[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki19\/dedicator-of-cytokinesis-protein-10\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki19\/dedicator-of-cytokinesis-protein-10\/","headline":"Dedicator of cytokinesis protein 10","name":"Dedicator of cytokinesis protein 10","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Dedicator of cytokinesis protein 10 (Dock10), also known","datePublished":"2015-07-05","dateModified":"2015-07-05","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki19\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki19\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki19\/dedicator-of-cytokinesis-protein-10\/","about":["Wiki"],"wordCount":2289,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensDedicator of cytokinesis protein 10 (Dock10), also known as Zizimin3, is a large (~240 kDa) protein involved in intracellular signalling networks that in humans is encoded by the DOCK10 gene.[5] It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors, which function as activators of small G proteins.Table of ContentsDiscovery[edit]Structure and function[edit]References[edit]Further reading[edit]External links[edit]Discovery[edit]Dock10 was identified via bioinformatic approaches as one of a family of evolutionarily conserved proteins (the DOCK family) that share significant sequence homology.[6] Dock10 is expressed in peripheral blood leukocytes[7] as well as in the brain, spleen, lung and thymus.[8]Structure and function[edit]Dock10 shares the same domain arrangement as other members of the DOCK-D\/Zizimin subfamily as well as a high level of sequence similarity.[8] It contains a DHR2 domain that is involved in G protein binding and a DHR1 domain, which, in some DOCK family proteins, interacts with membrane phospholipids. Like other DOCK-D subfamily proteins Dock10 contains an N-terminal PH domain, which, in Dock9\/Zizimin1, mediates recruitment to the plasma membrane.[9] The DHR2 domain of Dock10 appears to bind to the small G proteins Cdc42, TC10 and TCL although these interactions are of low affinity.[8]  The physiological role of Dock10 is poorly characterised, however a study in lymphocytes has shown that Dock10 expression is upregulated in B-lymphocytes and Chronic Lymphocytic Leukemia (CLL) cells in response to the cytokine IL-4.[7] This suggests that Dock10 may have a role in B-cell activation and proliferation. Another study identified Dock10 as a protein that was overexpressed in some aggressive papillary thyroid carcinomas.[10]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000135905 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038608 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: DOCK10 dedicator of cytokinesis 10”.^ C\u00f4t\u00e9 JF, Vuori K (December 2002). “Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity”. J. Cell Sci. 115 (Pt 24): 4901\u201313. doi:10.1242\/jcs.00219. PMID\u00a012432077.^ a b Yelo E, Bernardo MV, Gimeno L,  et\u00a0al. (July 2008). “Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes”. Mol. Immunol. 45 (12): 3411\u201318. doi:10.1016\/j.molimm.2008.04.003. PMID\u00a018499258.^ a b c Nishikimi A, Meller N, Uekawa N,  et\u00a0al. (February 2005). “Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes”. FEBS Letters. 579 (5): 1039\u201346. doi:10.1016\/j.febslet.2005.01.006. PMID\u00a015710388. S2CID\u00a036721405.^ Meller N, Westbrook MJ, Shannon JD,  et\u00a0al. (January 2008). “Function of the N-terminus of zizimin1: autoinhibition and membrane targeting”. Biochem. J. 409 (2): 525\u201333. doi:10.1042\/BJ20071263. PMC\u00a02740492. PMID\u00a017935486.^ Fluge \u00d8, Bruland O, Akslen LA,  et\u00a0al. (February 2006). “Gene expression in poorly differentiated papillary thyroid carcinomas”. Thyroid. 16 (2): 161\u201375. doi:10.1089\/thy.2006.16.161. PMID\u00a016676402.Further reading[edit]External links[edit]Overview of all the structural information available in the PDB for UniProt: Q96BY6 (Dedicator of cytokinesis protein 10) at the PDBe-KB.  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