[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/17667#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/17667","headline":"\u8102\u80aa\u9178\u30b7\u30f3\u30bf\u30fc\u30bc\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2","name":"\u8102\u80aa\u9178\u30b7\u30f3\u30bf\u30fc\u30bc\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2","description":"before-content-x4 \u8102\u80aa\u9178\u30b7\u30f3\u30bf\u30fc\u30bc \u5f8c 1xt \u65e2\u5b58\u306e\u69cb\u9020\u30c7\u30fc\u30bf\uff1a 1xt \u3001 2cg5 \u3001 2JFD \u3001 2JFK \u3001 2px6 \u3001 3HD \u3001 3tjm \u3001 4piv","datePublished":"2019-03-11","dateModified":"2019-03-11","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/f\/f2\/Protein_FASN_PDB_1xkt.png\/250px-Protein_FASN_PDB_1xkt.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/f\/f2\/Protein_FASN_PDB_1xkt.png\/250px-Protein_FASN_PDB_1xkt.png","height":"183","width":"250"},"url":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/17667","wordCount":2896,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4\u8102\u80aa\u9178\u30b7\u30f3\u30bf\u30fc\u30bc  \u5f8c 1xt  \u65e2\u5b58\u306e\u69cb\u9020\u30c7\u30fc\u30bf\uff1a 1xt \u3001 2cg5 \u3001 2JFD \u3001 2JFK \u3001 2px6 \u3001 3HD \u3001 3tjm \u3001 4piv \u3001 4W82 \u3001 4w9n  \u30d2\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7279\u6027 \u8cea\u91cf\/\u9577\u3055\u306e\u4e00\u6b21\u69cb\u9020 2511\u30a2\u30df\u30ce\u9178 \u7b2c\u56db\u7d00\u69cb\u9020\u306b\u7d9a\u767a\u3057\u307e\u3059 \u30db\u30e2\u30c7\u30a3\u30de\u30fc \u8b58\u5225\u5b50 \u907a\u4f1d\u5b50\u540d \u305f\u3089\u3044 fas; 519; SDR27x1 \u5916\u90e8ID  \u9175\u7d20\u5206\u985e EC\u3001\u30ab\u30c6\u30b4\u30ea 2.3.1.85 \u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30fc\u30bc \u53cd\u5fdc 2\u3064\u306eC\u539f\u5b50\u306b\u3088\u308bACP\u8102\u80aa\u9178\u9396\u306e\u62e1\u5f35 \u57fa\u677f \u30a2\u30bb\u30c1\u30eb-CoA + N\u30de\u30ed\u30cb\u30eb-CoA + 2N NADPH \u88fd\u54c1 \u9577\u9396\u8102\u80aa\u9178 +\uff08n + 1\uff09COA + N CO\uff082\uff09 + 2N NADP\uff08 +\uff09 \u30aa\u30eb\u30bd\u30ed\u30b8\u30e5  \u4eba \u30cf\u30a6\u30b9\u30de\u30a6\u30b9 \u304a\u5165\u308a\u304f\u3060\u3055\u3044 2194  14104  \u8a2d\u5b9a ensg00000169710  ensmusg000025153  uniprot P49327  P19096  refseq\uff08mRNA\uff09 NM_004104  NM_007988  refseq\uff08\u30bf\u30f3\u30d1\u30af\u8cea\uff09 NP_004095  NP_032014  \u30dd\u30b9\u30bf\u30fc  CHR 17\uff1a82.08-82.1 MB    CHR 11\uff1a120.81-120.82MB   PubMed\u691c\u7d22 2194  14104         (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4 \u8102\u80aa\u9178\u30b7\u30f3\u30bf\u30fc\u30bc\uff08FAS\uff09 \u306f\u3001\u54fa\u4e73\u985e\u304a\u3088\u3073\u771f\u83cc\u306e\u30a2\u30bb\u30c1\u30ebCOA\u304a\u3088\u3073\u30de\u30ed\u30cb\u30ebCOA\u304b\u3089\u306e\u8102\u80aa\u9178\u3001\u7279\u306b\u30d1\u30eb\u30df\u30c1\u30f3\u9178\u306e\u69cb\u9020\u3092\u89e6\u5a92\u3059\u308b\u9175\u7d20\u3067\u3059\u3002\u3053\u308c\u306f\u8102\u8cea\u751f\u6210\u306e\u4e3b\u306a\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308a\u3001\u4f53\u306e\u3059\u3079\u3066\u306e\u81d3\u5668\u3068\u90e8\u5206\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u84c4\u3048\u308b\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u4eba\u9593\u3067\u306f\u3001\u8133\u3001\u80ba\u3001\u809d\u81d3\u3067\u591a\u304f\u306eFA\u304c\u751f\u6210\u3055\u308c\u307e\u3059\u3002 [\u521d\u3081] \u5408\u6210\u30d7\u30ed\u30bb\u30b9\u306f\u3001\u540c\u3058\u9806\u5e8f\u30676\u56de\u9023\u7d9a\u3067\u5b9f\u884c\u3055\u308c\u308b7\u3064\u306e\u500b\u5225\u53cd\u5fdc\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u500b\u3005\u306e\u53cd\u5fdc\u306e\u305d\u308c\u305e\u308c\u306b\u306f\u3001\u8102\u80aa\u9178\u30b7\u30f3\u30bb\u5869\u57fa\u5206\u5b50\u306b\u72ec\u81ea\u306e\u89e6\u5a92\u4e2d\u5fc3\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u305d\u308c\u306f\u591a\u6a5f\u80fd\u9175\u7d20\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u89e6\u5a92\u4e2d\u5fc3\u306e\u6b63\u78ba\u306a\u4f4d\u7f6e\u306f\u3001\u7814\u7a76\u306e\u4e3b\u984c\u3067\u3059\u3002\u690d\u7269\u3084\u7d30\u83cc\u3067\u306f\u3001\u500b\u3005\u306e\u9175\u7d20\u304cFAS\u306e\u30bf\u30b9\u30af\u3092\u5f15\u304d\u53d7\u3051\u307e\u3059\u3002 [2] FAS\u306f\u3001\u591a\u304f\u306e\u816b\u760d\u7d30\u80de\u682a\u3001\u306a\u3089\u3073\u306bB\u578b\u809d\u708e\u304a\u3088\u3073C\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u3067\u904e\u5270\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002 FAS\u963b\u5bb3\u306f\u3001HCV\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u306e\u6e1b\u5c11\u306b\u3082\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u30a8\u30d4\u30ac\u30ed\u30ab\u30c6\u30ad\u30f3-3-\u30ac\u30e9\u30c3\u30c8\uff08\u7dd1\u8336\uff09\u307e\u305f\u306f\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u306e\u6210\u5206\u3084\u6210\u5206\u306a\u3069\u306e\u690d\u7269\u7269\u8cea\u306e\u5065\u5eb7\u4fc3\u9032\u52b9\u679c\u306f\u3001FA\u306e\u963b\u5bb3\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u8102\u80aa\u9178\u30b7\u30f3\u30bf\u30fc\u30bc\u306f\u3001\u88fd\u85ac\u696d\u754c\u306b\u3068\u3063\u3066\u8208\u5473\u6df1\u3044\u6a19\u7684\u3067\u3059\u3002 [3] [4] [5] [6] [7] [8] [9]        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4FAS\u306e\u767a\u73fe\u306f\u3001\u9178\u7d20\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u5834\u5408\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u5834\u5408\u306b\u30d6\u30ed\u30c3\u30af\u3055\u308c\u3001\u7cbe\u5de7\u306a\u8102\u80aa\u9178\u5408\u6210\u3092\u30b7\u30e3\u30c3\u30c8\u30c0\u30a6\u30f3\u3059\u308b\u3053\u3068\u3067\u7bc0\u7d04\u3055\u308c\u307e\u3059\u3002 Caveolin-1\u3067\u3042\u308b\u7d30\u80de\u819c\u306b\u4f4d\u7f6e\u3057\u3066\u3044\u307e\u3059\u3002 [\u5341] [11] \u8a18\u4e8b\u8102\u80aa\u9178\u5408\u6210\u3092\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044\u3002  \u2191  uniprot P49327  \u2191  A. 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KH\u3001Kim JB\u3001Park H\uff1a STRA13\/DEC1\u304a\u3088\u3073DEC2\u306f\u3001\u4f4e\u9178\u7d20\u8a98\u5c0e\u6027\u56e0\u5b50\u4f9d\u5b58\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u30b9\u30c6\u30ed\u30fc\u30eb\u8abf\u7bc0\u8981\u7d20\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea-1C\u3092\u963b\u5bb3\u3057\u307e\u3059 \u3002\u306e\uff1a \u6838\u9178res\u3002 36\u5e74\u76ee\u3001 \u3044\u3044\u3048\u3002  20 \u30012008\u5e7411\u6708\u3001 S.  6372\u201385 \u3001doi\uff1a 10.1093\/nar\/gkn620 \u3001 PMID 18838394 \u3001 PMC 2582599 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\u3002   \u2191  Di Vizio D\u3001Adam RM\u3001Kim J\u3001 et al \uff1a Caveolin-1\u306f\u3001\u8102\u80aa\u9178\u30b7\u30f3\u30bf\u30fc\u30bc\u306e\u8102\u8ceaRaft\u95a2\u9023\u96c6\u56e3\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b \u3002\u306e\uff1a \u7d30\u80de\u5468\u671f \u3002 7\u5e74\u76ee\u3001 \u3044\u3044\u3048\u3002  14 \u30012008\u5e747\u6708\u3001 S.  2257\u201367 \u3001 PMID 18635971 \uff08 landesbiosciving.com 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