[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/mrvi1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/mrvi1-wikipedia\/","headline":"MRVI1 – Wikipedia","name":"MRVI1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Protein MRVI1 is a protein that in humans","datePublished":"2014-10-15","dateModified":"2014-10-15","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/mrvi1-wikipedia\/","about":["Wiki"],"wordCount":4001,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensProtein MRVI1 is a protein that in humans is encoded by the MRVI1 gene.[5][6]Function[edit]This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcripts have been found for this gene, however, the full-length nature of some variants has not been determined. Of the two characterized variants which encode different isoforms, one initiates translation at a non-AUG start site.[6]Interactions[edit]MRVI1 has been shown to interact with ITPR1[7] and PRKG1.[7][8]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000072952 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005611 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Shaughnessy JD, Largaespada DA, Tian E, Fletcher CF, Cho BC, Vyas P, Jenkins NA, Copeland NG (June 1999). “Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1”. Oncogene. 18 (12): 2069\u201384. doi:10.1038\/sj.onc.1202419. PMID\u00a010321731.^ a b “Entrez Gene: MRVI1 murine retrovirus integration site 1 homolog”.^ a b Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (March 2000). “Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta”. Nature. 404 (6774): 197\u2013201. doi:10.1038\/35004606. PMID\u00a010724174. S2CID\u00a0205004996.^ Ammendola A, Geiselh\u00f6ringer A, Hofmann F, Schlossmann J (June 2001). “Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta”. J. Biol. Chem. 276 (26): 24153\u20139. doi:10.1074\/jbc.M101530200. PMID\u00a011309393.Further reading[edit]Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (1992). “Sequence identification of 2,375 human brain genes”. Nature. 355 (6361): 632\u20134. doi:10.1038\/355632a0. PMID\u00a01538749. S2CID\u00a04234345.Baltensperger K, Chiesi M, Carafoli E (1990). “Substrates of cGMP kinase in vascular smooth muscle and their role in the relaxation process”. Biochemistry. 29 (41): 9753\u201360. doi:10.1021\/bi00493a035. PMID\u00a02271613.Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (2000). “Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta”. Nature. 404 (6774): 197\u2013201. doi:10.1038\/35004606. PMID\u00a010724174. S2CID\u00a0205004996.Ammendola A, Geiselh\u00f6ringer A, Hofmann F, Schlossmann J (2001). “Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta”. J. Biol. Chem. 276 (26): 24153\u20139. doi:10.1074\/jbc.M101530200. PMID\u00a011309393.Koller A, Schlossmann J, Ashman K, Uttenweiler-Joseph S, Ruth P, Hofmann F (2003). “Association of phospholamban with a cGMP kinase signaling complex”. Biochem. Biophys. Res. Commun. 300 (1): 155\u201360. doi:10.1016\/S0006-291X(02)02799-7. PMID\u00a012480535.Fritsch RM, Saur D, Kurjak M, Oesterle D, Schlossmann J, Geiselh\u00f6ringer A, Hofmann F, Allescher HD (2004). “InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle”. J. Biol. Chem. 279 (13): 12551\u20139. doi:10.1074\/jbc.M313365200. PMID\u00a014729908.Casteel DE, Boss GR, Pilz RB (2005). “Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif”. J. Biol. Chem. 280 (46): 38211\u20138. doi:10.1074\/jbc.M507021200. PMID\u00a016166082.Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55\u201365. doi:10.1101\/gr.4039406. PMC\u00a01356129. PMID\u00a016344560.Antl M, von Br\u00fchl ML, Eiglsperger C, Werner M, Konrad I, Kocher T, Wilm M, Hofmann F, Massberg S, Schlossmann J (2007). “IRAG mediates NO\/cGMP-dependent inhibition of platelet aggregation and thrombus formation”. Blood. 109 (2): 552\u20139. doi:10.1182\/blood-2005-10-026294. PMID\u00a016990611.External links[edit]  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/mrvi1-wikipedia\/#breadcrumbitem","name":"MRVI1 – Wikipedia"}}]}]