[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/19902#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/19902","headline":"RNA\u30ef\u30af\u30c1\u30f3\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2","name":"RNA\u30ef\u30af\u30c1\u30f3\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2","description":"before-content-x4 \u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3057\u3066\u65b0\u898f\u30ef\u30af\u30c1\u30f3\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30d3\u30c7\u30aa\u306f\u3001mRNA\u30ef\u30af\u30c1\u30f3\u3092\u4f7f\u7528\u3057\u305f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304c\u3069\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3059\u308b\u304b\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 [\u521d\u3081] a RNA\u30ef\u30af\u30c1\u30f3 \u307e\u305f mRNA\u30ef\u30af\u30c1\u30f3 \uff08\u307e\u305f\u6642\u4ee3\u9045\u308c\u3067\u3059 RNS\u30ef\u30af\u30c1\u30f3 \uff09\u30ea\u30dc\u6838\u9178\uff08\u4e3b\u306b\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u3001\u30c9\u30a4\u30c4\u306e\u30dc\u30c6\u30f3-RNS\uff09\u307e\u305f\u306fmodRNA\u306b\u5bfe\u3059\u308b\u6d3b\u6027\u6210\u5206\u3068\u3057\u3066\u306e\u4f5c\u7528\u6a5f\u69cb\u306e\u30ef\u30af\u30c1\u30f3\u3067\u3059 [2] \u306b\u3082\u3068\u3065\u3044\u3066\u3002 RNA\u30ef\u30af\u30c1\u30f3\u306f\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3059RNA\u304b\u3089\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f5c\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u907a\u4f1d\u7684\u30ef\u30af\u30c1\u30f3\u306e1\u3064\u3067\u3059\u3002 RNA\u30ef\u30af\u30c1\u30f3\u306f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u3001RNA\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u306b\u5f93\u3063\u3066\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u4f53\u306e\u4f53\u306e\u7ffb\u8a33\u3092\u4f7f\u7528\u3057\u3066\u6297\u539f\u304c\u5f62\u6210\u3055\u308c\u308b\u305f\u3081\u3001\u3059\u3079\u3066\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30d9\u30fc\u30b9\u306e\u6297\u539f\u306b\u5bfe\u3057\u3066\u958b\u767a\u3067\u304d\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u305f\u3068\u3048\u3070\u3001\u30a6\u30a4\u30eb\u30b9\u3001\u7d30\u83cc\u307e\u305f\u306f\u816b\u760d\uff08\u816b\u760d\u6297\u539f\uff09\u306b\u7531\u6765\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 after-content-x4 \u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u4e2d\u306eRNA\u306e\u30d1\u30c3\u30b1\u30fc\u30b8\u306b\u3088\u308a\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u4eba\u306e\u7d30\u80de\u306b\u5bb9\u6613\u306b\u542b\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 [3] [4] \u3053\u308c\u304c\u60a3\u8005\u306e\u7d30\u80de\u306e\u7d30\u80de\u6db2\u306b\u5230\u9054\u3057\u305f\u5f8c\u3001\u7ffb\u8a33\u3092\u958b\u59cb\u3057\u3001\u305d\u308c\u304c\u76ee\u7684\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u6210\u3057\u3001\u305d\u308c\u304b\u3089\u305d\u308c\u306b\u5bfe\u3057\u3066\u5411\u3051\u3089\u308c\u305f\u514d\u75ab\u5fdc\u7b54\u3092\u4f5c\u6210\u3057\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u30ef\u30af\u30c1\u30f3\u81ea\u4f53\u306eRNA\u306f\u9069\u5fdc\u514d\u75ab\u5fdc\u7b54\u3092\u751f\u6210\u305b\u305a\u3001\u77ed\u6642\u9593\u5f8c\u306b\u7d30\u80de\u5185\u3067\u5206\u89e3\u3055\u308c\u307e\u3059\u3002 2020\u5e7412\u67082\u65e5\u3001mRNA\u30ef\u30af\u30c1\u30f3\u306f\u3001Covid","datePublished":"2022-10-06","dateModified":"2022-10-06","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/cc\/RNA_vaccine-en.svg\/350px-RNA_vaccine-en.svg.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/cc\/RNA_vaccine-en.svg\/350px-RNA_vaccine-en.svg.png","height":"307","width":"350"},"url":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/19902","wordCount":13766,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3057\u3066\u65b0\u898f\u30ef\u30af\u30c1\u30f3\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30d3\u30c7\u30aa\u306f\u3001mRNA\u30ef\u30af\u30c1\u30f3\u3092\u4f7f\u7528\u3057\u305f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304c\u3069\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3059\u308b\u304b\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 [\u521d\u3081] a RNA\u30ef\u30af\u30c1\u30f3 \u307e\u305f mRNA\u30ef\u30af\u30c1\u30f3 \uff08\u307e\u305f\u6642\u4ee3\u9045\u308c\u3067\u3059 RNS\u30ef\u30af\u30c1\u30f3 \uff09\u30ea\u30dc\u6838\u9178\uff08\u4e3b\u306b\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u3001\u30c9\u30a4\u30c4\u306e\u30dc\u30c6\u30f3-RNS\uff09\u307e\u305f\u306fmodRNA\u306b\u5bfe\u3059\u308b\u6d3b\u6027\u6210\u5206\u3068\u3057\u3066\u306e\u4f5c\u7528\u6a5f\u69cb\u306e\u30ef\u30af\u30c1\u30f3\u3067\u3059 [2] 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RNA\u30ef\u30af\u30c1\u30f3\u306f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u3001RNA\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u306b\u5f93\u3063\u3066\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u4f53\u306e\u4f53\u306e\u7ffb\u8a33\u3092\u4f7f\u7528\u3057\u3066\u6297\u539f\u304c\u5f62\u6210\u3055\u308c\u308b\u305f\u3081\u3001\u3059\u3079\u3066\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30d9\u30fc\u30b9\u306e\u6297\u539f\u306b\u5bfe\u3057\u3066\u958b\u767a\u3067\u304d\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u305f\u3068\u3048\u3070\u3001\u30a6\u30a4\u30eb\u30b9\u3001\u7d30\u83cc\u307e\u305f\u306f\u816b\u760d\uff08\u816b\u760d\u6297\u539f\uff09\u306b\u7531\u6765\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u4e2d\u306eRNA\u306e\u30d1\u30c3\u30b1\u30fc\u30b8\u306b\u3088\u308a\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u4eba\u306e\u7d30\u80de\u306b\u5bb9\u6613\u306b\u542b\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 [3] [4] \u3053\u308c\u304c\u60a3\u8005\u306e\u7d30\u80de\u306e\u7d30\u80de\u6db2\u306b\u5230\u9054\u3057\u305f\u5f8c\u3001\u7ffb\u8a33\u3092\u958b\u59cb\u3057\u3001\u305d\u308c\u304c\u76ee\u7684\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u6210\u3057\u3001\u305d\u308c\u304b\u3089\u305d\u308c\u306b\u5bfe\u3057\u3066\u5411\u3051\u3089\u308c\u305f\u514d\u75ab\u5fdc\u7b54\u3092\u4f5c\u6210\u3057\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u30ef\u30af\u30c1\u30f3\u81ea\u4f53\u306eRNA\u306f\u9069\u5fdc\u514d\u75ab\u5fdc\u7b54\u3092\u751f\u6210\u305b\u305a\u3001\u77ed\u6642\u9593\u5f8c\u306b\u7d30\u80de\u5185\u3067\u5206\u89e3\u3055\u308c\u307e\u3059\u3002 2020\u5e7412\u67082\u65e5\u3001mRNA\u30ef\u30af\u30c1\u30f3\u306f\u3001Covid 19\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u4e2d\u306b\u5dde\u306e\u898f\u5236\u5f53\u5c40\u306b\u3088\u3063\u3066\u6700\u521d\u306b\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002 \u30c8\u30b8\u30ca\u30e1\u30e9\u30f3 \uff08\u30d6\u30e9\u30f3\u30c9\u540d comirnaty \uff09\u3002 [5] [6] \u4ed6\u306e\u56fd\u3067\u306f\u627f\u8a8d\u304c\u7d9a\u304d\u307e\u3057\u305f\uff08\u627f\u8a8d\u3055\u308c\u305f\u30ef\u30af\u30c1\u30f3\u3092\u53c2\u7167\uff09\u3002        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4RNA\u30ef\u30af\u30c1\u30f3\u306e\u6709\u52b9\u6027\u3068\u30bb\u30ad\u30e5\u30ea\u30c6\u30a3\u306f\u30012002\u5e74\u4ee5\u6765\u3001Covid-19\u4ee5\u5916\u306e\u4ed6\u306e\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u5206\u91ce\uff08\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u306e\u764c\u304a\u3088\u3073\u611f\u67d3\u75c7\uff09\u3088\u308a\u3082\u3001\u30d2\u30c8\u306e\u81e8\u5e8a\u7814\u7a76\u3067\u8abf\u67fb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u591a\u6570\u306e\u524d\u81e8\u5e8a\u30c7\u30fc\u30bf\u304c\u5229\u7528\u53ef\u80fd\u3067\u3059\u3002 [7] [8] [9] [\u5341] [11] [6] Table of Contents\u8a71 \u4e88\u5099\u4f5c\u696d mRNA\u30ef\u30af\u30c1\u30f3 \u52d5\u7269\u306emRNA\u30ef\u30af\u30c1\u30f3\u691c\u67fb \u4eba\u9593\u306emRNA\u30ef\u30af\u30c1\u30f3 \u30a2\u30af\u30b7\u30e7\u30f3\u30e2\u30fc\u30c9 \u88fd\u9020 \u30ef\u30af\u30c1\u30f3\u958b\u767a\u306e\u30cf\u30fc\u30c9\u30eb \u4ed6\u306e\u30ef\u30af\u30c1\u30f3\u30bf\u30a4\u30d7\u3068\u306e\u6bd4\u8f03 \u81e8\u5e8a\u7814\u7a76 COVID 19 BNT162 mRNA-1273 cvncov \u5354\u529b \u3088\u308a\u591a\u304f\u306e\u30ef\u30af\u30c1\u30f3 \u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30ef\u30af\u30c1\u30f3 \u72c2\u72ac\u75c5\u30ef\u30af\u30c1\u30f3 \u304c\u3093\u30ef\u30af\u30c1\u30f3 \u611f\u67d3\u75c7\u306b\u95a2\u3059\u308b\u524d\u81e8\u5e8a\u7814\u7a76 \u4eba\u9593\u306e\u30a8\u30ea\u30a2 \u7363\u533b\u30a8\u30ea\u30a2 \u85ac\u7528\u5206\u985e \u6587\u5b66 \u30c9\u30ad\u30e5\u30e1\u30f3\u30c8 Web\u30ea\u30f3\u30af \u500b\u5225\u306b \u8a71 \u4e88\u5099\u4f5c\u696d mRNA\u306f\u30011961\u5e74\u306b\u30b7\u30c9\u30cb\u30fc\u30d6\u30ec\u30f3\u30ca\u30fc\u3001\u30d5\u30e9\u30f3\u30bd\u30ef\u30b8\u30a7\u30a4\u30b3\u30d6\u3001\u30de\u30b7\u30e5\u30fc\u30e1\u30bb\u30eb\u30bd\u30f3\u306b\u3088\u3063\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u751f\u5408\u6210\u306e\u305f\u3081\u306e\u60c5\u5831\u30ad\u30e3\u30ea\u30a2\u3068\u3057\u3066\u6700\u521d\u306b\u8a18\u8ff0\u3055\u308c\u307e\u3057\u305f\u3002 [12\u756a\u76ee] [13] 1971\u5e74\u3001\u30c1\u30e3\u30fc\u30eb\u30ba\u30c0\u30cb\u30a8\u30eb\u30ec\u30fc\u30f3\u7b49\u3002\u30ab\u30a8\u30eb\u30d2\u30fc\u30bf\u30fc\u3067\u3001\u7db2\u72b6\u8d64\u8840\u7403\u304b\u3089\u30a6\u30b5\u30ae\u304b\u3089\u8abf\u88fd\u3055\u308c\u305f\u6210\u529f\u3057\u305fRNA\u3002 [14] \u5b9f\u9a13\u306f\u3001mRNA\u30ab\u30a8\u30eb\u52a0\u71b1\u7d30\u80de\u304b\u3089\u306e\u7ffb\u8a33\u6a5f\u304c\u4ed6\u306e\u7a2e\u3068\u306f\u307e\u3063\u305f\u304f\u7570\u306a\u308b\u7d30\u80de\u578b\u3092\u53d7\u3051\u5165\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002 [14] 1978\u5e74\u3001Giorgos dimitriadis\u306f\u3001mRNA\u304c\u7d30\u80de\u306e\u30ea\u30dd\u30bd\u30fc\u30e0\u306b\u5438\u53ce\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002 [15] [13] \u540c\u3058\u5e74\u306b\u3001\u30de\u30fc\u30af\u30fb\u30aa\u30b9\u30c8\u30ed\u3068\u4ed6\u306e\u540c\u50da\u306fmRNA\u3092\u30d2\u30c8\u7d30\u80de\u306b\u8f38\u9001\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002 [16] 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[18] \u6700\u521d\u306eRNA\u30d9\u30fc\u30b9\u306e\u533b\u5b66\u306f\u30d1\u30c6\u30a3\u30b7\u30e9\u30f3\u3067\u30012018\u5e74\u306b\u30e8\u30fc\u30ed\u30c3\u30d1\u306eEMA\u3068\u7c73\u56fd\u306eFDA\u306b\u3088\u3063\u3066\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002 [20] mRNA\u30ef\u30af\u30c1\u30f3 \u52d5\u7269\u306emRNA\u30ef\u30af\u30c1\u30f3\u691c\u67fb 1993\u5e74\u30681994\u5e74\u306bRNA\u306f\u3001Fr\u00e9d\u00e9ricMartinon\u3001Pierre Meulien\u3001\u304a\u3088\u3073\u540c\u50da\u306b\u3088\u3063\u3066\u6700\u521d\u306b\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f [21] [18] \u305d\u3057\u3066\u3001\u5c11\u3057\u5f8c\u306bX. 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2005\u5e74\u3001\u30ab\u30bf\u30ea\u30f3\u30ab\u30ea\u30b3\u3068\u30c9\u30ea\u30e5\u30fc\u30ef\u30a4\u30b9\u30de\u30f3\u306f\u3001\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u306a\u3057\u3067\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4fee\u98feRNA\u306e\u4f7f\u7528\u3092\u767a\u8868\u3057\u307e\u3057\u305f\uff08\u3088\u308a\u6b63\u78ba\u306b\u306f\uff1aToll\u69d8\u53d7\u5bb9\u4f533\u30017\u30018\u304a\u3088\u3073MDA-5\u3001NLRP3\u3001RIG-I\u304a\u3088\u3073NOD2\uff09 [24] RNA\u81ea\u4f53\u306b\u3088\u3063\u3066\u904e\u5ea6\u306b\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002 [26] \u6b21\u306e\u5e74\u306b\u3001RNA\u30ef\u30af\u30c1\u30f3\u3092\u691c\u67fb\u3057\u3001\u6b21\u306e\u5e74\u306b\u764c\u30ef\u30af\u30c1\u30f3\u3068\u3057\u3066\u8aac\u660e\u3057\u307e\u3057\u305f\u3002 [7] [27] 2017\u5e74\u3001\u4e16\u754c\u4fdd\u5065\u6a5f\u95a2\u306f\u3001RNA\u30ef\u30af\u30c1\u30f3\u3092\u65b0\u3057\u3044\u30af\u30e9\u30b9\u306e\u6709\u52b9\u6210\u5206\u3068\u3057\u3066\u5438\u53ce\u3059\u308b\u3053\u3068\u3092\u6c7a\u5b9a\u3057\u307e\u3057\u305f\u3002 [28] \u3053\u306e\u6280\u8853\u306f\u3001mRNA\u30d9\u30fc\u30b9\u306eCOVID 19\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u306e\u57fa\u790e\u3092\u5f62\u6210\u3057\u307e\u3057\u305f\u3002 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\u3055\u3089\u306b\u3001\u9670\u30a4\u30aa\u30f3\u6027\u4e8c\u91cd\u5c64\u3092\u901a\u904e\u3067\u304d\u306a\u3044\u3088\u3046\u306b\u8ca0\u306b\u8ca0\u8377\u304c\u304b\u304b\u308a\u307e\u3059\u3002\u88f8\u306emRNA\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u6838\u7a2e\u3068\u81ea\u7136\u514d\u75ab\u7cfb\u306e\u76ee\u6a19\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001mRNA\u304c\u6bd2\u6027\u307e\u305f\u306f\u671b\u307e\u3057\u304f\u306a\u3044\u514d\u75ab\u539f\u6027\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u306a\u304f\u7d30\u80de\u3092\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30c8\u3067\u304d\u200b\u200b\u308b\u3088\u3046\u306b\u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u8a66\u85ac\u304c\u5fc5\u8981\u3067\u3059\u3002\u3053\u308c\u306b\u306f\u30ca\u30ce\u7c92\u5b50\u304c\u3042\u308a\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u306f\u8102\u8cea\u307e\u305f\u306f\u30dd\u30ea\u30de\u30fc\u306e\u3044\u305a\u308c\u304b\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002 [\u6700\u521d\u306b30] \u7d30\u80de\u5185\u306eRNA\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306f\u3001\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306e\u7d4c\u8def\u306e1\u3064\u3092\u4ecb\u3057\u3066\u884c\u308f\u308c\u307e\u3059\u3002\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3067\u306f\u3001\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u306f\u7d30\u80de\u8868\u9762\u306b\u3088\u3063\u3066\u53ce\u7e2e\u3055\u308c\u307e\u3059\u3002\u6b21\u306b\u3001RNA\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u3092\u542b\u3080\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u306e\u5185\u90e8\u3092\u9178\u6027\u5316\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u8a66\u85ac\u306b\u6b63\u306e\u96fb\u8377\u304c\u751f\u6210\u3055\u308c\u3001\u305d\u308c\u304c\u8ca0\u306b\u5e2f\u96fb\u3057\u305f\u5206\u5b50\u3068\u6c34\u3092\u7d50\u5408\u3057\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u306f\u304a\u305d\u3089\u304f\u816b\u308c\u3001\u5834\u6240\u3067\u4e00\u6642\u7684\u306b\u88c2\u3051\u307e\u3059\uff08\u30d7\u30ed\u30c8\u30f3\u30b9\u30dd\u30f3\u30b8\u4eee\u8aac\uff09\u3002 [32] RNA\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306f\u30b5\u30a4\u30c8\u30be\u30eb\u306b\u653e\u51fa\u3055\u308c\u307e\u3059\u3002 [32] \u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001RNA\u304b\u3089\u306e\u7ffb\u8a33\u306e\u904e\u7a0b\u3067\u30ea\u30dc\u30bd\u30fc\u30e0\u306b\u751f\u6210\u3055\u308c\u3001\u6297\u539f\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002 \u7d30\u80de\u306e\u30b5\u30a4\u30c8\u30be\u30eb\u4e2d\u306e\u6297\u539f\u306e\u88fd\u9020\uff08\u5370\u52a0mRNA\u306e\u30ea\u30dc\u30bd\u30fc\u30e0\u30bf\u30f3\u30d1\u30af\u8cea\u751f\u5408\u6210\uff09\u5f8c\u3001\u6700\u521d\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u9084\u5143\u3059\u308b\u9175\u7d20\uff08\u7279\u306b\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30de\u3092\u4ecb\u3057\u3066\uff09\u306b\u3088\u308b\u5206\u89e3\u304c\u3042\u308a\u3001\u6b21\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u65ad\u7247\uff08\u30da\u30d7\u30c1\u30c9\uff09\u3092\u6297\u4e9c\u925b\u98fc\u6599\u3092\u4ecb\u3057\u3066\u30a8\u30f3\u30c8\u30e9\u30ba\u30de\u985e\uff08\u30da\u30d7\u30c1\u30c9\uff09\u306b\u8f38\u51fa\u3057\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u30da\u30d7\u30c1\u30c9\u306fMHC\u8907\u5408\u4f53\u306b\u7d50\u5408\u3057\u3001\u7d30\u80de\u8868\u9762\u306b\u5206\u6ccc\u3055\u308c\u3001\u6297\u539f\u306e\u30a8\u30d4\u30c8\u30fc\u30d7\u3092\u63d0\u793a\u3057\u307e\u3059\u3002\u4e3b\u306a\u7d44\u7e54\u9069\u5408\u6027\u8907\u5408\u4f53MHC\u306b\u95a2\u3059\u308b\u30d7\u30ec\u30bc\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3I\u306f\u3001\u30b9\u30d1\u30a4\u30af\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u3057\u3066\u7d30\u80de\u6bd2\u6027T\u7d30\u80de\u304c\u5f62\u6210\u3055\u308c\u308b\u7d30\u80de\u514d\u75ab\u5fdc\u7b54\u3092\u4f5c\u6210\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001\u6297\u539f\u306e\u30a8\u30d4\u30c8\u30fc\u30d7\u306e\u307f\u304cMHC II\u306b\u63d0\u793a\u3055\u308c\u3001\u7d30\u80de\u306e\u5916\u5074\u304b\u3089\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u3063\u3066\u5438\u53ce\u3055\u308c\u3001\u30d7\u30ed\u30c6\u30a2\u30b7\u30eb\u306b\u3088\u3063\u3066\u5206\u89e3\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30a8\u30d4\u30c8\u30fc\u30d7\u306eMHC-II\u30d7\u30ec\u30bc\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3\u306f\u3001\u4f53\u6db2\u6027\u514d\u75ab\u5fdc\u7b54\u3092\u4f5c\u6210\u3057\u307e\u3059\u3002 [33] \u819c\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6297\u539f\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u308b\u5834\u5408\u3001\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u7d30\u80de\u8868\u9762\u306b\u3082\u5168\u9577\u306b\u308f\u305f\u3063\u3066\u63d0\u793a\u3055\u308c\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u6297\u4f53\u306f\u305d\u308c\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002  mRNA\u30ef\u30af\u30c1\u30f3\u306e\u69cb\u7bc9 \u7d30\u80de\u5185\u3067mRNA\u304c\u5206\u89e3\u3055\u308c\u308b\u307b\u3069\u3001\u3088\u308a\u983b\u7e41\u306b\u7ffb\u8a33\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u3053\u306emRNA\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u304b\u3089\u3088\u308a\u591a\u304f\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f5c\u6210\u3055\u308c\u307e\u3059\u3002 mRNA\u306e\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u306f\u975e\u5e38\u306b\u7570\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u3001mRNA\u306b\u5fdc\u3058\u3066\u6570\u5206\uff08\u305f\u3068\u3048\u3070\u591a\u304f\u306e\u8abf\u7bc0\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3042\u308b\u5834\u5408\uff09\u3068\u6570\u6642\u9593\u306e\u9593\u306b\u3042\u308a\u307e\u3059\u3002 [34] mRNA\u306e5 ‘\u672b\u7aef\u306b\u3042\u308b\u30ad\u30e3\u30c3\u30d7\u69cb\u9020\u30685’\u304a\u3088\u30733’\u7aef\u306e\u4e88\u6e2c\u4e0d\u53ef\u80fd\u306a\u9818\u57df\uff08UTR\uff09\u306f\u3001\u7d30\u80de\u8cea\u30a8\u30ad\u30bd\u30ea\u30dc\u30cc\u30af\u30ec\u30a2\u30b9\u306b\u3088\u3063\u3066\u5206\u89e3\u3055\u308c\u308b\u524d\u306bmRNA\u306e\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u3092\u5897\u52a0\u3055\u305b\u3001\u3088\u308a\u591a\u304f\u306e\u6297\u539f\u3092\u751f\u6210\u3057\u307e\u3059\u3002 [35] \u3055\u3089\u306b\u3001mRNA\u306e\u69cb\u9020\u306f\u3001\u81ea\u7136\u514d\u75ab\u7cfb\u306b\u3088\u3063\u3066\u8a8d\u8b58\u3055\u308c\u306a\u3044\u3088\u3046\u306b\u3001\u7570\u5e38\u306a\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u306e\u8a2d\u7f6e\u306b\u3088\u3063\u3066\u4fee\u6b63\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4fee\u98femRNA\uff08modRNA\uff09\u306f\u3001\u305f\u3068\u3048\u3070RNA\u30d9\u30fc\u30b9\u306eCovid 19\u30ef\u30af\u30c1\u30f3\u3067\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u30a2\u30b8\u30e5\u30d0\u30f3\u30c6\u30a3\u30a2\u3092\u4f7f\u7528\u3057\u3066\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u5f37\u5316\u3067\u304d\u307e\u3059\u3002 [36] RNA\u30ef\u30af\u30c1\u30f3\uff08\u30ef\u30af\u30c1\u30f3\uff09\u306f\u3001\u30ab\u30c1\u30aa\u30f3\u6027\u30ca\u30ce\u30a8\u30de\u30eb\u30b8\u30e7\u30f3\uff08\u6ef4\u4e0b\u76f4\u5f84100\u30ca\u30ce\u30e1\u30fc\u30c8\u30eb\u672a\u6e80\u306e\u30a8\u30de\u30eb\u30b8\u30e7\u30f3\uff09\u304a\u3088\u3073MF59\u307e\u305f\u306fMF59\u306e\u3088\u3046\u306a\u30a2\u30b8\u30e5\u30d0\u30f3\u3067\u914d\u5408\u3055\u308c\u308b\u5834\u5408\u3001\u3088\u308a\u52b9\u679c\u7684\u3067\u3059\u3002 Trimix \uff08CD40L\u3001CD70\u304a\u3088\u3073CATL\u200b\u200bR-4\u306emRNA\uff09\u3002 \u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u306e\u9650\u3089\u308c\u305f\u62e1\u5f35\u3001\u3057\u305f\u304c\u3063\u3066\u6297\u539f\u7523\u751f\u306e\u5897\u52a0\u306f\u3001\u8907\u88fd\u53ef\u80fd\u306amRNA\u306b\u3088\u308b\u3082\u306e\u3067\u3059\uff08 \u81ea\u5df1\u5897\u52a0mRNA \u3001samna\uff09\u306b\u5230\u9054\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u6297\u539f\u3092\u30b3\u30fc\u30c9\u3057\u3001\u3055\u3089\u306bRNA\u30ec\u30d7\u30ea\u30ab\u3092\u30b3\u30fc\u30c9\u3057\u307e\u3059\u3002\u3053\u306eRNA\u3092\u30b3\u30d4\u30fc\u3059\u308b\u9175\u7d20\u306e\u5834\u5408\u3002 Samna\u306f\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u7279\u5b9a\u306e\u967d\u6027\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u8abf\u7bc0\u306b\u304a\u3044\u3066\u7a4d\u6975\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u72ec\u81ea\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u30bb\u30f3\u30b5\u30fc\u3068\u523a\u6fc0\u88c5\u7f6e\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002 [35] [37] [38] \u305d\u306e\u7d50\u679c\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306b\u4f7f\u7528\u3055\u308c\u308bRNA\u306e\u91cf\u306f\u3001\u540c\u3058\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u52b9\u679c\u3067\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 [39] 50 ng RNA\u304c\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u52b9\u679c\u306b\u5341\u5206\u3067\u3042\u308b\u3068\u8aac\u660e\u3055\u308c\u305f\u305f\u3081\u3067\u3059\u3002 [40] Samna\u306f\u6297\u539f\u306e\u307f\u3092\u30b3\u30fc\u30c9\u3059\u308bmRNA\u3088\u308a\u3082\u5927\u5e45\u306b\u5927\u304d\u3044\u305f\u3081\u3001\u7d30\u80de\u306b\u542b\u3081\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u7570\u306a\u308b\u306f\u305a\u3067\u3059\u3002 [41] \u88fd\u9020 \u751f\u7523\u306f\u901a\u5e38\u3001in vitro\u8ee2\u5199\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u307e\u3059\u3002\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4fee\u98femRNA\u306f\u3001\u904e\u5ea6\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u53cd\u5fdc\u3092\u907f\u3051\u308b\u305f\u3081\u306b\u3057\u3070\u3057\u3070\u751f\u6210\u3055\u308c\u307e\u3059\u3002 [42] RNA\u306f\u3001RNA\u306e\u5206\u89e3\u3092\u9045\u304f\u3059\u308b\u305f\u3081\u306b\u3001\u30ad\u30e3\u30c3\u30d7\u69cb\u9020\u3068\u30dd\u30eaA\u30c6\u30fc\u30eb\u3092\u642d\u8f09\u3057\u3066\u3044\u307e\u3059\u3002 [43] \u3055\u3089\u306b\u3001RNA\u3067\u7279\u5b9a\u306e5 ‘\u304a\u3088\u30733’-UTR\u3092\u4f7f\u7528\u3057\u3066\u3001RNA\u306e\u5206\u89e3\u3092\u3055\u3089\u306b\u9045\u304f\u3057\u307e\u3059\u3002 [44] [45] \u751f\u6210\u3055\u308c\u305fRNA\u306e\u54c1\u8cea\u57fa\u6e96\u306b\u306f\u3001\u5b89\u5b9a\u6027\u3001\u5b8c\u5168\u6027\u3001\u540c\u4e00\u6027\u3001\u7d14\u5ea6\u3001\u5747\u4e00\u6027\u304c\u542b\u307e\u308c\u307e\u3059\u3002 [35] RNA\u3092\u7d30\u80de\u306b\u5165\u308c\u308b\u305f\u3081\u306b\u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u8a66\u85ac\u3092\u6ce8\u5165\u3057\u307e\u3059\u3002 [35] \u30a8\u30ec\u30af\u30c8\u30ed\u30dd\u30fc\u5316\u3001 [46] Gene Cannon\u306b\u3088\u3063\u3066\u7ba1\u7406\u3055\u308c\u3001 [40] \u307e\u305f\u306f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304c\u884c\u308f\u308c\u307e\u3059 ex vivo \u990a\u5b50\u7d30\u80de\u79fb\u52d5\u304c\u7d9a\u304d\u307e\u3059\u3002 [47] \u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u306e\u7d50\u679c\u306f\u5869\u57fa\u6027\u8102\u8ceaA\u30ea\u30dd\u30bd\u30fc\u30e0\u3067\u3057\u305f [48] \uff08\u3053\u308c\u306b\u3088\u308a\u3001\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u3001LNP\u304c\u4f5c\u6210\u3055\u308c\u307e\u3059\uff09\u3001 [49] [50] \u7d30\u80de\u6d78\u900f\u30da\u30d7\u30c1\u30c9\u3001 [51] \u30d7\u30ed\u30c6\u30a4\u30f3\u3001\u30d7\u30ed\u30bf\u30df\u30f3\u3001 [52] \u76f4\u5f84\u7d0480 nm\uff08AUNP\uff09\u306e\u30ab\u30c1\u30aa\u30f3\u6027\u30dd\u30ea\u30de\u30fc\u307e\u305f\u306f\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002 [50] [35] [53] RNA\u30ef\u30af\u30c1\u30f3mRNA-1273\u306f\u30ab\u30c1\u30aa\u30f3\u6027\u8102\u8ceaSM-102\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3001ALC-0315\u306f\u30c8\u30b8\u30f3\u30a2\u30e1\u30ea\u30ab\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002 [54] \u3055\u3089\u306b\u3001\u4e2d\u6027\u8102\u8cea\uff08 \u30d8\u30eb\u30d1\u30fc\u8102\u8cea \uff09\u30ea\u30dd\u30bd\u30fc\u30e0\uff08\u30c8\u30b8\u30f3\u30a2\u30e1\u30e9\u30f3\u306a\u3069\uff09\u3092\u5b89\u5b9a\u5316\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u3001pH\u5024\u3092\u5b89\u5b9a\u3055\u305b\u308b\u305f\u3081\u306b\u7269\u8cea\u3092\u7de9\u885d\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002 [54] \u7a4d\u6975\u7684\u306b\u5e2f\u96fb\u3057\u305f\u30ca\u30ce\u7c92\u5b50\u306e\u305f\u3081\u3001\u6ce8\u5c04\u5f8c\u306eRNA \u7121\u99c4\u306b \u7d30\u80de\u306b\u3088\u3063\u3066\u8a18\u9332\u3055\u308c\u3001RNA\u306e\u6e1b\u5c11\u306f\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u8a66\u85ac\u306b\u3088\u3063\u3066\u6e1b\u901f\u3055\u308c\u307e\u3059\u3002 [55] \u7d30\u80de\u5185\u306eRNA\u306f\u3001\u53d7\u5bb9\u4f53\u5a92\u4ecb\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u308b\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002 [56] [57] \u5c11\u306a\u304f\u3068\u3082DNA\uff08\u540c\u3058\u65b9\u6cd5\u304cRNA\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3001\u540c\u3058\u7d30\u80de\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u5438\u53ce\u3055\u308c\u308b\uff09\u306e\u5834\u5408\u3001\u7d30\u80de\u57f9\u990a\u306e\u6442\u53d6\u91cf\u3068\u7d30\u80de\u57f9\u990a\u306e\u6442\u53d6\u91cf\u3068\u306e\u9593\u306b\u306f\u5f31\u3044\u76f8\u95a2\u304c\u3042\u308a\u307e\u3059\u3002 \u7121\u99c4\u306b [58] \u307e\u305f\u3001\u7d30\u80de\u57f9\u990a\u306b\u304a\u3051\u308b\u8a18\u9332\u3068\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u52b9\u679c\u306e\u9593\u306b\u76f8\u95a2\u95a2\u4fc2\u306f\u3042\u308a\u307e\u305b\u3093\u3002 [59] \u3053\u308c\u306f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u52b9\u679c\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u4e88\u9632\u63a5\u7a2e\u52b9\u679c\u306f\u524d\u81e8\u5e8a\u7814\u7a76\u306e\u6bb5\u968e\u304b\u200b\u200b\u3089\u6700\u3082\u65e9\u3044\u6642\u306b\u63a8\u5b9a\u3067\u304d\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u3069\u3061\u3089\u306e\u30ef\u30af\u30c1\u30f3\u306b\u3082\u971c\u306e\u4fdd\u8b77\u3068\u3057\u3066\u306e\u30b5\u30f3\u30ab\u7cd6\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3001 [54] \u7d50\u679c\u3068\u3057\u3066\u5f97\u3089\u308c\u308b\u6c37\u306e\u7d50\u6676\u3092\u51cd\u7d50\u3059\u308b\u3068\u304d\u306b\u5c0f\u3055\u304f\u4fdd\u3061\u3001\u3057\u305f\u304c\u3063\u3066\u3001RNA\u304c\u65ad\u7247\u5316\u3067\u304d\u308b\u5927\u304d\u306a\u6c37\u306e\u7d50\u6676\u3092\u4ecb\u3057\u305f\u305b\u3093\u65ad\u529b\u3092\u907f\u3051\u308b\u305f\u3081\u3002 RNA\u30ef\u30af\u30c1\u30f3\u306e\u751f\u7523\u306b\u95a2\u3059\u308b\u6b27\u5dde\u9023\u5408\u306e\u898f\u5236\u8981\u4ef6\u304c2017\u5e74\u306b\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002 [60] \u30ef\u30af\u30c1\u30f3\u958b\u767a\u306e\u30cf\u30fc\u30c9\u30eb RNA\u30ef\u30af\u30c1\u30f3\u306e\u767a\u75c7\u306e\u554f\u984c\u306f\u3001RNA\u304c\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u306e\u6d3b\u6027\u5316\u306b\u3088\u308a\u904e\u5ea6\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3067\u3059\u3002 [35] [\u516d\u5341\u4e00] \u5148\u5929\u6027\u514d\u75ab\u5fdc\u7b54\u306f\u3001RNA\u3092TLR\u306e\u3088\u3046\u306a\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\uff08TLR 7\u3092\u542b\u3080 [62] \uff09\u3001\u30ea\u30b0I\u304a\u3088\u3073\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bcR [63] RNA\u306b\u5bfe\u3059\u308b\u904e\u5ea6\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u305f\u3081\u306b\u3001mRNA\u30ef\u30af\u30c1\u30f3\u914d\u5217\u306f\u54fa\u4e73\u985e\u7d30\u80de\u306b\u3088\u3063\u3066\u7523\u751f\u3055\u308c\u305f\u3082\u306e\u3092\u6a21\u5023\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 [\u516d\u5341\u56db] \u3055\u3089\u306b\u3001RNA\u306b\u5bfe\u3059\u308b\u514d\u75ab\u53cd\u5fdc\u306f\u3001\u4fee\u98fe\u3055\u308c\u305f\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u306b\u3088\u3063\u3066\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff08Pseudouridine\u3001 [65] n 1-\u30e1\u30c1\u30eb\u30d7\u30bb\u30c9\u30a5\u30ea\u30c7\u30a3\u30f3\u3001 [66] 5-\u30e1\u30c1\u30eb\u30b7\u30c1\u30b8\u30f3\u3001 [65] 2′-O-\u30e1\u30c1\u30eb\u5316\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\uff09 [\u516d\u5341\u4e00] [\u516d\u5341\u4e03] [68] \u307e\u305f\u306f\u3001\u30b3\u30c9\u30f3\u306e\u6700\u9069\u5316\u3068\u7279\u5b9a\u306e\u7ffb\u8a33\u3055\u308c\u3066\u3044\u306a\u3044\u9818\u57df\u306e\u4f7f\u7528\uff08\u5b9f\u969b\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u306a\u3044mRNA\u306e\u9650\u754c\u9818\u57df\uff09 [63] [69] \u6e1b\u3089\u3059\u305f\u3081\u306b\u3001\u3053\u308c\u3082RNA\u3092\u9045\u304f\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u58ca\u308c\u305f\u8ee2\u5199\u7523\u7269\u3068RNA\u5e72\u6e09\u306f\u3001mRNA\u306e\u4e8c\u672c\u9396\u65ad\u7247\u306b\u5bfe\u3059\u308b\u4f5c\u7528\u671f\u9593\u3092\u77ed\u7e2e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001mRNA\u306e\u65e9\u671f\u6e1b\u5c11\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002 [35] \u3057\u305f\u304c\u3063\u3066\u3001\u76ee\u7684\u306e\u9577\u3055\u3067\u6700\u3082\u304d\u308c\u3044\u3067\u4e00\u672c\u9396mRNA\u3092\u5f97\u308b\u305f\u3081\u306b\u306f\u3001\u591a\u6bb5\u968eRNA\u6d17\u6d44\u304c\u5fc5\u8981\u3067\u3059\u3002 [35] [70] [69] \u30bb\u30eb\u30ed\u30fc\u30b9\u306e\u5438\u7740\u306b\u3088\u308a\u3001\u671b\u307e\u3057\u304f\u306a\u3044\u4e8c\u91cd\u9396RNA\u3092\u6bd4\u8f03\u7684\u5b89\u4fa1\u306b\u9664\u53bb\u3067\u304d\u307e\u3059\u3002 [71] \u305f\u3068\u3048\u3070\u3001\u7279\u5b9a\u306e\u7cbe\u88fd\u6280\u8853\u306f\u3001\u307b\u307c\u30bf\u30f3\u30d1\u30af\u8cea\u6db2\u4f53\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\uff08FPLC\uff09\u306b\u3088\u308a\u3001\u7ffb\u8a33\u3092\u5897\u52a0\u3055\u305b\u3001\u3057\u305f\u304c\u3063\u3066\u6709\u52b9\u6027\u3092\u9ad8\u3081\u307e\u3059\u3002 [72] \u7d30\u80de\u306e\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u3067\u8a18\u9332\u3055\u308c\u3066\u3044\u308bRNA\u306e\u6700\u5927\u306e\u5272\u5408\u306f\u3001\u304a\u305d\u3089\u304f\u30b5\u30a4\u30c8\u30be\u30eb\u306b\u5230\u7740\u305b\u305a\u3001\u305d\u3053\u3067\u6a5f\u80fd\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u304c\u3001\u5206\u89e3\u3055\u308c\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u7528\u91cf\u3067\u3088\u308a\u5c11\u306a\u3044RNA\u3092\u4f7f\u7528\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u305f\u3081\u306b\u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u52b9\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 [\u4e03\u5341\u4e09] \u7d30\u80de\u5916RNA\u306f\u3001\u51dd\u56fa\u5264\u304a\u3088\u3073\u900f\u904e\u6027\u4fc3\u9032\u56e0\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5185\u76ae\u7d30\u80de\u306e\u900f\u904e\u6027\u306e\u5897\u52a0\u306f\u6d6e\u816b\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u8840\u6db2\u51dd\u56fa\u306e\u523a\u6fc0\u306f\u3001\u8840\u6813\u306e\u30ea\u30b9\u30af\u3092\u62b1\u304d\u307e\u3059\u3002 [74] \u4ed6\u306e\u30ef\u30af\u30c1\u30f3\u30bf\u30a4\u30d7\u3068\u306e\u6bd4\u8f03 DNA\u30ef\u30af\u30c1\u30f3\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001RNA\u30ef\u30af\u30c1\u30f3\u306f\u7d30\u80de\u6838\u3067\u8f38\u9001\u3055\u308c\u305a\u3001\u7d30\u80de\u6838\u304a\u3088\u3073\u8ee2\u5199\u306b\u8f38\u5165\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u305b\u3093\u3002 [35] DNA\u30ef\u30af\u30c1\u30f3\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u30b2\u30ce\u30e0DNA\u306b\u633f\u5165\u3059\u308b\u30ea\u30b9\u30af\u306f\u3042\u308a\u307e\u305b\u3093 [41] \u307e\u305f\u306f\u3001\u907a\u4f1d\u7684\u30d0\u30a6\u30c1\u30e3\u30fc\u306e\u5146\u5019\u3001\u3053\u306e2\u3064\u306e\u8ffd\u52a0\u306e\u9175\u7d20\u304c\u30d2\u30c8\u7d30\u80de\u3067\u306f\u767a\u751f\u3057\u306a\u3044\u305f\u3081\u306b\u5fc5\u8981\u306a\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002 [75] \u3057\u305f\u304c\u3063\u3066\u3001\u907a\u4f1d\u5b50\u6cbb\u7642\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u4f53\u7d30\u80de\u306eDNA\u306b\u5909\u5316\u306f\u3042\u308a\u307e\u305b\u3093\u3002 [76] mRNA\u306b\u306f\u3001\u6bd4\u8f03\u7684\u77ed\u3044\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u304c\u3042\u308a\u307e\u3059\u3002 [77] \u3057\u305f\u304c\u3063\u3066\u3001\u30bb\u30eb\u5185\u306e\u6c38\u7d9a\u7684\u306a\u5c45\u5834\u6240\u306f\u9664\u5916\u3055\u308c\u307e\u3059 [35] \u7279\u306b\u3001\u3053\u308c\u306f\u7d30\u80de\u6bd2\u6027T\u7d30\u80de\u306b\u3088\u308b\u514d\u75ab\u5fdc\u7b54\u306e\u904e\u7a0b\u3067\u3068\u306b\u304b\u304f\u7834\u58ca\u3055\u308c\u308b\u305f\u3081\u3067\u3059\u3002 DNA\u3068\u6bd4\u8f03\u3057\u3066\u3001RNA\u306f\u904d\u5728\u3059\u308b\u5206\u89e3\u9175\u7d20\uff08RNA\u3067\u306f\u30d0\u30e9\uff09\u306b\u6bd4\u8f03\u7684\u654f\u611f\u3067\u3059\u3002 [78] RNA\u306f\u3001\u30d7\u30e9\u30b9\u30df\u30c9DNA\u3088\u308a\u3082\u88fd\u9020\u3059\u308b\u305f\u3081\u306b\u3088\u308a\u30b3\u30b9\u30c8\u304c\u304b\u304b\u308a\u307e\u3059\u3002 [24] \u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3001DNA\u3001RNA\u3001\u304a\u3088\u3073\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u30ef\u30af\u30c1\u30f3\u3067\u306f\u3001\u5b8c\u5168\u306a\u75c5\u539f\u4f53\u306f\u751f\u7523\u306b\u4f7f\u7528\u3055\u308c\u307e\u305b\u3093\u3002\u3064\u307e\u308a\u3001\u611f\u67d3\u4fdd\u8b77\u6cd5\u3068\u751f\u4f53\u9020\u308a\u6761\u4f8b\u306b\u3088\u308b\u3068\u3001\u30c9\u30a4\u30c4\u306e\u751f\u7523\u65bd\u8a2d\u306b\u306f\u8ffd\u52a0\u306e\u627f\u8a8d\u306f\u5fc5\u8981\u3042\u308a\u307e\u305b\u3093\u3002\u30d3\u30c8\u30ed\u5185\u8ee2\u5199\u306b\u3088\u308bRNA\u30ef\u30af\u30c1\u30f3\u306e\u88fd\u9020\u3082\u3001\u751f\u7d30\u80de\u3092\u4f7f\u7528\u305b\u305a\u306b\u5b9f\u884c\u3055\u308c\u307e\u3059\uff08\u7121\u7d30\u80de\u7523\u751f\uff09\u3002 [72] \u653b\u6483\u3055\u308c\u305f\u3082\u306e\u3068\u306f\u5bfe\u7167\u7684\u306b\uff08\u52b9\u679c\u304c\u5f31\u4f53\u5316\u3055\u308c\u3066\u3044\u308b\u52b9\u679c\u304b\u3089\u5f8c\u9000\u3059\u308b\uff09\u3001\u75c5\u539f\u4f53\u306e\u500b\u3005\u306e\u6210\u5206\u306e\u307f\u304c\u4f7f\u7528\u3055\u308c\u308b\u305f\u3081\u3001\u75c5\u539f\u4f53\u306b\u5fa9\u5e30\uff08\u80cc\u5f8c\u7a81\u7136\u5909\u7570\uff09\u306f\u767a\u751f\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002 [35] \u3055\u3089\u306b\u3001RNA\u30ef\u30af\u30c1\u30f3\u306f\u6bd4\u8f03\u7684\u8fc5\u901f\u306b\u5927\u91cf\u306b\u751f\u6210\u3067\u304d\u3001\u751f\u7523\u306f\u6bd4\u8f03\u7684\u5b89\u4fa1\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002 [79] [80] \u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3068\u6bd4\u8f03\u3057\u3066\u3001RNA\uff08DNA\u306e\u3088\u3046\u306a\uff09\u306f\u30d9\u30af\u30bf\u30fc\u514d\u75ab\u3092\u751f\u6210\u3057\u307e\u305b\u3093\u3001 [24] RNA\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306b\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3068\u305d\u306e\u65b0\u3057\u3044\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30c8\u30eb\u306b\u65e9\u671f\u306b\u3064\u306a\u304c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u306a\u3044\u305f\u3081\u3067\u3059\u3002\u81f4\u547d\u7684\u306a\u30ef\u30af\u30c1\u30f3\u3001\u30b5\u30d6\u30e6\u30cb\u30c6\u30a3\u30ef\u30af\u30c1\u30f3\u3001\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3\u3001\u907a\u4f1d\u5b50\u30ef\u30af\u30c1\u30f3\uff08DNA\u30ef\u30af\u30c1\u30f3\u3001RNA\u30ef\u30af\u30c1\u30f3\u3001\u307e\u305f\u306f\u30d9\u30af\u30bf\u30fc\u30ef\u30af\u30c1\u30f3\uff09\u306a\u3069\u306e\u53e4\u3044\u30ef\u30af\u30c1\u30f3\u306e\u7a2e\u985e\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u30b5\u30a4\u30c8\u30be\u30eb\u306b\u6297\u539f\u304c\u751f\u6210\u3055\u308c\u3001\u6e7f\u6c17\u3060\u3051\u3067\u306a\u304f\u7d30\u80de\u514d\u75ab\u5fdc\u7b54\u3082\u5f15\u304d\u8d77\u3053\u3057\u307e\u3057\u305f\u3002 \u4ed6\u306e\u30bf\u30a4\u30d7\u306e\u30ef\u30af\u30c1\u30f3\u3068\u6bd4\u8f03\u3057\u3066\u5f37\u3044RNA\u30ef\u30af\u30c1\u30f3\u306e\u526f\u4f5c\u7528\u306f\u3001\u88fd\u9020\u30d7\u30ed\u30bb\u30b9\u306b\u8d77\u56e0\u3059\u308b\u6c5a\u67d3\u7269\u8cea\u306b\u57fa\u672c\u7684\u306b\u8d77\u56e0\u3057\u3001\u304a\u305d\u3089\u304f\u5b8c\u5168\u306b\u9632\u6b62\u3067\u304d\u306a\u3044\u3082\u306e\u3067\u3059\u3002\u3053\u306e\u70b9\u3067\u3001\u76ee\u6a19\u306f\u3001\u30ef\u30af\u30c1\u30f3\u3092\u3088\u308a\u4e92\u63db\u6027\u306e\u3042\u308b\u3082\u306e\u306b\u3059\u308b\u305f\u3081\u306b\u3001\u305d\u308c\u3089\u3092\u3055\u3089\u306b\u6e1b\u3089\u3059\u3053\u3068\u3067\u3059\u3002 [81] \u81e8\u5e8a\u7814\u7a76 COVID 19 RNA\u30ef\u30af\u30c1\u30f3\u3067\u306f\u306a\u3044\u4eba\u3092\u542b\u3080\u3059\u3079\u3066\u306eCOVID-19-\u30d0\u30af\u30b7\u30f3\u5019\u88dc\u306e\u8868\u73fe\u306b\u3064\u3044\u3066\u306f\u3001SARS-COV-2\u30ef\u30af\u30c1\u30f3\u5019\u88dc\u3092\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044\u3002  \u3055\u307e\u3056\u307e\u306aRNA\u30ef\u30af\u30c1\u30f3\u306f\u3001\u7279\u306bCovid 19\u30ef\u30af\u30c1\u30f3\u306e2019\u5e74\u672b\u4ee5\u6765\u3001\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u306b\u304a\u3051\u308b\u30ef\u30af\u30c1\u30f3\u5019\u88dc\u3067\u3059\u3002\u3053\u306e\u30bf\u30a4\u30d7\u306e\u30ed\u30b8\u30b9\u30c6\u30a3\u30af\u30b9\u306f\u3001\u3053\u306e\u30bf\u30a4\u30d7\u306e\u8ab2\u984c\u3068\u898b\u306a\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u30bf\u30a4\u30d7\u306f\u3001-70\u00b0C\u4ee5\u4e0b\u306e\u6e29\u5ea6\u3067\u4fdd\u7ba1\u304a\u3088\u3073\u8f38\u9001\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002 [82] [83] BNT162 2020\u5e744\u670822\u65e5\u3001\u3053\u306e\u3088\u3046\u306a\u30ef\u30af\u30c1\u30f3\u306e\u81e8\u5e8a\u7814\u7a76\u304c\u30c9\u30a4\u30c4\u3067\u521d\u3081\u3066\u30dd\u30fc\u30eb\u30fb\u30a8\u30fc\u30eb\u30ea\u30c3\u30d2\u7814\u7a76\u6240\u3068\u30d0\u30fc\u30c7\u30f3\u30fb\u30f4\u30e5\u30eb\u30c6\u30f3\u30d9\u30eb\u30af\u5dde\u502b\u7406\u59d4\u54e1\u4f1a\u306b\u3088\u3063\u3066\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u30c9\u30a4\u30c4\u306e\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f1a\u793eBiontech\u3068\u305d\u306e\u7c73\u56fd\u306e\u30d1\u30fc\u30c8\u30ca\u30fc\u306e\u30d5\u30a1\u30a4\u30b6\u30fc\u306e\u5019\u88dcBNT162\u3067\u3059\u3002 [84] [85] mRNA\u5f62\u5f0f\u306f\u3001\u514d\u75ab\u539f\u6027\u304c\u9ad8\u3044\u30a6\u30ea\u30b8\u30f3\u542b\u6709mRNA\uff08\u30a6\u30ca\uff09\u3001\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4fee\u98femRNA\uff08modRNA\uff09\u304a\u3088\u3073\u30bb\u30eb\u30d5\u30b9\u30bf\u30df\u30camRNA\uff08SARNA\uff09\u3067\u3059\u3002 [\u516b\u5341\u516d] \u8102\u8cea\u306fmRNA\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u8a66\u85ac\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306eLNP\u306f\u6ce8\u5c04\u5f8c\u306b\u5b89\u5b9a\u3057\u3066\u304a\u308a\u3001mRNA\u3068\u3068\u3082\u306b\u7d30\u80de\u306b\u5165\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 [\u516b\u5341\u4e03] \u305d\u308c\u3089\u306f\u3001\u5f37\u529b\u306a\u6297\u4f53\u5fdc\u7b54\u3068\u5f37\u529b\u306aT-Zell\u5fdc\u7b54\uff08CD8\u3001CD4\uff09\u3092\u4f5c\u6210\u3057\u307e\u3059\u3002 Phase-I-Studie 2020\u5e744\u670829\u65e5\u3001\u81e8\u5e8a\u691c\u67fb\u306fBionTech\u3067\u306e\u30d5\u30a7\u30fc\u30baI\u7814\u7a76\u304b\u3089\u59cb\u307e\u308a\u307e\u3057\u305f\u3002\u6700\u3082\u6709\u671b\u306a4\u4eba\u306e\u5019\u88dc\u8005\u306f\u300120\u306e\u30ef\u30af\u30c1\u30f3\u30d0\u30ea\u30a2\u30f3\u30c8\u306e\u3046\u3061\u9078\u629e\u3055\u308c\u307e\u3057\u305f\u3002\u30b5\u30d6\u540d\u306f\u3001A1\u3001B1\u3001B2\u3001C2\u3092\u642d\u8f09\u3057\u3066\u3044\u307e\u3059\u3002\u5f7c\u3089\u306f\u3001\u53c2\u52a0\u8005\u3092\u7814\u7a76\u3059\u308b\u305f\u3081\u306b\u5f15\u304d\u7d9a\u304d\u30c6\u30b9\u30c8\u3055\u308c\u308b\u3079\u304d\u3067\u3059 – 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[88] BNT162B1 2020\u5e747\u6708\u3001SARS-COV-2\u30ec\u30b7\u30d4\u30c9\u30e1\u30a4\u30f3\uff08RBD\uff09\u306e\u6700\u9069\u5316\u3055\u308c\u305f\u6297\u539f\u3092\u30b3\u30fc\u30c9\u3057\u305fName bnt162B1\u3092\u4f7f\u7528\u3057\u305f\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4fee\u98fe\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fc-RNA\uff08modRNA\uff09\u306e\u5019\u88dc\u306e\u4e88\u5099\u81e8\u5e8a\u30c7\u30fc\u30bf\u304c\u30aa\u30f3\u30e9\u30a4\u30f3\u5370\u5237\u30b5\u30fc\u30d0\u30fc\u3067\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002 [89] BNT162B2  \u5225\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3067\u3042\u308bBNT162B2\u306f\u3001\u30d5\u30a7\u30fc\u30baII\u304a\u3088\u3073\u30d5\u30a7\u30fc\u30baIII\u306e\u7814\u7a76\u3092\u4f7f\u7528\u3057\u305f\u3055\u3089\u306a\u308b\u30ec\u30d3\u30e5\u30fc\u306e\u305f\u3081\u306b\u3001\u3055\u3089\u306a\u308b\u30ec\u30d3\u30e5\u30fc\u306e\u305f\u3081\u306b\u9078\u629e\u3055\u308c\u307e\u3057\u305f\u3002 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J. dimitriadis\uff1a \u30ea\u30dd\u30bd\u30fc\u30e0\u306b\u3088\u3063\u3066\u30de\u30a6\u30b9\u30ea\u30f3\u30d1\u7403\u306b\u5c0e\u5165\u3055\u308c\u305f\u30a6\u30b5\u30ae\u30b0\u30ed\u30d3\u30f3mRNA\u306e\u7ffb\u8a33\u3002 \u306e\uff1a \u81ea\u7136\u3002 \u30d0\u30f3\u30c9274\u3001\u756a\u53f75674\u30011978\u5e748\u6708\u3001923\u301c924\u30da\u30fc\u30b8\u3002 doi\uff1a10.1038\/274923a0 \u3001 PMID 683336 \u3002  \u2191  Marc J. Ostro\u3001Dario Giacomoni\u3001Don Lavelle\u3001William Paxton\u3001Sheldon Dray\uff1a \u30ea\u30dd\u30bd\u30fc\u30e0\u5316\u3055\u308c\u305f\u30d2\u30c8\u7d30\u80de\u682a\u3078\u306e\u633f\u5165\u5f8c\u306e\u30a6\u30b5\u30ae\u30b0\u30ed\u30d3\u30f3mRNA\u306e\u7ffb\u8a33\u306e\u8a3c\u62e0 \u3002\u306e\uff1a \u81ea\u7136 \u3002 \u30d0\u30f3\u30c9  274 \u3001 \u3044\u3044\u3048\u3002  5674 \u30011978\u5e748\u6708\u3001ISSN 1476-4687 \u3001 S.  921\u2013923 \u3001doi\uff1a 10.1038\/274921a0 \uff08 Nature.com [2021\u5e7412\u670831\u65e5\u306b\u30a2\u30af\u30bb\u30b9]\uff09\u3002   \u2191  R. 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Reichmuth\u3001M\u3002A\u3002Oberli\u3001A\u3002Jaklenec\u3001R\u3002Langer\u3001D\u3002Blankschtein\uff1a \u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u3092\u4f7f\u7528\u3057\u305fmRNA\u30ef\u30af\u30c1\u30f3\u9001\u9054\u3002 \u306e\uff1a \u6cbb\u7642\u7684\u914d\u9054\u3002 \u30d0\u30f3\u30c97\u3001nr\u3002 5\u30012016\u3001S\u3002319-344; doi\uff1a10.4155\/TDE-2016-0006 \u3001 PMID 27075952 \u3001 PMC 5439223 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\u3002  \u2191 a b  G\u00f3mez-Aguado\u3001Rodr\u00edguez-Castej\u00f3n\u3001Vicente-Pascual\u3001Rodr\u00edguez-Manc\u00f3n\u3001AngelesSolin\u00eds\u3001Pozo-Rodr\u00edguez\uff1a mRNA\u3092\u4f9b\u7d66\u3059\u308b\u30ca\u30ce\u30e1\u30c7\u30a3\u30b7\u30f3\uff1a\u6700\u5148\u7aef\u3068\u5c06\u6765\u306e\u8996\u70b9 \u306e\uff1a \u30ca\u30ce\u30de\u30c6\u30ea\u30a2\u30eb\u3002 2020\u5e742\u670820\u65e5\u3002 doi\uff1a10.3390\/nano10020364 \u3002  \u2191  V. K. Udhayakumar\u3001A\u3002debe beucklater\u3001J\u3002McCafffreyet al\u3002\uff1a \u30a2\u30eb\u30ae\u30cb\u30f3\u304c\u8c4a\u5bcc\u306a\u30da\u30d7\u30c1\u30c9\u30d9\u30fc\u30b9\u306emRNA\u30ca\u30ce\u30b3\u30f3\u30d7\u30ec\u30c3\u30af\u30b9\u306f\u3001\u30da\u30d7\u30c1\u30c9\u306e\u4e21\u89aa\u5a92\u6027\u7d44\u7e54\u306b\u4f9d\u5b58\u3059\u308b\u7d30\u80de\u6bd2\u6027T\u7d30\u80de\u514d\u75ab\u3092\u52b9\u7387\u7684\u306b\u6247\u52d5\u3057\u307e\u3059\u3002 \u306e\uff1a \u9ad8\u5ea6\u306a\u30d8\u30eb\u30b9\u30b1\u30a2\u6750\u6599\u3002 \u30d0\u30f3\u30c96\u3001nr\u3002 13\u30012017\u5e747\u6708\u3001p\u3002; doi\uff1a10.1002\/adhm.201601412 \u3001 PMID 28436620 \u3002  \u2191  B. Weide\u3001S\u3002Pascolo\u3001B\u3002Scheel\u3001E\u3002Derhovanessian\u3001A\u3002Pflugfelder\u3001T.K\u3002Gestor\u3001G\u3002Pawelec\u3001I\u3002Hoerr\u3001H\u3002G\u3002Rammersee\u3001C\u3002Garbe\uff1a \u30d7\u30ed\u30bf\u30df\u30f3\u4fdd\u8b77mRNA\u306e\u76f4\u63a5\u6ce8\u5c04\uff1a\u8ee2\u79fb\u6027\u9ed2\u8272\u816b\u60a3\u8005\u306b\u304a\u3051\u308b\u7b2c1\/2\u76f8\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u8a66\u9a13\u306e\u7d50\u679c\u3002 \u306e\uff1a Journal of Immunotherapy\u3002 \u30d0\u30f3\u30c932\u3001\u756a\u53f75\u30012009\u5e746\u6708\u3001S\u3002498\u2013507; doi\uff1a10.1097\/cji.0b013e3181a00068 \u3001 PMID 19609242 \u3002  \u2191  T.D\u00e9moulins\u3001P\u3002C\u3002Englezou\u3001P\u3002Milona\u3001N\u3002Rugggli\u3001N\u3002Tirelli\u3001C\u3002Pichon\u3001C\u3002Sapet\u3001T\u3002Eventen\u3001C\u3002A\u3002Guzm\u00e1n\u3001C\u3002Cillough\uff1a \u6a39\u72b6\u7d30\u80de\u3078\u306eRNA\u30ef\u30af\u30c1\u30f3\u9001\u9054\u3092\u81ea\u5df1\u8907\u88fd\u3057\u307e\u3059\u3002 \u306e\uff1a \u5206\u5b50\u751f\u7269\u5b66\u306e\u65b9\u6cd5\u3002 \u30d0\u30f3\u30c91499\u30012017\u3001S\u300237\u201375\u30012\uff1a 10,1007\/978-1-4939-6481-9_3_3 \u3001 PMID 27987142 \u3002  \u2191 a b c  D. J.\u30af\u30ed\u30e1\u30ea\u30f3\u3001T\u3002J\u3002Anchordoquy\u3001D\u3002B\u3002Volkin\u3001W\u3002Jiskoot\u3001E\u3002Mastrobattista\uff1a mRNA\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5b9a\u6027\u306e\u5bd2\u3044\u73fe\u5b9f\u306b\u5bfe\u51e6\u3059\u308b\u3002 \u306e\uff1a Journal of Pharmaceutical Sciences\u3002 \u30d0\u30f3\u30c9110\u3001\u756a\u53f73\u300103 2021\u3001S\u3002997\u20131001; doi\uff1a10.1016\/j.xphs.2020.12.006 \u3001 PMID 33321139 \u3001 PMC 7834447 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\u3002  \u2191  S. Sohail Ahmed\u3001Ronald W. Ellis\u3001Rino Rappuoli\uff1a \u65b0\u3057\u3044\u30ef\u30af\u30c1\u30f3\u3092\u4f5c\u308b\u305f\u3081\u306e\u6280\u8853 \u3002 In\uff1aStanley A. Plotkin et al\u3002 \uff08hrsg\u3002\uff09\uff1a \u30d7\u30ed\u30c3\u30c8\u30ad\u30f3\u306e\u30ef\u30af\u30c1\u30f3 \u3002\u7b2c7\u7248\u3002\u30a8\u30eb\u30bc\u30d3\u30a2\u3001\u30d5\u30a3\u30e9\u30c7\u30eb\u30d5\u30a3\u30a22017\u3001ISBN 978-0-323-35761-6\u3001 S.  1297 \u3001doi\uff1a 10.1016\/b978-0-323-35761-600066-3 \uff08 Elsevier.com \uff09\u3002   \u2191  J. Probst\u3001B\u3002Weide\u3001B\u3002Scheel\u3001B\u3002J\u3002Pichler\u3001I\u3002Hoerr\u3001H\u3002G\u3002Rammensee\u3001S\u3002Pascolo\uff1a in vivo\u3067\u306e\u5916\u56e0\u6027\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u306e\u81ea\u767a\u7684\u306a\u7d30\u80de\u6442\u53d6\u306f\u3001\u6838\u9178\u7279\u7570\u7684\u3001\u98fd\u548c\u304a\u3088\u3073\u30a4\u30aa\u30f3\u4f9d\u5b58\u3067\u3059\u3002 \u306e\uff1a \u907a\u4f1d\u5b50\u6cbb\u7642\u3002 \u30d0\u30f3\u30c914\u3001nr\u3002 15\u30012007\u5e748\u6708\u3001S\u30021175\u20131180; doi\uff1a10.1038\/sj.gt.3302964 \u3001 PMID 17476302 \u3002  \u2191  C. Lorence\u3001M\u3002Fotin-Sleczek\u3001G\u3002Roth\u3001C\u3002Becker\u3001T\u3002D. D. D. Bruck\u3001J\u3002Smick\u3001T\u3002Foldest\u3001T\u3002Folding\uff1a \u5916\u56e0\u6027mRNA\u304b\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\uff1a\u30ea\u30bd\u30bd\u30fc\u30e0\u7d4c\u8def\u3092\u4ecb\u3057\u305f\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u304a\u3088\u3073\u4eba\u8eab\u58f2\u8cb7\u306b\u3088\u308b\u53d6\u308a\u8fbc\u307f\u3002 \u306e\uff1a RNA\u751f\u7269\u5b66\u3002 \u30d0\u30f3\u30c98\u3001nr\u3002 2011\u5e747\u67084\u65e5\u30018\u6708\u3001627\u301c636\u30da\u30fc\u30b8; 2\uff1a10.4161\/RNA.8.4.15394 \u3001 PMID 21654214 \u3002  \u2191  K. 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McNeil\u3001A\u3002Vangala\u3001V\u3002W\u3002Bramwell\u3001P\u3002J\u3002Hanson\u3001Y\u3002Perrie\uff1a \u30ea\u30dd\u30d7\u30ec\u30c3\u30af\u30b9\u306e\u5b9a\u5f0f\u5316\u3068\u6700\u9069\u5316\uff1ain vitro\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u7814\u7a76\u306f\u3001in vivo\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u7814\u7a76\u3068\u306e\u76f8\u95a2\u95a2\u4fc2\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u305b\u3093\u3002 \u306e\uff1a \u73fe\u5728\u306e\u85ac\u7269\u9001\u9054\u3002 2010\u3001\u30d0\u30f3\u30c97\u3001NR\u3002 2\u3001S\u3002175-187\u3001 PMID 20158478 \u3002  \u2191  Thomas Hinz et al\u3002\uff1a RNA\u30d9\u30fc\u30b9\u306e\u30ef\u30af\u30c1\u30f3\u306e\u6b27\u5dde\u898f\u5236\u74b0\u5883 \u3002\u306e\uff1a \u5206\u5b50\u751f\u7269\u5b66\u306e\u65b9\u6cd5\uff08\u30cb\u30e5\u30fc\u30b8\u30e3\u30fc\u30b8\u30fc\u5dde\u30af\u30ea\u30d5\u30c8\u30f3\uff09 \u3002 \u30d0\u30f3\u30c9  1499 \u30012017\u3001 S.  203\u2013222 \u3001doi\uff1a 10,1007\/978-1-4939-6481-9_13 \u3001 PMID 27987152 \u3002   \u2191 a b  KatalinKarik\u00f3\u3001H\u3002Muratma\u3001J\u3002Ludwig\u3001D\u3002Weissman\uff1a \u6cbb\u7642\u306b\u6700\u9069\u306amRNA\u3092\u751f\u6210\u3059\u308b\uff1aHPLC\u7cbe\u88fd\u306f\u514d\u75ab\u6d3b\u6027\u5316\u3092\u6392\u9664\u3057\u3001\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4fee\u98fe\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308bmRNA\u306e\u7ffb\u8a33\u3092\u6539\u5584\u3057\u307e\u3059\u3002 \u306e\uff1a \u6838\u9178\u7814\u7a76\u3002 \u30d0\u30f3\u30c939\u3001nr\u3002 21\u30012011\u5e7411\u6708\u3001S\u3002E142; doi\uff1a10.1093\/nar\/gkr695 \u3001 PMID 21890902 \u3001 PMC 3241667 \uff08\u7121\u6599\u306e\u5168\u6587\uff09\u3002  \u2191 a b  M. 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doi\uff1a10.1016\/j.immune.2005.06.008 \u3001 PMID 16111635 \u3002  \u2191  n\u3002Presin\u3001The.isser Man\uff1a \u611f\u67d3\u75c7\u306e\u305f\u3081\u306e\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4fee\u98femRNA\u30ef\u30af\u30c1\u30f3\u3002 \u306e\uff1a \u5206\u5b50\u751f\u7269\u5b66\u306e\u65b9\u6cd5\u3002 \u30d0\u30f3\u30c91499\u30012017\u3001S\u3002109\u2013121\u30012\uff1a 10,1007\/978-1-4939-6481-9_6_6 \u3001 PMID 27987145 \u3002  \u2191 a b  N.\u30d1\u30eb\u30c7\u30a3\u3001M\u3002J\u3002\u30db\u30fc\u30ac\u30f3\u3001D\u3002\u30ef\u30a4\u30b9\u30de\u30f3\uff1a mRNA\u30ef\u30af\u30c1\u30f3\u6280\u8853\u306e\u6700\u8fd1\u306e\u9032\u6b69\u3002 \u306e\uff1a \u514d\u75ab\u5b66\u306b\u304a\u3051\u308b\u73fe\u5728\u306e\u610f\u898b\u3002 [\u30d7\u30ec\u30c3\u30b7\u30e3\u30fc\u524d\u306e\u96fb\u5b50\u51fa\u7248] 2020\u5e743\u6708\u3002 doi\uff1a10.1016\/j.coi.2020.01.008 \u3001 PMID 32244193 \u3002  \u2191  G.\u30d8\u30a4\u30ac\u30fc\uff1a RNA\u30ef\u30af\u30c1\u30f3\u306e\u975e\u81e8\u5e8a\u5b89\u5168\u6027\u8a66\u9a13\u3002 \u306e\uff1a \u5206\u5b50\u751f\u7269\u5b66\u306e\u65b9\u6cd5\u3002 \u30d0\u30f3\u30c91499\u30012017\u3001S\u3002253\u2013272\u30012\uff1a 10,1007\/978-1-4939-6481-9_16 \u3001 PMID 27987155 \u3002  \u2191  M.Baiersd\u00f6rfer\u3001G\u3002Boros\u3001H\u3002Muratsu\u3001A\u3002Mahiny\u3001I\u3002Vatkovic\u3001U\u3002Sahin\u3001K\u3002Karik\u00f3\uff1a in vitro\u3067\u8ee2\u5199\u3055\u308c\u305fmRNA\u304b\u3089\u306edsRNA\u6c5a\u67d3\u7269\u8cea\u3092\u9664\u53bb\u3059\u308b\u305f\u3081\u306e\u5bb9\u6613\u306a\u65b9\u6cd5\u3002 \u306e\uff1a \u5206\u5b50\u7642\u6cd5\u3002\u6838\u9178\u3002 \u30d0\u30f3\u30c915\u30012019\u5e744\u6708\u3001S\u300226\u201335; 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Zhang et al\u3002\uff1a \u611f\u67d3\u75c7\u306emRNA\u30ef\u30af\u30c1\u30f3\u306e\u9032\u6b69 \u3002\u306e\uff1a \u514d\u75ab\u5b66\u306e\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2 \u3002 \u30d0\u30f3\u30c9  \u5341 \u30012019\u5e743\u670827\u65e5\u3001doi\uff1a 10.3389\/5.2019.00594 \u3002   \u2191  Paul-Ehrlich Institute\u306e\u8a18\u8005\u4f1a\u898b\u306e\u305f\u3081\u306eFAQ\u3002 Paul-Ehrlich-Institut\u30012020\u5e744\u670822\u65e5\u30015\u30da\u30fc\u30b8\u3002 \u5168\u6587 \uff08PDF\uff09\u3002  \u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u5065\u5eb7\u554f\u984c\u3092\u6271\u3044\u307e\u3059\u3002\u5f7c\u306f\u4ed5\u3048\u307e\u3059 \u3044\u3044\u3048 \u81ea\u5df1\u8a3a\u65ad\u3068\u4ea4\u63db \u3044\u3044\u3048 \u533b\u5e2b\u306b\u3088\u308b\u8a3a\u65ad\u3002\u5065\u5eb7\u554f\u984c\u306b\u95a2\u3059\u308b\u30e1\u30e2\u306b\u6ce8\u610f\u3057\u3066\u304f\u3060\u3055\u3044\uff01      (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki11\/archives\/19902#breadcrumbitem","name":"RNA\u30ef\u30af\u30c1\u30f3\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2"}}]}]