[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki21\/ccr4-not-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki21\/ccr4-not-wikipedia\/","headline":"CCR4-Not – Wikipedia","name":"CCR4-Not – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Multiprotein complex used in gene expression after-content-x4 Structure of human CNOT1-CNOT2-CNOT3 module (PDB","datePublished":"2021-08-12","dateModified":"2021-08-12","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki21\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki21\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/b\/bd\/PDB-4C0D-CNOT1-2-3-TC.png\/300px-PDB-4C0D-CNOT1-2-3-TC.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/b\/bd\/PDB-4C0D-CNOT1-2-3-TC.png\/300px-PDB-4C0D-CNOT1-2-3-TC.png","height":"263","width":"300"},"url":"https:\/\/wiki.edu.vn\/en\/wiki21\/ccr4-not-wikipedia\/","wordCount":4044,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Multiprotein complex used in gene expression         (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Structure of human CNOT1-CNOT2-CNOT3 module (PDB 4C0D).[1]Carbon Catabolite Repression\u2014Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression.[2][3] The complex has multiple enzymatic activities as both a poly(A) 3\u2032-5\u2032 exonuclease and a ubiquitin ligase.[4][5][6][7] The complex is present both in the nucleus where it regulates transcription and in the cytoplasm where it associates with translating ribosomes and RNA processing bodies.[2][3]Subunits[edit]The human CCR4-Not complex is composed of structural (non-catalytic) subunits and those that have exonuclease and E3 ligase activity. Some but not all of the human subunits are conserved in budding yeast.[8]A Molecular weight of human subunits from Uniprot.See also[edit]References[edit]^ Boland, Andreas; Chen, Ying; Raisch, Tobias; Jonas, Stefanie; Kuzuo\u011flu-\u00d6zt\u00fcrk, Duygu; Wohlbold, Lara; Weichenrieder, Oliver; Izaurralde, Elisa (2013-10-13). “Structure and assembly of the NOT module of the human CCR4\u2013NOT complex”. Nature Structural & Molecular Biology. Springer Science and Business Media LLC. 20 (11): 1289\u20131297. doi:10.1038\/nsmb.2681. ISSN\u00a01545-9993. PMID\u00a024121232. S2CID\u00a024288483.^ a b Collart, Martine A. (2016-01-29). “The Ccr4-Not complex is a key regulator of eukaryotic gene expression”. Wiley Interdisciplinary Reviews: RNA. Wiley. 7 (4): 438\u2013454. doi:10.1002\/wrna.1332. ISSN\u00a01757-7004. PMC\u00a05066686. PMID\u00a026821858.^ a b Miller, Jason E.; Reese, Joseph C. (2012-03-15). “Ccr4-Not complex: the control freak of eukaryotic cells”. Critical Reviews in Biochemistry and Molecular Biology. Informa UK Limited. 47 (4): 315\u2013333. doi:10.3109\/10409238.2012.667214. ISSN\u00a01040-9238. PMC\u00a03376659. PMID\u00a022416820.^ a b c Aslam, Akhmed; Mittal, Saloni; Koch, Frederic; Andrau, Jean-Christophe; Winkler, G. Sebastiaan (2009).  Wickens, Marvin (ed.). “The Ccr4\u2013Not Deadenylase Subunits CNOT7 and CNOT8 Have Overlapping Roles and Modulate Cell Proliferation”. Molecular Biology of the Cell. American Society for Cell Biology (ASCB). 20 (17): 3840\u20133850. doi:10.1091\/mbc.e09-02-0146. ISSN\u00a01059-1524. PMC\u00a02735483. PMID\u00a019605561.^ a b Chen J, Chiang YC, Denis CL (Mar 2002). “CCR4, a 3\u2032-5\u2032 poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase”. EMBO J. 21 (6): 1414\u201326. doi:10.1093\/emboj\/21.6.1414. PMC\u00a0125924. PMID\u00a011889047.^ “Entrez Gene: CNOT6 CCR4-NOT transcription complex, subunit 6”.^ a b Albert, Thomas K.; Hanzawa, Hiroyuki; Legtenberg, Yvonne I.A.; de Ruwe, Marjolein J.; van den Heuvel, Fiona A.J.; Collart, Martine A.; Boelens, Rolf; Timmers, H.Th.Marc (2002-02-01). “Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex”. The EMBO Journal. Wiley. 21 (3): 355\u2013364. doi:10.1093\/emboj\/21.3.355. ISSN\u00a00261-4189. PMC\u00a0125831. PMID\u00a011823428.^ Albert, T. K. (2000-02-01). “Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits”. Nucleic Acids Research. Oxford University Press (OUP). 28 (3): 809\u2013817. doi:10.1093\/nar\/28.3.809. ISSN\u00a01362-4962. PMC\u00a0102560. PMID\u00a010637334.^ a b c Zheng, Xiaofeng; Dumitru, Raluca; Lackford, Brad L.; Freudenberg, Johannes M.; Singh, Ajeet P.; Archer, Trevor K.; Jothi, Raja; Hu, Guang (2012-04-09). “Cnot1, Cnot2, and Cnot3 Maintain Mouse and Human ESC Identity and Inhibit Extraembryonic Differentiation”. Stem Cells. Wiley. 30 (5): 910\u2013922. doi:10.1002\/stem.1070. ISSN\u00a01066-5099. PMC\u00a03787717. PMID\u00a022367759.^ Hu, G.; Kim, J.; Xu, Q.; Leng, Y.; Orkin, S. H.; Elledge, S. J. (2009-04-01). “A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal”. Genes & Development. Cold Spring Harbor Laboratory. 23 (7): 837\u2013848. doi:10.1101\/gad.1769609. ISSN\u00a00890-9369. PMC\u00a02666338. PMID\u00a019339689.^ Pavanello, Lorenzo; Hall, Benjamin; Airhihen, Blessing; Winkler, Gerlof Sebastiaan (2018-11-09). central region of CNOT1 and CNOT9 stimulate deadenylation by the Ccr4-Not nuclease module “The central region of CNOT1 and CNOT9 stimulates deadenylation by the Ccr4\u2013Not nuclease module”. Biochemical Journal. Portland Press Ltd. 475 (21): 3437\u20133450. doi:10.1042\/bcj20180456. ISSN\u00a00264-6021. PMID\u00a030309886. S2CID\u00a052962278. ^ a b Mauxion, Fabienne; Pr\u00e8ve, Brigitte; S\u00e9raphin, Bertrand (2013). “C2ORF29\/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex”. RNA Biology. Informa UK Limited. 10 (2): 267\u2013276. doi:10.4161\/rna.23065. ISSN\u00a01547-6286. PMC\u00a03594285. PMID\u00a023232451.       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