[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki21\/minicell-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki21\/minicell-wikipedia\/","headline":"Minicell &#8211; Wikipedia","name":"Minicell &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 In bacteriology, minicells are bacterial cells that are smaller than usual. The first","datePublished":"2019-09-14","dateModified":"2019-09-14","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki21\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki21\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki21\/minicell-wikipedia\/","wordCount":5022,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4In bacteriology,  minicells  are bacterial cells that are smaller than usual.  The first minicells reported were from a strain of Escherichia coli that had a mutation in the Min System that lead to mis-localization of the septum during cell division and the production of cells of random sizes.[1][2]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsGeneration of minicells[edit]Normal role of minicells in bacteriology[edit]Applications of minicells[edit]References[edit]Further reading[edit]Generation of minicells[edit]The first report of minicells in the scientific literature dates to 1930.[3], but the first use of the name &#8220;minicell&#8221; dates to 1967[2]Minicells of a variety of gram negative[4] and gram positive[5][6] bacteria, including Escherichia coli[7] and Salmonella enterica,[8] have been reported, but in principle, minicells could be generated for any bacterial species that can be genetically edited.  Minicells can not reproduce because they do not contain a full copy of the genome.[9]Normal role of minicells in bacteriology[edit]Scientists hypothesize that minicells are produced by normal bacteria in times of stress so that damaged areas of the cell can be expelled.[9]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Applications of minicells[edit]Minicells have been extensively used to study ultrastructure of bacteria using electron cryotomography (cryoET).[10][11][12] Minicells are ideal for cryoET because they are small enough for the electron beam to penetrate in transmission electron microscopy.Bacterial minicells are being developed as a drug delivery system.[13][14] Minicells could be used to deliver genetic material to eukaryotic cells for gene editing.[15] They are also being investigated for vaccine development.[16]References[edit]^ de Boer, Piet A.J.; Crossley, Robin E.; Rothfield, Lawrence I. (February 1989). &#8220;A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli&#8221;. Cell. 56 (4): 641\u2013649. doi:10.1016\/0092-8674(89)90586-2. PMID\u00a02645057. S2CID\u00a07650379.^ a b Adler, H. I.; Fisher, W. D.; Cohen, A.; Hardigree, A. A. (1967-02-01). &#8220;MINIATURE escherichia coli CELLS DEFICIENT IN DNA&#8221;. Proceedings of the National Academy of Sciences. 57 (2): 321\u2013326. Bibcode:1967PNAS&#8230;57..321A. doi:10.1073\/pnas.57.2.321. ISSN\u00a00027-8424. PMC\u00a0335508. PMID\u00a016591472.^ Frazer, Anne Cornish; Curtiss, Roy (1975),  Arber, W.; Henle, W.; Hofschneider, P. H.; Humphrey, J. H. (eds.), &#8220;Production, Properties and Utility of Bacterial Minicells&#8221;, Current Topics in Microbiology and Immunology, Springer Berlin Heidelberg, 69: 1\u201384, doi:10.1007\/978-3-642-50112-8_1, ISBN\u00a0978-3-642-50114-2, PMID\u00a01098854, retrieved 2020-03-19^ Treuner-Lange, Anke; Aguiluz, Kryssia; van der Does, Chris; G\u00f3mez-Santos, Nuria; Harms, Andrea; Schumacher, Dominik; Lenz, Peter; Hoppert, Michael; Kahnt, J\u00f6rg; Mu\u00f1oz-Dorado, Jos\u00e9; S\u00f8gaard-Andersen, Lotte (January 2013). &#8220;PomZ, a ParA-like protein, regulates Z-ring formation and cell division in Myxococcus xanthus: Regulation of cell division in M. xanthus&#8221;. Molecular Microbiology. 87 (2): 235\u2013253. doi:10.1111\/mmi.12094. PMID\u00a023145985. S2CID\u00a0206191217.^ Lee, Jin-Young; Choy, Hyon E.; Lee, Jin-Ho; Kim, Geun-Joong (2015-04-28). &#8220;Generation of Minicells from an Endotoxin-Free Gram-Positive Strain Corynebacterium glutamicum&#8221;. Journal of Microbiology and Biotechnology. 25 (4): 554\u2013558. doi:10.4014\/jmb.1408.08037. ISSN\u00a01017-7825. PMID\u00a025341464.^ Reeve, John N.; Mendelson, Neil H.; Coyne, Sheila I.; Hallock, Linda L. (1973-05-01). &#8220;Minicells of Bacillus subtilis&#8221;. Journal of Bacteriology. 114 (2): 860\u2013873. doi:10.1128\/jb.114.2.860-873.1973. ISSN\u00a00021-9193. PMC\u00a0251848. PMID\u00a04196259.^ Ward, John E.; Lutkenhaus, Joe (October 1985). &#8220;Overproduction of FtsZ induces minicell formation in E. coli&#8221;. Cell. 42 (3): 941\u2013949. doi:10.1016\/0092-8674(85)90290-9. PMID\u00a02996784. S2CID\u00a036603663.^ Kawamoto, Akihiro; Morimoto, Yusuke V.; Miyata, Tomoko; Minamino, Tohru; Hughes, Kelly T.; Kato, Takayuki; Namba, Keiichi (December 2013). &#8220;Common and distinct structural features of Salmonella injectisome and flagellar basal body&#8221;. Scientific Reports. 3 (1): 3369. Bibcode:2013NatSR&#8230;3E3369K. doi:10.1038\/srep03369. ISSN\u00a02045-2322. PMC\u00a03842551. PMID\u00a024284544.^ a b Rang, Camilla U.; Proenca, Audrey; Buetz, Christen; Shi, Chao; Chao, Lin (2018-09-19).  Bowman, Grant R. (ed.). &#8220;Minicells as a Damage Disposal Mechanism in Escherichia coli&#8221;. mSphere. 3 (5): e00428\u201318, \/msphere\/3\/5\/mSphere428\u201318.atom. doi:10.1128\/mSphere.00428-18. ISSN\u00a02379-5042. PMC\u00a06147132. PMID\u00a030232168.^ Farley, Madeline M.; Hu, Bo; Margolin, William; Liu, Jun (2016-04-15).  de Boer, P. (ed.). &#8220;Minicells, Back in Fashion&#8221;. Journal of Bacteriology. 198 (8): 1186\u20131195. doi:10.1128\/JB.00901-15. ISSN\u00a00021-9193. PMC\u00a04859596. PMID\u00a026833418.^ Liu, Jun; Chen, Cheng-Yen; Shiomi, Daisuke; Niki, Hironori; Margolin, William (September 2011). &#8220;Visualization of bacteriophage P1 infection by cryo-electron tomography of tiny Escherichia coli&#8221;. Virology. 417 (2): 304\u2013311. doi:10.1016\/j.virol.2011.06.005. PMC\u00a03163801. PMID\u00a021745674.^ Briegel, A.; Li, X.; Bilwes, A. M.; Hughes, K. T.; Jensen, G. J.; Crane, B. R. (2012-03-06). &#8220;Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins&#8221;. Proceedings of the National Academy of Sciences. 109 (10): 3766\u20133771. Bibcode:2012PNAS..109.3766B. doi:10.1073\/pnas.1115719109. ISSN\u00a00027-8424. PMC\u00a03309718. PMID\u00a022355139.^ &#8220;Recombinant Bacterial Minicells (rBMCs)&#8221;. Vaxiion Therapeutics. Retrieved 2020-03-19.^ MacDiarmid, Jennifer A.; Mugridge, Nancy B.; Weiss, Jocelyn C.; Phillips, Leo; Burn, Adam L.; Paulin, Richard P.; Haasdyk, Joel E.; Dickson, Kristie-Ann; Brahmbhatt, Vatsala N.; Pattison, Scott T.; James, Alexander C. (May 2007). &#8220;Bacterially Derived 400 nm Particles for Encapsulation and Cancer Cell Targeting of Chemotherapeutics&#8221;. Cancer Cell. 11 (5): 431\u2013445. doi:10.1016\/j.ccr.2007.03.012. PMID\u00a017482133.^ Giacalone, Matthew J.; Gentile, Angela M.; Lovitt, Brian T.; Xu, Tong; Surber, Mark W.; Sabbadini, Roger A. (October 2006). &#8220;The use of bacterial minicells to transfer plasmid DNA to eukaryotic cells&#8221;. Cellular Microbiology. 8 (10): 1624\u20131633. doi:10.1111\/j.1462-5822.2006.00737.x. ISSN\u00a01462-5814. PMID\u00a016984417. S2CID\u00a039889761.^ Carleton, Heather A.; Lara-Tejero, Mar\u00eda; Liu, Xiaoyun; Gal\u00e1n, Jorge E. (June 2013). &#8220;Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery&#8221;. Nature Communications. 4 (1): 1590. Bibcode:2013NatCo&#8230;4.1590C. doi:10.1038\/ncomms2594. ISSN\u00a02041-1723. PMC\u00a03693737. PMID\u00a023481398.Further reading[edit]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki21\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki21\/minicell-wikipedia\/#breadcrumbitem","name":"Minicell &#8211; Wikipedia"}}]}]