[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki14\/mihai-ioan-botez-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki14\/mihai-ioan-botez-wikipedia\/","headline":"Mihai Ioan Botez &#8211; Wikipedia","name":"Mihai Ioan Botez &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Romanian neurologist Mihai Ioan Botez (29 June 1927 \u2013 2 June 1998) was","datePublished":"2016-06-20","dateModified":"2016-06-20","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki14\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki14\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/44a4cee54c4c053e967fe3e7d054edd4?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/c\/c4\/Botez01.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/c\/c4\/Botez01.jpg","height":"122","width":"95"},"url":"https:\/\/wiki.edu.vn\/en\/wiki14\/mihai-ioan-botez-wikipedia\/","wordCount":4106,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Romanian neurologistMihai Ioan Botez (29 June 1927 \u2013 2 June 1998) was born in Ploie\u0219ti, Romania, trained at Carol Davila University of Medicine and Pharmacy, a neurologist and academic who specialized in the field of neuropsychology. He immigrated to Montreal in the 1970s, becoming a professor at the  Universit\u00e9 de Montr\u00e9al and director of the department of Neurology at the hospital H\u00f4tel-Dieu de Montr\u00e9al.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4  Table of ContentsAcademic life[edit]Behavioral neurology[edit]Folic acid[edit]Cerebellum[edit]Neurochemistry[edit]References[edit]Academic life[edit]Botez trained at the Romanian School of Neurology founded by Gheorghe Marinescu. He immigrated to Canada in the 1970s, where he became professor of neurology at the Universit\u00e9 de Montr\u00e9al and head of the Neurology Service at the hospital H\u00f4tel-Dieu de Montr\u00e9al.[1][2] From 1985, his main work featured the role of the cerebellum on human behavior.[3]Behavioral neurology[edit]Botez became a proficient researcher in several fields of behavioral neurology in both human and animal subjects.[4]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Folic acid[edit]In the 1970s, Botez&#8217; main research subject was the effects of folic acid and thiamine on the central nervous system, relevant for restless legs syndrome, epilepsy, polyneuropathy, and chronic fatigue syndrome.[5][6][7]These articles demonstrated the use of B vitamins in the treatment of neurologic symptoms.Cerebellum[edit]In the 1980s, Botez pioneered studies on the effects of lesions to the cerebellum on cognition, including patients with spinocerebellar ataxia, Friedreich&#8217;s ataxia, and mice with spontaneous mutations causing cerebellar damage, such as GRID2-Lc Lurcher.[8][9][10][11][12][13][14]These articles demonstrated the role of the cerebellum in neuropsychology.Neurochemistry[edit]Together with neurochemists Simon N Young of the Allan Memorial Institute and Tomas A Reader of the Universit\u00e9 de Montr\u00e9al, Botez obtained measures of brain concentrations of neurotransmitters such as biogenic amine metabolites of dopamine, norepinephrine, and serotonin in patients, as well as concentrations and receptor density of these neurotransmitters and glutamic acid in mouse brain, he and his co-workers in neurochemistry provided vital cues to underlying neurochemical abnormalities in patients with B vitamin anomalies and patients with cerebellar atrophy.[15][16][17][18] Such studies lead to successful trials with amantadine, a substance facilitating dopamine transmission, to ameliorate reaction times in cerebellar atrophy,[19] as well as respiratory failure.[20]References[edit]^ L\u00e9veill\u00e9, Jean. &#8220;Hommage posthume au Dr. Mihai-Ioan Botez&#8221;. L&#8217;Association des m\u00e9decins de langue fran\u00e7aise du Canada. Archived from the original on September 13, 2004.{{cite web}}:  CS1 maint: unfit URL (link)^ Forum, Universit\u00e9 de Montr\u00e9al, 1987, vol 21, no 28, p 1.^ Forum, Universit\u00e9 de Montr\u00e9al, 1989, vol 24, no 10, p 5.^ MI Botez (\u00e9d) Neuropsychologie clinique et neurologie du comportement. Paris: Presses de l\u2019Universit\u00e9 de Montr\u00e9al et Masson, 2e \u00e9d., pp 319-337, 1996.^ Botez MI, Peyronnard JM, Bachevalier J, Charron L (September 1978). &#8220;Polyneuropathy and folate deficiency&#8221;. Archives of Neurology. 35 (9): 581\u20134. doi:10.1001\/archneur.1978.00500330029005. PMID\u00a0210747.[permanent dead link]^ Botez MI, Peyronnard JM, B\u00e9rub\u00e9 L, Labrecque R (1979). &#8220;Relapsing neuropathy, cerebral atrophy and folate deficiency. A close association&#8221;. Applied Neurophysiology. 42 (3): 171\u201383. doi:10.1159\/000102361. PMID\u00a0464598.^ Botez MI, Fontaine F, Botez T, Bachevalier J (1977). &#8220;Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies&#8221;. European Neurology. 16 (1\u20136): 230\u201346. doi:10.1159\/000114904. PMID\u00a0615714.^ Botez MI, Pedraza OL, Botez-Marquard T, V\u00e9zina JL, Elie R (1993). &#8220;Radiologic correlates of reaction time measurements in olivopontocerebellar atrophy&#8221;. European Neurology. 33 (4): 304\u20139. doi:10.1159\/000116959. PMID\u00a08348918.^ Botez-Marquard T, Botez MI (1997). &#8220;Olivopontocerebellar atrophy and Friedreich&#8217;s ataxia: neuropsychological consequences of bilateral versus unilateral cerebellar lesions&#8221;. International Review of Neurobiology. 41: 387\u2013410. doi:10.1016\/S0074-7742(08)60361-X. PMID\u00a09378599.^ Botez MI (1993). &#8220;Cerebellum and non-motor behaviour&#8221;. Romanian Journal of Neurology and Psychiatry. 31 (3\u20134): 189\u201393. PMID\u00a08011482.^ Botez-Marquard T, Botez MI (1993). &#8220;Cognitive behavior in heredodegenerative ataxias&#8221;. European Neurology. 33 (5): 351\u20137. doi:10.1159\/000116970. PMID\u00a08243509.^ Lalonde R, Botez MI (1990). &#8220;The cerebellum and learning processes in animals&#8221;. Brain Research. Brain Research Reviews. 15 (3): 325\u201332. doi:10.1016\/0165-0173(90)90006-A. PMID\u00a02289089.^ Botez MI, Botez T, Elie R, Attig E (June 1989). &#8220;Role of the cerebellum in complex human behavior&#8221;. Italian Journal of Neurological Sciences. 10 (3): 291\u2013300. doi:10.1007\/BF02333774. PMID\u00a02767936.^ Botez MI, Gravel J, Attig E, V\u00e9zina JL (August 1985). &#8220;Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought&#8221;. Neurology. 35 (8): 1152\u20137. doi:10.1212\/wnl.35.8.1152. PMID\u00a04022349.^ Botez MI, Young SN (May 2001). &#8220;Biogenic amine metabolites and thiamine in cerebrospinal fluid in heredo-degenerative ataxias&#8221;. The Canadian Journal of Neurological Sciences. 28 (2): 134\u201340. PMID\u00a011383938. Archived from the original on 2003-05-01. Retrieved 2010-04-10.^ Botez MI, Young SN (February 1991). &#8220;Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid&#8221;. Brain. 114 (1A): 333\u201348. PMID\u00a01705463.^ Reader TA, Strazielle C, Botez MI, Lalonde R (March 1998). &#8220;Brain dopamine and amino acid concentrations in Lurcher mutant mice&#8221;. Brain Research Bulletin. 45 (5): 489\u201393. doi:10.1016\/S0361-9230(97)00430-9. PMID\u00a09570718.^ Strazielle C, Lalonde R, Riopel L, Botez MI, Reader TA (April 1996). &#8220;Regional distribution of the 5-HT innervation in the brain of normal and lurcher mice as revealed by [3H]citalopram quantitative autoradiography&#8221;. Journal of Chemical Neuroanatomy. 10 (2): 157\u201371. doi:10.1016\/0891-0618(96)00115-9. PMID\u00a08783044.^ Botez MI, Botez-Marquard T, Elie R, Le Marec N, Pedraza OL, Lalonde R (1999). &#8220;Amantadine hydrochloride treatment in olivopontocerebellar atrophy: a long-term follow-up study&#8221;. European Neurology. 41 (4): 212\u20135. doi:10.1159\/000008053. PMID\u00a010343152.^ Botez MI, Mayer P, Bellemare F, Couture J (August 1997). &#8220;Can we treat respiratory failure in Friedreich ataxia?&#8221;. Archives of Neurology. 54 (8): 1030\u20133. doi:10.1001\/archneur.1997.00550200086015. 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