[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/archives\/14970#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/archives\/14970","headline":"Cytochrome P450 -Wikipedia\u3001\u7121\u6599\u767e\u79d1\u4e8b\u5178","name":"Cytochrome P450 -Wikipedia\u3001\u7121\u6599\u767e\u79d1\u4e8b\u5178","description":"Cytochrom P450 – \u30e2\u30ce\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\u306e\u6d3b\u6027\u3092\u793a\u3059\u9175\u7d20\u306e\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u306e\u30b7\u30c8\u30af\u30ed\u30e0\u3002\u305d\u308c\u3089\u306f\u4e00\u822c\u306b\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u306e\u7d44\u7e54\u3067\u767a\u751f\u3057\u307e\u3059\u304c\u3001\u809d\u81d3\u3068\u526f\u814e\u3092\u793a\u3057\u3066\u3044\u308b\u6700\u5927\u306e\u6d3b\u52d5\u3067\u3059\u3002\u305d\u308c\u3089\u306f\u3001\u6210\u719f\u3057\u305f\u8d64\u8840\u7403\u3084\u9aa8\u683c\u7b4b\u306b\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3055\u307e\u3056\u307e\u306a\u30b7\u30c8\u30af\u30ed\u30e0P450\u3092\u30b3\u30fc\u30c9\u3059\u308b\u30d2\u30c8\u30b2\u30ce\u30e0\uff08\u305d\u308c\u3089\u306e\u540d\u524d\u306fCYP\u304b\u3089\u59cb\u307e\u308b\uff09\u3067\u7d04150\u306e\u7570\u306a\u308b\u907a\u4f1d\u5b50\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3059\u3079\u3066\u306e\u751f\u7269\u5b66\u7684\u9818\u57df\u306e\u4ee3\u8868\u8005\u306e\u9593\u3067\u4f1a\u3063\u305f\uff1a\u7d30\u83cc\u3001\u8003\u53e4\u5b66\u3001\u52d5\u7269\u3001\u690d\u7269\u3001\u83cc\u985e\u3001\u305d\u306e\u4ed6\u306e\u6838\u5175\u5668\u3001\u3055\u3089\u306b\u306f\u30a6\u30a4\u30eb\u30b9\u306e\u9593\u3067\u3055\u3048\u3082 [\u521d\u3081] \u3002 \u3053\u308c\u3089\u306f\u3001\u5c0f\u80de\u4f53\u819c\u3068\u5185\u90e8\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u306b\u95a2\u9023\u3059\u308b50\u301c55 kDa\u306e\u5206\u5b50\u91cf\u306e\u4f1d\u9054\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u305d\u308c\u3089\u306f\u88dc\u7db4\u30b0\u30eb\u30fc\u30d7\u3068\u3057\u3066\u88fe\u3092\u542b\u3093\u3067\u3044\u307e\u3059\u3002\u7d50\u5408\u5f8c \u8a66\u9a13\u7ba1\u5185\u3067 \u4e00\u9178\u5316\u70ad\u7d20\u306e\u5834\u5408\u3001\u305d\u308c\u3089\u306e\u307b\u3068\u3093\u3069\u306f\u3001450 nm\u306e\u6ce2\u9577\u3067\u900f\u660e\u306a\u6700\u5927\u5149\u5438\u53ce\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002 \u30b7\u30c8\u30af\u30ed\u30e0P450\u306f\u3001\u8981\u7d04\u30d1\u30bf\u30fc\u30f3\u306b\u5f93\u3063\u3066\u5b9f\u884c\u3055\u308c\u308b\u30d2\u30c9\u30ed\u30ad\u30b7\u30eb\u5316\u53cd\u5fdc\u3092\u89e6\u5a92\u3057\u307e\u3059\u3002 rh + o 2 + nadph + h","datePublished":"2020-11-23","dateModified":"2020-11-23","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/archives\/author\/lordneo#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/archives\/author\/lordneo","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/56\/CytP450Oxidase-1OG2.png\/300px-CytP450Oxidase-1OG2.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/56\/CytP450Oxidase-1OG2.png\/300px-CytP450Oxidase-1OG2.png","height":"171","width":"300"},"url":"https:\/\/wiki.edu.vn\/all2jp\/wiki47\/archives\/14970","wordCount":380,"articleBody":" Cytochrom P450  – \u30e2\u30ce\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\u306e\u6d3b\u6027\u3092\u793a\u3059\u9175\u7d20\u306e\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u306e\u30b7\u30c8\u30af\u30ed\u30e0\u3002\u305d\u308c\u3089\u306f\u4e00\u822c\u306b\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u306e\u7d44\u7e54\u3067\u767a\u751f\u3057\u307e\u3059\u304c\u3001\u809d\u81d3\u3068\u526f\u814e\u3092\u793a\u3057\u3066\u3044\u308b\u6700\u5927\u306e\u6d3b\u52d5\u3067\u3059\u3002\u305d\u308c\u3089\u306f\u3001\u6210\u719f\u3057\u305f\u8d64\u8840\u7403\u3084\u9aa8\u683c\u7b4b\u306b\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3055\u307e\u3056\u307e\u306a\u30b7\u30c8\u30af\u30ed\u30e0P450\u3092\u30b3\u30fc\u30c9\u3059\u308b\u30d2\u30c8\u30b2\u30ce\u30e0\uff08\u305d\u308c\u3089\u306e\u540d\u524d\u306fCYP\u304b\u3089\u59cb\u307e\u308b\uff09\u3067\u7d04150\u306e\u7570\u306a\u308b\u907a\u4f1d\u5b50\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3059\u3079\u3066\u306e\u751f\u7269\u5b66\u7684\u9818\u57df\u306e\u4ee3\u8868\u8005\u306e\u9593\u3067\u4f1a\u3063\u305f\uff1a\u7d30\u83cc\u3001\u8003\u53e4\u5b66\u3001\u52d5\u7269\u3001\u690d\u7269\u3001\u83cc\u985e\u3001\u305d\u306e\u4ed6\u306e\u6838\u5175\u5668\u3001\u3055\u3089\u306b\u306f\u30a6\u30a4\u30eb\u30b9\u306e\u9593\u3067\u3055\u3048\u3082 [\u521d\u3081] \u3002 \u3053\u308c\u3089\u306f\u3001\u5c0f\u80de\u4f53\u819c\u3068\u5185\u90e8\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u306b\u95a2\u9023\u3059\u308b50\u301c55 kDa\u306e\u5206\u5b50\u91cf\u306e\u4f1d\u9054\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u305d\u308c\u3089\u306f\u88dc\u7db4\u30b0\u30eb\u30fc\u30d7\u3068\u3057\u3066\u88fe\u3092\u542b\u3093\u3067\u3044\u307e\u3059\u3002\u7d50\u5408\u5f8c \u8a66\u9a13\u7ba1\u5185\u3067 \u4e00\u9178\u5316\u70ad\u7d20\u306e\u5834\u5408\u3001\u305d\u308c\u3089\u306e\u307b\u3068\u3093\u3069\u306f\u3001450 nm\u306e\u6ce2\u9577\u3067\u900f\u660e\u306a\u6700\u5927\u5149\u5438\u53ce\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002 \u30b7\u30c8\u30af\u30ed\u30e0P450\u306f\u3001\u8981\u7d04\u30d1\u30bf\u30fc\u30f3\u306b\u5f93\u3063\u3066\u5b9f\u884c\u3055\u308c\u308b\u30d2\u30c9\u30ed\u30ad\u30b7\u30eb\u5316\u53cd\u5fdc\u3092\u89e6\u5a92\u3057\u307e\u3059\u3002 rh + o 2 + nadph + h + \u2192ROH + H 2 O + NADP + 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