[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2014\/10\/27\/sialidase-3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/2014\/10\/27\/sialidase-3-wikipedia\/","headline":"Sialidase-3 – Wikipedia","name":"Sialidase-3 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Sialidase-3 is an enzyme that in humans is","datePublished":"2014-10-27","dateModified":"2014-10-27","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/2014\/10\/27\/sialidase-3-wikipedia\/","about":["Wiki"],"wordCount":5796,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensSialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.[5][6]Table of ContentsFunction[edit]Interactions[edit]References[edit]Further reading[edit]Function[edit]This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.[6]Interactions[edit]Sialidase-3 has been shown to interact with Grb2.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000162139 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035239 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T (Aug 1999). “Cloning, expression, and chromosomal mapping of a human ganglioside sialidase”. Biochem Biophys Res Commun. 261 (1): 21\u20137. doi:10.1006\/bbrc.1999.0973. PMID\u00a010405317.^ a b “Entrez Gene: NEU3 sialidase 3 (membrane sialidase)”.^ Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, Obinata M, Tateno H, Suzuki H, Miyagi T (Jul 2003). “Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice”. J. Biol. Chem. 278 (30): 27896\u2013902. doi:10.1074\/jbc.M212200200. PMID\u00a012730204.Further reading[edit]Hu H, Shioda T, Moriya C, Xin X, Hasan MK, Miyake K, Shimada T, Nagai Y (1996). “Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface”. J. Virol. 70 (11): 7462\u201370. doi:10.1128\/JVI.70.11.7462-7470.1996. PMC\u00a0190813. PMID\u00a08892864.Monti E, Bassi MT, Papini N, Riboni M, Manzoni M, Venerando B, Croci G, Preti A, Ballabio A, Tettamanti G, Borsani G (2001). “Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane”. Biochem. J. 349 (Pt 1): 343\u201351. doi:10.1042\/0264-6021:3490343. PMC\u00a01221155. PMID\u00a010861246.Wang Y, Yamaguchi K, Wada T, Hata K, Zhao X, Fujimoto T, Miyagi T (2002). “A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains”. J. Biol. Chem. 277 (29): 26252\u20139. doi:10.1074\/jbc.M110515200. PMID\u00a012011038.Kakugawa Y, Wada T, Yamaguchi K, Yamanami H, Ouchi K, Sato I, Miyagi T (2002). “Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression”. Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10718\u201323. Bibcode:2002PNAS…9910718K. doi:10.1073\/pnas.152597199. PMC\u00a0125023. PMID\u00a012149448.Hart ML, Saifuddin M, Uemura K, Bremer EG, Hooker B, Kawasaki T, Spear GT (2003). “High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1”. AIDS Res. Hum. Retroviruses. 18 (17): 1311\u20137. doi:10.1089\/088922202320886352. PMID\u00a012487819.Oehler C, Kopitz J, Cantz M (2003). “Substrate specificity and inhibitor studies of a membrane-bound ganglioside sialidase isolated from human brain tissue”. Biol. Chem. 383 (11): 1735\u201342. doi:10.1515\/BC.2002.194. PMID\u00a012530538. S2CID\u00a044415771.Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, Obinata M, Tateno H, Suzuki H, Miyagi T (2003). “Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice”. J. Biol. Chem. 278 (30): 27896\u2013902. doi:10.1074\/jbc.M212200200. PMID\u00a012730204.Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). “Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation”. Nat. Biotechnol. 22 (6): 707\u201316. doi:10.1038\/nbt971. PMID\u00a015146197. S2CID\u00a027764390.Ha KT, Lee YC, Cho SH, Kim JK, Kim CH (2004). “Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli”. Mol. Cells. 17 (2): 267\u201373. PMID\u00a015179041.Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV (2005). “Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages”. FEBS J. 272 (10): 2545\u201356. doi:10.1111\/j.1742-4658.2005.04679.x. PMID\u00a015885103. S2CID\u00a027379898.Kato K, Shiga K, Yamaguchi K, Hata K, Kobayashi T, Miyazaki K, Saijo S, Miyagi T (2006). “Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling”. Biochem. J. 394 (Pt 3): 647\u201356. doi:10.1042\/BJ20050737. PMC\u00a01383714. PMID\u00a016241905.Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). “Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55\u201365. doi:10.1101\/gr.4039406. PMC\u00a01356129. PMID\u00a016344560.Ueno S, Saito S, Wada T, Yamaguchi K, Satoh M, Arai Y, Miyagi T (2006). “Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility”. J. Biol. Chem. 281 (12): 7756\u201364. doi:10.1074\/jbc.M509668200. PMID\u00a016428383.Yamaguchi K, Hata K, Wada T, Moriya S, Miyagi T (2006). “Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles”. Biochem. Biophys. Res. Commun. 346 (2): 484\u201390. doi:10.1016\/j.bbrc.2006.05.136. PMID\u00a016765317.Nan X, Carubelli I, Stamatos NM (2007). “Sialidase expression in activated human T lymphocytes influences production of IFN-gamma”. J. Leukoc. Biol. 81 (1): 284\u201396. CiteSeerX\u00a010.1.1.492.9566. doi:10.1189\/jlb.1105692. PMID\u00a017028199. S2CID\u00a036852644.Yoshizumi S, Suzuki S, Hirai M, Hinokio Y, Yamada T, Yamada T, Tsunoda U, Aburatani H, Yamaguchi K, Miyagi T, Oka Y (2007). “Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice”. Metab. Clin. Exp. 56 (3): 420\u20139. doi:10.1016\/j.metabol.2006.10.027. PMID\u00a017292733.Wada T, Hata K, Yamaguchi K, Shiozaki K, Koseki K, Moriya S, Miyagi T (2007). “A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells”. Oncogene. 26 (17): 2483\u201390. doi:10.1038\/sj.onc.1210341. PMID\u00a017334392.Azuma Y, Sato H, Higai K, Matsumoto K (2007). “Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis”. Biol. Pharm. Bull. 30 (9): 1680\u20134. doi:10.1248\/bpb.30.1680. PMID\u00a017827720.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2014\/10\/27\/sialidase-3-wikipedia\/#breadcrumbitem","name":"Sialidase-3 – Wikipedia"}}]}]