Hossein Baharvand – Wikipedia

Hossein Baharvand is an Iranian stem cell and developmental biologist. He received his B.Sc. in biology from Shiraz University in 1994, and M.Sc. in Developmental Biology from Shahid Beheshti University, Tehran in 1996. He then obtained his Ph.D. in Cell and Developmental Biology from Khwarizmi University (former Tarbiat Moallem University) in 2004. He joined the Royan Institute in 1995 in which he founded the Stem Cell Biology and Technology department.[2][3]

For the first time, he generated the mouse and human embryonic stem cells (2003) and induced pluripotent stem cells (2008) in Iran.[4] This has enabled his team to pursue many avenues of research into translational research and regenerative medicine. He has focused his research interests on improving the translational research and regenerative medicine mainly through the understanding of Stem Cells and Developmental Biology and Biologically inspired Engineering.[5] He has been working on transdifferentiation and pluripotent stem cell differentiation into cardiomyocytes, neural cells and hepatocytes. He has also been studying the pluripotency mechanism and germ cell biology. He has also been making numerous contributions to clinical trials and tissue-specific stem cell transplantation; as well as developing cell manufacturing.[6]

He has given numerous tutorials and invited talks in many congresses such as ISSCR (2018).[7] He is the editor of four international books which were published by Springer (2010 and 2012) and John Wiley, USA (2015). He has published 354 international [8] and 102 national peer-reviewed papers, as well as seven chapters in international books, seven books in Persian, and eight translated English text books into Persian. Eight figures of his peer-reviewed publications were selected as cover pages of international journals.[9]

As of November 2020, Google Scholar reports over 14,000 citations and h-index 57 to his work.[10] He is currently the editorial board member of eight international journals (e.g., Journal of Biological Chemistry[11] and Scientific Reports from Nature Publishing Group[12]). He holds two USA patents on the basis of his research. He has received 30 international and national awards including 10th (2004), 12th (2006), and 17th (2012) annual Razi research award on medical science hosted by Iran Ministry of Health and Medical Education, 26th Khwarizmi International Award (2013), hosted by Iran Ministry of Science, Research and Technology, 27th annual book of the year of the Islamic republic of Iran (2010), Academy of Medical Sciences of Iran (Dr. Hadavi’s Award in 2010, 2014), International Prof. Yalda Award for Excellence in Medical Sciences (2015) and distinguished Iranian scientist in Biotechnology (2015) and Genetics (2016). He is the winner of the Islamic Educational, Scientific, and Cultural Organization (ISESCO) Prize for research in the field of Biology (2010). Moreover, he was introduced as Prominent Professor in 3rd term of Allameh Tabatabaei’s Award hosted by Iran vice Presidency for Science and Technology, Presidency and National Elite Foundation (2014). He is the winner of the United Nations educational, scientific and cultural organization (UNESCO)-Equatorial Guinea International Prize (2014) for Research in the Life Sciences aimed at improving the quality of human life with his stem cell research and its numerous applications in regenerative medicine.[13] He was also selected as one of the 20 stem cell person of the year 2017 award nominees hosted by THE NICHE site.[14]
He is also the winner of the World Academy of Sciences (TWAS) prize in Biology (2019) for his fundamental contribution to the understanding of how pluripotency and differentiation establish and maintain in stem cells.[15]

Moreover, as of now three companies are spun off from the work he initiated and directed at the Royan Institute for Stem Cell Biology and Technology including Cell Tech Pharmed as a cell factory for cell therapy,[16] Royan Biotech for production of recombinant proteins,[17] and Royan Stem Cell Technology for banking of cord blood stem cells.[18]

Furthermore, he has had several efforts in publicizing the stem cell biology in Iran and in this regard he with his team established a lab entitled “Stem Cells for all” and a “mobile adventure lab” by an equipped bus.[19] The aim of these participatory teaching and learning methods is to motivate and empower learners to acquire the knowledge, skills, attitudes and values necessary to shape a sustainable future for stem cells and their potentials in regenerative medicine. He has also established “annual international summer school” program since 2010. The participants were trained by invited speakers from abroad to increase international and national interactions and training methods in this field.[20]


As of 2020 many of his published papers came under controversy due to potential imagine fraud[21] leading to the retraction of several studies.[22] Retractions were mainly based on image problems and occurred in several journals such as Scientific reports,[23] Molecular Biotechnology,[24] Stel cell and development[25] and Cell and Tissue Research[26]


  1. ^ “Mustafa Prize”.
  2. ^ “Royan Institute for Stem Cell Biology and Technology”.
  3. ^ “Hossein Baharvand’s webpage at official portal of Royan Ins”. Royan Institute. Retrieved April 28, 2014.
  4. ^ “Royan Institute official web site: institute developments”.
  5. ^ “The Washington Times: Iran at forefront of stem cell research”. The Washington Times.
  6. ^ “Hossein Baharvand’s web page at Royan Institute for Stem Cell Biology and Technology website”.
  7. ^ “ISSCR Speakers-Topics”.
  8. ^ Bose, K. S.; Sarma, R. H. (1975). “PubMed papers authored by Hossein Baharvand”. Biochemical and Biophysical Research Communications. 66 (4): 1173–9. doi:10.1016/0006-291x(75)90482-9. PMID 2.
  9. ^ “Hossein Baharvand’s CV at Royan Institute for Stem Cell Biology and Technology website” (PDF).
  10. ^ “Hossein Baharvand’s Google Scholar”. Retrieved November 5, 2020.
  11. ^ “JBC Editorial Board”.
  12. ^ “SREP Editorial Board”.
  13. ^ “UNESCO Prize for Research in Life Sciences”.
  14. ^ “20 Stem Cell Person of The Year 2017 Award Nominees”. November 26, 2017.
  15. ^ “Winners of 2019 TWAS Prizes”.
  16. ^ “Cell Tech Pharmed company”.
  17. ^ “Royan Biotech company”.
  18. ^ “Royan Stem Cell Technology for banking of cord blood stem cells”.
  19. ^ “Stem Cells for All Lab”.
  20. ^ “Royan International Summer School”.
  21. ^ eliesbik, Author (November 12, 2020). “46 papers from a Royan Institute professor”. Science Integrity Digest.
  22. ^ “PubPeer – Search publications and join the conversation”. pubpeer.com.
  23. ^ Ahmadi, Amin; Moghadasali, Reza; Ezzatizadeh, Vahid; Taghizadeh, Zeinab; Nassiri, Seyed Mahdi; Asghari-Vostikolaee, Mohammad Hassan; Alikhani, Mehdi; Hadi, Fatemeh; Rahbarghazi, Reza; Yazdi, Reza Salman; Baharvand, Hossein; Aghdami, Nasser (July 5, 2021). “Retraction Note: Transplantation of Mouse Induced Pluripotent Stem Cell-Derived Podocytes in a Mouse Model of Membranous Nephropathy Attenuates Proteinuria”. Scientific Reports. 11 (1): 13831. Bibcode:2021NatSR..1113831A. doi:10.1038/s41598-021-93174-z. PMC 8257699. PMID 34226599.
  24. ^ Ghazizadeh, Zaniar; Rassouli, Hassan; Fonoudi, Hananeh; Alikhani, Mehdi; Talkhabi, Mahmood; Darbandi-Azar, Amir; Chen, Shuibing; Baharvand, Hossein; Aghdami, Nasser; Salekdeh, Ghasem Hosseini (September 9, 2021). “Retraction Note to: Transient Activation of Reprogramming Transcription Factors Using Protein Transduction Facilitates Conversion of Human Fibroblasts Toward Cardiomyocyte-Like Cells”. Molecular Biotechnology. doi:10.1007/s12033-021-00387-8. PMID 34499327. S2CID 237454309.
  25. ^ “Retraction of: Long-Term Maintenance of Undifferentiated Human Embryonic and Induced Pluripotent Stem Cells in Suspension (doi.org/10.1089/scd.2010.0517)”. Stem Cells and Development. 30 (21): 1092. November 1, 2021. doi:10.1089/scd.2010.0517.retract. PMID 34613840. S2CID 238421629.
  26. ^ Oryan, Ahmad; Eslaminejad, Mohamadreza Baghaban; Kamali, Amir; Hosseini, Samaneh; Moshiri, Ali; Baharvand, Hossein (October 1, 2021). “Retraction Note to: Mesenchymal stem cells seeded onto tissue-engineered osteoinductive scaffolds enhance the healing process of critical-sized radial bone defects in rat”. Cell and Tissue Research. 386 (1): 211. doi:10.1007/s00441-021-03520-w. PMID 34424398. S2CID 237268542.