[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki19\/mink1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki19\/mink1-wikipedia\/","headline":"MINK1 &#8211; Wikipedia","name":"MINK1 &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Misshapen-like kinase 1 is an enzyme","datePublished":"2020-03-03","dateModified":"2020-03-03","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki19\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki19\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki19\/mink1-wikipedia\/","about":["Wiki"],"wordCount":3496,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensMisshapen-like kinase 1 is an enzyme that in humans is encoded by the MINK1 gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Interactions[edit]References[edit]Further reading[edit]Function[edit]Misshapen-like kinase 1 is  a serine\/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.[7]Interactions[edit]MINK1 has been shown to interact with NCK1.[8]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000141503 &#8211; Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020827 &#8211; Ensembl, May 2017^ &#8220;Human PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ &#8220;Mouse PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Dan I, Watanabe NM, Kobayashi T, Yamashita-Suzuki K, Fukagaya Y, Kajikawa E, Kimura WK, Nakashima TM, Matsumoto K, Ninomiya-Tsuji J, Kusumi A (Mar 2000). &#8220;Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development&#8221;. FEBS Letters. 469 (1): 19\u201323. doi:10.1016\/S0014-5793(00)01247-3. PMID\u00a010708748. S2CID\u00a039793431.^ Dan I, Watanabe NM, Kajikawa E, Ishida T, Pandey A, Kusumi A (Jul 2002). &#8220;Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution&#8221;. Nucleic Acids Research. 30 (13): 2906\u201310. doi:10.1093\/nar\/gkf407. PMC\u00a0117062. PMID\u00a012087176.^ a b &#8220;Entrez Gene: MINK1 misshapen-like kinase 1 (zebrafish)&#8221;.^ Hu Y, Leo C, Yu S, Huang BC, Wang H, Shen M, Luo Y, Daniel-Issakani S, Payan DG, Xu X (Dec 2004). &#8220;Identification and functional characterization of a novel human misshapen\/Nck interacting kinase-related kinase, hMINK beta&#8221;. The Journal of Biological Chemistry. 279 (52): 54387\u201397. doi:10.1074\/jbc.M404497200. PMID\u00a015469942.Further reading[edit]Bonaldo MF, Lennon G, Soares MB (Sep 1996). &#8220;Normalization and subtraction: two approaches to facilitate gene discovery&#8221;. Genome Research. 6 (9): 791\u2013806. doi:10.1101\/gr.6.9.791. PMID\u00a08889548.Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). &#8220;Expressed sequence tag analysis of human RPE\/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants&#8221;. Molecular Vision. 8: 205\u201320. PMID\u00a012107410.Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). &#8220;Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides&#8221;. Nature Biotechnology. 21 (5): 566\u20139. doi:10.1038\/nbt810. PMID\u00a012665801. S2CID\u00a023783563.Campdelacreu J, Ezquerra M, Mu\u00f1oz E, Oliva R, Tolosa E (Apr 2003). &#8220;Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy&#8221;. Neuroscience Letters. 340 (2): 158\u201360. doi:10.1016\/S0304-3940(03)00105-8. PMID\u00a012668260. S2CID\u00a045355312.Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Vill\u00e9n J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). &#8220;Large-scale characterization of HeLa cell nuclear phosphoproteins&#8221;. Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130\u20135. Bibcode:2004PNAS..10112130B. doi:10.1073\/pnas.0404720101. PMC\u00a0514446. PMID\u00a015302935.Hu Y, Leo C, Yu S, Huang BC, Wang H, Shen M, Luo Y, Daniel-Issakani S, Payan DG, Xu X (Dec 2004). &#8220;Identification and functional characterization of a novel human misshapen\/Nck interacting kinase-related kinase, hMINK beta&#8221;. The Journal of Biological Chemistry. 279 (52): 54387\u201397. doi:10.1074\/jbc.M404497200. PMID\u00a015469942.Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). &#8220;Global, in vivo, and site-specific phosphorylation dynamics in signaling networks&#8221;. Cell. 127 (3): 635\u201348. doi:10.1016\/j.cell.2006.09.026. PMID\u00a017081983. S2CID\u00a07827573.       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