[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki2\/fred-gage-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki2\/fred-gage-wikipedia\/","headline":"Fred Gage – Wikipedia","name":"Fred Gage – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 American geneticist Fred “Rusty” Gage (born October 8, 1950) is the President of","datePublished":"2016-03-23","dateModified":"2016-03-23","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki2\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki2\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki2\/fred-gage-wikipedia\/","wordCount":1869,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4American geneticistFred “Rusty” Gage (born October 8, 1950) is the President of the Salk Institute for Biological Studies[1] and the Adler Professor in the Laboratory of Genetics at the Salk Institute, and has concentrated on the adult central nervous system and the unexpected plasticity and adaptability that remains throughout the life of all mammals. His work may lead to methods of replacing brain tissue lost to stroke or Alzheimer’s disease and repairing spinal cords damaged by trauma. He was the President-elect of the ISSCR in 2012.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4In 1998, Gage (Salk Institute for Biological Studies, La Jolla, California) and Peter Eriksson (Sahlgrenska University Hospital, Gothenburg, Sweden) discovered and announced that the human brain produces new nerve cells in adulthood. Until then, it had been assumed that humans are born with all the brain cells they will ever have.Gage\u2019s lab showed that, contrary to years of dogma, human beings are capable of growing new nerve cells throughout life. Small populations of immature nerve cells are found in the adult mammalian brain, and Gage is working to understand how these cells can be induced to become mature nerve cells. His team is investigating how such cells can be transplanted back to the brain and spinal cord. They have showed that physical exercise can enhance the growth of new brain cells in the hippocampus, a brain structure that is important for the formation of new memories.  Furthermore, his team is examining the underlying molecular mechanisms that are critical to the birth of new brain cells, work that may lead to new therapeutics for neurodegenerative conditions.His lab studies the genomic mosaicism that exists in the brain as a result of \u201cjumping genes,\u201d mobile elements, and DNA damage that occurs during development. Specifically, he is interested in how this mosaicism may lead to difference in brain function between individuals. His lab published work showing that Human induced pluripotent stem cells (hiPSCs) erase aging signatures and hiPSC-derived neurons remain rejuvenated, while direct conversion into induced neurons (iNs) preserve donor fibroblast age-dependent transcriptomic signatures.[2]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsEducation[edit]Relationship with Phineas Gage[edit]Awards and honors[edit]References[edit]Education[edit]Gage graduated from St. Stephen’s High School in Rome, Italy in 1968 and received his Bachelor of Science degree from the University of Florida and a Ph.D. from Johns Hopkins University. He did his post-doctoral work at Lund University in Sweden, under the direction of cell transplantation pioneer Anders Bjorklund.  He serves as a member of the Science Advisory Board of the Genetics Policy Institute. He also served on the Life Sciences jury for the Infosys Prize in 2015.Relationship with Phineas Gage[edit]Fred Gage has been said to be a descendant of[3] (or more specifically, the great-grandson of)[4]Phineas Gage, through whose brain an iron bar 1-1\/4-inches in diameter was accidentally driven in 1848, transforming him into perhaps the most famous of all brain-injury survivors.  However, this proposition faces considerable difficulties, chief of which being that Phineas Gage had no known children.[5]Awards and honors[edit]IPSEN Prize in Neuronal Plasticity, 1990[6]Charles A. Dana Award for Pioneering Achievements in Health and Education, 1993Christopher Reeve Research Medal, 1997Max Planck Research Prize, 1999Metlife Foundation Award for Medical Research in Alzheimer’s Disease, 2001[7]President, Society for Neuroscience, 2001MetLife Award for Medical Research, 2002National Academy of Sciences 2003Keio Medical Science Prize, 2008Member, American Philosophical Society, 2010[8]References[edit]^ Gage, Rusty. “President”. www.salk.edu. Salk Institute. Retrieved 31 October 2019.^ Mertons, Jerome (2015). “Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects”. Cell Stem Cell. 17 (6): 705\u2013718. doi:10.1016\/j.stem.2015.09.001. PMC\u00a05929130. PMID\u00a026456686.^ “Rethinking the Brain” Archived 2019-06-30 at the Wayback Machine, Michael Specter, The New Yorker, July 23, 2001;^ Black, Ira B. (2002). The Changing Brain: Alzheimer’s Disease and Advances in Neuroscience, pp.235-6. Oxford University Press. ISBN\u00a00-19-515697-8, ISBN\u00a0978-0-19-515697-3.^ Macmillan, Malcolm (2002). An Odd Kind of Fame: Stories of Phineas Gage, pp.16-18.  MIT Press. ISBN\u00a00-262-63259-4, ISBN\u00a0978-0-262-63259-1^ “Professor Rusty Gage, Laboratory of Genetics”. Salk Institute for Biological Studies. Retrieved 27 May 2016.^ “Awards for Medical Research, Metlife Foundation” (PDF). Retrieved 27 May 2016.^ “APS Member History”. search.amphilsoc.org. Retrieved 2021-04-16.     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki2\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki2\/fred-gage-wikipedia\/#breadcrumbitem","name":"Fred Gage – Wikipedia"}}]}]