[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/16332#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/16332","headline":"Zellseneszenz  – \u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2","name":"Zellseneszenz  – \u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2","description":"before-content-x4 \uff08\u4e0a\uff09\u8001\u5316\u306e\u524d\u306e\u30de\u30a6\u30b9\u306e\u4e00\u6b21\u80da\u7dda\u7dad\u82bd\u7d30\u80de\uff08MEF\uff09\u3001\u7d21\u9318\u5f62\u306e\u5f62\u614b\u3092\u5099\u3048\u3066\u3044\u307e\u3059\u3002 \uff08\u4ee5\u4e0b\uff09\u7d30\u80de\u57f9\u990a\u306e\u3055\u3089\u306a\u308b\u901a\u8def\u306e\u5f8c\u306b\u8001\u5316\u3057\u305fMEF\u3002\u7d30\u80de\u306f\u5927\u304d\u304f\u3001\u5e73\u3089\u3067\u3001\u7d30\u80de\u306e\u8001\u5316\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u8001\u5316\u95a2\u9023\u03b2-\u30ac\u30e9\u30af\u30c8\u30b7\u30c0\u30fc\u30bc\uff08SABG\u3001\u9752\u3044\u9818\u57df\uff09\u3092\u767a\u73fe\u3057\u307e\u3059\u3002 \u7d30\u80de\u306e\u8001\u5316 \uff08\u30e9\u30c6\u30f3\u8a9e\u304b\u3089 \u8001\u4eba = “\u53e4\u304f\u3001\u8001\u5316\u3057\u3066\u304f\u3060\u3055\u3044”\uff09\u306f\u3001\u7d30\u80de\u304c\u5171\u6709\u3092\u505c\u6b62\u3059\u308b\u73fe\u8c61\u3067\u3059\u3002 1960\u5e74\u4ee3\u521d\u982d\u304b\u3089\u306e\u5b9f\u9a13\u3067\u3001\u30ec\u30ca\u30fc\u30c9\u30fb\u30d8\u30a4\u30d5\u30ea\u30c3\u30af\u3068\u30dd\u30fc\u30eb\u30fb\u30e0\u30fc\u30a2\u30d8\u30c3\u30c9\u306f\u3001\u57f9\u990a\u4e2d\u306e\u6b63\u5e38\u306a\u30d2\u30c8\u80ce\u5150\u7dda\u7dad\u82bd\u7d30\u80de\u304c\u5e74\u9f62\u3092\u91cd\u306d\u308b\u524d\u306b\u6700\u5927\u7d0450\u306e\u7d30\u80de\u96c6\u56e3\u306b\u9054\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002 [\u521d\u3081] [2] [3] \u3002\u3053\u306e\u73fe\u8c61\u306f\u3001\u8907\u88fd\u8001\u5316\u307e\u305f\u306f\u30d8\u30a4\u30d5\u30ea\u30c3\u30af\u306e\u5883\u754c\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u6b63\u5e38\u306a\u7d30\u80de\u304c\u81f4\u547d\u7684\u3067\u3042\u308b\u3068\u3044\u3046\u30d8\u30a4\u30d5\u30ea\u30c3\u30af\u306e\u767a\u898b\u306f\u3001\u7d30\u80de\u751f\u7269\u5b66\u306e60\u5e74\u306e\u6559\u7fa9\u3092\u7a81\u304d\u7834\u308a\u3001\u3059\u3079\u3066\u306e\u98fc\u80b2\u7d30\u80de\u306f\u4e0d\u6ec5\u3067\u3042\u308b\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u30d8\u30a4\u30d5\u30ea\u30c3\u30af\u306f\u3001\u552f\u4e00\u306e\u4e0d\u6ec5\u306e\u57f9\u990a\u7d30\u80de\u304c\u764c\u7d30\u80de\u3067\u3042\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f [4] \u3002\u7d30\u80de\u306e\u8001\u5316\u306f\u3001\u3057\u3070\u3057\u3070\u8001\u5316\u306e\u65b9\u5411\u306e\u9032\u884c\u3092\u9632\u304e\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u764c\u3092\u53ef\u80fd\u306b\u3059\u308b\u305f\u3081\u306b\u4e0d\u6d3b\u6027\u5316\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u816b\u760d\u5438\u5f15\u5668\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066\u958b\u59cb\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u816b\u760d\u5438\u5f15\u5668\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u514b\u670d\u307e\u305f\u306f\u30d0\u30a4\u30d1\u30b9\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u764c\u7d30\u80de\u306f\u7d30\u80de\u5468\u671f\u306e\u5236\u5fa1\u3092\u56de\u907f\u3057\u3001\u30b2\u30ce\u30e0\u306e\u4e0d\u5b89\u5b9a\u6027\u3068\u5236\u5fa1\u3055\u308c\u3066\u3044\u306a\u3044\u5897\u6b96\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002 MicroRNA\uff08miRNA\uff09\u306f\u3001\u7d30\u80de\u306e\u8001\u5316\u306b\u5bc4\u4e0e\u3059\u308b\u3001\u307e\u305f\u306f\u305d\u308c\u3089\u3092\u9632\u3050\u91cd\u8981\u306a\u8981\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002 [5] after-content-x4 \u7d30\u80de\u306e\u8001\u5316\u306f\u3001\u3059\u3079\u3066\u306e\u7d30\u80de\u5206\u88c2\u30d7\u30ed\u30bb\u30b9\u3067\u306e\u30c6\u30ed\u30e1\u30a2\u306e\u77ed\u7e2e\u306b\u8d77\u56e0\u3059\u308bDNA\u3092\u5909\u66f4\u3059\u308b\u3053\u3068\u3067\u6a5f\u68b0\u7684\u306b\u30c8\u30ea\u30ac\u30fc\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u7279\u5225\u306a\u30b1\u30fc\u30b9\u3067\u306f\u3001\u8907\u88fd\u306e\u8001\u5316\u306b\u3064\u3044\u3066\u8a9e\u3063\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u7d30\u80de\u306f\u3001\u7d30\u80de\u5206\u88c2\u306e\u6570\u306b\u95a2\u4fc2\u306a\u304f\u3001\u305f\u3068\u3048\u3070\u3001\u764c\u907a\u4f1d\u5b50\u3068\u7d30\u80de\u7d30\u80de\u878d\u5408\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u53cd\u5fdc\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306e\u5897\u52a0\u306b\u5fdc\u3058\u3066DNA\u640d\u50b7\u3092\u4ecb\u3057\u3066\u8001\u5316\u306b\u6301\u3061\u8fbc\u3080\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002\u7d44\u7e54\u5185\u306e\u8001\u5316\u7d30\u80de\u306e\u6570\u306f\u3001\u901a\u5e38\u306e\u8001\u5316\u4e2d\u306b\u5927\u5e45\u306b\u5897\u52a0\u3057\u307e\u3059\u3002 [6]","datePublished":"2020-07-10","dateModified":"2020-07-10","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/7\/7d\/SABG_MEFs.jpg\/220px-SABG_MEFs.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/7\/7d\/SABG_MEFs.jpg\/220px-SABG_MEFs.jpg","height":"337","width":"220"},"url":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/16332","wordCount":1388,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4 \uff08\u4e0a\uff09\u8001\u5316\u306e\u524d\u306e\u30de\u30a6\u30b9\u306e\u4e00\u6b21\u80da\u7dda\u7dad\u82bd\u7d30\u80de\uff08MEF\uff09\u3001\u7d21\u9318\u5f62\u306e\u5f62\u614b\u3092\u5099\u3048\u3066\u3044\u307e\u3059\u3002 \uff08\u4ee5\u4e0b\uff09\u7d30\u80de\u57f9\u990a\u306e\u3055\u3089\u306a\u308b\u901a\u8def\u306e\u5f8c\u306b\u8001\u5316\u3057\u305fMEF\u3002\u7d30\u80de\u306f\u5927\u304d\u304f\u3001\u5e73\u3089\u3067\u3001\u7d30\u80de\u306e\u8001\u5316\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u8001\u5316\u95a2\u9023\u03b2-\u30ac\u30e9\u30af\u30c8\u30b7\u30c0\u30fc\u30bc\uff08SABG\u3001\u9752\u3044\u9818\u57df\uff09\u3092\u767a\u73fe\u3057\u307e\u3059\u3002 \u7d30\u80de\u306e\u8001\u5316 \uff08\u30e9\u30c6\u30f3\u8a9e\u304b\u3089 \u8001\u4eba = “\u53e4\u304f\u3001\u8001\u5316\u3057\u3066\u304f\u3060\u3055\u3044”\uff09\u306f\u3001\u7d30\u80de\u304c\u5171\u6709\u3092\u505c\u6b62\u3059\u308b\u73fe\u8c61\u3067\u3059\u3002 1960\u5e74\u4ee3\u521d\u982d\u304b\u3089\u306e\u5b9f\u9a13\u3067\u3001\u30ec\u30ca\u30fc\u30c9\u30fb\u30d8\u30a4\u30d5\u30ea\u30c3\u30af\u3068\u30dd\u30fc\u30eb\u30fb\u30e0\u30fc\u30a2\u30d8\u30c3\u30c9\u306f\u3001\u57f9\u990a\u4e2d\u306e\u6b63\u5e38\u306a\u30d2\u30c8\u80ce\u5150\u7dda\u7dad\u82bd\u7d30\u80de\u304c\u5e74\u9f62\u3092\u91cd\u306d\u308b\u524d\u306b\u6700\u5927\u7d0450\u306e\u7d30\u80de\u96c6\u56e3\u306b\u9054\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002 [\u521d\u3081] [2] [3] \u3002\u3053\u306e\u73fe\u8c61\u306f\u3001\u8907\u88fd\u8001\u5316\u307e\u305f\u306f\u30d8\u30a4\u30d5\u30ea\u30c3\u30af\u306e\u5883\u754c\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u6b63\u5e38\u306a\u7d30\u80de\u304c\u81f4\u547d\u7684\u3067\u3042\u308b\u3068\u3044\u3046\u30d8\u30a4\u30d5\u30ea\u30c3\u30af\u306e\u767a\u898b\u306f\u3001\u7d30\u80de\u751f\u7269\u5b66\u306e60\u5e74\u306e\u6559\u7fa9\u3092\u7a81\u304d\u7834\u308a\u3001\u3059\u3079\u3066\u306e\u98fc\u80b2\u7d30\u80de\u306f\u4e0d\u6ec5\u3067\u3042\u308b\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u30d8\u30a4\u30d5\u30ea\u30c3\u30af\u306f\u3001\u552f\u4e00\u306e\u4e0d\u6ec5\u306e\u57f9\u990a\u7d30\u80de\u304c\u764c\u7d30\u80de\u3067\u3042\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f [4] \u3002\u7d30\u80de\u306e\u8001\u5316\u306f\u3001\u3057\u3070\u3057\u3070\u8001\u5316\u306e\u65b9\u5411\u306e\u9032\u884c\u3092\u9632\u304e\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u764c\u3092\u53ef\u80fd\u306b\u3059\u308b\u305f\u3081\u306b\u4e0d\u6d3b\u6027\u5316\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u816b\u760d\u5438\u5f15\u5668\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066\u958b\u59cb\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u816b\u760d\u5438\u5f15\u5668\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u514b\u670d\u307e\u305f\u306f\u30d0\u30a4\u30d1\u30b9\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u764c\u7d30\u80de\u306f\u7d30\u80de\u5468\u671f\u306e\u5236\u5fa1\u3092\u56de\u907f\u3057\u3001\u30b2\u30ce\u30e0\u306e\u4e0d\u5b89\u5b9a\u6027\u3068\u5236\u5fa1\u3055\u308c\u3066\u3044\u306a\u3044\u5897\u6b96\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002 MicroRNA\uff08miRNA\uff09\u306f\u3001\u7d30\u80de\u306e\u8001\u5316\u306b\u5bc4\u4e0e\u3059\u308b\u3001\u307e\u305f\u306f\u305d\u308c\u3089\u3092\u9632\u3050\u91cd\u8981\u306a\u8981\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002 [5]        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4\u7d30\u80de\u306e\u8001\u5316\u306f\u3001\u3059\u3079\u3066\u306e\u7d30\u80de\u5206\u88c2\u30d7\u30ed\u30bb\u30b9\u3067\u306e\u30c6\u30ed\u30e1\u30a2\u306e\u77ed\u7e2e\u306b\u8d77\u56e0\u3059\u308bDNA\u3092\u5909\u66f4\u3059\u308b\u3053\u3068\u3067\u6a5f\u68b0\u7684\u306b\u30c8\u30ea\u30ac\u30fc\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u7279\u5225\u306a\u30b1\u30fc\u30b9\u3067\u306f\u3001\u8907\u88fd\u306e\u8001\u5316\u306b\u3064\u3044\u3066\u8a9e\u3063\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u7d30\u80de\u306f\u3001\u7d30\u80de\u5206\u88c2\u306e\u6570\u306b\u95a2\u4fc2\u306a\u304f\u3001\u305f\u3068\u3048\u3070\u3001\u764c\u907a\u4f1d\u5b50\u3068\u7d30\u80de\u7d30\u80de\u878d\u5408\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u53cd\u5fdc\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306e\u5897\u52a0\u306b\u5fdc\u3058\u3066DNA\u640d\u50b7\u3092\u4ecb\u3057\u3066\u8001\u5316\u306b\u6301\u3061\u8fbc\u3080\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002\u7d44\u7e54\u5185\u306e\u8001\u5316\u7d30\u80de\u306e\u6570\u306f\u3001\u901a\u5e38\u306e\u8001\u5316\u4e2d\u306b\u5927\u5e45\u306b\u5897\u52a0\u3057\u307e\u3059\u3002 [6] \u52a0\u9f62\u7d30\u80de\u306f\u3082\u306f\u3084\u5897\u6b96\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u304c\u3001\u4ee3\u8b1d\u3092\u7dad\u6301\u3057\u3001\u4e00\u822c\u7684\u306b\u514d\u75ab\u539f\u6027\u306e\u8868\u73fe\u578b\u3092\u6442\u53d6\u3057\u307e\u3059\u3002 PRO\u708e\u75c7\u6027\u79d8\u5bc6\u816b\u3068\u514d\u75ab\u30ea\u30fc\u30b0\u306e\u9ad8\u3044\u8abf\u7bc0\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002 CDK\u963b\u5bb3\u52642A\uff08CDKN2A\uff09\uff08CDKN2A\uff09\u3068\u3068\u3082\u306b\u3001\u8001\u5316\u95a2\u9023\u03b2-\u30ac\u30e9\u30af\u30c8\u30b7\u30c0\u30fc\u30bc\u304c\u9069\u7528\u3055\u308c\u307e\u3059 \u30b5\u30a4\u30af\u30ea\u30f3\u4f9d\u5b58\u6027\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u52642a \u3001p16\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff09\u7d30\u80de\u8001\u5316\u306e\u305f\u3081\u306e\u512a\u308c\u305f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3002\u305f\u3060\u3057\u3001\u719f\u6210\u7d44\u7e54\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306f\u8001\u5316\u95a2\u9023\u03b2-\u30ac\u30e9\u30af\u30c8\u30b7\u30c0\u30fc\u30bc\u3082\u793a\u3059\u3060\u3051\u3067\u306a\u304f\u3001T\u7d30\u80de\u304cCdKN2a\u3092\u767a\u73fe\u3059\u308b\u305f\u3081\u3001\u3053\u308c\u306f\u507d\u967d\u6027\u30b7\u30b0\u30ca\u30eb\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002 [6] DNA\u640d\u50b7\u5fdc\u7b54\uff08 DNA\u640d\u50b7\u5fdc\u7b54 \u3001gdr\uff09\u306f\u3001\u4e8c\u91cd\u30b9\u30c8\u30e9\u30f3\u30c9\u30d6\u30ec\u30fc\u30af\uff08DSB\uff09\u306a\u3069\u306e\u640d\u50b7\u304c\u4fee\u5fa9\u3055\u308c\u308b\u307e\u3067\u3001\u7d30\u80de\u5468\u671f\u306e\u7d4c\u904e\u3092\u30d6\u30ed\u30c3\u30af\u3057\u307e\u3059\u3002\u8001\u5316\u7d30\u80de\u306f\u3001\u5185\u56e0\u6027DNA\u4fee\u5fa9\u6d3b\u6027\u306b\u8010\u6027\u304c\u3042\u308b\u3068\u601d\u308f\u308c\u308bDNA\u640d\u50b7\u3092\u4f34\u3046\u6301\u7d9a\u7684\u306a\u9818\u57df\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u57f9\u990a\u304a\u3088\u3073\u8001\u5316\u3057\u305f\u54fa\u4e73\u985e\u306e\u7d44\u7e54\u306b\u304a\u3051\u308b\u8001\u5316\u7d30\u80de\u306f\u3001GDR\u30de\u30fc\u30ab\u30fc\u306b\u95a2\u9023\u3059\u308bDSB\u3092\u4fdd\u5b58\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306eDSB\u306f\u3001\u8001\u5316\u30d7\u30ed\u30bb\u30b9\u306e\u91cd\u8981\u306a\u8981\u56e0\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002 [7] \u6700\u8fd1\u3001\u30c6\u30ed\u30e1\u30a2\u306e\u5f79\u5272\u306f\u3001\u7279\u306b\u30af\u30ed\u30fc\u30f3\u306e\u526f\u4f5c\u7528\u306e\u53ef\u80fd\u6027\u306b\u95a2\u3057\u3066\u3001\u7d30\u80de\u306e\u8001\u5316\u306b\u5bfe\u3059\u308b\u95a2\u5fc3\u3092\u547c\u3073\u8d77\u3053\u3057\u3066\u3044\u307e\u3059\u3002\u5404\u7d30\u80de\u5468\u671f\u3067\u306f\u3001\u67d3\u8272\u4f53\u30c6\u30ed\u30e1\u30a2\u304c\u5f90\u3005\u306b\u6e1b\u5c11\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u7d30\u80de\u306e\u5206\u88c2\u306e\u6570\u304c\u5236\u9650\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u8001\u5316\u306b\u8ca2\u732e\u3057\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u30c6\u30ed\u30de\u30fc\u306e\u30b7\u30e7\u30fc\u30c8\u30ab\u30c3\u30c8\u306f\u3001\u4ee3\u66ffRNA\u30b9\u30d7\u30e9\u30a4\u30b9\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3082\u5909\u66f4\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u5206\u89e3\u3068\u7d44\u7e54\u306e\u6a5f\u80fd\u7684\u5236\u9650\u306b\u3088\u3063\u3066\u8001\u5316\u30d7\u30ed\u30bb\u30b9\u3092\u8a98\u767a\u3059\u308b\u30d7\u30ed\u30b2\u30ea\u30f3\u306a\u3069\u306e\u6bd2\u7d20\u3092\u751f\u6210\u3057\u307e\u3059\u3002 [8] \u305f\u3068\u3048\u3070\u3001\uff08\u305f\u3068\u3048\u3070\u3001\u30cf\u30c3\u30c1\u30f3\u30bd\u30f3 – \u30ae\u30eb\u30d5\u30a9\u30fc\u30c9\u30d7\u30ed\u30d5\u30a7\u30c3\u30b7\u30e7\u30ca\u30eb\u75c7\u5019\u7fa4\u306e\u5834\u5408\uff09\u3001\u30e9\u30df\u30f3A\u306e\u4ee3\u308f\u308a\u306b\u30e9\u30df\u30f3A\u306e\u4ee3\u308f\u308a\u306b\u30e9\u30df\u30f3A\u306e\u4ee3\u308f\u308a\u306b\u751f\u3058\u308b\u7d30\u80de\u306e\u56fa\u6709\u7a2e\u306f\u3001\u30b3\u30a2\u306e\u5f62\u614b\u306b\u6c38\u4e45\u306b\u7d50\u5408\u3055\u308c\u3001DNA\u640d\u50b7\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u304a\u3088\u3073\u4ee3\u8b1d\u6027\u306e\u5909\u5316\u3001\u8ee2\u5199\u969c\u5bb3\u3001\u30d7\u30ed\u30c6\u30a4\u30f3\u30db\u30e1\u30ed\u30b8\u30fc\u578b\u306e\u5206\u89e3\u306e\u55aa\u5931\u306e\u55aa\u5931\u306e\u55aa\u5931\u306e\u5897\u52a0\u304c\u3042\u308a\u307e\u3059\u3002\u6b7b\u3002 [9]        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4a \u8001\u5316\u95a2\u9023\u306e\u5206\u6ccc\u8868\u73fe\u578b \uff08SASP\uff09\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u6210\u9577\u56e0\u5b50\u3001\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002 [\u5341] SASP\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u3084\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3092\u542b\u3080\u591a\u304f\u306e\u52a0\u9f62\u6027\u75be\u60a3\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059 [6] \u3002\u3053\u306e\u3084\u308b\u6c17\u306e\u3042\u308b\u7814\u7a76\u8005 \u8001\u5316\u85ac \uff08Senolytika\uff09\u9ad8\u9f62\u8005\u306e\u5065\u5eb7\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u8001\u5316\u7d30\u80de\u3092\u6bba\u3057\u305f\u308a\u6392\u9664\u3057\u305f\u308a\u3059\u308b [6] \u3002\u305d\u308c\u3089\u306e\u30d7\u30e9\u30b9\u306e\u52b9\u679c\u306f\u3059\u3067\u306b\u30de\u30a6\u30b9\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 [11] \u8001\u5316\u7d30\u80de\u306e\u30b3\u30a2\u306f\u3001\u8001\u5316\u306b\u95a2\u9023\u3059\u308b\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u30fb\u30d5\u30a9\u30b7\uff08SAHF\uff09\u3068\u30af\u30ed\u30de\u30c1\u30f3\u306e\u5909\u5316\u3092\u4f34\u3046DNA\u30bb\u30b0\u30e1\u30f3\u30c8\u306b\u3088\u3063\u3066\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u3001\u8001\u5316\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\uff08DNA\u50b7\u8de1\uff09\u3002 [12\u756a\u76ee] \u8001\u5316\u7d30\u80de\u306f\u3001\u816b\u760d\u306e\u6291\u5236\u3001\u5275\u50b7\u6cbb\u7652\u3001\u80da \/\u80ce\u76e4\u306e\u767a\u9054\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u304c\u3001\u5e74\u9f62\u95a2\u9023\u75be\u60a3\u3067\u75c5\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002 [13] \u7d30\u80de\u306e\u8001\u5316\u306f\u3001\u3059\u3079\u3066\u306e\u751f\u7269\u3067\u306f\u89b3\u5bdf\u3055\u308c\u307e\u305b\u3093\u3002\u7d30\u80de\u306e\u8001\u5316\u304c\u89b3\u5bdf\u3055\u308c\u308b\u7a2e\u3067\u306f\u3001\u7d30\u80de\u306f\u30df\u30bf\u30fc\u5f8c\u3001\u3064\u307e\u308a\u3001\u6709\u7cf8\u5206\u88c2\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u3063\u3066\u3082\u306f\u3084\u8907\u88fd\u3055\u308c\u306a\u304f\u306a\u308a\u307e\u3059\u3002\u5f7c\u3089\u306f\u8907\u88fd\u8001\u5316\u306e\u72b6\u614b\u306b\u3042\u308a\u307e\u3059\u3002\u3044\u304f\u3064\u304b\u306e\u30bf\u30a4\u30d7\u3067\u3044\u304f\u3064\u304b\u306e\u7d30\u80de\u304c\u30de\u30a4\u30fc\u30c8\u5f8c\u306b\u3069\u306e\u3088\u3046\u306b\u3001\u305d\u3057\u3066\u306a\u305c\u30de\u30a4\u30ca\u30b9\u304c\u591a\u304f\u306e\u7814\u7a76\u3068\u63a8\u6e2c\u306e\u4e3b\u984c\u3067\u3057\u305f\u304c\u3001\u7d30\u80de\u306e\u8001\u5316\u306a\u3069\u304c\u60f3\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u764c\u306e\u59cb\u307e\u308a\u3068spread\u5ef6\u3092\u9632\u3050\u305f\u3081\u306b\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002\u3057\u3070\u3057\u3070\u5171\u6709\u3055\u308c\u3066\u3044\u308b\u4f53\u7d30\u80de\u306f\u3001\u3088\u308a\u591a\u304f\u306eDNA\u5909\u7570\u3092\u6301\u3061\u3001\u3057\u305f\u304c\u3063\u3066\u3001\u5206\u88c2\u304c\u7d99\u7d9a\u3057\u305f\u5834\u5408\u3001\u304c\u3093\u7d30\u80de\u306b\u767a\u9054\u3059\u308b\u30ea\u30b9\u30af\u3092\u4f34\u3044\u307e\u3059\u3002\u52a0\u9f62\u7d30\u80de\u306f\u307e\u305f\u3001\u514d\u75ab\u539f\u6027\u306e\u8868\u73fe\u578b\u3092\u767a\u75c7\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\uff08\u4e0a\u8a18\u53c2\u7167\uff09\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u514d\u75ab\u7cfb\u304c\u305d\u308c\u3089\u3092\u8a8d\u8b58\u3057\u3066\u6392\u9664\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 [14] \u2191  M.\u30b3\u30e9\u30c9\u3001M\u3002A\u3002\u30d6\u30e9\u30b9\u30b3\u3001M\u3002\u30bb\u30e9\u30fc\u30ce\uff1a \u764c\u3068\u52a0\u9f62\u306b\u304a\u3051\u308b\u7d30\u80de\u8001\u5316\u3002 \u306e\uff1a \u7d30\u80de\u3002 \u30d0\u30f3\u30c9130\u3001\u756a\u53f72\u30012007\u5e747\u6708\u3001S\u3002223\u2013233\u3001doi\uff1a 10.1016\/j.cell.2007.07.003 \u3001 PMID 17662938 \uff08\u30ec\u30d3\u30e5\u30fc\uff09\u3002  \u2191  M Hayat\uff1a \u816b\u760d\u306e\u4f11\u7720\u3001\u9759\u6b62\u3001\u8001\u5316\u3001\u7b2c2\u5dfb\uff1a\u8001\u5316\u3001\u764c\u3001\u304a\u3088\u3073\u975e\u764c\u306e\u75c5\u7406\u5b66 \u3002\u30b9\u30d7\u30ea\u30f3\u30ac\u30fc\u30012014\u5e74 S.  188 \u3002   \u2191  Tolls Boll\uff1a \u8001\u5316\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9 \u3002 Springs\u30012010\u3001ISBN 978-1-4419-0638-0\u3001 S.  227 \u3002   \u2191  J. W.\u30b7\u30a7\u30a4\u3001W\u3002E\u3002\u30e9\u30a4\u30c8\uff1a Hayflick\u3001\u5f7c\u306e\u9650\u754c\u3001\u304a\u3088\u3073\u7d30\u80de\u8001\u5316\u3002 \u306e\uff1a \u81ea\u7136\u306e\u30ec\u30d3\u30e5\u30fc\u3002\u5206\u5b50\u7d30\u80de\u751f\u7269\u5b66\u3002 \u30d0\u30f3\u30c91\u3001\u30ca\u30f3\u30d0\u30fc1\u300110 2000\u3001S\u300272\u201376\u3001doi\uff1a 10.1038\/35036093 \u3001 PMID 11413492 \u3002  \u2191  M. Neault\u3001F\u3002Couteauu\u3002\u306b\u3002\uff1a \u30de\u30a4\u30af\u30edRNA\u306b\u3088\u308b\u7d30\u80de\u8001\u5316\u306e\u5206\u5b50\u8abf\u7bc0\uff1a\u764c\u304a\u3088\u3073\u52a0\u9f62\u6027\u75be\u60a3\u3078\u306e\u5f71\u97ff\u3002 \u306e\uff1a \u7d30\u80de\u304a\u3088\u3073\u5206\u5b50\u751f\u7269\u5b66\u306e\u56fd\u969b\u30ec\u30d3\u30e5\u30fc\u3002 \u30d0\u30f3\u30c9334\u30012017\u3001S\u300227\u201398\u30012\uff1a 10.1016\/bs.ircmb.2017.04.001 \u3001 PMID 28838541 \uff08\u30ec\u30d3\u30e5\u30fc\uff09\u3002  \u2191 a b c d  B. G.\u30c1\u30e3\u30a4\u30eb\u30ba\u3001M\u3002\u30c7\u30e5\u30ea\u30c3\u30afu\u3002 a\u3002\uff1a \u52a0\u9f62\u304a\u3088\u3073\u52a0\u9f62\u6027\u75be\u60a3\u306e\u7d30\u80de\u8001\u5316\uff1a\u30e1\u30ab\u30cb\u30ba\u30e0\u304b\u3089\u6cbb\u7642\u307e\u3067\u3002 \u306e\uff1a \u81ea\u7136\u533b\u5b66\u3002 \u7b2c21\u5dfb\u3001\u756a\u53f712\u30012015\u5e7412\u6708\u3001pp\u30021424\u20131435\u3001doi\uff1a 10.1038\/nm.4000 \u3001 PMID 26646499 \u3001 PMC 4748967 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\uff08\u30ec\u30d3\u30e5\u30fc\uff09\u3002  \u2191  A. Noda, S. Mishima, Y. Hirai, K. Hamasaki, R. D. Landes, H. Mitani, K. Haga, T. Kiyono, N. Nakamura, Y. 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R.\u30e1\u30f3\u30c7\u30eb\u30bd\u30fc\u30f3\u3001J\u3002W\u3002\u30e9\u30ea\u30c3\u30af\uff1a \u30bf\u30a6\u3092\u4ecb\u3057\u305f\u795e\u7d4c\u5909\u6027\u306e\u91cd\u8981\u306a\u4e2d\u9593\u4f53\u3068\u3057\u3066\u306e\u7d30\u80de\u8001\u5316\u3002 \u306e\uff1a \u82e5\u8fd4\u308a\u7814\u7a76\u3002 \u7b2c21\u5dfb\u30016\u756a\u30012018\u5e7412\u6708\u3001pp\u3002572\u2013579\u3001doi\uff1a 10.1089\/REJ 2018.2155 \u3001 PMID 30489222 \u3002  \u2191  F. Rhier\u3001J\u3002Patrisi\uff1a \u7d30\u80de\u8001\u5316\u306e4\u3064\u306e\u9854\u3002 \u306e\uff1a Journal of Cell Biology\u3002 \u30d0\u30f3\u30c9192\u3001\u30ca\u30f3\u30d0\u30fc4\u30012011\u5e742\u6708\u3001pp\u3002547\u2013556\u3001doi\uff1a 10.1083\/jcb.201009094 \u3001 PMID 21321098 \u3001 PMC 3044123 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\uff08\u30ec\u30d3\u30e5\u30fc\uff09\u3002  \u2191  D. G. 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