[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/5951#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/5951","headline":"\u30c8\u30ea\u30d5\u30a3\u30b1\u30fc\u30b7\u30e7\u30f3\u30d7\u30ea\u30f3\u5408\u6210\u30bf\u30f3\u30d1\u30af\u8cea-Wikipedia","name":"\u30c8\u30ea\u30d5\u30a3\u30b1\u30fc\u30b7\u30e7\u30f3\u30d7\u30ea\u30f3\u5408\u6210\u30bf\u30f3\u30d1\u30af\u8cea-Wikipedia","description":"before-content-x4 \u30c8\u30ea\u30d5\u30a3\u30af\u30b7\u30e7\u30f3\u7684\u30d7\u30ea\u30f3\u5408\u6210\u30bf\u30f3\u30d1\u30af\u8cea PDB\u306b\u57fa\u3065\u304f\u30d7\u30ec\u30bc\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3 1rbm \u65e2\u5b58\u306e\u69cb\u9020\u30c7\u30fc\u30bf\uff1a 1\u30e1\u30b8 \u3001 1\u4eba \u3001 1meo \u3001 1njs \u3001 1rbm \u3001 1rbq \u3001 1rby \u3001 1rbz","datePublished":"2019-08-23","dateModified":"2019-08-23","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/45\/PDB_1rbm_EBI.jpg\/250px-PDB_1rbm_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/45\/PDB_1rbm_EBI.jpg\/250px-PDB_1rbm_EBI.jpg","height":"188","width":"250"},"url":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/5951","wordCount":2428,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4\u30c8\u30ea\u30d5\u30a3\u30af\u30b7\u30e7\u30f3\u7684\u30d7\u30ea\u30f3\u5408\u6210\u30bf\u30f3\u30d1\u30af\u8cea  PDB\u306b\u57fa\u3065\u304f\u30d7\u30ec\u30bc\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3 1rbm  \u65e2\u5b58\u306e\u69cb\u9020\u30c7\u30fc\u30bf\uff1a 1\u30e1\u30b8 \u3001 1\u4eba \u3001 1meo \u3001 1njs \u3001 1rbm \u3001 1rbq \u3001 1rby \u3001 1rbz \u3001 1RC0 \u3001 1RC1 \u3001 1zlx \u3001 1zly \u3001 2QK4 \u3001 2v9y \u3001 4ew1 \u3001 4ew2 \u3001 4ew3  \u30d2\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7279\u6027 \u8cea\u91cf\/\u9577\u3055\u306e\u4e00\u6b21\u69cb\u9020 1009\u30a2\u30df\u30ce\u9178 \u88dc\u56e0\u5b50 Mn 2+ \u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0 \u30e9\u30f3\u30b0\u3001\u30b7\u30e7\u30fc\u30c8\uff08433 AA\uff09 \u8b58\u5225\u5b50 \u907a\u4f1d\u5b50\u540d \u30ac\u30fc\u30c9 \u7a7a\u6c17;\u9577\u3055; gartf; Pais; PGFT; prg \u5916\u90e8ID  \u9175\u7d20\u5206\u985e EC\u3001\u30ab\u30c6\u30b4\u30ea 6.3.4.13 \u3001\u30ea\u30ac\u30fc\u30bc \u53cd\u5fdc \u30b0\u30ea\u30b7\u30f3\u306e\u8ffd\u52a0 \u57fa\u677f 5-\u30db\u30b9\u30db\u30ea\u30dc\u30b7\u30eb\u30a2\u30df\u30f3 + ATP +\u30b0\u30ea\u30b7\u30f3 \u88fd\u54c1 Glycinamidribonukleotid + Adp + p \u79c1 EC\u3001\u30ab\u30c6\u30b4\u30ea 2.1.2.2 \u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30fc\u30bc \u53cd\u5fdc \u30db\u30eb\u30df\u30fc\u30eb\u4f11\u61a9\u306e\u79fb\u52d5 \u57fa\u677f Glycinamidribonukleotid + n \u5341 -thf \u88fd\u54c1 FORMYLGLYCINAMIDRIBONUKLEOTID + THF EC\u3001\u30ab\u30c6\u30b4\u30ea 6.3.3.1 \u3001\u30ea\u30ac\u30fc\u30bc \u53cd\u5fdc \u30ea\u30f3\u30b0\u30af\u30ed\u30fc\u30b8\u30e3\u30fc \u57fa\u677f FORMYLGLYCINAMIDINRIBONUKLEOTID + ATP \u88fd\u54c1 5-Aminidazoltazolbonuklibonuotid + h 2 O + ADP + p \u79c1 \u8d77\u3053\u308b \u30aa\u30fc\u30d0\u30fc\u30e9\u30a4\u30c9\u3059\u308b\u5206\u985e\u7fa4 \u751f\u304d\u7269 \u30aa\u30eb\u30bd\u30ed\u30b8\u30e5  \u4eba \u30cf\u30a6\u30b9\u30de\u30a6\u30b9 \u304a\u5165\u308a\u304f\u3060\u3055\u3044 2618  14450  \u8a2d\u5b9a ensg00000159131  Ensmusg000022962  uniprot P22102  Q64737  refseq\uff08mRNA\uff09 NM_000819  NM_010256  refseq\uff08\u30bf\u30f3\u30d1\u30af\u8cea\uff09 NP_000810  NP_034386  \u30dd\u30b9\u30bf\u30fc  CHR 21\uff1a33.5-33.54 MB    CHR 16\uff1a91.62-91.65 MB   PubMed\u691c\u7d22 2618  14450         (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4 \u30c8\u30ea\u30d5\u30eb\u6a5f\u80fd\u30d7\u30ea\u30f3\u5408\u6210\u30bf\u30f3\u30d1\u30af\u8cea\uff08Gars-Airs-Gart\uff09 \uff08\u307e\u305f \u30a2\u30c7\u30ce\u30b7\u30f3-3 \uff093\u3064\u306e\u7570\u306a\u308b\u9175\u7d20\u30c9\u30e1\u30a4\u30f3\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u878d\u5408\u3055\u308c\u308b\u52d5\u7269\u306e\u9175\u7d20\u3067\u3059\u3002 \u30db\u30b9\u30db\u30ea\u30dc\u30b7\u30eb\u30a2\u30df\u30f3 – \u30b0\u30ea\u30b7\u30f3 – \u30ea\u30ac\u30fc\u30bc \uff08\u5927\u9ea6\uff09\u3001 \u30db\u30b9\u30db\u30ea\u30dc\u30b7\u30eb\u30b0\u30ea\u30b7\u30f3\u30a2\u30df\u30c9 – \u30db\u30eb\u30df\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc \uff08\u30ac\u30fc\u30c8\uff09\u3068 \u30db\u30b9\u30db\u30ea\u30dc\u30b7\u30eb\u30db\u30eb\u30df\u30eb\u30b0\u30ea\u30b7\u30f3\u30df\u30b8\u30f3\u30b7\u30af\u30ed\u30ea\u30ac\u30fc\u30bc \uff08\u30a8\u30a2\u30ba\uff09\u3002\u3053\u308c\u3089\u306e\u6d3b\u6027\u306f\u3001\u7cbe\u88fd\u6027\u306e\u4e00\u90e8\u3067\u3042\u308a\u3001\u3059\u3079\u3066\u306e\u751f\u7269\u3067\u767a\u751f\u3057\u307e\u3059\uff1a\u539f\u6838\u751f\u7269\u306e\u500b\u3005\u306e\u9175\u7d20\u3068\u3057\u3066\u3001\u304a\u3088\u3073\u9175\u6bcd\u306e\u90e8\u5206\u7684\u306b\u4e8c\u6a5f\u80fd\u6027\u9175\u7d20\u3068\u3057\u3066\u3002 [\u521d\u3081] [2] \u30a2\u30c7\u30ce\u30b7\u30f3-3\u306e\u30c9\u30e1\u30a4\u30f3\u306f\u7dda\u5f62\u306b\u914d\u7f6e\u3055\u308c\u3001IMP\u306e10\u6bb5\u968e\u306e\u751f\u5408\u6210\u306e\u3046\u3061\u3001\u30b9\u30c6\u30c3\u30d72\u30015\u3001\u304a\u3088\u30733\u3092\u89e6\u5a92\u3057\u307e\u3059\u3002\u30a2\u30c7\u30ce\u30b7\u30f3-3\u907a\u4f1d\u5b50\u306e\u4eba\u9593\u306e\u751f\u6210 \u30ac\u30fc\u30c9 \u67d3\u8272\u4f5321\u306b\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30c0\u30a6\u30f3\u75c7\u5019\u7fa4\u306e\u30d7\u30ea\u30f3\u5024\u306e\u5897\u52a0\u306e\u539f\u56e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 [3] \u5f7c\u3089 [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] + + ATP         (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4\u27f6 {displaystyle longrightarrow} \u27f6 {displaystyle longrightarrow}  + ADP + p \u79c1 \u30db\u30b9\u30db\u30ea\u30dc\u30b7\u30eb\u30a2\u30df\u30f3 – \u30b0\u30ea\u30b7\u30f3\u30ea\u30fc\u30b0\u30c9\u30e1\u30a4\u30f3\u306f\u30015-\u30db\u30b9\u30db\u30ea\u30dc\u30b7\u30eb\u30a2\u30df\u30f3\uff08PRA\uff09\u3078\u306e\u30b0\u30ea\u30b7\u30f3\u306e\u6dfb\u52a0\u3092\u30b0\u30ea\u30b7\u30f3\u30a2\u30df\u30c9\u30ea\u30dc\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08GAR\uff09\u306b\u4fc3\u9032\u3057\u307e\u3059\u3002 \u30ac\u30fc\u30c9 [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] + 10-formyl- thf         (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4\u27f6 {displaystyle longrightarrow} \u27f6 {displaystyle longrightarrow}  + thf  \u30db\u30b9\u30db\u30ea\u30dc\u30b7\u30eb\u30b0\u30ea\u30b7\u30f3\u30a2\u30df\u30c9\u30db\u30eb\u30df\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08GART\uff09\u306f\u3001\u30db\u30eb\u30df\u30eb\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u8449\u9178\u3092\u4f7f\u7528\u3057\u3066\u3001\u30b0\u30ea\u30b7\u30ca\u30df\u30c9\u30ea\u30dc\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08GAR\uff09\u306e\u30db\u30eb\u30df\u30eb\u30b0\u30ea\u30b7\u30f3\u30a2\u30df\u30c9\u30ea\u30dc\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08FGA\uff09\u3078\u306e\u30db\u30eb\u30df\u30eb\u5316\u3092\u89e6\u5a92\u3057\u307e\u3059\u3002 \u7a7a\u6c17 [ \u7de8\u96c6 | \u30bd\u30fc\u30b9\u30c6\u30ad\u30b9\u30c8\u3092\u7de8\u96c6\u3057\u307e\u3059 ] + ATP  \u27f6 {displaystyle longrightarrow}  + ADP + p \u79c1 + h 2 o \u30db\u30b9\u30db\u30ea\u30dc\u30b7\u30eb\u30db\u30eb\u30df\u30ed\u30b0\u30ea\u30b7\u30f3\u30a2\u30df\u30c9\u30b7\u30af\u30ed\u30ea\u30fc\u30b0\u30c9\u30e1\u30a4\u30f3\u30b5\u30a4\u30af\u30eb\u306f\u3001\u30b0\u30ea\u30b7\u30ca\u30df\u30b8\u30f3\u30ea\u30dc\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08FGAM\uff09\u304b\u30895-\u30a2\u30df\u30ce\u30a4\u30df\u30c0\u30be\u30eb\u30ea\u30dc\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08AIR\uff09\u3092\u5faa\u74b0\u3057\u307e\u3059\u3002 \u2191  uniprot P22102  \u2191  D. Burrijee\u3001K\u3002Nandagopal\uff1a \u7cfb\u7d71\u89e3\u6790\u3068in novo\u30d7\u30ea\u30f3\u751f\u5408\u6210\u306b\u95a2\u4e0e\u3059\u308b\u4e09\u5b98\u80fd\u6027\u9175\u7d20\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308bGars-airs-gart\u907a\u4f1d\u5b50\u306ein silico\u7279\u6027\u3002 \u306e\uff1a \u5206\u5b50\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3002 \u30d0\u30f3\u30c942\u3001\u756a\u53f73\u30012009\u5e747\u6708\u3001S\u3002306\u2013319\u3001doi\uff1a 10.1007\/s12033-009-9160-1 \u3002 PMID 19301155 \u3002  \u2191  D.\u30d1\u30bf\u30fc\u30bd\u30f3\u3001S\u3002\u30b0\u30ed\u30fc\u3001C\u3002\u30b8\u30e7\u30fc\u30f3\u30ba\uff1a \u4f53\u7d30\u80de\u907a\u4f1d\u5b66\u306b\u3088\u308b\u3001\u30d2\u30c8\u67d3\u8272\u4f53\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u305f2\u3064\u306e\u30d7\u30ea\u30f3\u5408\u6210\u306e\u907a\u4f1d\u5b50\u306e\u5ea7\u6a19\u8abf\u7bc0\u306e\u5b9f\u8a3c21\u3002 \u306e\uff1a \u56fd\u7acb\u79d1\u5b66\u30a2\u30ab\u30c7\u30df\u30fc\u306e\u8b70\u4e8b\u9332\u3002 \u30d0\u30f3\u30c978\u3001\u30ca\u30f3\u30d0\u30fc1\u30011981\u5e741\u6708\u3001pp\u3002405-409\u3001 PMID 6941256 \u3002 PMC 319062 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\u3002        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki10\/archives\/5951#breadcrumbitem","name":"\u30c8\u30ea\u30d5\u30a3\u30b1\u30fc\u30b7\u30e7\u30f3\u30d7\u30ea\u30f3\u5408\u6210\u30bf\u30f3\u30d1\u30af\u8cea-Wikipedia"}}]}]