[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki12\/mtch2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki12\/mtch2-wikipedia\/","headline":"MTCH2 – Wikipedia","name":"MTCH2 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Mitochondrial carrier homolog 2 also known","datePublished":"2017-09-14","dateModified":"2017-09-14","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki12\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki12\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/7\/77\/Open_Access_logo_PLoS_transparent.svg\/9px-Open_Access_logo_PLoS_transparent.svg.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/7\/77\/Open_Access_logo_PLoS_transparent.svg\/9px-Open_Access_logo_PLoS_transparent.svg.png","height":"14","width":"9"},"url":"https:\/\/wiki.edu.vn\/en\/wiki12\/mtch2-wikipedia\/","wordCount":5277,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensMitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.[5][6][7][8]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4MTCH2 resides on the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID.[9]Table of ContentsClinical significance[edit]See also[edit]References[edit]Further reading[edit]Clinical significance[edit]MTCH2 assists in the recruitment of BID into the mitochondria during apoptosis.[9]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Variants of the MTCH2 gene may be associated with obesity.[10] MTCH2 represses mitochondrial metabolism such that a deficiency of MTCH2 increases energy consumption and production by mitochondria.[9]See also[edit]References[edit]^ a b c ENSG00000285121 GRCh38: Ensembl release 89: ENSG00000109919, ENSG00000285121 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027282 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A (June 2005). “Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha”. Molecular and Cellular Biology. 25 (11): 4579\u201390. doi:10.1128\/MCB.25.11.4579-4590.2005. PMC\u00a01140633. PMID\u00a015899861.^ Gross A (June 2005). “Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?”. Journal of Bioenergetics and Biomembranes. 37 (3): 113\u20139. doi:10.1007\/s10863-005-6222-3. PMID\u00a016167168. S2CID\u00a02395673.^ Schwarz M, Andrade-Navarro MA, Gross A (May 2007). “Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?”. Apoptosis. 12 (5): 869\u201376. doi:10.1007\/s10495-007-0748-2. PMID\u00a017453157.^ Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD,  et\u00a0al. (July 2008).  Chang HY (ed.). “A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers”. PLOS Genetics. 4 (7): e1000129. doi:10.1371\/journal.pgen.1000129. PMC\u00a02444049. PMID\u00a018636107. ^ a b c Gross A (August 2016). “BCL-2 family proteins as regulators of mitochondria metabolism”. Biochimica et Biophysica Acta (BBA) – Bioenergetics. 1857 (8): 1243\u20131246. doi:10.1016\/j.bbabio.2016.01.017. PMID\u00a026827940.^ Renstr\u00f6m F, Payne F, Nordstr\u00f6m A, Brito EC, Rolandsson O, Hallmans G,  et\u00a0al. (April 2009). “Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden”. Human Molecular Genetics. 18 (8): 1489\u201396. doi:10.1093\/hmg\/ddp041. PMC\u00a02664142. PMID\u00a019164386.Further reading[edit]Yerushalmi GM, Leibowitz-Amit R, Shaharabany M, Tsarfaty I (2002). “Met-HGF\/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization”. Neoplasia. 4 (6): 510\u201322. doi:10.1038\/sj.neo.7900272. PMC\u00a01503665. PMID\u00a012407445.Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F,  et\u00a0al. (June 2010). “Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI\/MRS study”. Obesity. 18 (6): 1212\u20137. doi:10.1038\/oby.2009.413. PMID\u00a019910938. S2CID\u00a09601431.Albers M, Kranz H, Kober I, Kaiser C, Klink M, Suckow J,  et\u00a0al. (February 2005). “Automated yeast two-hybrid screening for nuclear receptor-interacting proteins”. Molecular & Cellular Proteomics. 4 (2): 205\u201313. doi:10.1074\/mcp.M400169-MCP200. PMID\u00a015604093.Li S, Zhao JH, Luan J, Luben RN, Rodwell SA, Khaw KT,  et\u00a0al. (January 2010). “Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies”. The American Journal of Clinical Nutrition. 91 (1): 184\u201390. doi:10.3945\/ajcn.2009.28403. PMID\u00a019812171.Brandys MK, van Elburg AA, Loos RJ, Bauer F, Hendriks J, van der Schouw YT, Adan RA (March 2010). “Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?”. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 153B (2): 695\u2013699. doi:10.1002\/ajmg.b.31026. PMID\u00a019746409. S2CID\u00a045793585.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ,  et\u00a0al. (October 2000). “Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem\/progenitor cells”. Genome Research. 10 (10): 1546\u201360. doi:10.1101\/gr.140200. PMC\u00a0310934. PMID\u00a011042152.Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, Grobbee DE,  et\u00a0al. (October 2009). “Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference”. The American Journal of Clinical Nutrition. 90 (4): 951\u20139. doi:10.3945\/ajcn.2009.27781. PMID\u00a019692490.Maruyama K, Sugano S (January 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.He M, Cornelis MC, Franks PW, Zhang C, Hu FB, Qi L (February 2010). “Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus”. Arteriosclerosis, Thrombosis, and Vascular Biology. 30 (2): 327\u201332. doi:10.1161\/ATVBAHA.109.196196. PMC\u00a03061473. PMID\u00a019910641.Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S,  et\u00a0al. (December 2009). “Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population”. Journal of Human Genetics. 54 (12): 727\u201331. doi:10.1038\/jhg.2009.106. PMID\u00a019851340.     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