[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/archives\/2270#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/archives\/2270","headline":"BRCA1-\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2\u3001\u7121\u6599\u200b\u200b\u767e\u79d1\u4e8b\u5178","name":"BRCA1-\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2\u3001\u7121\u6599\u200b\u200b\u767e\u79d1\u4e8b\u5178","description":"before-content-x4 \u7dd1\u8272\u3067\u30de\u30fc\u30af\u3055\u308c\u305fBRCA1\u907a\u4f1d\u5b50\u306e\u4f4d\u7f6e KRCA1 – 17\u67d3\u8272\u4f53\u306e\u9577\u3044\u8155\u306e\u30d2\u30c8\u6291\u5236\u907a\u4f1d\u5b50 \u8ecc\u8de1 17Q21 [\u521d\u3081] \u3002\u3053\u308c\u306f\u975e\u5e38\u306b\u5927\u304d\u306a\u907a\u4f1d\u5b50\u3067\u3059 – 80 kpz DNA\u3092\u8986\u3044\u300124\u306e\u30a8\u30af\u30bd\u30f3\u3092\u542b\u3093\u3067\u3044\u307e\u3059\u3002\u5f7c\u306emRNA\u306b\u306f7.8 kpz\u304c\u3042\u308a\u307e\u3059\u3002 BRCA1\u30bf\u30f3\u30d1\u30af\u8cea\u306f1863\u30a2\u30df\u30ce\u9178\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059 [2] \u3002 BRCA1\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001BRCA2\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u540c\u69d8\u306b\u3001\u640d\u50b7\u3057\u305fDNA\u3092\u4fee\u5fa9\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002 BRCA1\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u3068\u6a5f\u80fd [","datePublished":"2021-11-01","dateModified":"2021-11-01","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/cb\/BRCA1_location.svg\/150px-BRCA1_location.svg.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/cb\/BRCA1_location.svg\/150px-BRCA1_location.svg.png","height":"274","width":"150"},"url":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/archives\/2270","wordCount":6555,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4 \u7dd1\u8272\u3067\u30de\u30fc\u30af\u3055\u308c\u305fBRCA1\u907a\u4f1d\u5b50\u306e\u4f4d\u7f6e KRCA1  –  17\u67d3\u8272\u4f53\u306e\u9577\u3044\u8155\u306e\u30d2\u30c8\u6291\u5236\u907a\u4f1d\u5b50 \u8ecc\u8de1 17Q21 [\u521d\u3081] \u3002\u3053\u308c\u306f\u975e\u5e38\u306b\u5927\u304d\u306a\u907a\u4f1d\u5b50\u3067\u3059 –  80 kpz DNA\u3092\u8986\u3044\u300124\u306e\u30a8\u30af\u30bd\u30f3\u3092\u542b\u3093\u3067\u3044\u307e\u3059\u3002\u5f7c\u306emRNA\u306b\u306f7.8 kpz\u304c\u3042\u308a\u307e\u3059\u3002 BRCA1\u30bf\u30f3\u30d1\u30af\u8cea\u306f1863\u30a2\u30df\u30ce\u9178\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059 [2] \u3002 BRCA1\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001BRCA2\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u540c\u69d8\u306b\u3001\u640d\u50b7\u3057\u305fDNA\u3092\u4fee\u5fa9\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002 BRCA1\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u3068\u6a5f\u80fd [ \u7de8\u96c6 | \u30b3\u30fc\u30c9\u3092\u7de8\u96c6\u3057\u307e\u3059 ]  BRCA1\u30bf\u30f3\u30d1\u30af\u8cea\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\u69cb\u9020\u30b9\u30ad\u30fc\u30e0\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u7d50\u5408\u5834\u6240\u3002\u30ad\u30ca\u30fc\u30bc\u306b\u3088\u3063\u3066\u30ea\u30f3\u9178\u5316\u3055\u308c\u305fBRCA1\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u3082\u30de\u30fc\u30af\u3055\u308c\u307e\u3057\u305f [3]        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4BRCA1\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f\u30012\u3064\u306e\u6ce8\u76ee\u306b\u5024\u3059\u308b\u30bf\u30a4\u30d7\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30c9\u30e1\u30a4\u30f3\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002N\u30df\u30fc\u30c8\u306e\u30ea\u30f3\u30b0\u3068C\u30de\u30a4\u30f3\u306e2\u3064\u306eBRCT\u30c9\u30e1\u30a4\u30f3\u3067\u3059\u3002\u85ac\u6307\u306f\u3001Brca1\u306e\u3088\u3046\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u4e9c\u925b\u30a4\u30aa\u30f3\u7d50\u5408Bard1\u30bf\u30f3\u30d1\u30af\u8cea\uff08Brca1-Hessociated Ring\u30c9\u30e1\u30a4\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3092\u542b\u3080\u30c9\u30e1\u30a4\u30f3\u3067\u3059\u3002 BRCA1 -BARD1\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u304c\u3093\u306e\u7d20\u56e0\u3068\u306a\u308bBRCA1\u74b0\u30c9\u30e1\u30a4\u30f3\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u5bb9\u8a8d\u3055\u308c\u307e\u3059\u3002\u304a\u305d\u3089\u304f\u764c\u306e\u6291\u5236\u306f\u3001\u30d8\u30c6\u30ed\u30de\u30fcBRCA1-BARD1\u8907\u5408\u4f53\u306b\u4f9d\u5b58\u3057\u307e\u3059 [4] \u3002 Brca1bia\u0142ka1\u306e\u30c9\u30e1\u30a4\u30f3\u306f\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u30d2\u30c9\u30ed\u30e9\u30fc\u30bc\u306ec\u672b\u7aef\u3067\u3042\u308bBap1\u30bf\u30f3\u30d1\u30af\u8cea\uff08Brca1-hessociated\u30bf\u30f3\u30d1\u30af\u8cea1\uff09\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u307e\u3059\u3002 BRCT BRCA1\u30c9\u30e1\u30a4\u30f3\u306f\u8ee2\u5199\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001DNA\u4fee\u5fa9\u30d7\u30ed\u30bb\u30b9\u3068\u7d30\u80de\u5468\u671f\u306e\u8abf\u6574\u306b\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3057\u3070\u3057\u3070\u898b\u3089\u308c\u307e\u3059 [5] [6] \u3002        (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4BRCA1\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u7d30\u80de\u6838\u306b\u3042\u308a\u307e\u3059 [7] [8] \u30de\u30a6\u30b9\u80da\u306e\u767a\u9054\u4e2d\u3001\u7279\u306b\u5897\u6b96\u304a\u3088\u3073\u7570\u306a\u308b\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u3055\u307e\u3056\u307e\u306a\u30bf\u30a4\u30d7\u306e\u7d44\u7e54\u3067\u767a\u73fe\u3059\u308b\u3053\u3068\u306b\u3055\u3089\u3055\u308c\u307e\u3059 [9] [\u5341] \u3002 \u907a\u4f1d\u5b50\u767a\u73fe KRCA1 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\u3001\u3053\u308c\u306f\u3001\u7d30\u80de\u5897\u6b96\u306e\u8abf\u7bc0\u306b\u304a\u3051\u308bBRCA1\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u91cd\u8981\u306a\u5f79\u5272\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4eee\u8aac\u306f\u3001\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3044\u3046\u89b3\u5bdf\u306b\u3088\u3063\u3066\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059 KRCA1 \u4e73\u982d\u817a\u4e0a\u76ae\u306e\u7d30\u80de\u3067\u306f\u3001\u305d\u308c\u3089\u306f\u30b1\u30fc\u30d6\u30eb\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u5f62\u614b\u5f62\u6210\u306e\u969c\u5bb3\u306b\u3064\u306a\u304c\u308a\u307e\u3059 [18] \u3002\u7d30\u80de\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9 KRCA1  – \/  –  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[21] \u3002 \u907a\u4f1d\u5b50\u5909\u7570 KRCA1 \u305d\u308c\u3089\u306f\u3057\u3070\u3057\u3070\u898b\u3064\u304b\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u5275\u8a2d\u8005\u306e\u52b9\u679c\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u3001\u6c11\u65cf\u7684\u306b\u5747\u8cea\u306a\u96c6\u56e3\u306e\u7a81\u7136\u5909\u7570\u306e\u983b\u5ea6\u304c\u9ad8\u304f\u3001\u305d\u308c\u306b\u95a2\u9023\u3059\u308b\u3082\u306e\u304c\u3088\u308a\u907a\u4f1d\u7684\u306b\u5747\u8cea\u3067\u3059\u3002\u3053\u306e\u4eba\u53e3\u306f\u3001\u3068\u308a\u308f\u3051\u30dd\u30fc\u30e9\u30f3\u30c9\u4eba\u53e3\u3067\u3059 [22] \u3002\u907a\u4f1d\u5b50\u5909\u7570\u306f\u3069\u306e\u5834\u6240\u3067\u3082\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5c11\u6570\u306e\u5909\u7570\u306e\u307f\u306e\u983b\u5ea6\u304c\u306f\u308b\u304b\u306b\u9ad8\u3044\u3067\u3059\u3002\u30dd\u30fc\u30e9\u30f3\u30c9\u3067\u306f\u3001\u3053\u308c\u3089\u306f\u5909\u7570C\u3067\u3059\u3002 5382INSC \u3001c\u3002 C61G IC\u3002 4153dela \u3001\u3059\u3079\u3066\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306e91\uff05\u3092\u69cb\u6210\u3057\u307e\u3059 [22] \u3002 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\u7d0440\u5e74\u3067\u3059\u3002\u304a\u305d\u3089\u304f\u3001\u7a81\u7136\u5909\u7570\u306e\u7a2e\u985e\u3068\u4f4d\u7f6e\u306f\u3001\u304c\u3093\u767a\u751f\u306e\u30ea\u30b9\u30af\u306e\u91cf\u306b\u5f71\u97ff\u3057\u307e\u3059\u3002 \u7a81\u7136\u5909\u7570 KRCA1 \u305d\u308c\u3089\u306f\u3001\u4e73\u304c\u3093\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u304c\u4f4e\u3044\u3053\u3068\u3092\u7d20\u56e0\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u4e73\u304c\u3093\u60a3\u8005\u306e\u5927\u898f\u6a21\u306a\u30b0\u30eb\u30fc\u30d7\u306b\u95a2\u3059\u308b\u591a\u30b5\u30a4\u30ba\u306e\u9061\u53ca\u7684\u7121\u4f5c\u70ba\u5316\u7814\u7a76\u3067\u306f\u3001\u7b2c\u4e8c\u4e73\u304c\u3093\u306e\u767a\u751f\u306b\u5bfe\u3057\u3066\u4fdd\u8b77\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u52b9\u679c\u304c\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002\u767a\u751f\u7387\u306e\u6e1b\u5c11\u306f\u7d0450\uff05\u3067\u3057\u305f [23] \u3002 \u30cd\u30aa\u30a2\u30c7\u30a3\u30ef\u30f3\u30c8\u7642\u6cd5\u306e\u975e\u52b9\u7387\u6027\u306f\u3001\u7a81\u7136\u5909\u7570\u306e\u30ad\u30e3\u30ea\u30a2\u3067\u3042\u308b\u4e73\u304c\u3093\u60a3\u8005\u3067\u3082\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f KRCA1 \u5206\u985e\u7fa4\uff08\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u3001\u30d1\u30af\u30ea\u30bf\u30ad\u30bb\u30eb\uff09\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001BRCA1\u5909\u7570\u3092\u4f34\u3046\u4e73\u304c\u3093\u306e\u5834\u5408\u306e\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u306e\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u304a\u305d\u3089\u304f\u4e21\u65b9\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50 KRCA1 \u305d\u308c\u3089\u306f\u3001\u5206\u5272\u7d21\u9318\u4f53\u306e\u6bd2\u306b\u3088\u308b\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u81e8\u5e8a\u7684\u53cd\u5fdc\u306b\u5fc5\u8981\u3067\u3059 [24] \u3002  \u5225\u306e\u8a18\u4e8b\uff1a\u907a\u4f1d\u6027\u4e73\u623f\u3068\u5375\u5de3\u764c\u3002 \u2191  \u3068\u3002 \u3068\u3002  \u6f70\u760d  \u3068\u3002 \u3068\u3002 \u79c1\u306f\u30a4\u30cb \u3001 \u4e73\u623f\u304a\u3088\u3073\u5375\u5de3\u764c\u611f\u53d7\u6027\u907a\u4f1d\u5b50BRCA1\u306e\u5f37\u529b\u306a\u5019\u88dc \u3001\u300c\u79d1\u5b66\u300d\u3001266\uff085182\uff09\u30011994\u3001s\u3002 66\u201371\u3001doi\uff1a 10.1126\/science.7545954 \u3001PMID\uff1a 7545954  \u3002  \u2191  J.S. J.S.  \u4f8d\u5f93  J.S. J.S. \u79c1\u306f\u30a4\u30cb \u3001 BRCA1\u306f\u3001\u907a\u4f1d\u5206\u6790\u306b\u3088\u308b\u67d3\u8272\u4f5317Q21\u306eD17S579\u306b\u8fd1\u4f4d\u306b\u306a\u3063\u3066\u3044\u307e\u3059 \u3001\u300cAmerican Journal of Human Genetics\u300d\u300152\uff084\uff09\u30011993\u3001s\u3002 792\u2013798\u3001PMID\uff1a 8460646 \u3001PMCID\uff1a PMC1682065  \u3002  \u2191  J.S. J.S.  \u30ea\u30fc  J.S. J.S. \u3001 J.H. J.H.  \u5171\u6709  J.H. J.H. \u3001 DNA\u640d\u50b7\u5fdc\u7b54\u306b\u304a\u3051\u308bBRCA1\u306e\u591a\u69d8\u306a\u6a5f\u80fd \u3001\u300c\u5206\u5b50\u533b\u5b66\u306e\u5c02\u9580\u5bb6\u306e\u30ec\u30d3\u30e5\u30fc\u300d\u30012001\u30012001\u3001s\u3002 1\u201311\u3001doi\uff1a 10.1017\/s1462399401003131 \u3001PMID\uff1a 14987363  \u3002  \u2191  L.C. L.C.  \u30a6\u30fc  L.C. L.C. \u79c1\u306f\u30a4\u30cb \u3001 BRCA1\u907a\u4f1d\u5b50\u7523\u7269\u3068in vivo\u3067\u76f8\u4e92\u4f5c\u7528\u3067\u304d\u308b\u30ea\u30f3\u30b0\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8b58\u5225 \u3001\u300c\u81ea\u7136\u907a\u4f1d\u5b66\u300d\u300114\uff084\uff09\u30011996\u3001s\u3002 430\u2013440\u3001doi\uff1a 10.1038\/ng1296-430 \u3001PMID\uff1a 8944023  \u3002  \u2191 a b  K. K.  \u30bd\u30de\u30b9\u30f3\u30c0\u30e9\u30e0  K. K. \u79c1\u306f\u30a4\u30cb \u3001 \u816b\u760d\u30b5\u30d7\u30ec\u30c3\u30b5\u30fcBRCA1\u306b\u3088\u308b\u7d30\u80de\u5468\u671f\u306e\u505c\u6b62\u306b\u306f\u3001CDK\u963b\u5bb3\u5264P21WAF1\/CIP1\u304c\u5fc5\u8981\u3067\u3059 \u3001\u300c\u81ea\u7136\u300d\u3001389\uff086647\uff09\u30011997\u3001s\u3002 187\u2013190\u3001doi\uff1a 10.1038\/38291 \u3001PMID\uff1a 9296497  \u3002  \u2191  A.N. A.N.  \u30e2\u30f3\u30c6\u30a4\u30ed  A.N. A.N. \u3001 A. A.  8\u6708  A. A. \u3001 H. H.  \u5e7d\u970a  H. H. \u3001 BRCA1 C\u672b\u7aef\u9818\u57df\u306e\u8ee2\u5199\u6d3b\u6027\u5316\u6a5f\u80fd\u306e\u8a3c\u62e0 \u3001\u300c\u30a2\u30e1\u30ea\u30ab\u5408\u8846\u56fd\u79d1\u5b66\u30a2\u30ab\u30c7\u30df\u30fc\u306e\u8b70\u4e8b\u9332\u300d\u300193\uff0824\uff09\u30011996\u3001s\u3002 13595\u201313599\u3001doi\uff1a 10.1073\/pnas.93.24.13595 \u3001PMID\uff1a 8942979 \u3001PMCID\uff1a PMC19361  \u3002  \u2191  J.E. J.E.  \u30c8\u30fc\u30de\u30b9  J.E. J.E. \u79c1\u306f\u30a4\u30cb \u3001 \u4e73\u304c\u3093\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u306e\u898b\u304b\u3051\u306e180 kDa\u304a\u3088\u3073220 kDa\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d30\u80de\u5185\u5c40\u5728\u3068\u5206\u6790\u3001BRCA1 \u3001\u300cJournal of Biological Chemistry\u300d\u3001271\uff0845\uff09\u30011996\u3001s\u3002 28630\u201328635\u3001doi\uff1a 10.1074\/jbc.271.45.28630 \u3001PMID\uff1a 8910495  \u3002  \u2191  \u3068\u3002 \u3068\u3002  \u30c1\u30a7\u30f3  \u3068\u3002 \u3068\u3002 \u79c1\u306f\u30a4\u30cb \u3001 BRCA1\u306f\u3001\u7d30\u80de\u5468\u671f\u4f9d\u5b58\u7684\u306b\u767a\u73fe\u304a\u3088\u3073\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b220 kDA\u6838\u30ea\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002 \u3001\u300c\u304c\u3093\u7814\u7a76\u300d\u300156\uff0814\uff09\u30011996\u3001s\u3002 3168\u20133172\u3001PMID\uff1a 8764100  \u3002  \u2191  T.F. T.F.  LANE  T.F. T.F. \u79c1\u306f\u30a4\u30cb \u3001 BRCA1\u306e\u767a\u73fe\u306f\u3001\u30de\u30a6\u30b9\u306e\u5916\u76ae\u304a\u3088\u3073\u4e2d\u80da\u8449\u7531\u6765\u7d44\u7e54\u306e\u672b\u7aef\u5206\u5316\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059 \u3001\u300c\u907a\u4f1d\u5b50\u3068\u958b\u767a\u300d\u30019\uff0821\uff09\u30011995\u3001s\u3002 2712\u20132722\u3001doi\uff1a 10.1101\/gad.9.21.2712 \u3001PMID\uff1a 7590247  \u3002  \u2191  S.T. S.T.  \u30de\u30fc\u30ad\u30b9  S.T. S.T. \u79c1\u306f\u30a4\u30cb \u3001 BRCA1\u767a\u73fe\u306e\u767a\u9054\u30d1\u30bf\u30fc\u30f3\u306f\u3001\u4e73\u623f\u3068\u4ed6\u306e\u7d44\u7e54\u306e\u5206\u5316\u306b\u304a\u3051\u308b\u5f79\u5272\u3092\u610f\u5473\u3057\u307e\u3059 \u3001\u300c\u81ea\u7136\u907a\u4f1d\u5b66\u300d\u300111\uff081\uff09\u30011995\u3001s\u3002 17\u201326\u3001doi\uff1a 10.1038 \/ nk0995-17 \u3001PMID\uff1a 7550308  \u3002  \u2191  J.M. J.M.  \u30b0\u30c0  J.M. J.M. \u79c1\u306f\u30a4\u30cb \u3001 \u30d2\u30c8\u4e73\u764c\u7d30\u80de\u306b\u304a\u3051\u308bBRCA1\u306e\u30db\u30eb\u30e2\u30f3\u4f9d\u5b58\u6027\u8abf\u7bc0 \u3001\u300c\u304c\u3093\u7814\u7a76\u300d\u300155\uff0820\uff09\u3001 1995\u5e74 \u3001s\u30024561\u20134565\u30012\uff1a 10.1038 \/ nk0995-17 \u3001ISSN 0008-5472 \u3001PMID\uff1a 7553629 [\u30a2\u30af\u30bb\u30b92019-02-10]  \u3002  \u2191  J.M. J.M.  \u30b0\u30c0  J.M. J.M. \u79c1\u306f\u30a4\u30cb \u3001 \u30d2\u30c8\u4e73\u623f\u4e0a\u76ae\u7d30\u80de\u306b\u304a\u3051\u308bBRCA1\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u306e\u7d30\u80de\u5468\u671f\u8abf\u7bc0 \u3001\u300c\u7d30\u80de\u306e\u6210\u9577\u3068\u5206\u5316\u300d\u30017\uff086\uff09\u30011996\u3001s\u3002 717\u2013723\u3001PMID\uff1a 8780885  \u3002  \u2191  J.P. J.P.  \u30f4\u30a9\u30fc\u30f3  J.P. J.P. \u79c1\u306f\u30a4\u30cb \u3001 BRCA1\u767a\u73fe\u306f\u3001\u6b63\u5e38\u304a\u3088\u3073\u816b\u760d\u7531\u6765\u306e\u4e21\u65b9\u306e\u4e73\u623f\u7d30\u80de\u306e\u4e21\u65b9\u3067DNA\u5408\u6210\u306e\u524d\u306b\u8a98\u5c0e\u3055\u308c\u307e\u3059 \u3001\u300c\u7d30\u80de\u306e\u6210\u9577\u3068\u5206\u5316\u300d\u30017\uff086\uff09\u30011996\u3001s\u3002 711\u2013715\u3001PMID\uff1a 8780884  \u3002  \u2191  C.Y. C.Y.  li  C.Y. C.Y. \u79c1\u306f\u30a4\u30cb \u3001 \u30de\u30a6\u30b9BRCA1\u907a\u4f1d\u5b50\u306e\u4e0d\u6d3b\u6027\u5316\u306f\u3001\u79fb\u690d\u5f8c\u65e9\u671f\u306e\u767a\u9054\u306b\u304a\u3051\u308b\u5375\u5186\u67f1\u306e\u5f62\u614b\u5f62\u6210\u306e\u5931\u6557\u306b\u3064\u306a\u304c\u308a\u307e\u3059 \u3001\u300c\u907a\u4f1d\u5b50\u3068\u958b\u767a\u300d\u300110\uff0814\uff09\u30011996\u3001s\u3002 1835\u20131843\u3001doi\uff1a 10.1101\/gad.10.14.1835 \u3001PMID\uff1a 8698242  \u3002  \u2191 a b  R. R.  \u30b8\u30e3\u30c3\u30b8  R. R. \u79c1\u306f\u30a4\u30cb \u3001 \u816b\u760d\u6291\u5236\u6027\u907a\u4f1d\u5b50BRCA1\u306f\u3001\u30de\u30a6\u30b9\u306e\u80da\u7d30\u80de\u5897\u6b96\u306b\u5fc5\u8981\u3067\u3059 \u3001\u300c\u30bb\u30eb\u300d\u300185\uff087\uff09\u3001 1996\u5e74 \u3001s\u30021009\u20131023\u30012\uff1a 10.1016\/s0092-8674\uff0800\uff0981302-1 \u3001ISSN 0092-8674 \u3001PMID\uff1a 8674108 [\u30a2\u30af\u30bb\u30b92019-02-10]  \u3002  \u2191  L.C. L.C.  \u30b4\u30fc\u30a6\u30a7\u30f3  L.C. L.C. \u79c1\u306f\u30a4\u30cb \u3001 BRCA1\u6b20\u4e4f\u75c7\u306f\u3001\u795e\u7d4c\u4e0a\u76ae\u306e\u7570\u5e38\u3092\u7279\u5fb4\u3068\u3059\u308b\u521d\u671f\u306e\u80da\u306e\u81f4\u6b7b\u6027\u3092\u3082\u305f\u3089\u3057\u307e\u3059 \u3001\u300c\u81ea\u7136\u907a\u4f1d\u5b66\u300d\u300112\uff082\uff09\u30011996\u3001s\u3002 191\u2013194\u3001doi\uff1a 10.1038\/NG0296-191 \u3001PMID\uff1a 8563759  \u3002  \u2191  R. R.  \u30b8\u30e3\u30c3\u30b8  R. R. \u79c1\u306f\u30a4\u30cb \u3001 BRCA1\uff085-6\uff09P53\u307e\u305f\u306fP21\u30cc\u30eb\u5909\u7570\u306b\u3088\u308b\u521d\u671f\u80da\u6027\u81f4\u6b7b\u306e\u90e8\u5206\u7684\u6551\u52a9 \u3001\u300c\u81ea\u7136\u907a\u4f1d\u5b66\u300d\u300116\uff083\uff09\u30011997\u3001s\u3002 298\u2013302\u3001doi\uff1a 10.1038\/NG0797-298 \u3001PMID\uff1a 9207798  \u3002  \u2191  \u30d0\u30c4\u3002 \u30d0\u30c4\u3002  \u30b3\u30a4\u30f3  \u30d0\u30c4\u3002 \u30d0\u30c4\u3002 \u79c1\u306f\u30a4\u30cb \u3001 \u4e73\u817a\u4e0a\u76ae\u7d30\u80de\u306b\u304a\u3051\u308bBRCA1\u306e\u6761\u4ef6\u4ed8\u304d\u5909\u7570\u306f\u3001\u920d\u5316\u3057\u305f\u4e73\u7ba1\u5f62\u614b\u5f62\u6210\u3068\u816b\u760d\u5f62\u6210\u3092\u3082\u305f\u3089\u3057\u307e\u3059 \u3001\u300c\u81ea\u7136\u907a\u4f1d\u5b66\u300d\u300122\uff081\uff09\u30011999\u3001s\u3002 37\u201343\u3001doi\uff1a 10.1038\/8743 \u3001PMID\uff1a 10319859  \u3002  \u2191 a b  \u30d0\u30c4\u3002 \u30d0\u30c4\u3002  \u30b3\u30a4\u30f3  \u30d0\u30c4\u3002 \u30d0\u30c4\u3002 \u79c1\u306f\u30a4\u30cb \u3001 \u4e2d\u5fc3\u4f53\u5897\u5e45\u3068\u6b20\u9665\u306e\u3042\u308bG2-M\u7d30\u80de\u5468\u671f\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u306f\u3001BRCA1\u30a8\u30af\u30bd\u30f311\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u6b20\u640d\u7d30\u80de\u306e\u907a\u4f1d\u7684\u4e0d\u5b89\u5b9a\u6027\u3092\u8a98\u767a\u3057\u307e\u3059 \u3001\u300c\u5206\u5b50\u7d30\u80de\u300d\u30013\uff083\uff09\u30011999\u3001s\u3002 389\u2013395\u3001doi\uff1a 10.1016\/s1097-2765\uff0800\uff0980466-9 \u3001PMID\uff1a 10198641  \u3002  \u2191  L.C. L.C.  HSU  L.C. L.C. \u3001 R.L. R.L.  \u767d  R.L. R.L. \u3001 BRCA1\u306f\u3001\u6709\u7cf8\u5206\u88c2\u4e2d\u306e\u4e2d\u5fc3\u4f53\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059 \u3001\u300c\u30a2\u30e1\u30ea\u30ab\u5408\u8846\u56fd\u79d1\u5b66\u30a2\u30ab\u30c7\u30df\u30fc\u306e\u8b70\u4e8b\u9332\u300d\u300195\uff0822\uff09\u30011998\u3001s\u3002 12983\u201312988\u3001doi\uff1a 10.1073\/pnas.95.22.12983 \u3001PMID\uff1a 9789027 \u3001PMCID\uff1a PMC23679  \u3002  \u2191  J.S. J.S.  \u30e9\u30fc\u30bd\u30f3  J.S. J.S. \u3001 J.L. J.L.  Tonkinson  J.L. J.L. \u3001 M.T. M.T.  \u30cf\u30a4\u30d6\u30ea\u30c3\u30c9  M.T. M.T. \u3001 BRCA1\u5909\u7570\u4f53\u306f\u3001\u30d2\u30c8\u4e73\u817a\u4e0a\u76ae\u7d30\u80de\u306eG2-M\u7d30\u80de\u5468\u671f\u5236\u5fa1\u3092\u5909\u5316\u3055\u305b\u307e\u3059 \u3001\u300c\u304c\u3093\u7814\u7a76\u300d\u300157\uff0816\uff09\u3001 1997\u5e74 \u3001s\u3002 3351\u20133355 \u3001ISSN 0008-5472 \u3001PMID\uff1a 9269994 [\u30a2\u30af\u30bb\u30b92019-02-10]  \u3002  \u2191 a b  \u30dc\u30fc\u30c0\u30f3 B.  \u5c71  \u30dc\u30fc\u30c0\u30f3 B. \u79c1\u306f\u30a4\u30cb \u3001 \u30dd\u30fc\u30e9\u30f3\u30c9\u306e\u4e73\u304c\u3093\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u304a\u3051\u308b\u5275\u8a2d\u8005BRCA1\u5909\u7570\u306e\u9ad8\u3044\u5272\u5408 \u3001\u300c\u304c\u3093\u306e\u56fd\u969b\u30b8\u30e3\u30fc\u30ca\u30eb\u300d\u3001110\uff085\uff09\u30012004\u5e74\u3001s\u3002 683\u2013686\u3001doi\uff1a 10,1002\/IJC.20162 \u3001PMID\uff1a 15146557  \u3002  \u2191  S.A. S.A.  \u4eba\u3005  S.A. S.A. \u79c1\u306f\u30a4\u30cb \u3001 \u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u3068BRCA1\u304a\u3088\u3073BRCA2\u5909\u7570\u30ad\u30e3\u30ea\u30a2\u306e\u53cd\u5bfe\u5074\u306e\u4e73\u304c\u3093\u306e\u30ea\u30b9\u30af\uff1a\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3002\u907a\u4f1d\u6027\u4e73\u304c\u3093\u81e8\u5e8a\u7814\u7a76\u30b0\u30eb\u30fc\u30d7 \u3001\u300cThe Lancet\u300d\u3001356\uff089245\uff09\u30012000\u3001s\u3002 1876\u20131881\u3001doi\uff1a 10.1016\/s0140-6736\uff0800\uff0903258-x \u3001PMID\uff1a 11130383  \u3002  \u2191  T. T.  Byrski  T. T. \u79c1\u306f\u30a4\u30cb \u3001 BRCA1\u967d\u6027\u4e73\u304c\u3093\u306e\u5973\u6027\u306b\u304a\u3051\u308b\u30cd\u30aa\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u5316\u5b66\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u53cd\u5fdc \u3001\u300c\u4e73\u304c\u3093\u306e\u7814\u7a76\u3068\u6cbb\u7642\u300d\u3001108\uff082\uff09\u30012008\u5e74\u3001s\u3002 289\u2013296\u3001doi\uff1a 10.1007\/s10549-007-9600-1 \u3001PMID\uff1a 17492376  \u3002  A. A.  \u30a2\u30f3\u30c8\u30cb\u30aa\u30a6  A. A. \u79c1\u306f\u30a4\u30cb \u3001 \u4e73\u623f\u304a\u3088\u3073\u5375\u5de3\u764c\u306e\u5e73\u5747\u30ea\u30b9\u30afBRCA1\u307e\u305f\u306fBRCA2\u5909\u7570\u306f\u3001\u5bb6\u65cf\u6b74\u306e\u305f\u3081\u306b\u9078\u629e\u3055\u308c\u3066\u3044\u306a\u3044\u30b1\u30fc\u30b9\u30b7\u30ea\u30fc\u30ba\u3067\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\uff1a22\u306e\u7814\u7a76\u306e\u7d44\u307f\u5408\u308f\u305b\u5206\u6790 \u3001\u300cAmerican Journal of Human Genetics\u300d\u300172\uff085\uff09\u30012003\u3001s\u3002 1117\u20131130\u3001doi\uff1a 10.1086\/375033 \u3001PMID\uff1a 12677558 \u3001PMCID\uff1a PMC1180265  \u3002 \u30c8\u30e0 T.  \u30a6\u30a9\u30eb\u30b7\u30e5  \u30c8\u30e0 T. \u79c1\u306f\u30a4\u30cb \u3001 \u4e73\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u5bb6\u65cf\u306eBRCA1\u3001BRCA2\u3001CHEK2\u3001\u304a\u3088\u3073TP53\u306e\u5909\u7570\u306e\u30b9\u30da\u30af\u30c8\u30eb \u3001\u300cJournal of the American Medical Association\u300d\u3001295\uff0812\uff09\u30012006\u3001s\u3002 1379\u20131388\u3001doi\uff1a 10.1001 \u3001PMID\uff1a 16551709  \u3002 \u30a8\u30ea\u30b6\u30d9\u30b9B. E.B.  \u30af\u30e9\u30a6\u30b9  \u30a8\u30ea\u30b6\u30d9\u30b9B. E.B. \u79c1\u306f\u30a4\u30cb \u3001 \u305d\u306e\u5834\u3067\u4e73\u7ba1\u764c\u3068\u8a3a\u65ad\u3055\u308c\u305f\u5973\u6027\u306eBRCA1\u304a\u3088\u3073BRCA2\u5909\u7570\u306e\u6709\u75c5\u7387 \u3001\u300c\u30a2\u30e1\u30ea\u30ab\u533b\u5e2b\u4f1a\u306e\u30b8\u30e3\u30fc\u30ca\u30eb\u300d\u3001293\uff088\uff09\u3001 2005\u5e74 \u3001s\u3002964\u2013969\u30012\uff1a 10.1001 \/ jama.293.8.964 \u3001ISSN 1538-3598 \u3001PMID\uff1a 15728167 [\u30a2\u30af\u30bb\u30b92019-02-10]  \u3002 \u907a\u4f1d\u6027\u4e73\u623f\u3068\u5375\u5de3\u764c \u3002 In\uff1aJacek Gronwald\u3001Tomasz Byrski\u3001Tomasz Huzarski\u3001Oleg Szurazek\u3001Janusz Menkiszak\u3001Izabella rzepka-g\u00f3rska\u3001JanLubi\u0144ski\uff1a \u907a\u4f1d\u6027\u816b\u760d2002.\u4e88\u9632\u3001\u8a3a\u65ad\u3001\u6cbb\u7642 \u3002\u30e4\u30f3\u30fb\u30eb\u30d3\u30b9\u30ad\uff08\u7de8\uff09\u3002\u30dd\u30ba\u30ca\u30f3\uff1aTermedia Medical Publishing\u30012002\u3001pp\u300235-49\u3002 ISBN 83-916594-1-0 \u3002 J.S. J.S.  \u30ea\u30fc  J.S. J.S. \u3001 J.H. J.H.  \u5171\u6709  J.H. J.H. \u3001 DNA\u640d\u50b7\u5fdc\u7b54\u306b\u304a\u3051\u308bBRCA1\u306e\u591a\u69d8\u306a\u6a5f\u80fd \u3001\u300c\u5206\u5b50\u533b\u5b66\u306e\u5c02\u9580\u5bb6\u306e\u30ec\u30d3\u30e5\u30fc\u300d\u30012001\u30012001\u3001s\u3002 1\u201311\u3001doi\uff1a 10.1017\/s1462399401003131 \u3001PMID\uff1a 14987363  \u3002 ewa \u3068\u3002  \u30ad\u30ce\u30b3  ewa \u3068\u3002 \u79c1\u306f\u30a4\u30cb \u3001 BRCA1\u907a\u4f1d\u5b50\u306e\u30b2\u30eb\u30de\u30f3\u30ad\u30e3\u30ea\u30a2\u3067\u306e\u4e73\u304c\u3093\u306e\u81e8\u5e8a\u30b3\u30fc\u30b9 \u3001\u300cContemporary Oncology\u300d\u30017\uff0810\uff09\u30012003\u3001pp\u3002742-753 [\u30a2\u30af\u30bb\u30b92019-02-10]  \u3002 \u30a2\u30f3\u30ca A.  Jakubowska  \u30a2\u30f3\u30ca A. \u79c1\u306f\u30a4\u30cb \u3001 \u907a\u4f1d\u6027\u4e73\u304c\u3093\u306e\u5316\u5b66\u30d7\u30ec\u30fc\u30f3\u306b\u304a\u3051\u308bBRCA1\u5909\u7570\u306e\u30ad\u30e3\u30ea\u30a2\u3067\u306e\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u306e\u5f79\u5272 \u3001\u300cContemporary Oncology\u300d\u30019\uff086\uff09\u30012002\u3001pp\u3002597-601 [\u30a2\u30af\u30bb\u30b92019-02-10]  \u3002       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/archives\/2270#breadcrumbitem","name":"BRCA1-\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2\u3001\u7121\u6599\u200b\u200b\u767e\u79d1\u4e8b\u5178"}}]}]