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\u3053\u306e\u6c7a\u5b9a\u306b\u3088\u308a\u3001BRCA1\u304a\u3088\u3073BRCA2\u7279\u8a31\u304c\u7121\u52b9\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u3053\u306e\u554f\u984c\u306b\u95a2\u3059\u308b\u6cd5\u7684\u624b\u7d9a\u304d\u306f\u73fe\u5728\u3001\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u9023\u90a6\u88c1\u5224\u6240\u306b\u3088\u3063\u3066\u958b\u304b\u308c\u3066\u3044\u307e\u3059\u3002 [ 16 ] \u200b \u53c2\u7167 [ \u7de8\u96c6\u3057\u307e\u3059 ] \u2191  BRCA1\/2\u5909\u7570\u306e\u5973\u6027\u30ad\u30e3\u30ea\u30a2\u306b\u304a\u3051\u308b\u4e88\u9632\u30d7\u30ed\u30c8\u30b3\u30eb\u306e\u6709\u52b9\u6027 \u3002 Cochrane Plus Library\u30012013\u756a\u53f73 ISSN 1745-9990  \u2191  ‘Hall JM\u3001Lee MK\u3001Newman B\u3001Morrow JE\u3001Anderson LA\u3001Huey B\u3001King MC\uff08Diciembre 1990\uff09\u3002 \u300c\u67d3\u8272\u4f5317q21\u3078\u306e\u521d\u671f\u767a\u75c7\u306e\u5bb6\u65cf\u6027\u4e73\u304c\u3093\u306e\u7d50\u5408\u300d\u3002 \u5316\u5b66  250 \uff084988\uff09\uff1a1684\u20139\u3002 ‘ http:\/\/www.sciencemag.org\/content\/250\/4988\/1684  \u2191  http:\/\/scienceblog.cancerresearchuk.org\/2012\/02\/28\/high-impact-science-racking-down-the-genes-part-1\/\/  \u2191  ‘Miki Y\u3001Swensen J\u3001Shattuck-Eidens D\u3001Futreal PA\u3001Harshman K\u3001Tavtigian S\u3001Liu Q\u3001Cochran C\u3001Bennett LM\u3001Ding W\u3001 et al\u3002 \uff081994\u5e74Octubre\uff09\u3002 \u300c\u4e73\u623f\u304a\u3088\u3073\u5375\u5de3\u764c\u611f\u53d7\u6027\u907a\u4f1d\u5b50BRCA1\u306e\u5f37\u529b\u306a\u5019\u88dc\u300d\u3002 \u5316\u5b66  266 \uff085182\uff09\uff1a66\u201371\u3002 http:\/\/www.sciencemag.org\/content\/266\/5182\/66  \u2191  Mazoyer S.\uff082005\uff09\u3002 \u00abBRCA1\u304a\u3088\u3073BRCA2\u907a\u4f1d\u5b50\u306e\u30b2\u30ce\u30e0\u518d\u7de8\u6210\u00bb\u3002 \u30cf\u30e0\u30b7\u30e7\u30fc\u3002  25 \uff085\uff09\uff1a415-22\u3002 PMID 15832305 \u3002 doi\uff1a 10.1002\/here.20169 \u3002   \u2191  Barrois M. et al\uff082004\uff09\u3002 \u00ab\u4e73\u623f\u83cc\u764c\u5bb6\u65cf\u306eBRCA1\u518d\u914d\u7f6e\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\u30d9\u30fc\u30b9\u306e\u907a\u4f1d\u5b50\u6295\u4e0e\u91cf\u30a2\u30c3\u30bb\u30a4\u00bb\u3002 Clin Genet\u3002  65 \uff082\uff09\uff1a131-6\u3002 PMID 14984472 \u3002 doi\uff1a 10.1111\/j.0009-9163.2004.00200.x \u3002   \u2191  Hogervorst FB\u3002 et al\uff082003\uff09\u3002 \u00ab\u65b0\u3057\u3044\u5b9a\u91cf\u7684\u65b9\u6cd5\u306b\u3088\u3063\u3066\u8b58\u5225\u3055\u308c\u305fBRCA1\u907a\u4f1d\u5b50\u306e\u5927\u304d\u306a\u30b2\u30ce\u30e0\u306e\u524a\u9664\u3068\u91cd\u8907\u00bb\u3002 Cancer Res\u3002  63 \uff087\uff09\uff1a1449-53\u3002 PMID 12670888 \u3002   \u2191  Casilli F. et al\uff082002\uff09\u3002 \u00ab\u77ed\u3044\u86cd\u5149\u65ad\u7247\u306e\u591a\u91cdPCR\u3092\u4f7f\u7528\u3057\u3066\u3001\u9ad8\u30ea\u30b9\u30af\u306e\u4e73\u623f\u83cc\u83cc\u83cc\u306e\u65b0\u898fBRCA1\u518d\u914d\u7f6e\u306e\u8fc5\u901f\u306a\u691c\u51fa\u00bb\u3002 \u30cf\u30e0\u30b7\u30e7\u30fc\u3002  20 \uff083\uff09\uff1a218-26\u3002 PMID 12203994 \u3002 doi\uff1a 10.1002\/here.10108 \u3002   \u2191  Rouleau E. et al\uff082007\uff09\u3002 \u00ab\u907a\u4f1d\u6027\u4e73\u304c\u3093\u907a\u4f1d\u5b50BRCA1\u306b\u304a\u3051\u308b\u5927\u304d\u306a\u518d\u7de8\u6210\u306e\u691c\u51fa\u3068\u7279\u6027\u8a55\u4fa1\u306b\u9069\u7528\u3055\u308c\u308b\u9ad8\u89e3\u50cf\u5ea6\u306e\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u30a2\u30ec\u30a4-CGH\u00bb\u3002 Clin Genet\u3002  72 \uff083\uff09\uff1a199-207\u3002 PMID 17718857 \u3002 doi\uff1a 10.1111\/j.1399-0004.2007.00849.x \u3002   \u2191  Tapia T\u3001Smalley SV\u3001Kohen P\u3001Mu\u00f1oz\u3001Solis LM\u3001Corvalan\u3001Fendez P\u3001Devoto L\u3001Camus M\u3001Alvarez M\u3001Carvallo P.\uff082008\uff09\u3002 \u00abBRCA1\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u904e\u5270\u30e1\u30c1\u30eb\u5316\u306f\u3001\u907a\u4f1d\u6027\u4e73\u764c\u816b\u760d\u306b\u304a\u3051\u308b\u767a\u73fe\u306e\u6b20\u5982\u3068\u76f8\u95a2\u3057\u3066\u3044\u307e\u3059\u3002\u00bb\u3002 \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3002  3 \uff083\uff09\uff1a157-163\u3002 PMID 18567944 \u3002    \u2191  \u30cb\u30c3\u30af\u30fb\u30b8\u30ca\u30eb\u3001\u30bb\u30ec\u30ca\u3002\u30c7\u30a4\u30d3\u30b9\u3001\u30d8\u30ec\u30f3\u3002\u7814\u7a76\u3001\u30a4\u30a7\u30b7\u30e3\u30f3;\u30e9\u30de\u30af\u30ea\u30b7\u30e5\u30ca\u3001\u30de\u30ca\u30b5\u3002\u30b0\u30ed\u30b8\u30af\u3001\u30c9\u30df\u30cb\u30af\u3002\u30b7\u30e3\u30c3\u30c8\u3001xueqing; Martincorena\u3001\u30a4\u30cb\u30b4;\u30a2\u30ec\u30af\u30b5\u30f3\u30c9\u30ed\u30d5\u3001\u30eb\u30c9\u30df\u30ebb\u3002 et al\u3002 \u3002 \u00ab560\u4e73\u304c\u3093\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9\u306b\u304a\u3051\u308b\u4f53\u7d30\u80de\u5909\u7570\u306e\u98a8\u666f\u00bb \u3002 \u81ea\u7136  534 \uff087605\uff09\uff1a47-54\u3002 PMC 4910866 \u3002 PMID 27135926 \u3002 doi\uff1a 10.1038\/nature17676 \u3002    \u2191  ‘Skolnick HS\u3001Goldgar DE\u3001Miki Y\u3001Swenson J\u3001Kamb A\u3001Harshman KD\u3001Shattuck-Eidens DM\u3001Tavtigian SV\u3001Wiseman RW\u3001Futreal PA\u3001 “7Q\u30ea\u30f3\u30af\u4e73\u623f\u304a\u3088\u3073\u5375\u5de3\u764c\u611f\u53d7\u6027\u907a\u4f1d\u5b50” http:\/\/worldwide.espacenet.com\/publicationdetails\/biblio?c=us&nr=5747282&kc   \u2191  \u300cTavtigian SV\u3001Kamb A\u3001Simard J\u3001Couch F\u3001Rommens JM\u3001Weber BL\u3001\u300c\u67d3\u8272\u4f5313\u30ea\u30f3\u30af\u4e73\u304c\u3093\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u300d http:\/\/worldwide.espacenet.com\/publicationdetails\/biblio?c=us&nr=5837492&kc  \u2191  http:\/\/www.nytimes.com\/2009\/05\/13\/health\/13Patent.html  \u2191  http:\/\/www.nytimes.com\/2013\/04\/14\/us\/supreme-court-rules-human-genes-may-not-be-patented.html \uff1f_r = 0  \u2191  http:\/\/www.smh.com.au\/national\/health\/landmark-patent-ruling-over-lob-reast-cancer-gene-rcca1-20130215-2egsq.html  \u5916\u90e8\u30ea\u30f3\u30af [ \u7de8\u96c6\u3057\u307e\u3059 ]           (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/11368#breadcrumbitem","name":"BCCA1 -Speedylook Encyclopedia"}}]}]