35\u3055\u308c\u305f\u30b9\u30da\u30af\u30c8\u30eb\u03b2-\u30e9\u30af\u30bf\u30de\u30fc\u30bc\u7523\u751f\u75c5\u539f\u4f53\u306f\u3001\u03b2-\u30e9\u30af\u30bf\u30de\u30fc\u30bc\u9175\u7d20\u304c\u767a\u73fe\u3057\u305f\u70b9\u7a81\u7136\u5909\u7570\u306b\u3088\u3063\u3066\u767a\u73fe\u3067\u304d\u308b\u30d0\u30af\u30c6\u30ea\u30a2\u3067\u3042\u308b\u30d0\u30af\u30c6\u30ea\u30a2\u3067\u3059\u3002 \u62e1\u5f35\u30b9\u30da\u30af\u30c8\u30eb\u03b2-\u30e9\u30af\u30bf\u30de\u30fc\u30bc \u751f\u7523\u3059\u308b\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u9175\u7d20\u304c\u5909\u5316\u3059\u308b\u3068\u3001\u03b2-\u30e9\u30af\u30bf\u30e0\u542b\u6709\u6297\u751f\u7269\u8cea\u306e\u3088\u308a\u5927\u304d\u306a\u30b9\u30da\u30af\u30c8\u30eb\u3092\u5206\u5272\u3067\u304d\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u7d30\u83cc\u306e\u8ca0\u8377\u3092\u8ca0\u62c5\u3059\u308b\u3053\u3068\u306f\u3001\u30da\u30cb\u30b7\u30ea\u30f3\u3001\u30bb\u30d5\u30a1\u30ed\u30b9\u30dd\u30ea\u30f3\uff08\u751f\u62101\u301c4\uff09\u304a\u3088\u3073\u30e2\u30ce\u30d0\u30af\u30bf\u30e1\u30f3\u306b\u5bfe\u3057\u3066\u8010\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4e3b\u306b \u305d\u3057\u3066..\u5927\u8178\u83cc \u30af\u30ea\u30fc\u30d6\u30b9\uff08\u30b0\u30e9\u30e0\u9670\u6027\u7d30\u83cc\uff09\u306b\u306fESBL\u907a\u4f1d\u5b50\u304c\u3042\u308a\u307e\u3059\u3002 Carbapenem-Resistant Klebsiella pneumoniae \uff08KPC\uff09\u30c8\u30e9\u30f3\u30af [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] 2001\u5e74\u306b\u6700\u521d\u306e\u3082\u306e\u304c\u7279\u5b9a\u306e\u3082\u306e\u3067\u3057\u305f Klebsiella pneumoniae -Tamm\u306e\u30ab\u30eb\u30d0\u30da\u30cd\u30de\u30fc\u30bc\u306e\u5f62\u6210\uff08 Carbapenem-Hedrololzing beta-Lactamase \uff09\u3001SO -Caled KPC\u3001\u89b3\u5bdf\u3002 KPC\u306f\u3001\u7279\u5b9a\u306e\u6297\u751f\u7269\u8cea\u3067\u3042\u308b\u30ab\u30eb\u30d0\u30da\u30cd\u30e0\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30af\u30ea\u30fc\u30d6\u30b9\uff08\u30b0\u30e9\u30e0\u9670\u6027\u83cc\uff09\u306b\u8010\u6027\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306b\u306f\u3001\u305f\u3068\u3048\u3070\u3001\u85ac\u7269\u3084\u30e1\u30ed\u30da\u30cd\u30e0\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u30ab\u30eb\u30d0\u30da\u30cd\u30de\u30fc\u30bc\u306e\u6d3b\u6027\u306f\u3001\u30af\u30e9\u30d6\u30e9\u30f3\u9178\u306e\u5b58\u5728\u4e0b\u3067\u6291\u5236\u3055\u308c\u307e\u3059\u3002\u691c\u67fb\u3055\u308c\u305fCarbapenemor Klebsiella pneumoniae -Tribe\uff08 Carbapenem-Resistant Klebsiella pneumoniae \u3001CRKP\uff09\u300c1534\u300d\u306f\u3001\u3059\u3079\u3066\u306e\u30bb\u30d5\u30a1\u30ed\u30b9\u30dd\u30ea\u30f3\u3068\u30a2\u30ba\u30c8\u30ec\u30aa\u30ca\u30e0\u306b\u5bfe\u3059\u308b\u8010\u6027\u3092\u793a\u3057\u7d9a\u3051\u305f\u305f\u3081\u3001\u591a\u304f\u306e\u73fe\u4ee3\u306e\u6297\u751f\u7269\u8cea\u306b\u306f\u5927\u90e8\u5206\u304c\u920d\u611f\u3067\u3059\u3002 [\u5341] KPC-1\u3001KPC-2\u3001KPC-3\u306a\u3069\u3001Klebsielle Carbapenemase\u306e\u3055\u307e\u3056\u307e\u306a\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002 [11] [12\u756a\u76ee] \u30cb\u30e5\u30fc\u30c7\u30ea\u30fc\u30e1\u30bf\u30ed-\u03b2-\u30e9\u30af\u30bf\u30de\u30fc\u30bc1\uff08NDM-1\uff09\u30c8\u30e9\u30f3\u30af [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u5c02\u9580\u96d1\u8a8c\u300cThe Lancet\u300d\u306e\u8a18\u4e8b\u306b\u3088\u308b\u3068\u3001NDM-1\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u907a\u4f1d\u5b50\u3092\u6301\u3064\u7d30\u83cc\u682a\u306f\u4e16\u754c\u4e2d\u3067\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002 \u30c6\u30a3\u30b2\u30b7\u30af\u30ea\u30f3 \u3068 \u30b3\u30ea\u30b9\u30c1\u30f3 \u3001\u8010\u6027\u304c\u3042\u308b\u306f\u305a\u3067\u3059\u3002 [13] \u3053\u308c\u307e\u3067\u306e\u3068\u3053\u308d\u3001\u907a\u4f1d\u5b50\u306f\u30b0\u30e9\u30e0\u9670\u6027\u8178\u83cc\u306b\u3042\u308a\u307e\u3057\u305f \u5927\u8178\u83cc \u3068 Klebsiella pneumoniae \u7279\u306b\u30a4\u30f3\u30c9\u3068\u30d1\u30ad\u30b9\u30bf\u30f3\u306b\u767b\u5834\u3057\u3001\u5e83\u304c\u308a\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u30a4\u30ae\u30ea\u30b9\u3001\u30aa\u30e9\u30f3\u30c0\u3001\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u3001\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u306e\u75c7\u4f8b\u306f\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u65e7\u30a2\u30b8\u30a2\u8af8\u56fd\u3067\u306e\u624b\u8853\uff08\u7279\u306b\u7f8e\u5bb9\u624b\u8853\uff09\u306e\u5f8c\u306b\u3059\u3067\u306b\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u591a\u62b5\u6297\u6027\u30b0\u30e9\u30e0\u9670\u6027\u7d30\u83cc\uff08MRGN\uff09 [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30b0\u30e9\u30e0\u9670\u6027\u83cc\u306e\u307e\u3059\u307e\u3059\u591a\u304f\u306e\u7570\u306a\u308b\u8010\u6027\u907a\u4f1d\u5b50\u306f\u30012012\u5e74\u306b\u516c\u958b\u3055\u308c\u305f\u75c5\u9662\u306e\u885b\u751f\u59d4\u54e1\u4f1a\u3068\u611f\u67d3\u4e88\u9632\u59d4\u54e1\u4f1a\uff08Krinko\uff09\u306b\u3088\u308b\u65b0\u3057\u3044\u5b9a\u7fa9\u3092\u3082\u305f\u3089\u3057\u3001MRGN\u306f\u3053\u306e\u7d30\u83cc\u7fa4\u306e\u7565\u8a9e\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002 [\u521d\u3081] \u82f1\u8a9e\u306e\u51fa\u7248\u7269\u3067\u306f\u3001MDR\uff08\u300c\u591a\u5264\u8010\u6027\u300d\uff09\u307e\u305f\u306fMDRGN\u3068\u3044\u3046\u540d\u524d\u3082\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u30af\u30ea\u30f3\u30b3\u5b9a\u7fa9\u306f\u3001\u30b0\u30e9\u30e0\u9670\u6027\u83cc\uff08\u8178\u5185\u83cc\u3068\u3044\u308f\u3086\u308b\u975e\u767a\u9175\u56e0\u5b50\u306e\u4e21\u65b9\u306e\u30e1\u30f3\u30d0\u30fc\uff09\u306e\u91cd\u5ea6\u306e\u611f\u67d3\u306b\u4f7f\u7528\u3055\u308c\u3001\u57fa\u6e963MRGN\uff084\u3064\u306e\u6297\u751f\u7269\u8cea\u30b0\u30eb\u30fc\u30d7\u306e\u3046\u30613\u3064\u306b\u5bfe\u3059\u308b\u8010\u6027\uff09\u304a\u3088\u30734MRGN\uff084\u3064\u306e\u6297\u751f\u30b0\u30eb\u30fc\u30d7\u306b\u8010\u6027\uff09\u3092\u30ea\u30b9\u30c8\u3057\u305f4\u3064\u306e\u533b\u5b66\u7684\u306b\u95a2\u9023\u3059\u308b\u6297\u751f\u7269\u8cea\u30b0\u30eb\u30fc\u30d7\u3092\u5b9a\u7fa9\u3057\u307e\u3059\u3002\u9023\u90a6\u5065\u5eb7\u306e\u8cac\u4efb\u306b\u63b2\u8f09\u3055\u308c\u305f\u30af\u30ea\u30f3\u30b3\u306e\u63a8\u5968\u4e8b\u9805\u3067 MRGN\u3068\u306e\u611f\u67d3\u307e\u305f\u306f\u548c\u89e3\u306e\u885b\u751f\u63aa\u7f6e \u3044\u304f\u3064\u304b\u306e\u4f8b\u3092\u4f7f\u7528\u3057\u3066\u3001\u88683\u306b\u30ea\u30b9\u30c8\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6761\u4ef6\u3067\u306f\u3001\u7d30\u83cc\u304c3MRGN\u307e\u305f\u306f4MRG\u306e\u610f\u5473\u3067\u591a\u62b5\u6297\u6027\u3068\u3057\u3066\u5206\u985e\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u8010\u6027\u304c\u3042\u308b\u6297\u751f\u7269\u8cea\u306b\u5fdc\u3058\u3066\u884c\u308f\u308c\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u30ea\u30b9\u30c8\u3055\u308c\u3066\u3044\u308b\u7d30\u83cc\u7a2e\u304c\u3042\u308a\u307e\u3059\u3002 acinetobacter baumannii \uff08\u975e\u767a\u9175\u5264\uff093mrgn\u3068\u3057\u3066 A. baumannii \u30d4\u30da\u30e9\u30b7\u30ea\u30f3\u3001\u30bb\u30d5\u30a9\u30bf\u30ad\u30b7\u30e0\u3001\u30b7\u30d7\u30ed\u30d5\u30ed\u30ad\u30b5\u30b7\u30f3\u306b\u5bfe\u3059\u308b\u8010\u6027\uff08R\uff09\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u30a4\u30df\u30da\u30cd\u30e0\u3084\u30e1\u30ed\u30da\u30cd\u30e0\u3068\u6bd4\u8f03\u3057\u3066\u654f\u611f\u3067\u3059\u3002 4mrgn\u3068\u3057\u3066 A. baumannii \u30d4\u30da\u30e9\u30b7\u30ea\u30f3\u3001\u30bb\u30d5\u30bf\u30ad\u30b7\u30e0\u3001\u30a4\u30df\u30da\u30cd\u30e0\u3001\u30e1\u30ed\u30da\u30cd\u30e0\u3001\u30b7\u30d7\u30ed\u30d5\u30ed\u30ad\u30b5\u30b7\u30f3\u306b\u5bfe\u3059\u308b\u8010\u6027\uff08R\uff09\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u30b9\u30eb\u30d0\u30af\u30bf\u30e0\u3068\u6bd4\u8f03\u3057\u3066\u654f\u611f\u3067\u3059\uff08\u30b9\u30eb\u30d0\u30af\u30bf\u30e0\u306f\u591a\u62b5\u6297\u5b9a\u7fa9\u306b\u306f\u5165\u308a\u307e\u305b\u3093\uff09\u3002 [\u521d\u3081] A. baumannii \u80ba\u708e\uff08\u80ba\u708e\uff09\u3001\u5275\u50b7\u611f\u67d3\u75c7\u3001\u6557\u8840\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 [14] \u6570\u5e74\u524d\u307e\u3067\u3001\u7d30\u83cc\u306e\u767a\u751f\u7387\u30c7\u30fc\u30bf\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305f\u3060\u3057\u30012000\u5e74\u4ee5\u964d\u3001\u30b9\u30eb\u30fc A. baumannii \u4e3b\u306b\u30ab\u30eb\u30d0\u30da\u30cd\u30e0\u8010\u6027\u5206\u96e2\u682a\u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u305f\u9662\u5185\u611f\u67d3\u75c7\u306e\u767a\u751f\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3057\u305f\u3002\u306e\u5206\u6790 A. baumannii  – \u30c9\u30a4\u30c4\u306e\u5927\u5b66\u8a3a\u7642\u6240\u306e\u9694\u96e2\u306f\u30012006\u5e74\u306b9\uff05\u304c\u591a\u62b5\u6297\u6027\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u4e16\u754c\u4e2d\u306b\u96c6\u307e\u308a\u307e\u3057\u305f A. baumannii  – \u30bd\u30ec\u30fc\u30c8\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u30af\u30ed\u30fc\u30f3\u30e9\u30a4\u30f3\u3057\u304b\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3068\u308a\u308f\u3051\u8010\u6027\u907a\u4f1d\u5b50\u3002\u30ab\u30eb\u30d0\u30da\u30cd\u30e0\u8010\u6027\u306e\u539f\u56e0\u3067\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u7684\u306b\u540c\u4e00\u306e\u90e8\u65cf\u306e\u4e16\u754c\u7684\u306a\u62e1\u6563\u5f8c\u307e\u305f\u306f\u4e16\u754c\u7684\u306b\u63a1\u53d6\u3055\u308c\u307e\u3057\u305f\u3002\u306e\u907a\u4f1d\u7684\u7814\u7a76\u306e\u7d50\u679c A. baumannii  – \u75c5\u9662\u306e\u60a3\u8005\u3067\u898b\u3064\u304b\u3063\u305f\u5206\u6790\u306f\u3001\u6cbb\u7642\u671f\u9593\u4e2d\u306b\u306e\u307f\u548c\u89e3\u307e\u305f\u306f\u611f\u67d3\u304c\u884c\u308f\u308c\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 [\u521d\u3081] Pseudomonas aeruginosa \uff08\u975e\u767a\u9175\u5264\uff093mrgn\u3068\u3057\u3066 P. aeruginosa \u4e0a\u8a18\u306e4\u3064\u306e\u6297\u751f\u7269\u8cea\u30af\u30e9\u30b9\u306e\u3046\u30613\u3064\u306b\u5bfe\u3059\u308b\u8010\u6027\uff08R\uff09\u3092\u4f7f\u7528\u3057\u3066\u3001\u30d4\u30da\u30e9\u30b7\u30ea\u30f3\u3001\u30a4\u30df\u30da\u30cd\u30e0\u3001\u30e1\u30ed\u30da\u30cd\u30e0\u3001\u30b7\u30d7\u30ed\u30d5\u30ed\u30ad\u30b5\u30b7\u30f3\u3067\u3059\u304c\u3001\u30bb\u30d5\u30a1\u30b8\u30b8\u30e0\u304a\u3088\u3073\u30bb\u30d5\u30a7\u30d4\u30e0\u3068\u6bd4\u8f03\u3057\u3066\uff08S\uff09\u307e\u305f\u306f\uff08i =\u66dd\u9732\u306e\u5897\u52a0\uff09\u3002 4mrgn\u3068\u3057\u3066 P. aeruginosa 4\u3064\u306e\u6297\u751f\u7269\u8cea\u30af\u30e9\u30b9\u306e\u3059\u3079\u3066\u3068\u6bd4\u8f03\u3057\u3066\u8010\u6027\uff08R\uff09\u3067\u30d4\u30da\u30e9\u30b7\u30ea\u30f3\u3001\u30bb\u30d5\u30a7\u30d4\u30e0\u3001\u30a4\u30df\u30da\u30cd\u30e0\u3001\u30b7\u30d7\u30ed\u30d5\u30ed\u30ad\u30b5\u30b7\u30f3\u3002\u4e2d\u9593\u306e\u7d50\u679c\u306f\u30012019\u5e74\u4ee5\u964d\u306e\u8010\u6027\u306e\u7d50\u679c\u3068\u3057\u3066\u306e\u8a55\u4fa1\u3067\u306f\u306a\u304f\u3001\u5b9a\u7fa9\u4e0a\u3001\u6a19\u6e96\u7684\u306a\u6295\u4e0e\u91cf\u3068\u6bd4\u8f03\u3057\u3066\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002 [15] \u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u306f\u3001\u691c\u67fb\u3055\u308c\u305f\u5206\u96e2\u682a\u306e16\uff05\u304c\u30e8\u30fc\u30ed\u30c3\u30d1\u306b\u3042\u308a\u307e\u3057\u305f P. aeruginosa 3MRGN\u307e\u305f\u306f4MRGN\u306e\u610f\u5473\u3067\u306e\u591a\u62b5\u6297\u6027\u3002 [\u521d\u3081] P. aeruginosa \u305d\u306e\u4ee3\u8b1d\u3068\u305d\u306e\u7d30\u80de\u819c\u69cb\u9020\u306e\u305f\u3081\u306b\u3001\u6297\u751f\u7269\u8cea\u306b\u5bfe\u3057\u3066\u8907\u6570\u306e\u8010\u6027\u3092\u6301\u3063\u3066\u3044\u308b\u75c5\u9662\u306e\u751f\u6b96\u3067\u3059\u3002 [16] \u3059\u3079\u3066\u306e\u75c5\u9662\u611f\u67d3\u75c7\u306e\u7d0410\uff05\u3067\u805e\u3044\u305f P. aeruginosa \u30c9\u30a4\u30c4\u3067\u6700\u3082\u4e00\u822c\u7684\u306a\u75c5\u9662\u7d30\u83cc\u306b\uff082008\u5e74\u73fe\u5728\uff09\u3002 [17] Klebsiella pneumoniae \uff08Enterobakterien\uff093mrgn\u3068\u3057\u3066 K.\u80ba\u708e \u30b7\u30d7\u30ed\u30d5\u30ed\u30ad\u30b5\u30b7\u30f3\uff08R\uff09\u304a\u3088\u3073ESBL\u3092\u4f7f\u7528\u3002 4mrgn\u3068\u3057\u3066 K.\u80ba\u708e \u30d4\u30da\u30e9\u30b7\u30ea\u30f3\uff08R\uff09\u3001\u30bb\u30d5\u30bf\u30ad\u30b7\u30e0\uff08R\uff09\u3001\u30a4\u30df\u30da\u30cd\u30e0\uff08R\uff09\u3001\u30e1\u30ed\u30da\u30cd\u30e0\uff08R\uff09\u3001\u30b7\u30d7\u30ed\u30d5\u30ed\u30ad\u30b5\u30b7\u30f3\uff08R\uff09\u3092\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u304c\u3001Ceftazidim\u3068\u6bd4\u8f03\u3057\u3066\u654f\u611f\u3067\u3059\uff08\u5b9a\u7fa9\u306b\u3088\u308b \u307e\u305f ceftazidim r sein\uff09\u3002 [\u521d\u3081] \u3053\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\u3001KPC\u682a\u3068\u3082\u547c\u3070\u308c\u307e\u3059\uff08\u4e0a\u8a18\u53c2\u7167\uff09\u3002 \u4ed6\u306e\u30bf\u30a4\u30d7\u306e\u8178\u5185\u7d30\u83cc\u306f\u30013MRGN\u307e\u305f\u306f4MRGN\u3088\u308a\u3082\u5206\u985e\u3055\u308c\u308b\u3053\u3068\u306f\u3081\u3063\u305f\u306b\u3042\u308a\u307e\u305b\u3093\u3002\u3067 \u30d7\u30ed\u30c6\u30a6\u30b9 spp\u3002 \uff08Z\u3002B. \u30d7\u30ed\u30c6\u30a6\u30b9\u7d20\u6674\u3089\u3057\u3044 \uff09\u3001\u3001 Morganella morganii \u3068 \u6442\u7406 spp\u3002\u30a4\u30df\u30da\u30cd\u30e0\u306b\u5bfe\u3059\u308b\u611f\u5ea6\u306e\u4f4e\u4e0b\u306f\u3001\u81ea\u7136\u306b\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u3053\u306e\u57fa\u790e\u3078\u306e\u5206\u985e\u306f3MRGN\u307e\u305f\u306f4MRGN\u3068\u3057\u3066\u306e\u307f\u3067\u3059\u304c\u3001\u3059\u3067\u306b\u30e1\u30ed\u30da\u30cd\u30e0\u3068\u306e\u95a2\u4fc2\u304c\u3042\u308a\u307e\u3059\u3002 Enterobacter cloacae \u3001 Enterobacter aerogenes \uff08\u73fe\u5728\u306e\u540d\u524d\u306f\u3067\u3059 Klebsiella aerogenes \uff09\u3001\u3001 Citrobacter Freundii \u3001 Serratia Marcescens \u307e\u305f\u306f\u3001\u67d3\u8272\u4f53AMPC\u3092\u6301\u3064\u4ed6\u306e\u7a2e\u3082\u3001\u3053\u306e\u907a\u4f1d\u5b50\u3092\u4ecb\u3057\u3066\u30bb\u30d5\u30a1\u30ed\u30b9\u30dd\u30ea\u30f3\u306b\u5bfe\u3057\u3066\u81ea\u7136\u306a\u8010\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u30b7\u30d7\u30ed\u30d5\u30ed\u30ad\u30b5\u30b7\u30f3\u306b\u3082\u8010\u6027\u304c\u3042\u308b\u5834\u5408\u306b\u306e\u307f\u30013MRGN\u3068\u547c\u3070\u308c\u307e\u3059\u3002 [\u521d\u3081] \u3088\u308a\u591a\u304f\u306e\u554f\u984c\u306e\u7d30\u83cc [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u591a\u8010\u6027\u30b0\u30e9\u30e0\u967d\u6027\u7d30\u83cc\uff08MRGP\/MDRGP\uff09 \u591a\u8010\u6027\u30b0\u30e9\u30e0\u9670\u6027\u83cc\u5c5e\u306e\u7d30\u83cc \u30ab\u30f3\u30d4\u30ed\u30d0\u30af\u30bf\u30fc \u30ab\u30f3\u30d4\u30ed\u30d0\u30af\u30c6\u30f3\u30c6\u30a3\u30b9\u708e\u306e\u539f\u56e0\u3068\u3057\u3066 [19] [20] \u5c5e\u306e\u7d30\u83cc \u30b5\u30eb\u30e2\u30cd\u30e9 \u3001\u4e00\u822c\u306b\u30b5\u30eb\u30e2\u30cd\u30e9\u3068\u547c\u3070\u308c\u3001\u4e0b\u75e2\u306e\u539f\u56e0\u3068\u3057\u3066\uff08\u4ee5\u524d\u306f\u591a\u8010\u6027\u682a\u306b\u52a0\u3048\u3066 salmonella choleraesuis [21] \u3068 \u30b5\u30eb\u30e2\u30cd\u30e9Typhimurium [22] \u4eca\u3082 \u30b5\u30eb\u30e2\u30cd\u30e9\u30fb\u30b5\u30f3\u30d1\u30a6\u30eb \u3068 \u30b5\u30eb\u30e2\u30cd\u30e9\u30a2\u30d2\u30eb \uff09\uff09 [23] \u30b5\u30eb\u30e2\u30cd\u30e9 SSP\u3002\u901a\u5e38\u3001\u9662\u5185\u611f\u67d3\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u306a\u3044\u305f\u3081\u3001MRGN\u306e\u30af\u30ea\u30f3\u30b3\u5b9a\u7fa9\u306b\u306f\u8a18\u9332\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001ESBL\u3068\u30ab\u30eb\u30d0\u30da\u30cd\u30e0\u8010\u6027\u3092\u6301\u3064\u7a2e\u304c\u3042\u308a\u307e\u3059\u3002 [\u521d\u3081] \u8178\u809d\u8840\u75c7\u306e\u3044\u304f\u3064\u304b\u306e\u6df1\u523b\u306a\u30b0\u30eb\u30fc\u30d7 \u5927\u8178\u83cc \u7d30\u83cc\uff08EHEC\uff09\u3001\u7279\u306b\u30b7\u30fc\u30b1\u30f3\u30b9\u578bST678\u306e\u75c5\u539f\u4f53\u90e8\u65cfHusec 41\u3001\u8840\u6e05\u578bO104\u3068\u3082\u547c\u3070\u308c\u307e\u3059\u3002 [24] 2016\u5e74\u306e\u521d\u3081\u306b\u3001\u30da\u30f3\u30b7\u30eb\u30d9\u30cb\u30a2\u5dde\u306e\u60a3\u8005\u306f\u30da\u30f3\u30b7\u30eb\u30d9\u30cb\u30a2\u5dde\u3067\u591a\u62b5\u6297\u6027\u304c\u3042\u308a\u307e\u3059 \u5927\u8178\u83cc Colistess\u306b\u8010\u6027\u304c\u3042\u308b\u7d30\u83cc\u304c\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u7d30\u83cc\u4f53\u5e79\u3067\u306f\u3001\u4ed6\u306e14\u306e\u8010\u6027\u907a\u4f1d\u5b50\u306b\u52a0\u3048\u3066\u3001MCR-1\u907a\u4f1d\u5b50\u304c2\u3064\u306e\u74b0\u578b\u907a\u4f1d\u7247\uff08\u30d7\u30e9\u30b9\u30df\u30c9\uff09\u3067\u898b\u3064\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d30\u83cc\u306f\u73fe\u5728\u3001\u6700\u5f8c\u306e\u4e88\u5099\u6297\u751f\u7269\u8cea\u306b\u5bfe\u3057\u3066\u8010\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7814\u7a76\u8005\u306b\u3088\u308b\u3068\u3001MCR-1\u306f\u672c\u5f53\u306b\u6c4e\u8010\u6027\u83cc\u306e\u5f62\u6210\u3092\u544a\u3052\u3066\u3044\u307e\u3059\u3002 [25] 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\u30b5\u30eb\u30e2\u30cd\u30e9 \u3001fluorchinolon-Resistent; Neisseria gonorrhoeae \u3001\u30bb\u30d5\u30a1\u30ed\u30b9\u30dd\u30ea\u30f3\u8010\u6027\u3001\u30d5\u30eb\u30aa\u30eb\u30ad\u30ce\u30ed\u30f3\u8010\u6027\u3002 \u30ab\u30c6\u30b4\u30ea\u30fc3\uff1a\u5e73\u5747\uff08\u82f1\u8a9e\u300c\u512a\u5148\u5ea63\uff1a\u4e2d “\uff09\u304c\u542b\u307e\u308c\u307e\u3059 \u80ba\u708e\u9023\u9396\u7403\u83cc \u3001\u30da\u30cb\u30b7\u30ea\u30f3\u306b\u654f\u611f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002 \u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30d8\u30e2\u30d5\u30a3\u30eb\u30b9 \u3001\u30a2\u30f3\u30d4\u30b7\u30ea\u30f3\u8010\u6027; \u305d\u305a\u307f spp\u3002\u3001fluorchinolon-Resistent\u3002 [28] \u96c6\u4e2d\u6cbb\u7642\u30e6\u30cb\u30c3\u30c8\u306b\u304a\u3051\u308b\u6297\u751f\u7269\u8cea\u6563\u5e03\u304a\u3088\u3073\u7d30\u83cc\u8010\u6027\u306e\u30b5\u30ea\u30fc\u5c64\u3002 \u306e\uff1a \u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u30b5\u30ea\u3002 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\u591a\u8010\u6027\u7d30\u83cc\u3068\u306e\u6226\u3044\u3002 Deutschlandfunk.DE- 2017\u5e747\u67087\u65e5\u3001\u80cc\u666f\u3002 Albert Ludwig University Freiburg-Completed Projects\u306e\u533b\u7642\u30d0\u30a4\u30aa\u30e1\u30c8\u30ea\u30fc\u304a\u3088\u3073\u7d71\u8a08\u7814\u7a76\u6240\uff1a EU Projekt  – \u30e8\u30fc\u30ed\u30c3\u30d1\u8af8\u56fd\u306e\u62b5\u6297\u3068\u75c5\u6c17\u306e\u8ca0\u62c5\u3002 \uff08\u300c\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u6297\u751f\u7269\u8cea\u8010\u6027\u306b\u3088\u308b\u91d1\u878d\u8ca0\u62c5\u300d\uff09portal.uni-freiburg.de; 2017\u5e747\u670830\u65e5\u306b\u53d6\u5f97\u3002 \u30af\u30ea\u30b9\u30c1\u30e3\u30f3\u30fb\u30d0\u30fc\u30ba\u3001\u30aa\u30c0\u30fb\u30e9\u30e0\u30d6\u30ec\u30d2\u30c8\uff1a \u5c0f\u5ddd\u3001\u5ddd\u3001\u6e56\u306e\u5371\u967a\u306a\u7d30\u83cc \u3002 \u306e\u4e0a\uff1a ndr.de  –  2018\u5e742\u67086\u65e5\u304b\u3089\u306e\u30cb\u30e5\u30fc\u30b9\u3002 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\u30d0\u30f3\u30c955\u30012012\u3001S\u30021311\u20131354\u3001 ISSN 1437-1588 \u3002 2\uff1a10.1007\/s00103-012-1549-5 \u3002  \u2191  W.\u30a6\u30a3\u30c3\u30c6\u3001M\u3002\u30df\u30a8\u30eb\u30b1\u3001\u30ed\u30d0\u30fc\u30c8\u30fb\u30b3\u30c3\u30db\u30fb\u30a4\u30f3\u30b9\u30c6\u30a3\u30c3\u30c8\uff1a \u5e45\u5e83\u3044\u52b9\u679c\u3092\u6301\u3064\u03b2\u30e9\u30af\u30bf\u30de\u30fc\u30bc\u3002 \u306e\uff1a \u9023\u90a6\u5065\u5eb7\u5b98\u5831 – \u5065\u5eb7\u7814\u7a76 – \u5065\u5eb7\u4fdd\u8b77\u3002 \u30d0\u30f3\u30c946\u30012003\u3001S\u3002881\u2013890\u3001 ISSN 1437-1588 \u3002 2\uff1a10.1007\/s00103-003-0693-3 \u3002  \u2191   ESBL\u304a\u3088\u3073AMPC\uff1a\u8178\u5185\u83cc\u306b\u304a\u3051\u308b\u30bb\u30d5\u30a1\u30ed\u30b9\u30dd\u30ea\u30f3\u62b5\u6297\u6027\u306e\u4e3b\u306a\u539f\u56e0\u3068\u3057\u3066\u306e\u03b2\u30e9\u30af\u30bf\u30de\u30fc\u30bc \u3002 In\uff1aRobert Koch Institute\uff08\u7de8\uff09\uff1a \u75ab\u5b66\u901f\u5ea6\u901f\u583128\/2007 \u3002 2007\u5e747\u670818\u65e5\u3001 S.  1\u20134\uff08\u30cd\u30c3\u30af\u30e9\u30a4\u30f3\uff09 \uff08 rki.de [PDF; 103  KB ; 2018\u5e744\u67081\u65e5\u306b\u30a2\u30af\u30bb\u30b9]\uff09\u3002   \u2191   \u75ab\u5b66der Verona-Integron-Metallo-\u03b2-Laktamasen\uff08VIM\uff09\u3001Hessen\u30012012\u20132016 \u3002 In\uff1aRobert Koch Institute\uff08\u7de8\uff09\uff1a Epidemiologisches Bulletin 49\/2017 \u3002 2017\u5e7412\u67088\u65e5\u3001 S.  555\u2013562 \uff08 rki.de [PDF; 294  KB ; 2018\u5e744\u67081\u65e5\u306b\u30a2\u30af\u30bb\u30b9]\uff09\u3002   \u2191 a b c  \u30ed\u30d0\u30fc\u30c8\u30fb\u30b3\u30c3\u30db\u7814\u7a76\u6240\uff08\u7de8\uff09\uff1a \u75c5\u539f\u4f53\u3068\u8010\u6027\u306b\u95a2\u3059\u308b\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u306e\u6982\u8981 \u3002 2015\u5e741\u670829\u65e5\u3001 S.  1\u20133 \uff08 rki.de [PDF; 141  KB ; 2018\u5e743\u670830\u65e5\u306b\u30a2\u30af\u30bb\u30b9]\uff09\u3002   \u2191 a b   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\u30012013\u5e74\u3001ISSN 1559-6834 \u3001 S.  1\u201314 \u3001doi\uff1a 10.1086\/668770 \u3001 PMID 23221186 \u3002   \u2191  \u75c5\u9662\u7d30\u83cc\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u6297\u751f\u7269\u8cea\uff1aHZI\u306e\u7814\u7a76\u8005\u306f\u3001\u591a\u62b5\u6297\u6027\u306e\u7d30\u83cc\u306b\u5bfe\u3059\u308b\u7269\u8cea\u3092\u767a\u898b\u3057\u307e\u3059 \u3002 Helmholtz-Hzi.de\u30012014\u5e7410\u670810\u65e5\u3002 2015\u5e742\u670828\u65e5\u306b\u30a2\u30af\u30bb\u30b9\u3002  \u2191  \u30d5\u30e9\u30f3\u30af\u30fb\u30b9\u30eb\u30c3\u30d7\u3001\u30b3\u30f3\u30e9\u30c3\u30c9\u30fb\u30f4\u30a3\u30fc\u30ea\u30b0\u3001\u30ab\u30c8\u30ea\u30f3I.\u30e2\u30fc\u30eb\u7b49\uff1a Disciformycins A\u304a\u3088\u3073B\uff1aMyxobacterium pyxidicoccus fallax\u304b\u3089\u306e12\u30e1\u30f3\u30d0\u30fc\u306e\u30de\u30af\u30ed\u30e9\u30a4\u30c9\u30b0\u30ea\u30b3\u30b7\u30c9\u6297\u751f\u7269\u8cea\u306f\u3001\u591a\u767a\u6027\u306e\u30d6\u30c9\u30a6\u7403\u83cc\u306b\u5bfe\u3057\u3066\u6d3b\u52d5\u3057\u307e\u3059\u3002 \u306e\uff1a Applied Chemistry International Edition\u3002 \u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u516c\u958b\u3055\u308c\u305f\u8a18\u4e8b\u6700\u521d\uff1a2014\u5e7410\u67087\u65e5\u3001 2\uff1a10.1002\/anie.201406973 \u3002  \u2191  H. Yigit\u3001a\u3002m\u3002Queenanu\u3002A\u3002 Klebsiella pneumoniae\u306e\u30ab\u30eb\u30d0\u30da\u30cd\u30e0\u8010\u6027\u682a\u304b\u3089\u306e\u65b0\u3057\u3044\u30ab\u30eb\u30d0\u30da\u30cd\u30e0\u6c34\u6eb6\u89e3\u30d9\u30fc\u30bf\u30e9\u30af\u30bf\u30de\u30fc\u30bc\u3001KPC-1\u3002 \u306e\uff1a \u6297\u83cc\u85ac\u3068\u5316\u5b66\u7642\u6cd5\u3002 \u30d0\u30f3\u30c945\u3001\u30ca\u30f3\u30d0\u30fc4\u30012001\u5e744\u6708\u3001S\u30021151\u20131161\u3001 doi\uff1a10.1128\/aac.45.4.1151-1161.2001 \u3002 PMID 11257029 \u3002 PMC 90438 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\u3002  \u2191  Ashfaque Hossain et al\u3002\uff1a \u30a8\u30f3\u30c6\u30ed\u30d0\u30af\u30bf\u30fcsp\u3002 \u6297\u5264\u30a8\u30fc\u30b8\u30a7\u30f3\u30c8\u5316\u5b66\u8005\u3002 2004\u5e7411\u6708\u3002 48\uff0811\uff09\uff1a4438\u20134440\u3002 doi\uff1a10.1128\/aac.48.11.4438-4440.2004 \u3002 PMC 525415 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\u3002  \u2191  \u30d9\u30f3M.\u30ed\u30de\u30a8\u30b9\u30c8\u30ed\uff1a Klebsiella Pneumoniae Carbapenemase\u306e\u5e83\u304c\u308a – \u80ba\u708e\u3092\u5ef6\u9577\u3059\u308b\u30cb\u30e5\u30fc\u30e8\u30fc\u30af\u5dde\u5317\u90e8\u3078 \u3001\u81e8\u5e8a\u611f\u67d3\u75c7\u3001vol\u3002 43\u30012006\u3001S\u3002E26-E28  \u2191  Karthikeyan K. 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