[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki\/cronkhite-canada-syndrome-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki\/cronkhite-canada-syndrome-wikipedia\/","headline":"Cronkhite\u2013Canada syndrome – Wikipedia","name":"Cronkhite\u2013Canada syndrome – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Medical condition Cronkhite\u2013Canada syndrome Other names Gastrointestinal polyposis-skin pigmentation-alopecia-fingernail changes syndrome Cronkhite\u2013Canada syndrome","datePublished":"2022-08-08","dateModified":"2022-08-08","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/4b\/Blausen_0432_GastroIntestinalSystem.png\/300px-Blausen_0432_GastroIntestinalSystem.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/4b\/Blausen_0432_GastroIntestinalSystem.png\/300px-Blausen_0432_GastroIntestinalSystem.png","height":"232","width":"300"},"url":"https:\/\/wiki.edu.vn\/en\/wiki\/cronkhite-canada-syndrome-wikipedia\/","wordCount":2998,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Medical conditionCronkhite\u2013Canada syndromeOther namesGastrointestinal polyposis-skin pigmentation-alopecia-fingernail changes syndromeCronkhite\u2013Canada syndrome affects the digestive tractSpecialtyGastroenterology\u00a0Cronkhite\u2013Canada syndrome is a rare syndrome characterized by multiple polyps of the digestive tract. It is sporadic (i.e. it does not seem to be a hereditary disease),[1] and it is currently considered acquired[2] and idiopathic (i.e. cause remains unknown).       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4About two-thirds of patients are of Japanese descent and the male to female ratio is 3:2.[3]  It was characterized in 1955[4][5] by internal medicine physician Leonard Wolsey Cronkhite Jr. and radiologist Wilma Jeanne Canada.[6]Table of ContentsSigns and symptoms[edit]Diagnosis[edit]Management[edit]References[edit]External links[edit]Signs and symptoms[edit]Polyps are found throughout the GI tract (most frequently in the stomach and large intestine, followed by the small intestine) though typically avoid the esophagus.[6] A biopsy will reveal them to be hamartomas; the possibility that they progress to cancer is generally considered to be low,[7] although it has been reported multiple times in the past. Chronic diarrhea and protein-losing enteropathy are often observed. Possible collateral features include variable anomalies of ectodermal tissues, such as alopecia, atrophy of the nails, or skin pigmentation[3]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The cause of the disease is unknown. It was originally thought that the epidermal changes were secondary to profound malnutrition as a result of protein-losing enteropathy. Recent findings have called this hypothesis into question; specifically, the hair and nail changes may not improve with improved nutrition.[citation needed]Other conditions consisting of multiple hamartomatous polyps of the digestive tract include Peutz\u2013Jeghers syndrome, juvenile polyposis, and Cowden disease. Related polyposis conditions are familial adenomatous polyposis, attenuated familial adenomatous polyposis, Birt\u2013Hogg\u2013Dub\u00e9 syndrome and MUTYH.[citation needed]Diagnosis[edit]There is no specific test to diagnose Cronkhite\u2013Canada syndrome. Diagnosis is based on symptoms and features of the disease.[8]Management[edit]Nutritional support is fundamental, and may include dietary guidance, supplements, tube feeding, or intravenous solutions.[9] Treatments proposed include cromolyn sodium and prednisone,[10] as well as histamine (H2) receptor antagonists or proton pump inhibitors.[9]References[edit]^ Vernia P, Marcheggiano A, Marinaro V, Morabito S, Guzzo I, Pierucci A (October 2005). “Is Cronkhite-Canada Syndrome necessarily a late-onset disease?”. Eur J Gastroenterol Hepatol. 17 (10): 1139\u201341. doi:10.1097\/00042737-200510000-00022. PMID\u00a016148564.^ Calva D, Howe JR (August 2008). “Hamartomatous polyposis syndromes”. The Surgical Clinics of North America. 88 (4): 779\u2013817, vii. doi:10.1016\/j.suc.2008.05.002. PMC\u00a02659506. PMID\u00a018672141.^ a b Yuan, Wei; Tian, Li; Ai, Fei-Yan; Liu, Shao-Jun; Shen, Shou-Rong; Wang, Xiao-Yan; Liu, Fen (June 2018). “Cronkhite-Canada syndrome: A case report”. Oncology Letters. 15 (6): 8447\u20138453. doi:10.3892\/ol.2018.8409. ISSN\u00a01792-1074. PMC\u00a05950510. PMID\u00a029805581.^ Cronkhite LW, Canada WJ (June 1955). “Generalized gastrointestinal polyposis; an unusual syndrome of polyposis, pigmentation, alopecia and onychotrophia”. N. Engl. J. Med. 252 (24): 1011\u20135. doi:10.1056\/NEJM195506162522401. PMID\u00a014383952.^ Junnarkar SP, Sloan JM, Johnston BT, Laird JD, Irwin ST (May 2001). “Cronkhite-Canada syndrome”. The Ulster Medical Journal. 70 (1): 56\u20138. PMC\u00a02449205. PMID\u00a011428328.^ a b Samoha S, Arber N (2005). “Cronkhite-Canada Syndrome”. Digestion. 71 (4): 199\u2013200. doi:10.1159\/000086134. PMID\u00a015942206.^ Nagata J, Kijima H, Hasumi K, Suzuki T, Shirai T, Mine T (June 2003). “Adenocarcinoma and multiple adenomas of the large intestine, associated with Cronkhite-Canada syndrome”. Dig Liver Dis. 35 (6): 434\u20138. doi:10.1016\/s1590-8658(03)00160-9. PMID\u00a012868681.^ “Cronkhite-Canada Syndrome”. NORD (National Organization for Rare Disorders). Retrieved 2019-05-19.^ a b Ward EM, Wolfsen HC (2003). “Pharmacological management of Cronkhite-Canada syndrome”. Expert Opin. Pharmacother. 4 (3): 385\u2013389. doi:10.1517\/14656566.4.3.385. PMID\u00a012614190. S2CID\u00a036982546.^ Ward E, Wolfsen HC, Ng C (February 2002). “Medical management of Cronkhite-Canada syndrome”. South. Med. J. 95 (2): 272\u20134. doi:10.1097\/00007611-200202000-00025. PMID\u00a011846261.External links[edit]     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki\/cronkhite-canada-syndrome-wikipedia\/#breadcrumbitem","name":"Cronkhite\u2013Canada syndrome – Wikipedia"}}]}]