[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki21\/retinoblastoma-like-protein-2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki21\/retinoblastoma-like-protein-2-wikipedia\/","headline":"Retinoblastoma-like protein 2 – Wikipedia","name":"Retinoblastoma-like protein 2 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Retinoblastoma-like protein 2 is a protein","datePublished":"2020-06-20","dateModified":"2020-06-20","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki21\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki21\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki21\/retinoblastoma-like-protein-2-wikipedia\/","wordCount":8141,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensRetinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsInteractions[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Interactions[edit]Retinoblastoma-like protein 2 has been shown to interact with:See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000103479 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031666 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Mayol X, Gra\u00f1a X, Baldi A, Sang N, Hu Q, Giordano A (Sep 1993). “Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain”. Oncogene. 8 (9): 2561\u20136. PMID\u00a08361765.^ Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (May 1996). “Genomic structure of the human retinoblastoma-related Rb2\/p130 gene”. Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4629\u201332. Bibcode:1996PNAS…93.4629B. doi:10.1073\/pnas.93.10.4629. PMC\u00a039329. PMID\u00a08643454.^ Fan S, Yuan R, Ma YX, Xiong J, Meng Q, Erdos M, Zhao JN, Goldberg ID, Pestell RG, Rosen EM (Aug 2001). “Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding”. Oncogene. 20 (35): 4827\u201341. doi:10.1038\/sj.onc.1204666. PMID\u00a011521194.^ Sutcliffe JE, Cairns CA, McLees A, Allison SJ, Tosh K, White RJ (Jun 1999). “RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130”. Molecular and Cellular Biology. 19 (6): 4255\u201361. doi:10.1128\/mcb.19.6.4255. PMC\u00a0104385. PMID\u00a010330166.^ Wang S, Ghosh RN, Chellappan SP (Dec 1998). “Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation”. Molecular and Cellular Biology. 18 (12): 7487\u201398. doi:10.1128\/mcb.18.12.7487. PMC\u00a0109329. PMID\u00a09819434.^ a b Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (Feb 1999). “Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest”. Molecular and Cellular Biology. 19 (2): 1460\u20139. doi:10.1128\/mcb.19.2.1460. PMC\u00a0116074. PMID\u00a09891079.^ Li Y, Graham C, Lacy S, Duncan AM, Whyte P (Dec 1993). “The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E”. Genes & Development. 7 (12A): 2366\u201377. doi:10.1101\/gad.7.12a.2366. PMID\u00a08253383.^ Lacy S, Whyte P (May 1997). “Identification of a p130 domain mediating interactions with cyclin A\/cdk 2 and cyclin E\/cdk 2 complexes”. Oncogene. 14 (20): 2395\u2013406. doi:10.1038\/sj.onc.1201085. PMID\u00a09188854.^ Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep 1998). “The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase”. Proceedings of the National Academy of Sciences of the United States of America. 95 (18): 10493\u20138. Bibcode:1998PNAS…9510493F. doi:10.1073\/pnas.95.18.10493. PMC\u00a027922. PMID\u00a09724731.^ Bouzahzah B, Fu M, Iavarone A, Factor VM, Thorgeirsson SS, Pestell RG (Aug 2000). “Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo”. Cancer Research. 60 (16): 4531\u20137. PMID\u00a010969803.^ Wang S, Nath N, Adlam M, Chellappan S (Jun 1999). “Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function”. Oncogene. 18 (23): 3501\u201310. doi:10.1038\/sj.onc.1202684. PMID\u00a010376528.^ Meloni AR, Smith EJ, Nevins JR (Aug 1999). “A mechanism for Rb\/p130-mediated transcription repression involving recruitment of the CtBP corepressor”. Proceedings of the National Academy of Sciences of the United States of America. 96 (17): 9574\u20139. Bibcode:1999PNAS…96.9574M. doi:10.1073\/pnas.96.17.9574. PMC\u00a022250. PMID\u00a010449734.^ Fusco C, Reymond A, Zervos AS (Aug 1998). “Molecular cloning and characterization of a novel retinoblastoma-binding protein”. Genomics. 51 (3): 351\u20138. doi:10.1006\/geno.1998.5368. PMID\u00a09721205.Further reading[edit]Soprano KJ, Purev E, Vuocolo S, Soprano DR (Aug 2006). “Rb2\/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid”. Oncogene. 25 (38): 5315\u201325. doi:10.1038\/sj.onc.1209679. PMID\u00a016936753.De Falco G, Giordano A (Aug 2006). “pRb2\/p130: a new candidate for retinoblastoma tumor formation”. Oncogene. 25 (38): 5333\u201340. doi:10.1038\/sj.onc.1209614. PMID\u00a016936755.Hijmans EM, Voorhoeve PM, Beijersbergen RL, van ‘t Veer LJ, Bernards R (Jun 1995). “E2F-5, a new E2F family member that interacts with p130 in vivo”. Molecular and Cellular Biology. 15 (6): 3082\u20139. doi:10.1128\/mcb.15.6.3082. PMC\u00a0230539. PMID\u00a07760804.Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (Mar 1995). “E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle”. Proceedings of the National Academy of Sciences of the United States of America. 92 (6): 2403\u20137. Bibcode:1995PNAS…92.2403S. doi:10.1073\/pnas.92.6.2403. PMC\u00a042492. PMID\u00a07892279.Yeung RS, Bell DW, Testa JR, Mayol X, Baldi A, Gra\u00f1a X, Klinga-Levan K, Knudson AG, Giordano A (Dec 1993). “The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19”. Oncogene. 8 (12): 3465\u20138. PMID\u00a08247552.Li Y, Graham C, Lacy S, Duncan AM, Whyte P (Dec 1993). “The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E”. Genes & Development. 7 (12A): 2366\u201377. doi:10.1101\/gad.7.12a.2366. PMID\u00a08253383.Hannon GJ, Demetrick D, Beach D (Dec 1993). “Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins”. Genes & Development. 7 (12A): 2378\u201391. doi:10.1101\/gad.7.12a.2378. PMID\u00a08253384.Lavender P, Vandel L, Bannister AJ, Kouzarides T (Jun 1997). “The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A”. Oncogene. 14 (22): 2721\u20138. doi:10.1038\/sj.onc.1201243. PMID\u00a09178770.Lacy S, Whyte P (May 1997). “Identification of a p130 domain mediating interactions with cyclin A\/cdk 2 and cyclin E\/cdk 2 complexes”. Oncogene. 14 (20): 2395\u2013406. doi:10.1038\/sj.onc.1201085. PMID\u00a09188854.Shao Z, Siegert JL, Ruppert S, Robbins PD (Jul 1997). “Rb interacts with TAF(II)250\/TFIID through multiple domains”. Oncogene. 15 (4): 385\u201392. doi:10.1038\/sj.onc.1201204. PMID\u00a09242374.Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM (May 1998). “Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7”. Molecular and Cellular Biology. 18 (5): 2748\u201357. doi:10.1128\/mcb.18.5.2748. PMC\u00a0110654. PMID\u00a09566894.Veal E, Eisenstein M, Tseng ZH, Gill G (Sep 1998). “A cellular repressor of E1A-stimulated genes that inhibits activation by E2F”. Molecular and Cellular Biology. 18 (9): 5032\u201341. doi:10.1128\/mcb.18.9.5032. PMC\u00a0109088. PMID\u00a09710587.Fusco C, Reymond A, Zervos AS (Aug 1998). “Molecular cloning and characterization of a novel retinoblastoma-binding protein”. Genomics. 51 (3): 351\u20138. doi:10.1006\/geno.1998.5368. PMID\u00a09721205.Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep 1998). “The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase”. Proceedings of the National Academy of Sciences of the United States of America. 95 (18): 10493\u20138. Bibcode:1998PNAS…9510493F. doi:10.1073\/pnas.95.18.10493. PMC\u00a027922. PMID\u00a09724731.Paramio JM, La\u00edn S, Segrelles C, Lane EB, Jorcano JL (Aug 1998). “Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation”. Oncogene. 17 (8): 949\u201357. doi:10.1038\/sj.onc.1202031. PMID\u00a09747874. S2CID\u00a021804961.Wang S, Ghosh RN, Chellappan SP (Dec 1998). “Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation”. Molecular and Cellular Biology. 18 (12): 7487\u201398. doi:10.1128\/mcb.18.12.7487. PMC\u00a0109329. PMID\u00a09819434.Yang R, M\u00fcller C, Huynh V, Fung YK, Yee AS, Koeffler HP (Mar 1999). “Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins”. Molecular and Cellular Biology. 19 (3): 2400\u20137. doi:10.1128\/mcb.19.3.2400. PMC\u00a084032. PMID\u00a010022926.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki21\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki21\/retinoblastoma-like-protein-2-wikipedia\/#breadcrumbitem","name":"Retinoblastoma-like protein 2 – Wikipedia"}}]}]