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[16] \u3001\u6210\u9577\u3068\u4f53\u91cd\u306e\u6b20\u4e4f\u3002\u3053\u306e\u75be\u60a3\u306e\u5f62\u614b\u306f\u3001\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u60a3\u8005\u306e\u7b2c\u4e00\u7d1a\u60a3\u8005\u3001\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u4eba\u3067\u3088\u308a\u3088\u304f\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002 \u6f5c\u5728 [17] \uff08\u30e9\u30c6\u30f3\u30ca\u3001\u5f8c\u671f\uff09 – \u904e\u53bb\u306b\u8178\u7d68\u6bdb\u3068\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u81e8\u5e8a\u75c7\u72b6\u3068\u8a3a\u65ad\u3055\u308c\u305f\u304c\u3001\u30b0\u30eb\u30c6\u30f3\u306e\u306a\u3044\u98df\u4e8b\u3092\u4f7f\u7528\u3057\u305f\u5f8c\u306b\u9053\u3092\u8b72\u3063\u305f\u5e74\u9577\u306e\u5b50\u4f9b\u3084\u6210\u4eba\u3067\u767a\u751f\u3057\u307e\u3059\u3002\u4e0d\u5229\u306a\u8981\u56e0\u306e\u5f71\u97ff\u4e0b\uff08\u30b9\u30c8\u30ec\u30b9\u3001\u624b\u8853\u3001\u598a\u5a20\u3001\u6162\u6027\u80c3\u8178\u7ba1 [17] \uff09\u75c7\u72b6\u306e\u518d\u767a\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002 \u6f5c\u5728\u7684\u306a\u6570\u5b57 [17]  – \u3053\u306e\u5f62\u3067\u306f\u3001\u81e8\u5e8a\u75c7\u72b6\u306f\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\u306f\u8178\u7d68\u6bdb\u306f\u840e\u7e2e\u3067\u3059\u304c\u3001HLLA DQ2\u304a\u3088\u3073\/\u307e\u305f\u306fDQ8\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u3068\u5185\u81d3\u306b\u7279\u7570\u7684\u306a\u6297\u4f53\u306e\u5b58\u5728\u304c\u8a3a\u65ad\u3055\u308c\u307e\u3059\u3002 \u5185\u81d3\u75c5\u306e\u5206\u985e \u81e8\u5e8a\u75c7\u72b6 \u5341\u4e8c\u6307\u8178\u751f\u691c\uff08\u30de\u30fc\u30b7\u30e3\u5206\u985e\uff09 EMA\u3001TTG\u3001DPG\u6297\u4f53 DQ2 I \/ The Cross DQ8\u3092\u8d85\u3048\u308b\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7 \u660e\u793a\u7684\u306a\u5185\u81d3\u75c5 \u8178\u75c7\u306e\u5178\u578b\u7684\u306a\u75c7\u72b6 3 a\u3001b\u3001c + + \u5185\u81d3\u75c5\u306f\u3042\u308a\u307e\u305b\u3093 \u975e\u5b9a\u578b 2\u30013 + + \u6f5c\u5728\u7684\u306a\u5185\u81d3\u75c5 \u75c7\u72b6\u306f\u3042\u308a\u307e\u305b\u3093 0\u30011 +\/  –  + \u6f5c\u5728\u7684\u306a\u5185\u81d3\u75be\u60a3 \u75c7\u72b6\u306f\u3042\u308a\u307e\u305b\u3093 0 + + Table of Contents\u89aa\u306e\u75c7\u72b6 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30ed\u30e9\u30fb\u30d7\u30ed\u30e9\u30df\u30f3 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\u3068\u81ea\u5df1\u6297\u4f53\u306e\u5f79\u5272 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u907a\u4f1d\u5b66 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u514d\u75ab\u56e0\u5b50 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u8840\u6e05\u5b66\u7684\u30c6\u30b9\u30c8 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u907a\u4f1d\u5b50\u691c\u67fb [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u7d44\u7e54\u75c5\u7406\u5b66 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u5185\u8996\u93e1\u691c\u67fb [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u81e8\u5e8a\u691c\u67fb [45] [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c6\u30b9\u30c8\u306e\u9069\u5fdc [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30b0\u30eb\u30fc\u30d71-\u539f\u56e0\u4e0d\u660e\u306e\u4e3b\u89b3\u7684\u304a\u3088\u3073\u88ab\u9a13\u8005\u306e\u75c7\u72b6\u306e\u3042\u308b\u60a3\u8005 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30b0\u30eb\u30fc\u30d72-\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u72b6\u614b\u306e\u75c7\u72b6\u306e\u306a\u3044\u60a3\u8005 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u8010\u6027\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\uff08RCD\uff09\u3068\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306f\u75c7\u5019\u6027\u3067\u3059\uff08\u975e\u5fdc\u7b54\uff09 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u5185\u81d3\u75c5\u306e\u4e88\u9632 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u89aa\u306e\u75c7\u72b6 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30b7\u30b9\u30c6\u30e0\/\u30aa\u30eb\u30ac\u30f3 \u75c7\u72b6 \u6d1e\u7a9f\u53e3\u982d \u518d\u767a\u6027\u30a2\u30d5\u30bf [11] \u3001\u30a8\u30ca\u30e1\u30eb\u8cea\u4f4e\u4e0b [15] \u3001 \u866b\u6b6f [2] \u3002 \u808c \u30c7\u30e5\u30f3\u30ae\u30e3\u75c5 \u5185\u5206\u6ccc\u7cfb \u30bf\u30a4\u30d7I\u7cd6\u5c3f\u75c5 [15] \u3001\u6a4b\u672c\u7532\u72b6\u817a\u708e [15] \u3001\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7 [2] \u3001\u30a2\u30c7\u30a3\u30bd\u30f3\u75c5 [2] , choroba Gravesa-Basedowa [2] \u3001\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7 [2] \u3002 \u8840\u6db2\u969c\u5bb3 lax [2] \u3001\u8ca7\u8840 [2] \u3001\u81ea\u5df1\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8ca7\u8840 [2] \u3002 \u5faa\u74b0\u7cfb \u30ec\u30a4\u30ce\u30fc\u75c5 [2] \u3002 \u9aa8\u95a2\u7bc0\u7cfb \u7b4b\u529b\u306e\u8870\u5f31 [15] \u3001\u95a2\u7bc0\u708e\u3002 \u4ee3\u8b1d\u5909\u5316 \u8102\u80aa\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u306e\u6b20\u4e4f [16] \uff08A\u3001D\u3001E\u3001K\uff09\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607 [18] \u3001\u30c6\u30c8\u30ea\u30a6\u30b9\uff08\u4f4e\u7403\u6027\u8840\u75c7\uff09 [15] \u3002 \u76ee\u306e\u75c7\u72b6 \u8679\u5f69\u708e\u75c7 [2] \u3001\u6bdb\u69d8\u4f53 [2] \u3002 \u795e\u7d4c\u7cfb \u30a2\u30c6\u30ab\u30fc [15] [19] \u3001\u3066\u3093\u304b\u3093 [15] \u3001\u7247\u982d\u75db [15] \u3001\u9032\u884c\u6027\u5c0f\u8133\u75c7\u5019\u7fa4 [2] \u3001\u30b3\u30a2\u5909\u6027 [2] \u3001\u767a\u4f5c\u306b\u3088\u308b\u8133\u306e\u77f3\u7070\u5316 [11] \u3001\u30df\u30aa\u30d1\u30b7\u30fc [20] \u304a\u3088\u3073\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\uff08\u30d3\u30bf\u30df\u30f3B\u6b20\u4e4f\u75c7 12\u756a\u76ee I b \u521d\u3081 \uff09\u3002 \u7cbe\u795e\u969c\u5bb3 \u7d71\u5408\u5931\u8abf\u75c7 [21] [22] [23] \u3001\u81ea\u9589\u75c7 [21] \u3001 \u8a8d\u77e5\u75c7 [24] \u3001 \u3046\u3064 [21] [2] \u3002 \u751f\u6b96\u30b7\u30b9\u30c6\u30e0 \u6708\u7d4c\u306e\u671f\u9593\u306f\u3042\u308a\u307e\u305b\u3093 [15] \u3001\u6708\u7d4c\u9045\u5ef6 [15] \u3001\u4e0d\u898f\u5247\u306a\u6708\u7d4c [2] \u3001\u4e0d\u598a [15] [25] \u3001\u7fd2\u6163\u7684\u306a\u6d41\u7523 [15] [25] \u3001\u5b50\u5bae\u5185\u4f4e\u6804\u990a [25] \u3001\u4f4e\u51fa\u751f\u4f53\u91cd [25] \u3002 \u7d50\u8178\u76f4\u8178\u764c\u306e\u30ea\u30b9\u30af\u304c\u308f\u305a\u304b\u306b\u5897\u52a0\u3059\u308b\u5831\u544a\u304c\u3042\u308a\u307e\u3059 [26] \u3002 \u5185\u81d3\u75be\u60a3\u306e\u75c5\u56e0\u306f\u591a\u56e0\u5b50\u3067\u3059\u3002\u3042\u306a\u305f\u81ea\u8eab\u306e\u6297\u539f\u306b\u5bfe\u3059\u308b\u6297\u4f53\u304c\u3042\u308b\u305f\u3081\u3001visocular\u75be\u60a3\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3068\u3057\u3066\u6cbb\u7642\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u305d\u308c\u306f\u3001\u907a\u4f1d\u7684\u306b\u7d20\u56e0\u3068\u306a\u308b\u4eba\u3005\u3067\u306f\u308b\u304b\u306b\u983b\u7e41\u306b\u767a\u751f\u3057\u307e\u3059\u3002\u4ed6\u306e\u75be\u60a3\u3068\u306e\u9055\u3044\u306f\u3001\u75be\u60a3\u306e\u75c7\u72b6\u3001\u8178\u306e\u5909\u5316\u3001\u304a\u3088\u3073\u30b0\u30eb\u30c6\u30f3\u3092\u9664\u53bb\u3057\u305f\u5f8c\u306e\u6297\u4f53\u306e\u6d88\u5931\u306b\u5909\u308f\u308b\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u306f\u539f\u56e0\u56e0\u5b50\u3067\u3059\u3002 \u76ee\u306b\u898b\u3048\u308b\u75c5\u6c17\u306f\u3001\u30dd\u30fc\u30e9\u30f3\u30c9\u306e\u4eba\u6c17\u306e\u7a40\u7269\u306e\u6210\u5206\u3001\u5c0f\u9ea6\u3001\u30e9\u30a4\u9ea6\u3001\u5927\u9ea6\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002 \u30b0\u30eb\u30c6\u30f3 \u5c0f\u9ea6\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3001 \u30bb\u30ab\u30ea\u30fc\u30ca \uff08\u30e9\u30a4\u9ea6\u6210\u5206\uff09i \u30db\u30eb\u30c7\u30a4\u30ca \uff08\u5927\u9ea6\u6210\u5206\uff09\u306f\u3001\u7d20\u56e0\u306e\u3042\u308b\u4eba\u3005\u306e\u8aa4\u3063\u305f\u514d\u75ab\u5fdc\u7b54\u306e\u539f\u56e0\u3067\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u6d88\u5316\u30d7\u30ed\u30bb\u30b9\u306e\u7523\u7269\u3067\u3042\u308b\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3092\u5438\u53ce\u3059\u308b\u3053\u3068\u304c\u751f\u7406\u5b66\u7684\u5f79\u5272\u306e\u751f\u7406\u5b66\u7684\u5f79\u5272\u306e\u640d\u50b7\u307e\u305f\u306f\u5b8c\u5168\u306a\u6d88\u5931\u3055\u3048\u3042\u308a\u307e\u3059\u3002 DisacharyDase\u306e\u6d3b\u52d5\u3082\u6e1b\u5c11\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u4e73\u7cd6\u4e0d\u8010\u75c7\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8178\u30db\u30eb\u30e2\u30f3\u3092\u751f\u6210\u3059\u308b\u7d30\u80de\u306e\u6570\u306f\u6e1b\u5c11\u3057\u307e\u3059 [27] \u3001\u904b\u52d5\u969c\u5bb3\u3001\u81b5\u81d3\u306e\u969c\u5bb3\u3001\u6d88\u5316\u5668\u304a\u3088\u3073\u5438\u53ce\u969c\u5bb3\u306e\u91cd\u75c7\u5ea6\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306e\u7d50\u679c\u3001\u6804\u990a\u7d20\u306e\u5438\u53ce\u3001\u6162\u6027\u4e0b\u75e2\u306e\u767a\u751f\u3001\u6b20\u4e4f\u75c7\u3001\u304a\u3088\u3073\u4f53\u306e\u7834\u58ca\u304c\u640d\u306a\u308f\u308c\u307e\u3059\u3002\u98df\u4e8b\u6cbb\u7642\u306e\u5c0e\u5165\u524d\u306f\u3001\u5185\u81d3\u75be\u60a3\u306f12\uff05\u306e\u6b7b\u4ea1\u7387\u3068\u95a2\u9023\u3057\u3066\u3044\u305f [7] \uff081939\u5e74\u304b\u3089\u306e\u9061\u53ca\u7684\u691c\u67fb\uff09\u3002 \u30ed\u30e9\u30fb\u30d7\u30ed\u30e9\u30df\u30f3 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30d7\u30ed\u30e9\u30df\u30f3\u306f\u3001\u7a40\u7269\u3092\u542b\u3080\u8349\u306e\u7a2e\u5b50\u306b\u5b58\u5728\u3059\u308b\u4e88\u5099\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u3084\u30d7\u30ed\u30ea\u30f3\u304c\u8c4a\u5bcc\u3067\u3059 [28] \u3002\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30d7\u30ed\u30c6\u30a2\u306b\u8010\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30b0\u30eb\u30c6\u30f3\u3001\u30bb\u30ab\u30ea\u30f3\u3001\u30db\u30eb\u30c0\u30a4\u30f3\u3082\u30d7\u30ed\u30e9\u30df\u30f3\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u30b0\u30eb\u30c6\u30a4\u30f3\u306e\u5143\u7d20\u306e1\u3064\uff08\u6c34\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u53ef\u6eb6\u6027\u306e\u30b0\u30eb\u30c6\u30f3\u753b\u5206\uff09\u306f\u8178\u7d30\u80de\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u7dca\u5bc6\u306a\u7d30\u80de\u9593\u63a5\u7d9a\u306e\u7dca\u5bc6\u3055\u3092\u6e1b\u3089\u3057\u3001\u8178\u5185\u969c\u58c1\u306e\u900f\u904e\u6027\u3092\u5897\u52a0\u3055\u305b\u307e\u3059 [29] \u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30b0\u30eb\u30c6\u30f3\u3092\u542b\u3080\u30de\u30af\u30ed\u30da\u30d7\u30c1\u30c9\u5faa\u74b0\u3078\u306e\u79fb\u884c\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u305d\u3053\u3067\u514d\u75ab\u7cfb\u304c\u5229\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u3001thuts\u304b\u3089\u306e\u53cd\u5fdc\u304c\u751f\u3058\u307e\u3059 [29] [30] \u3002 \u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\u3068\u81ea\u5df1\u6297\u4f53\u306e\u5f79\u5272 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ]  \u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc \u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\uff08TTG\uff09\u306f\u3001\u591a\u304f\u306e\u751f\u5316\u5b66\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u9175\u7d20\u3067\u3059\u3002 Glyadine\u306f\u305d\u306e\u57fa\u8cea\u306e1\u3064\u3067\u3059\u3002\u30da\u30d7\u30c1\u30c9\u306f\u30012\u3064\u306e\u53cd\u5fdc\u3067TTG\u306b\u3088\u3063\u3066\u4fee\u98fe\u3055\u308c\u307e\u3059 [\u6700\u521d\u306b30] \uff1a\u8131\u30a2\u30df\u30c9\u5316\uff08\u6b8b\u308a\u306e\u30b0\u30eb\u30bf\u30df\u30f3\u304b\u3089\u306eAMID\u57fa\u306e\u9664\u53bb\uff09\u307e\u305f\u306f\u30c8\u30e9\u30f3\u30b9\u30a2\u30df\u30c9\u5316\uff083\u500d\u306e\u983b\u7e41\u306a\u53cd\u5fdc\u306f\u3001\u30b0\u30ea\u30e3\u30b8\u30ca\u304b\u3089\u30ea\u30b8\u30f3\u307e\u3067\u306e\u6b8b\u308a\u306e\u30b0\u30eb\u30bf\u30df\u30f3\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30ad\u30f3\u30b0\u306b\u3042\u308a\u307e\u3059\uff09\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u304b\u3089\u751f\u3058\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u3088\u308a\u514d\u75ab\u539f\u6027\u306b\u306a\u308a\u307e\u3059 [32] \u3002\u30a2\u30df\u30c9\u5316\u306f\u9175\u7d20\u306e\u6d3b\u6027\u4e2d\u5fc3\u306e\u5916\u3067\u3082\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u540c\u6642\u306b\u3001Gladyna\u3068TTG\u306e\u6c38\u7d9a\u7684\u306a\u7d50\u5408\u304c\u4f5c\u6210\u3055\u308c\u307e\u3059 [33] \u3002\u3053\u308c\u306b\u3088\u308a\u3001TTG\u306b\u5bfe\u3059\u308b\u6297\u4f53\u306e\u5f62\u6210\u3068\u3068\u3082\u306b\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3059\u65b0\u3057\u3044\u30a8\u30d4\u30c8\u30fc\u30d7\u304c\u4f5c\u6210\u3055\u308c\u307e\u3059 [34] \u3002 \u60a3\u8005\u306e\u8840\u6e05\u3067\u306f\u3001\u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\u306b\u5bfe\u3059\u308b\u6297\u4f53\u306b\u52a0\u3048\u3066\u3001\u691c\u51fa\u3055\u308c\u307e\u3059\u3002 TTG \uff09\u3001antandomisal\u6297\u4f53\uff08 \u6bcd\u89aa \uff09\u3001\u6297\u6bd2\u7d20\uff08 \u79c1\u305f\u3061\u306f\u8cb7\u3046 \uff09\u3001anti -gaps\uff08 \u3057\u304b\u3057 \uff09\u30b0\u30ea\u30e3\u30b8\u30f3\u306e\u6392\u6c34\u30da\u30d7\u30c1\u30c9\u306b\u5bfe\u3059\u308b\u6297\u4f53\uff08 DGP \uff09\uff09 [17] \u3002\u30a2\u30f3\u30bf\u30f3\u30c9\u30df\u30b9\u6297\u4f53\u306f\u3001\u7d30\u80de\u306e\u8868\u9762\u306b\u3042\u308b\u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\u306b\u5bfe\u3059\u308b\u4e00\u7a2e\u306e\u6297\u4f53\u3068\u898b\u306a\u3055\u308c\u3066\u3044\u307e\u3059 [2] \u3002\u6297\u4f53\u306f\u3001\u75be\u60a3\u306e\u8a3a\u65ad\u3001IGA\u30af\u30e9\u30b9\u30a2\u30f3\u30bf\u30f3\u30c9\u30df\u30b9\u6297\u4f53\uff08EMA\uff09\u3001\u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\uff08TTG\uff09\u306b\u5bfe\u3059\u308b\u3001\u304a\u3088\u3073\u30b0\u30ea\u30b8\u30f3\u306e\u6392\u6c34\u30da\u30d7\u30c1\u30c9\uff08DGP\uff09\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3067\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002 [17] \u3002 \u30ed\u30bf\u30a6\u30a4\u30eb\u30b9\u4e0b\u75e2\u3092\u3057\u305f\u5c0f\u5150\u306e\u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3092\u691c\u51fa\u3059\u308b\u691c\u67fb\u306e\u30bb\u30ed\u30b3\u30f3\u30d0\u30fc\u30b8\u30e7\u30f3\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3059 [35] \u3002 \u907a\u4f1d\u5b66 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u60a3\u8005\u306e\u5927\u591a\u6570\u306f\u3001HLA-DQ2\u307e\u305f\u306fDQ8\u306e2\u7a2e\u985e\u306eHLA-DQ\u306e\u3044\u305a\u308c\u304b\u3092\u6301\u3063\u3066\u3044\u307e\u3059 [17] [36] \u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u6297\u539f\u3092\u63d0\u793a\u3059\u308bMHC\u30af\u30e9\u30b9II\u53d7\u5bb9\u4f53\u30b7\u30b9\u30c6\u30e0\u306e\u4e00\u90e8\u3067\u3042\u308a\u3001\u514d\u75ab\u7cfb\u304c\u72ec\u81ea\u306e\u7d30\u80de\u3068\u898b\u77e5\u3089\u306c\u4eba\u3092\u533a\u5225\u3067\u304d\u308b\u3088\u3046\u306b\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f6\u756a\u76ee\u306e\u67d3\u8272\u4f53\u306e\u77ed\u3044\u80a9\u306b\u3042\u308a\u3001\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u3068\u306e\u95a2\u4fc2\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u5ea7\u306f\u30bb\u30ea\u30a2\u30c3\u30af\u3068\u547c\u3070\u308c\u307e\u30591 [37] \u3002 7\u7a2e\u985e\u306eHLA DQ\uff08DQ2\u304a\u3088\u3073DQ4 -DQ9\uff09\u304c\u6388\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002 DQ2\u307e\u305f\u306fDQ8\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u60a3\u8005\u306e99\uff05\u4ee5\u4e0a\u3092\u6301\u3063\u3066\u3044\u307e\u3059 [11] [17] \u3002 \u8ca0\u306b\u5e2f\u96fb\u3057\u305f\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u3092\u7d50\u5408\u3059\u308b\u80fd\u529b\u304c\u5927\u304d\u3044\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u7523\u7269\u3067\u3042\u308b\u53d7\u5bb9\u4f53\u306f\u3001\u3053\u306e\u53d7\u5bb9\u4f53\u306e\u4ed6\u306e\u5f62\u614b\u3088\u308a\u3082\u786c\u3044\u30b0\u30ea\u30b8\u30f3\u306e\u30da\u30d7\u30c1\u30c9\u3092\u7d50\u5408\u3057\u307e\u3059 [38] \u3002\u6b21\u306b\u3001MHC\u30af\u30e9\u30b9II\u7c92\u5b50\u306b\u95a2\u9023\u3059\u308b\u6297\u539f\u304cCD4\u30ea\u30f3\u30d1\u7403\u3092\u63d0\u793a\u3057\u307e\u3059 + \u305d\u3057\u3066\u305d\u308c\u3089\u3092\u30a2\u30af\u30c6\u30a3\u30d6\u306b\u3057\u307e\u3059 [38] [39] \u3002 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u307b\u3068\u3093\u3069\u306e\u60a3\u8005\u306f\u3001DQ2.5\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u3068\u547c\u3070\u308c\u308bTwogen HLA-DQ2\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u3092\u7740\u7528\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u306f\u30012\u3064\u306e\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3001DQ\u03b15\u3068DQ\u03b22\u3092\u30b3\u30fc\u30c9\u3059\u308b2\u3064\u306e\u96a3\u63a5\u3059\u308b\u907a\u4f1d\u5b50\u5bfe\u7acb\u907a\u4f1d\u5b50\u3001DQA1*0501\u304a\u3088\u3073DQB1*0201\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001DQ2.5\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u4e21\u89aa\u304b\u3089\u907a\u4f1d\u3059\u308b2\u3064\u306e\u67d3\u8272\u4f536\u306e\u3044\u305a\u308c\u304b\u306b\u3088\u3063\u3066\u30b3\u30fc\u30c9\u5316\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307b\u3068\u3093\u3069\u306e\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306f\u3001DQ2.5\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u306e1\u3064\u306e\u30b3\u30d4\u30fc\u3092\u7d99\u627f\u3057\u307e\u3059\u304c\u3001\u4e21\u89aa\u306e\u4e21\u65b9\u304b\u3089\u7d99\u627f\u3059\u308b\u4eba\u3082\u3044\u308c\u3070\u3001\u6df1\u523b\u306a\u5408\u4f75\u75c7\u306b\u3055\u3089\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u90e8\u306e\u4eba\u3005\u306f\u3001\u89aa\u306e1\u4eba\u304b\u3089DQ2.5\u3092\u7d99\u627f\u3057\u3001\u4ed6\u306e\u89aa\u304b\u3089\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u306e\u4e00\u90e8\uff08DQB1*02\u307e\u305f\u306fDQA1*05\uff09\u3092\u7d99\u627f\u3057\u3001\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u307e\u3059 [40] \u3002 \u5185\u81d3\u75be\u60a3\u306e\u4eba\u306e\u7d041\uff05\u306e\u307f\u304cHLA DQ2\u304a\u3088\u3073\/\u307e\u305f\u306fDQ8\u3092\u6301\u3063\u3066\u3044\u307e\u305b\u3093 [17] [41] [42] \u3002 \u514d\u75ab\u56e0\u5b50 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] T CD4\u30ea\u30f3\u30d1\u7403\u306b\u3088\u308b\u7570\u5e38\u306a\u8abf\u7bc0\u306f\u3001\u7570\u5e38\u306a\u514d\u75ab\u5fdc\u7b54\u306e\u958b\u59cb\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059 + TCR\u03b1\u03b2\u3002 HLA-DQ2\u304a\u3088\u3073HLA-DQ8\u5206\u5b50\u306f\u3001\u8ca0\u96fb\u8377\u306e\u30a2\u30df\u30ce\u9178\u304c\u8c4a\u5bcc\u306a\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\u3068\u306e\u63a5\u7d9a\u3092\u597d\u3080\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059 [2] \u3002\u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\u306b\u3088\u308b\u30b0\u30eb\u30c6\u30f3\u306e\u8efdami\u306f\u3001\u30b0\u30eb\u30c6\u30f3\u3001\u30d7\u30ed\u30ea\u30f3\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u304c\u8c4a\u5bcc\u306a\u30b0\u30eb\u30c6\u30f3\u306b\u89aa\u8fd1\u611f\u3092\u3055\u3089\u306b\u5897\u52a0\u3055\u305b\u307e\u3059\u3002\u30b0\u30eb\u30c6\u30f3\u306e\u683c\u5dee\u306f\u3001TCR\u53d7\u5bb9\u4f53\u306b\u5bfe\u3059\u308b\u305d\u306e\u89aa\u548c\u6027\u309250\u301c100\u500d\u5897\u52a0\u3055\u305b\u307e\u3059 [2] \u3002\u30b0\u30eb\u30c6\u30f3\u306f\u98df\u4f5c\u7528\u3092\u53d7\u3051\u3001\u6b21\u306bAPC\u7d30\u80de\u306b\u3088\u308b\u63d0\u793a\u3092\u53d7\u3051\u307e\u3059\u3002\u6297\u539f\u306f\u3001IFN-\u03b1\u3001TNF-\u03b1\u3001IL-2\u3001IL-6\u3092\u542b\u3080\u708e\u75c7\u8a98\u767a\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7279\u5b9a\u306eTCR\u53d7\u5bb9\u4f53\u306b\u3088\u3063\u3066\u8a3a\u65ad\u3055\u308c\u307e\u3059\u3002\u52b9\u679c\u7684\u306a\u5fdc\u7b54\u6bb5\u968e\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6bb5\u968e\u3067CD8\u30ea\u30f3\u30d1\u7403\u304c\u6700\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059 +  – \u8178\u7d30\u80de\u306e\u7834\u58ca\u306b\u3064\u306a\u304c\u308b\u7d30\u80de\u6bd2\u6027T\u30ea\u30f3\u30d1\u7403 [2] \u3002\u305d\u306e\u7d50\u679c\u3001\u6d88\u5316\u5668\u9175\u7d20\u306e\u7523\u751f\u3068\u6d88\u5316\u7ba1\u3067\u7523\u751f\u3055\u308c\u308b\u7d44\u7e54\u30db\u30eb\u30e2\u30f3\u306e\u969c\u5bb3\u3092\u6e1b\u3089\u3059\u305f\u3081\u3001\u5c0f\u8178\u7c98\u819c\u306e\u8178\u7d68\u6bdb\u306e\u640d\u50b7\u3002\u3053\u308c\u3089\u306e\u640d\u50b7\u306e\u7d50\u679c\u3001\u8178\u306e\u904b\u52d5\u6027\u969c\u5bb3\u3001\u98df\u7269\u306b\u542b\u307e\u308c\u308b\u7269\u8cea\u306e\u7570\u5e38\u306a\u6d88\u5316\u3068\u5438\u53ce\u3001\u304a\u3088\u3073\u95a2\u9023\u3059\u308b\u6b20\u9665\u306e\u5f62\u6210 [27] \u3002 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306b\u304a\u3051\u308b\u6297\u4f53\u306e\u6e2c\u5b9a [36] \u30c6\u30b9\u30c8 \u611f\u5ea6 \u7279\u7570\u6027 \u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\u306b\u5bfe\u3059\u308b\u6297\u4f53 91\uff05 99\uff05 \u5b50\u5bae\u5185\u819c\u306b\u5bfe\u3059\u308b\u6297\u4f53 81\uff05 99\uff05 \u8a3a\u65ad\u3067\u306f\u3001\u6700\u3082\u91cd\u8981\u306a\u306e\u306f\u3001\u7279\u5fb4\u7684\u306a\u6297\u4f53\u306e\u6c7a\u5b9a\u3001\u5341\u4e8c\u6307\u8178\u7c98\u819c\u30d0\u30a4\u30aa\u30d7\u30c6\u30fc\u30c8\u306e\u5909\u5316\u306e\u7d44\u7e54\u75c5\u7406\u5b66\u7684\u691c\u67fb\u3001\u304a\u3088\u3073HLA DQ2\u304a\u3088\u3073\/\u307e\u305f\u306fDQ8\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u306e\u58f0\u660e\u3067\u3059\u3002 \u8840\u6e05\u5b66\u7684\u30c6\u30b9\u30c8 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ]  \u514d\u75ab\u969c\u5bb3 – \u30a2\u30f3\u30bf\u30f3\u30c9\u30df\u30b9\u6297\u4f53 \u5185\u81d3\u75be\u60a3\u306e\u8a3a\u65ad\u3067\u306f\u3001\u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\uff08TTG\uff09\u306b\u5bfe\u3059\u308b\u6297\u5185\u79d1\u6297\u4f53\uff08EMA\uff09\u304a\u3088\u3073\u30b0\u30ea\u30b8\u30f3\u306e\u963b\u5bb3\u30da\u30d7\u30c1\u30c9\uff08DGP\uff09\u306b\u5bfe\u3059\u308b\u6297\u4f53\u304c\u6c7a\u5b9a\u3055\u308c\u307e\u3059 [17] IGA\u30af\u30e9\u30b9\u3067\u306f\u3001IGA\u6b20\u4e4f\u3092\u4e8b\u524d\u306b\u9664\u5916\u3057\u305f\u5f8c\u3001\u7dcfIgA\u30ec\u30d9\u30eb\u3092\u8a55\u4fa1\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059 [11] \u3002 IgA\u30ec\u30d9\u30eb\u304c0.2 g\/L\u672a\u6e80\u306e\u5834\u5408\u3001\u6297\u4f53\u306fIgG\u30af\u30e9\u30b9\u3067\u30de\u30fc\u30af\u3055\u308c\u3066\u3044\u307e\u3059 [\u521d\u3081] \u3002\u6297GAP\u6297\u4f53\uff08AGA\uff09\u306f\u975e\u7279\u7570\u7684\u3068\u898b\u306a\u3055\u308c\u3066\u3044\u307e\u3059 [2] \u3002 \u30ec\u30d9\u30eb\u306e\u7d50\u679c\u306e\u89e3\u91c8\u3067\u306f\u3001\u8840\u6e05\u306e\u7dcfIgA\u30ec\u30d9\u30eb\u3001\u6d88\u8cbb\u3055\u308c\u308b\u30b0\u30eb\u30c6\u30f3\u3001\u30b0\u30eb\u30c6\u30f3\u6d88\u8cbb\u3001\u60a3\u8005\u306e\u5e74\u9f62\u3001\u514d\u75ab\u6291\u5236\u85ac\u306e\u7dcf\u30ec\u30d9\u30eb [\u521d\u3081] \u3002\u30b0\u30eb\u30c6\u30f3\u304c\u9577\u671f\u9593\uff08\u6570\u9031\u9593\u304b\u30891\u5e74\uff09\u98df\u4e8b\u304b\u3089\u64a4\u56de\u3055\u308c\u305f\u5834\u5408\u3001\u307e\u305f\u306f\u5c55\u793a\u4f1a\u304c\u77ed\u304b\u3063\u305f\u5834\u5408\u3001\u5426\u5b9a\u7684\u306a\u7d50\u679c\u306f\u4fe1\u983c\u3067\u304d\u307e\u305b\u3093 [\u521d\u3081] \u3002 TTGA\u306e\u6307\u5b9a\u306f\u3001\u975e\u5e38\u306b\u9ad8\u3044\u611f\u5ea6\uff0890\uff05\u4ee5\u4e0a\uff09\u3068\u7279\u7570\u6027\uff08\u307b\u307c100\uff05\uff09\u3092\u6301\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u63a8\u5968\u3055\u308c\u308b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c6\u30b9\u30c8\u3067\u3059\u3002\u8840\u6e05\u5b66\u7684\u691c\u67fb\u306f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u4fa1\u5024\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u80af\u5b9a\u7684\u306a\u7d50\u679c\u306b\u57fa\u3065\u3044\u3066\u8a3a\u65ad\u3092\u4e0b\u3059\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u304c\u3001\u5426\u5b9a\u7684\u306a\u7d50\u679c\u306e\u5834\u5408\u3001\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306f\u9664\u5916\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 [17] [a] \u3002 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u8840\u6e05\u5b66\u7684\u30de\u30fc\u30ab\u30fc\u306f\u3001\u4e16\u754c\u3067\u521d\u3081\u3066\u4e16\u754c\u3067\u521d\u3081\u3066\u8a18\u8ff0\u3055\u308c\u307e\u3057\u305f\u3002 [43] [44] \u3002 \u907a\u4f1d\u5b50\u691c\u67fb [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u5185\u81d3\u75be\u60a3\u306e\u8a3a\u65ad\u3067\u306f\u3001HLA-DQ2\u304a\u3088\u3073\/\u307e\u305f\u306fDQ8\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u3092\u304a\u52e7\u3081\u3057\u307e\u3059 [17] \u3002\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u60a3\u8005\u3067\u306f\u3001HLA-DQ2\u306e\u767a\u751f\u7387\u306f90-95\uff05\u3001HLA-DQ8\u306f5-10\uff05\u3067\u3001\u4e00\u822c\u96c6\u56e3DQ2\u306725-30\uff05\u3001HLA-DQ8\u306f5\u301c15\uff05\u3068\u63a8\u5b9a\u3055\u308c\u307e\u3059\u3002 [11] [17] \u3002\u5185\u81d3\u75be\u60a3\u306e\u4eba\u306e\u7d041\uff05\u306e\u307f\u304cHLA DQ2\u304a\u3088\u3073\/\u307e\u305f\u306fDQ8\u3092\u6301\u3063\u3066\u3044\u307e\u305b\u3093 [17] [41] [42] \u3002 HLA-DQ2\u307e\u305f\u306fHLA-DQ8\u6297\u539f\u304c\u306a\u3044\u3053\u3068\u306f\u3001\u5b9f\u969b\u306b\u3053\u306e\u75c5\u6c17\u3092\u9664\u5916\u3057\u3066\u3044\u307e\u3059 [\u521d\u3081] [30] [38] [45] [46] \u3002 \u7d44\u7e54\u75c5\u7406\u5b66 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ]  \u30de\u30fc\u30b7\u30e3\u30b9\u30b1\u30fc\u30eb\u306e\u6982\u7565\u56f3 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\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306b\u306f\u3001\u30b0\u30eb\u30c6\u30f3\u306e\u96e2\u8131\u306b\u53cd\u5fdc\u3057\u306a\u3044\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u304c\u4f34\u3046\u5834\u5408\u304c\u3042\u308a\u307e\u3059 [62] \u3002 \u9593\u9055\u3063\u305f\u8a3a\u65ad [62] \u3002 \u8010\u6027\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u8a3a\u65ad\u306f\u56f0\u96e3\u3067\u8b70\u8ad6\u306e\u4f59\u5730\u304c\u3042\u308a\u307e\u3059\u3002\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001\u30b0\u30eb\u30c6\u30f3\u6d88\u8cbb\u304c\u3042\u308b\u304b\u3001\u30b0\u30eb\u30c6\u30f3\u306e\u611f\u53d7\u6027\u304c\u975e\u5e38\u306b\u9ad8\u3044\u305f\u3081\u3001\u305d\u306e\u9664\u53bb\u306f\u56f0\u96e3\u307e\u305f\u306f\u4e0d\u53ef\u80fd\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059 [63] \u3002\u8010\u6027\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u60a3\u8005\u306e\u5341\u4e8c\u6307\u8178\u7c98\u819c\u306b\u304a\u3051\u308b\u30ea\u30f3\u30d1\u7403\u306e\u5206\u6790\u306e\u7d50\u679c\u3001\u7570\u5e38\u306a\u30ea\u30f3\u30d1\u7403\u304c\u767a\u898b\u3055\u308c\u3001\u305d\u306e\u5b58\u5728\u306fRCD\u306e\u5b9a\u7fa9\u3092\u4fc3\u9032\u3057\u307e\u3059 [\u516d\u5341\u56db] [65] \u3002\u975e\u5b9a\u578b\u30ea\u30f3\u30d1\u7403\u306f\u3001\u8178\u75c7\u6027T\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306b\u898b\u3089\u308c\u308b\u7d30\u80de\u3068\u306e\u985e\u4f3c\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\uff08EATL\u3001\u82f1\u8a9e \u8178\u75c7\u306b\u95a2\u9023\u3059\u308bT\u7d30\u80de\u30ea\u30f3\u30d1\u816b 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\u3002\u6709\u5bb3\u6027\u306e\u4f4e\u3044\u30d6\u30c7\u30bd\u30cb\u30c9\u3067\u306f\u3001\u6cbb\u7642\u306e\u8a66\u307f\u304c\u8a18\u8ff0\u3055\u308c\u307e\u3057\u305f [71] [72] \u4e3b\u89b3\u7684\u306a\u6539\u5584\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u7d44\u7e54\u5b66\u7684\u6539\u5584\u306f\u8a18\u8f09\u3055\u308c\u3066\u304a\u3089\u305a\u30016\u4eba\u306e\u60a3\u8005\u306e\u3046\u30615\u4eba\u3067\u9aa8\u7c97\u9b06\u75c7\u304c\u767a\u751f\u3057\u307e\u3057\u305f [72] \u3002\u8ffd\u52a0\u306e\u554f\u984c\u306f\u3001\u591a\u304f\u306e\u60a3\u8005\u304c\u30b0\u30eb\u30c6\u30f3\u3092\u542b\u307e\u306a\u3044\u98df\u4e8b\u306b\u3086\u3063\u304f\u308a\u3068\u53cd\u5fdc\u3057\u3066\u304a\u308a\u3001\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u85ac\u7406\u5b66\u7684\u6cbb\u7642\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u4e8b\u5b9f\u3067\u3059\u3002 [62] \u3002 \u30a2\u30b6\u30c1\u30aa\u30d7\u30ea\u30f3\u306f\u8010\u6027\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u6cbb\u7642\u306b\u3082\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u526f\u4f5c\u7528\u306e\u305f\u3081\u306b\u6cbb\u7642\u3092\u4e2d\u65ad\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3057\u305f [69] [\u4e03\u5341\u4e09] [74] \u3002\u540c\u6642\u306b\u300110\u4eba\u306e\u60a3\u8005\u306e\u3046\u30618\u4eba\u3067\u7d44\u7e54\u5b66\u7684\u6539\u5584\u304c\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002\u30af\u30e9\u30c9\u30ea\u30d3\u30f3\u3082\u7814\u7a76\u3055\u308c\u307e\u3057\u305f [75] [76] \u3001\u3088\u308a\u3088\u304f\u8a31\u5bb9\u3055\u308c\u3001\u81e8\u5e8a\u7684\u304a\u3088\u3073\u7d44\u7e54\u5b66\u7684\u306a\u7b54\u3048\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u4ed6\u306e\u85ac\u7269\u306f\u3001\u5c0f\u60a3\u8005\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u3082\u691c\u67fb\u3055\u308c\u307e\u3057\u305f\u3002\u30a2\u30ec\u30e0\u30c4\u30ba\u30de\u30d6\u306e\u4f7f\u7528\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f [77] [60] \u3001\u30a4\u30f3\u30b9\u30d4\u30ec\u30fc\u30b7\u30e7\u30f3 [78] [79] [80] [81] [60] Methotreksatu [60] \u3001\u7d44\u63db\u3048IL-10 [82] \u3002\u7d44\u7e54\u75c5\u7406\u5b66\u7684\u30a4\u30e1\u30fc\u30b8\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u306a\u304f\u3001\u81e8\u5e8a\u7684\u6539\u5584\u304c\u793a\u3055\u308c\u307e\u3057\u305f [62] \u3002 \u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306b\u95a2\u3059\u308b\u591a\u65b9\u5411\u7814\u7a76\u306b\u3082\u304b\u304b\u308f\u3089\u305a [83] \u3002\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u671b\u307e\u3057\u3044\u52b9\u679c\u306f\u3001\u5c11\u91cf\u306e\u30b0\u30eb\u30c6\u30f3\u3092\u6d88\u8cbb\u3059\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3059\u308b\u3053\u3068\u3067\u3059\u3002 [83] \u3002 Prolylyendopeptydaza  – \u305d\u308c\u306f\u5fae\u751f\u7269\u3068\u690d\u7269\u306e\u9175\u7d20\u3067\u3059\u3002\u9175\u7d20\u306f\u30b0\u30eb\u30c6\u30f3 – \u30ea\u30c3\u30c1\u30b0\u30eb\u30c6\u30f3\u3092\u5c0f\u3055\u306a\u30da\u30d7\u30c1\u30c9\u306b\u5206\u5272\u3057\u3001\u8178\u306e\u9175\u7d20\u3067\u6d88\u5316\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u85ac\u306e\u4f7f\u7528\u306e\u7d50\u679c\u3068\u3057\u3066\u306e\u5438\u53ce\u75c7\u5019\u7fa4\u306e\u91cd\u75c7\u5ea6\u306e\u6e1b\u5c11\u304c\u898b\u3064\u304b\u308a\u307e\u3057\u305f [84] [85] \u3002\u3057\u304b\u3057\u3001\u9175\u7d20\u306f\u3001\u98df\u7269\u9175\u7d20\u306e3\u6642\u9593\u306e\u5fc5\u8981\u306a\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u308a\u3001\u9650\u3089\u308c\u305f\u81e8\u5e8a\u7684\u9069\u5408\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059 [\u516b\u5341\u516d] \u3002 ALV003  – \u30b0\u30eb\u30c6\u30f3\u3092\u5e83\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u308b2\u3064\u306e\u30b0\u30eb\u30bf\u30df\u30f3\u3001\u9175\u7d20\u306e\u6df7\u5408\u7269\u3067\u3059 [\u516b\u5341\u4e03] \u3002\u7121\u4f5c\u70ba\u5316\u7814\u7a76\u3067\u306f\u3001ALV003\u306f\u75c7\u72b6\u3092\u7de9\u548c\u3057\u307e\u305b\u3093\u304c\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u8178\u7c98\u819c\u640d\u50b7\u306e\u6e1b\u5c11\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 [\u516b\u5341\u4e03] \u3002 lactobacillus  – \u767a\u9175\u306e\u7d50\u679c\u3068\u3057\u3066\u306e\u7d30\u83cc\u306f\u3001\u30b0\u30eb\u30c6\u30f3\u6eb6\u89e3\u306b\u3064\u306a\u304c\u308a\u3001\u305d\u306e\u514d\u75ab\u539f\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 [88] [89] \u3002 VSL  – \u305d\u308c\u306f\u7d30\u83cc\u3092\u542b\u3080\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3067\u3059 \u30d3\u30d5\u30a3\u30c9\u30d0\u30af\u30c6\u30ea\u30a2 \u3001 lactobacillus \u3068 Streptococcus salivarius \u3002\u98df\u54c1\u7523\u696d\u306e\u5c0f\u9ea6\u7c89\u306e\u4e8b\u524d\u51e6\u7406\u306b\u4f7f\u7528\u3057\u3066\u3001\u30b0\u30eb\u30c6\u30f3\u88fd\u54c1\u3092\u5165\u624b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059 [90] \u3002 \u30e9\u30e9\u30be\u30c1\u30c9  – \u6bd2\u7d20\u304b\u3089\u306e\u5408\u6210\u30d8\u30ad\u30b5\u30da\u30d7\u30c1\u30c9\u3067\u3059 Vibrio cholerae \u3002\u305d\u308c\u306f\u3001\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3067\u4e0a\u76ae\u306e\u7d30\u80de\u9593\u306e\u53b3\u5bc6\u306a\u3064\u306a\u304c\u308a\u3092\u9589\u3058\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u3001\u3057\u305f\u304c\u3063\u3066\u30b0\u30ea\u30e3\u30b8\u30f3\u306e\u5438\u53ce\u3092\u963b\u5bb3\u3059\u308b [91] \u3002\u3053\u306e\u6cbb\u7642\u6226\u7565\u306f\u4ed6\u306e\u85ac\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059 [85] \u3002\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306a\u9055\u3044\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f [92] \u3002 \u5408\u6210HEMA-CO-SS\u30dd\u30ea\u30de\u30fc  – \u30b0\u30ea\u30a2\u30b8\u30f3\u3068\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3001\u8178\u4e0a\u76ae\u3078\u306e\u5f71\u97ff\u3092\u6e1b\u3089\u3057\u307e\u3059\u3002\u30b0\u30ea\u30b8\u30f3\u306b\u5bfe\u3059\u308b\u6d88\u5316\u9175\u7d20\u306e\u6709\u52b9\u6027\u306e\u52a3\u5316\u306b\u3088\u308a\u3001\u3088\u308a\u514d\u75ab\u539f\u6027\u30da\u30d7\u30c1\u30c9\u306e\u5f62\u6210\u3092\u6e1b\u5c11\u3055\u305b\u308b [93] [\u4e5d\u5341\u56db] \u3002\u81e8\u5e8a\u8a66\u9a13\u3092\u5b9f\u65bd\u3059\u308b\u524d\u306b\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059 [62] \u3002 \u7d4c\u53e3\u6297\u30af\u30e9\u30fc\u30eb  – \u305d\u308c\u306f\u53d7\u52d5\u7684\u514d\u75ab\u7642\u6cd5\u306e\u4e00\u5f62\u614b\u3067\u3042\u308a\u3001\u6d88\u5316\u7ba1\u306b\u304a\u3051\u308b\u30b0\u30ea\u30e3\u30b8\u30f3\u306e\u4e2d\u548c\u3068\u305d\u306e\u5438\u53ce\u3092\u9632\u3050\u305f\u3081\u306e\u4ee3\u66ff\u624b\u6bb5\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30ad\u30e3\u30b9\u30c8\u5375\u9ec4\u6297\u4f53\u304c\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u5375\u9ec4\u304b\u3089\u6bd4\u8f03\u7684\u7c21\u5358\u304b\u3064\u7d4c\u6e08\u7684\u306b\u5165\u624b\u3067\u304d\u307e\u3059\u3002\u6297\u4f53\u3092\u4e0e\u3048\u3089\u308c\u305f\u30de\u30a6\u30b9\u306f\u3001\u30b0\u30eb\u30c6\u30f3\u306e\u5438\u53ce\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u307e\u3057\u305f [95] \u3002 \u7d44\u7e54\u30c8\u30e9\u30f3\u30b9\u30b0\u30eb\u30bf\u30df\u30ca\u30fc\u30bc\u306e\u9078\u629e\u7684\u30d6\u30ed\u30c3\u30ad\u30f3\u30b0  – \u30b0\u30eb\u30c6\u30f3\u6442\u53d6\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u708e\u75c7\u30d7\u30ed\u30bb\u30b9\u3092\u963b\u5bb3\u3059\u308b\u6709\u671b\u306a\u6f5c\u5728\u7684\u306a\u65b9\u6cd5\u3067\u3059 [85] \u3002 \u514d\u75ab\u7642\u6cd5  – \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u75c5\u56e0\u3067\u306f\u3001\u30b0\u30eb\u30c6\u30f3\u306b\u5bfe\u3059\u308b\u8aa4\u3063\u305f\u514d\u75ab\u5fdc\u7b54\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30b0\u30eb\u30c6\u30f3\u306b\u5bfe\u3059\u308b\u514d\u75ab\u8010\u6027\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u514d\u75ab\u7642\u6cd5\u3092\u4f5c\u6210\u3059\u308b\u305f\u3081\u306e\u7406\u8ad6\u7684\u57fa\u790e\u3067\u3059\u3002 [85] \u3002 \u514d\u75ab\u5fdc\u7b54\u306e\u4fee\u6b63  – \u6297\u539f\u63d0\u793a\uff08HLA\u30d6\u30ed\u30fc\u30ab\u30fc\uff09\u3092\u30d6\u30ed\u30c3\u30af\u3057\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\uff08IL-10\u3001IL-15\uff09\u3092\u30d6\u30ed\u30c3\u30af\u3057\u3001NKG2D\u53d7\u5bb9\u4f53\u306e\u30d6\u30ed\u30c3\u30af\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u56de\u7b54\u3092\u4fee\u6b63\u3059\u308b\u5b58\u5728 [85] \u3002 \u5185\u81d3\u75c5\u306e\u4e88\u9632 [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ] \u591a\u304f\u306e\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001\u6bcd\u4e73\u80b2\u5150\u4e2d\u306b\u30b0\u30eb\u30c6\u30f3\u3092\u5f90\u3005\u306b\u5c0e\u5165\u3059\u308b\u3068\u3001\u5185\u81d3\u75be\u60a3\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002 [96] [97] [98] [99] \u3002\u751f\u5f8c3\u304b\u6708\u9593\u306b\u98df\u4e8b\u306b\u30b0\u30eb\u30c6\u30f3\u3092\u5c0e\u5165\u3059\u308b\u3068\u30014\u301c6\u304b\u6708\u306e\u5e74\u9f62\u3067\u306e\u5c0e\u5165\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c5\u56de\u5897\u52a0\u3057\u307e\u3059\u3002 [99] \u3002\u30b0\u30eb\u30c6\u30f3\u3082\u751f\u5f8c7\u30f6\u6708\u5f8c\u306b\u907f\u3051\u308b\u3079\u304d\u3067\u3059 [96] \u3002 New Baby Nutrition Schemes\u306b\u3088\u308b\u3068 [13] [100] [101] \u3002\u66dd\u9732\u7528\u91cf\u306f\u3001100 ml\u306e\u98df\u4e8b\u3042\u305f\u308a2\u301c3\u30b0\u30e9\u30e0\uff08\u30bb\u30e2\u30ea\u30ca\u306a\u3069\uff09\u3067\u306a\u3051\u308c\u3070\u306a\u3089\u305a\u3001\u4eca\u5f8c2\u304b\u6708\u30674\u301c6\u30b0\u30e9\u30e0\u306b\u5897\u52a0\u3057\u307e\u3059\u3002 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\u306e \u30d0\u30c4 \u3068  FranciszekIwa\u0144czak\uff08\u7de8\uff09\uff1a \u5b50\u4f9b\u306e\u6d88\u5316\u5668\u79d1\u3002\u9078\u629e\u3055\u308c\u305f\u554f\u984c \u3002\u30ef\u30eb\u30b7\u30e3\u30ef\uff1a\u30dc\u30eb\u30ae\u30b9\u30012003\u5e74\u3001pp\u3002142\u2013157\u3002 ISBN 83-85284-40-0-0 \u3002  \u2191 a b c d \u305d\u3046\u3067\u3059 f  \u725bC. \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u98df\u4e8b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3068\u5b9f\u88c5 \u3002 \u300c\u80c3\u8178\u79d1\u300d\u30012005-04\u3002 PMID\uff1a 15825119 \u3002   \u2191  \u3042\u306a\u305f\u306b\u5730\u9707\u304c\u3042\u308a\u307e\u3059\u3002You.ll\u3002 \u6210\u4eba\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306b\u304a\u3051\u308b\u30aa\u30fc\u30c8\u9ea6\u306e\u6bd2\u6027\u306e\u6b20\u5982 \u3002 \u201e BMJ\uff08Clinical Research ed\u3002\uff09\u300d\u3002 7068\uff08313\uff09\u3001s\u3002 1300\u20131301\u3001Listopad1996\u3002PMID\uff1a 8942690 \u3002   \u2191  Holm K.\u3001M\u00e4kiM.\u3001Vuolteenaho N.\u3001Mustalahti K.\u3001Ashorn M.\u3001Ruuska T.\u3001Kaukinen K. \u5c0f\u5150\u671f\u306e\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u6cbb\u7642\u306b\u304a\u3051\u308b\u30aa\u30fc\u30c8\u9ea6\uff1a2\u5e74\u9593\u306e\u5bfe\u7167\u8a66\u9a13\u3068\u9577\u671f\u81e8\u5e8a\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u7814\u7a76 \u3002 \u300c\u9ad8\u5316\u85ac\u7406\u5b66\u3068\u6cbb\u7642\u6cd5\u300d\u3002 10\uff0823\uff09\u3001s\u3002 1463\u20131472\u3001Maj2006\u3002Doi\uff1a 10.1111\/j.1365-2036.2006.02908.x \u3002 PMID\uff1a 16669961 \u3002   \u2191 a b c d \u305d\u3046\u3067\u3059 f g h \u79c1 j k  J. J.  \u306f\u3044  J. J. \u79c1\u306f\u30a4\u30cb \u3001 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5 [\u30a2\u30af\u30bb\u30b92014-03-25] [\u30a2\u30fc\u30ab\u30a4\u30d6 \u4f4f\u6240 2009-01-23]  \u3002  \u2191 a b c d \u305d\u3046\u3067\u3059 f  Detlef Schuppan\u3001Melinda D. Dennis\u3001Ciaran P. Kelly\u3002 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\uff1a\u75ab\u5b66\u3001\u75c5\u56e0\u3001\u8a3a\u65ad\u3001\u6804\u990a\u7ba1\u7406 \u3002 \u201e Nutr Clin Care\u3002\u300d\u30012005-04\u3002 PMID\uff1a 16013224 \u3002   \u2191 a b  Alessio Fasano\u3001Irene Berti\u3001Tania gerarduzzi\u3001Tarcisio not I Inni\u3002 \u7c73\u56fd\u306e\u30ea\u30b9\u30af\u306e\u3042\u308b\u30ea\u30b9\u30af\u306e\u306a\u3044\u30ea\u30b9\u30af\u306e\u306a\u3044\u30b0\u30eb\u30fc\u30d7\u306b\u304a\u3051\u308b\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u6709\u75c5\u7387 \u3002 \u300c\u5185\u79d1\u306e\u30a2\u30fc\u30ab\u30a4\u30d6\u300d\u3002 163\uff083\uff09\u3001s\u3002 286\u30012003-02-10\u3002\u30a2\u30e1\u30ea\u30ab\u533b\u5e2b\u4f1a\uff08AMA\uff09\u3002 doi\uff1a 10.1001\/archinte.163.3.286 \u3002 ISSN 0003-9926 \u3002 \uff08 \u3002 \uff09\uff09 \u3002   \u2191  T\u3067\u306f\u306a\u3044\u3001K Horvath\u3001Id Hill\u3001J Partanen I Inni\u3002 \u7c73\u56fd\u306e\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u30ea\u30b9\u30af\uff1a\u5065\u5eb7\u306a\u732e\u8840\u8005\u306b\u304a\u3051\u308b\u6297\u30a8\u30f3\u30c9\u30df\u30b7\u30a6\u30e0\u6297\u4f53\u306e\u9ad8\u3044\u6709\u75c5\u7387\u3002 \u3002 \u300c\u30b9\u30ab\u30f3\u30b8\u30ca\u30d3\u30a2\u80c3\u8178\u79d1\u5b66\u30b8\u30e3\u30fc\u30ca\u30eb\u300d\u3002 33\uff085\uff09\u3001s\u3002 494\u20138\u30011998\u3002 ISSN 0036-5521 \u3002 PMID\uff1a 9648988 \u3002 \uff08 \u3002 \uff09\uff09 \u3002   \u2191  S. Lohi\u3001K\u3002Mustalahti\u3001K\u3002Kaukinen\u3001K\u3002Laurila\u3001P\u3002Collin\u3001H\u3002Rissanen\u3001O\u3002Lohi\u3001E\u3002Bravi\u3001M\u3002Gasparin\u3001A\u3002Reunanen\u3001M\u3002M\u00e4ki\u3002 \u6642\u9593\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u6709\u75c5\u7387\u306e\u5897\u52a0 \u3002 \u300cAlimentary Pharmacology\uff06Therapeutics\u300d\u30012007-10\u3002 doi\uff1a 0.1111\/j.1365-2036.2007.03502.x \u3002   \u2191 a b c d \u305d\u3046\u3067\u3059 f g h \u79c1 j  Hanna Szajewska\u3001Piotr Dziechciarz\u3001Anna Chmielewska\uff1a \u5c02\u9580\u5bb6\u306b\u5c0b\u306d\u3066\u304f\u3060\u3055\u3044\u3002\u30bb\u30ea\u30a2\u30c3\u30af\u75c5 \u3002 [\u30a2\u30af\u30bb\u30b92014-03-24]\u3002  \u2191 a b  Anna Szaflarska-Pop\u0142awska\u3001Krystyna Karczewska\u3001Alicja abka\u3001ewa\u201e rycharska\u3001Mieczys\u0142awCzerwionka-Szaflarska\u3001Piotor Albrecht\u3001Jacek Brengda Ja-Bulsa\u3001Adam Daukszewicz\u3001AgnieszkaGawro\u0144ska\u3001Ewa Hapyn\u3001BarbaraIwa\u0144czak\u3001Franciszek\u3001Mon ka Jakubik\u3001Eljbieta Jarocka-Cyrta\u3001Janj\u00f3zefczuk\u3001bojenakzak\u3001ewa kochaszzak\u3001ewa kochaszzak\u3001 Ki\u3001Ma\u0142gorzataMokrzycka\u3001Agnieszka Mroczkowska-Juchkiewicz\u3001Beata olelewska\u3001Andrzej Radzikowski\u3001Wanda Reyman\u3001Edyta Sienkiewicz\u3001KamilaSk\u00f3ra\u3001Jadwiga Szymanowiga symanowiga symawiga asymawigz\u3001agamawiga\u30a2\u30f3\u30c9\u30e9\u30fb\u30b6\u30ec\u30d5\u30b9\u30ab\u3001\u30b8\u30e3\u30c9\u30a6\u30a3\u30ac\u30fb\u30b6\u30a6\u30b9\u30ab\u3002 \u30dd\u30fc\u30e9\u30f3\u30c9\u306e\u30bb\u30ea\u30a2\u30c3\u30af\u75c5 – \u30de\u30eb\u30c1\u30b5\u30a4\u30ba\u306e\u7814\u7a76 \u3002 \u300c\u5c0f\u5150\u79d1\u306e\u73fe\u4ee3\u306e\u80c3\u8178\u79d1\u3001\u809d\u81d3\u5b66\u3001\u5b50\u4f9b\u306e\u6804\u990a\u3002\u300d 11\u30012009\u3002[\u30a2\u30af\u30bb\u30b92014-03-24]\u3002   \u2191 a b c d \u305d\u3046\u3067\u3059 f g h  Edyta Santorek-Struumi\u0142o\uff1a \u30bb\u30ea\u30a2\u30b7\u30a2 \u3002 [\u30a2\u30af\u30bb\u30b92014-03-23]\u3002  \u2191  Troncone R.\u3001Greco L.\u3001Mayer M.\u3001Mazzarella G.\u3001Maiuri L.\u3001Coenis M.\u3001Frau F.\u3001Virgiliis S.\u3001Auricchio S. \u30bb\u30ea\u30a2\u30c3\u30af\u8a9e\u306e\u5b50\u4f9b\u306e\u5144\u5f1f\u3067\u306f\u3001\u76f4\u8178\u30b0\u30eb\u30c6\u30f3\u30c1\u30e3\u30ec\u30f3\u30b8\u306f\u3001\u30bb\u30ea\u30a2\u30c3\u30afHLA\u306b\u9650\u5b9a\u3055\u308c\u3066\u3044\u306a\u3044\u30b0\u30eb\u30c6\u30f3\u611f\u4f5c\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059 \u3002 \u300c\u6d88\u5316\u5668\u79d1\u300d\u30011996-08\u3002 PMID\uff1a 8690196 \u3002   \u2191 a b c d \u305d\u3046\u3067\u3059 f g h \u79c1 j k l m n  Aleksandra Bartosik\u3002 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5 – \u5730\u9762\u3001\u75c7\u72b6\u3001\u8a3a\u65ad\u3001\u6cbb\u7642 \u3002 \u300cNutrilife\u306e\u30b8\u30e3\u30fc\u30ca\u30eb\u300d\u3002 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[\u30a2\u30af\u30bb\u30b92014-03-23]\u3002   \u2191  Van Heel D.A.\u3001West J. \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u6700\u8fd1\u306e\u9032\u6b69 \u3002 “\u8178”\u3002 7\uff0855\uff09\u3001pp\u30021037\u20131046\u30012006\u5e747\u6708\u3002Doi\uff1a 10.1136\/gut.2005.075119 \u3002 PMID\uff1a 16766754 \u3002   \u2191 a b c d \u305d\u3046\u3067\u3059 f  Sapone A.\u3001Bai J.C.\u3001Ciacci C.\u3001Dolinsek J.\u3001Green P.H.\u3001Hadjivassiliou M.\u3001Kaukinen K.\u3001Rostami K.\u3001Sanders D.S.\u3001Schumann M.\u3001Ullrich R.\u3001Villalt D.\u3001Volta U.\u3001Catassi C.\u3001Fasano A. \u30b0\u30eb\u30c6\u30f3\u95a2\u9023\u969c\u5bb3\u306e\u30b9\u30da\u30af\u30c8\u30eb\uff1a\u65b0\u3057\u3044\u547d\u540d\u6cd5\u3068\u5206\u985e\u306b\u95a2\u3059\u308b\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9 \u3002 \u300cBMC Med\u3002\u300d\u30012012-02-07\u3002\u4e8c\uff1a 0.1186\/1741-7015-10-13\u3002 \u3002 PMID\uff1a 22313950 \u3002 [\u30a2\u30af\u30bb\u30b92014-04-03]\u3002   \u2191  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\u300c\u7cbe\u795e\u79d1\u533bQ.\u300d\u30012012-03\u3002 doi\uff1a 10.1007\/s11126-011-9186-y \u3002 PMID\uff1a 21877216 \u3002 PMCID\uff1a PMC3641836 \u3002   \u2191  Lachance L.R.\u3001McKenzie K. \u975e\u611f\u60c5\u7cbe\u795e\u75c5\u60a3\u8005\u306e\u30b0\u30eb\u30c6\u30f3\u611f\u53d7\u6027\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff1a\u30e1\u30bf\u5206\u6790\u3002 \u3002 \u201e Schizophr res\u3002\u300d\u30012014-01\u3002 PMID\uff1a 24368154 \u3002   \u2191  \u795e\u7d4c\u7cbe\u795e\u969c\u5bb3\u3068\u3057\u3066\u5b58\u5728\u3059\u308b\u30b0\u30eb\u30c6\u30f3\u611f\u53d7\u6027 \u3002 \u201e Gastroenterol Res Pract\u3002\u300d\u30012014\u5e74\u3002PMID\uff1a 24693281 \u3002   \u2191  Czerwionka-Szaflarska M. \u30dd\u30fc\u30e9\u30f3\u30c9\u306e\u5185\u81d3\u75c5\u306e\u5909\u5316\u3059\u308b\u30a4\u30e1\u30fc\u30b8 \u79d1\u5b6624.com \u3002  \u2191 a b c d  Tersigni C.\u3001Castellani R.\u3001De Waure C.\u3001Fattorossi A.\u3001De Spirito M.\u3001Gasbarrini 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HLA-DQB1*0201\u30db\u30e2\u63a5\u5408\u4f53\u306f\u3001\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u91cd\u5ea6\u306e\u8178\u640d\u50b7\u306e\u7d20\u56e0\u3068\u306a\u308a\u307e\u3059 \u3002 \u300c\u30e9\u30f3\u30bb\u30c3\u30c8\u300d\u30012003-04\u3002 PMID\uff1a 12699968 \u3002   \u2191 a b  Anderson R.P.\u3001Henry M.J.\u3001Taylor R.\u3001Duncan E.L.\u3001Danoy P.\u3001Costa M.J.\u3001Addison K.\u3001Tye-Din J.A.\u3001Kotowicz M.A.\u3001Knight R.E.\u3001Pollock W.\u3001Nicholson G.C.\u3001Toh B.H.\u3001Brown M.A.\u3001Pasco J.A. \u65b0\u3057\u3044\u8840\u6e05\u907a\u4f1d\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u306e\u6709\u75c5\u7387\u3092\u6c7a\u5b9a\u3057\u3001\u8a3a\u65ad\u7d4c\u8def\u306e\u6539\u5584\u3092\u901a\u77e5\u3057\u307e\u3059 \u3002 \u201e BMC Med\u3002\u300d\u30012013-08\u3002 PMID\uff1a 23981538 \u3002 PMCID\uff1a PMC3765645 \u3002   \u2191 a b  Povi a\u3002\u3001Araranz e\u3002\u3001Fernandez-Arquero M.\u3001Collin P.\u3001M\u00e4kiM.\u3001Sanz A.\u3001Calvo c\u3002\u3001Thunders c\u3002\u3001Westman P.\u3001Concha E.G.\u3001Partanen J\u3002 \u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u3068\u30b9\u30da\u30a4\u30f3\u306eHLA-DQ2\u9670\u6027\u30bb\u30ea\u30a2\u30c3\u30af\u75c5 \u3002 \u201e Hum Immunol\u3002\u300d\u30011998-03\u3002 PMID\uff1a 9548076 \u3002   \u2191 a b  Chorzelski T.P.\u3001Suul J.\u3001Tchorzewska H.\u3001Jablonska S.\u3001Beutner E.H.\u3001Kumar V. Herpetiformis\u76ae\u819a\u708e\u304a\u3088\u3073\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306b\u304a\u3051\u308bIGA\u30af\u30e9\u30b9\u306e\u5b50\u5bae\u5185\u819c\u6297\u4f53\u3002 \u3002 \u201e Ann n y Acad Sci\u3002\u300d\u30011983\u5e74\u3002PMID\uff1a 6586098 \u3002   \u2191  Walewski P. \u8033\u306a\u3057\u3067\u565b\u3080 \u3001\u300cPolityka\u300dNo\u300234\uff082618\uff09\u306e2007\u5e748\u670825\u65e5\u3001pp\u300276\u201377\u3002  \u2191 a b c d \u305d\u3046\u3067\u3059  Andrzej Szczeklik\uff08\u7de8\uff09\uff1a \u5185\u75be\u60a3 \u3002 Krakow\uff1aMedycyna Practical Publishing House\u30012010\u3002ISBN 978-83-7430-216-6 \u3002  \u2191  \u3068\u3057\u3066\u3002 Abdulkarim\u3001J.A\u3002\u30de\u30ec\u30fc\u3002 \u30ec\u30d3\u30e5\u30fc\u8a18\u4e8b\uff1a\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u8a3a\u65ad \u3002 \u201e Alient Pharmacol Ther\u3002\u300d\u30012003-04\u3002 doi\uff1a 10.1046\/j.1365-2036.2003.01442.x \u3002 PMID\uff1a 12694080 \u3002   \u2191  \u30ab\u30df\u30eb\u304c\u3082\u305f\u3089\u3059\u3002 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5 – \u7b2c3\u30df\u30ec\u30cb\u30a2\u30e0\u306e\u6311\u6226 \u3002 “\u5e38\u5099\u85ac”\u3002   \u2191 a b  Str\u00f6hleA\u3002\u3001Wolters M.\u3001Hahn A. \u30bb\u30ea\u30a2\u30c3\u30af\u75c5 – \u98df\u7269\u4e0d\u8010\u6027\u306e\u4e2d\u3067\u30ab\u30e1\u30ec\u30aa\u30f3 \u3002 \u300cMed Monthly Pharm\u3002\u300d\u30012013-10\u3002 PMID\uff1a 24266248 \u3002   \u2191  \u5f7c\u306fA.K.\u3001Thomas A.G.\u306b\u96fb\u8a71\u3057\u307e\u3059\u3002 \u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\uff1a\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u4eba\u306e\u305f\u3081\u306e\u30b0\u30eb\u30c6\u30f3\u306e\u8a31\u5bb9\u91cf\u306e\u91cf \u3002 \u201e Alient Pharmacol Ther\u3002\u300d\u30012008\u5e74\u3002Doi\uff1a 10.1111\/j.1365-2036.2008.03669.x\u3002 \u3002 PMID\uff1a 18315587 \u3002   \u2191  Jerzy Kruszewski\u3002 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u3002\u75c5\u56e0\u304b\u3089\u6cbb\u7642\u307e\u3067 \u3002 “\u30a2\u30ec\u30eb\u30ae\u30fc”\u3002 1\/8\u30012001\u3002\u8abf\u548c\u5b66\u7684\u51fa\u7248\u793e\u300c\u5065\u5eb7\u300d\u3002 urszulasamoli\u0144ska-zawisza\u3002 ISSN 1641-5728 \u3002 [\u30a2\u30fc\u30ab\u30a4\u30d6 \u4f4f\u6240 ]\u3002   \u2191  Janeczko C.E.\u3001Sweeney K.\u3001Connaghan G. \u88dc\u8db3\u7684\u306a\u30d3\u30bf\u30df\u30f3K\u306f\u3001\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306b\u7d9a\u767a\u3059\u308b\u30d3\u30bf\u30df\u30f3K\u306e\u4f4e\u7d44\u7e54\u8caf\u8535\u306e\u4f4e\u3044\u60a3\u8005\u306e\u6297\u51dd\u56fa\u306e\u5b89\u5b9a\u6027\u3092\u6539\u5584\u3059\u308b \u3002 \u300cBMJ\u30b1\u30fc\u30b9\u62c5\u5f53\u8005\u300d\u3002 PMID\uff1a 21686472 \u3002   \u2191  Szajewska H\u3002; 2005\u5e74\u306e\u80c3\u8178\u79d1\u3068\u5b50\u4f9b\u306e\u6804\u990a\u5b66\u306e\u9032\u6b69 \u3002\u5b9f\u7528\u7684\u306a\u85ac \u3002  \u2191  Tadataka Yamada: \u6d88\u5316\u5668\u79d1\u30cf\u30f3\u30c9\u30d6\u30c3\u30af \u3002 Lublin\uff1aCzelej Publishing House\u30012006\u3001p\u3002378\u3002ISBN 978-83-89309-92-1 \u3002  \u2191  \u59d4\u54e1\u4f1a\u898f\u5236\uff08EC\uff092009\u5e741\u670820\u65e5\u306e41\/2009\u306e\u4eba\u3005\u306f\u3001\u30b0\u30eb\u30c6\u30f3\u8010\u6027\u306e\u4eba\u3005\u306b\u9069\u3057\u305f\u98df\u54c1\u306e\u7d44\u6210\u3068\u30e9\u30d9\u30eb\u4ed8\u3051\u306b\u95a2\u3057\u3066 \u3002\u6b27\u5dde\u9023\u5408\u306e\u516c\u5f0f\u30b8\u30e3\u30fc\u30ca\u30eb\u30012009-01-20\u3002 [\u30a2\u30af\u30bb\u30b92012-11-27]\u3002 \uff08 pol\u3002 \uff09\uff09 \u3002  \u2191  \u30b0\u30eb\u30c6\u30f3\u30d5\u30ea\u30fc\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f FDA\u306b\u306f\u7b54\u3048\u304c\u3042\u308a\u307e\u3059 \u3001 \u98df\u54c1\u533b\u85ac\u54c1\u5c40 [\u30a2\u30af\u30bb\u30b92014-04-03]  \u3002  \u2191 a b c d \u305d\u3046\u3067\u3059 f g h  Ludvigsson J.F.\u3001Leffler D.A.\u3001Bai J.C.\u3001Life f\u3002\u3001Fasano a\u3002\u3001Green P.H.\u3001Hadjivassiliou m\u3002\u3001\u99b4\u67d3\u307f\u306e\u3042\u308bK.P.\u3001Keukenen C.P.\u3001Leonard J.N.\u3001Lundin K.E. \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u304a\u3088\u3073\u95a2\u9023\u7528\u8a9e\u306e\u30aa\u30b9\u30ed\u5b9a\u7fa9 \u3002 \u300c\u30b0\u30c3\u30c9\u300d\u30012013-01\u3002 doi\uff1a 0.1136\/gutjnl-2011-301346\u3002 \u3002 PMID\uff1a 22345659 \u3002 PMCID\uff1a PMC3440559 \u3002   \u2191  \u30a2\u30f3\u30ca\u30fb\u30b7\u30e5\u30df\u30a8\u30eb\u30a6\u30a7\u30b9\u30ab\u3001\u30d4\u30aa\u30c8\u30eb\u30fb\u30c7\u30a3\u30a8\u30c1\u30a7\u30c1\u30a2\u30eb\u30c4\u3001\u30c9\u30ed\u30bf\u30fb\u30ae\u30a8\u30eb\u30b9\u30fb\u30d3\u30a2\u30a6\u30af\u3001\u30a2\u30f3\u30c9\u30ec\u30a2\u30fb\u30db\u30eb\u30f4\u30a1\u30b9\u3001\u30be\u30d5\u30a3\u30a2\u30fb\u30b3\u30ca\u30eb\u30b9\u30ab\u3001\u30d9\u30eb\u30ca\u30c7\u30bf\u30fb\u30d1\u30c8\u30ed\u3001\u30de\u30a6\u30b4\u30eb\u30b6\u30bf\u30fb\u30d4\u30a8\u30b7\u30c3\u30af\u30fb\u30ec\u30c3\u30af\u3001\u30de\u30ec\u30af\u30fb\u30e9\u30b7\u30e5\u30c1\u30a7\u30b9\u30ad\u3001\u305d\u3057\u3066\u30cf\u30f3\u30ca\u30fb\u30b9\u30b8\u30a8\u30d5\u30b9\u30ab\u3002 2012\u5e74\u306e\u5b50\u4f9b\u306e\u6804\u990a\u3068\u9078\u629e\u3055\u308c\u305f\u80c3\u8178\u75be\u60a3\u306e\u9032\u6b69 \u3002 \u300c\u5b9f\u7528\u7684\u306a\u85ac\u3002\u5c0f\u5150\u79d1\u300d\u30012013-03\u3002\u5b9f\u7528\u7684\u306a\u85ac\u3002 [\u30a2\u30af\u30bb\u30b92014-04-05]\u3002   \u2191 a b  Grajyna Rowicka\u3002 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u975e\u5b9a\u578b\u5f62\u614b – \u8a3a\u65ad\u306e\u96e3\u3057\u3055 \u3002 \u300c\u767a\u9054\u671f\u9593\u533b\u5b66\uff08\u767a\u9054\u6642\u4ee3\u306e\u533b\u5b66\uff09\u300d\u3002 2\u3001pp\u3002124-127\u30012012\u3002\u6bcd\u3068\u5b50\u306e\u7814\u7a76\u6240\u3002 Aluna Publishing House\u3002 \uff08 pol\u3002 \uff09\uff09 \u3002   \u2191  A.\u30eb\u30d3\u30aa\u30bf\u30d4\u30a2\u3001J.A\u3002\u30de\u30ec\u30fc\u3002 \u96e3\u6cbb\u6027\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u5206\u985e\u3068\u7ba1\u7406\u3002 \u3002 “\u826f\u3044”\u3002 59\uff084\uff09\u3001p\u3002547\u2013557\u30012010\u5e744\u6708\u3002Doi\uff1a 10.1136\/gut.2009.195131 \u3002 PMID\uff1a 20332526 \u3002   \u2191 a b c d \u305d\u3046\u3067\u3059 f g  Malamut G\u3001Afchain P.\u3001Verkarre V.\u3001Lecomte T.\u3001Amiot A.\u3001Damotte D.\u3001Bouhnik Y.\u3001Colombel J.F.\u3001Delchier J.C.\u3001Come On M.\u3001Cosnes J.\u3001Lavergne B.\u3001Meresse B.\u3001Trinquart L.\u3001Macintyre E. \u96e3\u6cbb\u6027\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u30d7\u30ec\u30bc\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3\u3068\u9577\u671f\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\uff1aI\u578b\u3068\u30bf\u30a4\u30d7II\u306e\u6bd4\u8f03\u3002 \u3002 \u300c\u6d88\u5316\u5668\u79d1\u300d\u30012009-01\u3002 PMID\uff1a 19014942 \u3002   \u2191 a b  W.H. Verbeek\u3001M.S\u3002\u30b4\u30ec\u30b9\u3001B.M\u3002 Von Blomberg\u3001J.J\u3002 Oudejans I Inni\u3002 \u7570\u5e38\u306a\u4e0a\u76ae\u5185\u30ea\u30f3\u30d1\u7403\u306e\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u6e2c\u5b9a\u306f\u3001\u96e3\u6cbb\u6027\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306b\u304a\u3051\u308bT\u7d30\u80de\u30af\u30ed\u30fc\u30f3\u6027\u5206\u6790\u3088\u308a\u3082T\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306e\u767a\u9054\u3092\u3088\u308a\u6b63\u78ba\u306b\u4e88\u6e2c\u3057\u307e\u3059\u3002 \u3002 \u300c\u30af\u30ea\u30f3\u30a4\u30e0\u30ce\u30fc\u30eb\u300d\u3002 126\uff081\uff09\u3001s\u3002 48\u201356\u30012008\u5e741\u6708\u3002doi\uff1a 10.1016\/j.clim\u30022007.09.002 \u3002 PMID\uff1a 18024205 \u3002   \u2191 a b c d \u305d\u3046\u3067\u3059 f g h \u79c1 j k l m n o p Q  \u30a6\u30c3\u30c9\u30ef\u30fc\u30c9J. \u96e3\u6cbb\u6027\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306e\u7ba1\u7406 \u3002 \u201e Ther Adv Chronic Dis\u3002\u300d\u30012013-03\u3002 PMID\uff1a 23556127 \u3002 PMCID\uff1a PMC3610261 \u3002   \u2191 a b  \u30c7\u30d3\u30c3\u30c9\u30fbH\u30fb\u30c7\u30ef\u30fc\u30eb\u3001\u30b9\u30b6\u30f3\u30cc\u30fbC\u30fb\u30c9\u30cd\u30ea\u30fc\u3001\u30b5\u30a4\u30e2\u30f3\u30fbD\u30fb\u30de\u30af\u30e9\u30d5\u30ea\u30f3\u3001\u30de\u30b7\u30e5\u30fc\u30fbW\u30fb\u30b8\u30e7\u30f3\u30bd\u30f3\u3001H\u3002\u30b8\u30e5\u30ea\u30a2\u30fb\u30a8\u30ea\u30b9\u3001\u30dd\u30fc\u30eb\u30fbJ\u30fb\u30b7\u30af\u30ea\u30c6\u30a3\u30e9\u3002 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\uff1a\u30b0\u30eb\u30c6\u30f3\u3092\u542b\u307e\u306a\u3044\u98df\u4e8b\u3092\u3057\u3066\u3044\u308b\u60a3\u8005\u306e\u6301\u7d9a\u7684\u306a\u75c7\u72b6\u306e\u7ba1\u7406 \u3002 \u201e World J Gastroenterol\u3002\u300d\u30012012-03\u3002 doi\uff1a 10.3748\/wjg.v18.i12.1348 \u3002 PMCID\uff1a PM33319961 \u3002   \u2191 a b  E. Bagdi\u3001T.C\u3002 Diss\u3001P\u3002Munson\u3001P.G\u3002\u30a2\u30a4\u30b6\u30af\u30bd\u30f3\u3002 \u8178\u75c7\u306b\u95a2\u9023\u3057\u305fT\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u3001\u6f70\u760d\u6027\u30bb\u30a4\u30b8\u30e5\u30f3\u708e\u3001\u304a\u3088\u3073\u96e3\u6cbb\u6027\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306b\u304a\u3051\u308b\u7c98\u819c\u5185\u4e0a\u76ae\u30ea\u30f3\u30d1\u7403\u7403\u7403\u306f\u3001\u65b0\u751f\u7269\u96c6\u56e3\u3092\u69cb\u6210\u3057\u307e\u3059\u3002 \u3002 “\u8840”\u3002 94\uff081\uff09\u3001s\u3002 260\u2013264\u30011999\u5e747\u6708\u3002PMID\uff1a 10381521 \u3002   \u2191  C.\u30d1\u30c6\u30a3\u3001nl\u3002\u30de\u30a6\u30d3\u30d6\u4eba\u306f\u3042\u306a\u305f\u306e\u4e2d\u306b\u3044\u307e\u3059\u3002 \u96e3\u6cbb\u6027\u30b9\u30d7\u30eb\u30fc\u306e\u7570\u5e38\u306a\u8178\u4e0a\u76ae\u5185\u30ea\u30f3\u30d1\u7403\u3002 \u3002 \u300c\u6d88\u5316\u5668\u79d1\u300d\u3002 114\uff083\uff09\u3001s\u3002 471\u2013481\u30011998\u5e743\u6708\u3002PMID\uff1a 9496937 \u3002   \u2191  G.C. Alfsen\u3001K\u3002Beiske\u3001H\u3002Bell\u3001P.F\u3002\u30de\u30fc\u30c8\u30f3\u3002 \u4f75\u7528\u6027\u8178\u75c7\u8178\u75c7\u306b\u95a2\u9023\u3059\u308bT\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u3092\u4f34\u3046\u4e0a\u76ae\u5185T\u30ea\u30f3\u30d1\u7403\u306e\u4f4e\u30b0\u30ec\u30fc\u30c9\u8178\u30ea\u30f3\u30d1\u816b\uff1a\u7d44\u7e54\u907a\u4f1d\u5b66\u7684\u95a2\u4fc2\u306e\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u75c7\u4f8b\u5831\u544a\u3002 \u3002 \u300c\u30cf\u30e0\u30d1\u30c8\u30eb\u300d\u3002 20\uff089\uff09\u3001s\u3002 909\u2013913\u30011989\u5e749\u6708\u3002PMID\uff1a 2789173 \u3002   \u2191  C. Cellier\u3001E\u3002Delabesse\u3001C\u3002Helmer\u3001N\u3002Pocy1 Inni\u3002 \u96e3\u6cbb\u6027\u30b9\u30d7\u30eb\u30fc\u3001\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u3001\u8178\u75c7\u306b\u95a2\u9023\u3059\u308bT\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u3002\u30d5\u30e9\u30f3\u30b9\u306e\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3002 \u3002 \u300c\u30e9\u30f3\u30bb\u30c3\u30c8\u300d\u3002 356\uff089225\uff09\u3001s\u3002 203\u2013208\u30012000\u5e747\u6708\u3002PMID\uff1a 10963198 \u3002   \u2191  N. Patey-Mariaud de Serre\u3001C\u3002Cellier\u3001B\u3002Jabri\u3001E\u3002DelabesseIInni\u3002 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u3068\u96e3\u6cbb\u6027\u306e\u30b9\u30d7\u30eb\u30fc\u306e\u533a\u5225\uff1a\u5358\u7d14\u306a\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u7684\u65b9\u6cd5\u3002 \u3002 \u300c\u7d44\u7e54\u75c5\u7406\u5b66\u300d\u3002 37\uff081\uff09\u3001s\u3002 70\u201377\u30012000\u5e747\u6708\u3002PMID\uff1a 10931221 \u3002   \u2191 a b  Enns R.\u3001Lay T.\u3001Bridges R. \u975e\u672b\u982d\u816b\u760d\u6027\u6f70\u760d\u6027\u30bb\u30b8\u30e5\u30ce\u30a4\u30eb\u708e\u306e\u305f\u3081\u306e\u30a2\u30b6\u30c1\u30aa\u30d7\u30ea\u30f3\u306e\u4f7f\u7528 \u3002 \u201e Can J Gastroenterol\u3002\u300d\u30012009-09\u3002 PMID\uff1a 9347165 \u3002   \u2191  A.\u30a2\u30eb\u30c8\u30de\u3001W.H.M\u3002 Verbeek\u3001M\u3002Hadithi\u3001B.M.E\u3002 Von Blomberg\u3001C.J.J\u3002\u30e2\u30eb\u30c0\u30fc\u3002 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\u30bb\u30ea\u30a2\u30c3\u30af\u30b9\u30d7\u30eb\u30fc\u306e\u30b0\u30eb\u30c6\u30f3\u8a98\u767a\u6027\u5438\u53ce\u4e0d\u826f\u306b\u5bfe\u3059\u308b\u30d7\u30ed\u30ea\u30eb\u30a8\u30f3\u30c9\u30da\u30d7\u30c1\u30c0\u30fc\u30bc\u306b\u3088\u308b\u98df\u7269\u30b0\u30eb\u30c6\u30f3\u306e\u524d\u51e6\u7406\u306e\u52b9\u679c\u3002 \u3002 \u300cClin Gastroenterol Hepatol\u300d\u3002 3\uff087\uff09\u3001s\u3002 687\u2013694\u30012005\u5e747\u6708\u3002PMID\uff1a 16206502 \u3002   \u2191 a b c d \u305d\u3046\u3067\u3059  S.A.\u30b9\u30ad\u30e3\u30f3\u30ed\u30f3\u3001J.A\u3002\u30de\u30ec\u30fc\u3002 \u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u306b\u95a2\u3059\u308b\u6700\u65b0\u60c5\u5831 – \u75c5\u56e0\u3001\u9451\u5225\u8a3a\u65ad\u3001\u85ac\u7269\u6a19\u7684\u3001\u304a\u3088\u3073\u7ba1\u7406\u306e\u9032\u6b69\u3002 \u3002 \u300cClin Exp Gastroenterol\u300d\u3002 4\u3001s\u3002 297\u2013311\u30012011\u3002doi\uff1a 10.2147 \/ legs.s8315 \u3002 PMID\uff1a 22235174 \u3002 PMCID\uff1a 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Immunol\u3002\u300d\u30012010-03\u3002 PMID\uff1a 19942485 \u3002   \u2191  Greco L.\u3001Gobbetti M.\u3001Auricchio R.\u3001Mase R.\u3001Mase R.\u3001Landolfo F.\u3001Paparo F.\u3001Paparo F.\u3001Cagno R.\u3001De Angelis M.\u3001Rizzello C.G.\u3001Cassone A.\u3001Terrone G.\u3001Timpone L.\u3001D\u2019Aniello M.\u3001Maglio M.\u3001Troncone R.\u3001Auricchio S. \u98df\u54c1\u52a0\u5de5\u4e2d\u306b\u52a0\u6c34\u5206\u89e3\u3055\u308c\u305f\u5c0f\u9ea6\u7c89\u3067\u4f5c\u3089\u308c\u305f\u713c\u304d\u83d3\u5b50\u306e\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u60a3\u8005\u306e\u5b89\u5168 \u3002 \u201e Clin Gastroenterol Hepatol\u3002\u300d\u30012011-01\u3002 PMID\uff1a 20951830 \u3002   \u2191  Cagno R.\u3001De Angelis M.\u3001Auricchio S.\u3001Greco L.\u3001Clarke C.\u3001De Vincenzi M.\u3001Giovannini C.\u3001Archival M.\u3001Landolfo F.\u3001Parrilli G.\u3001Minervini F.\u3001Arendt E.\u3001Gobbetti M. 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