[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2015\/03\/04\/ostalpha-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/2015\/03\/04\/ostalpha-wikipedia\/","headline":"OSTalpha – Wikipedia","name":"OSTalpha – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Organic solute transporter alpha, also known as OST-alpha,","datePublished":"2015-03-04","dateModified":"2015-03-04","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/2015\/03\/04\/ostalpha-wikipedia\/","about":["Wiki"],"wordCount":3847,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensOrganic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the SLC51A gene.[5][6]Table of ContentsFunction[edit]See also[edit]References[edit]Further reading[edit]Function[edit]OST-alpha together with OST-beta is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.[6][7] The Ost-alpha \/ Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.[7] The heterodimer furthermore is essential for intestinal bile acid transport.[8]OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[6]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000163959 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035699 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: OSTalpha organic solute transporter alpha”.^ a b c Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). “Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta”. J. Biol. Chem. 278 (30): 27473\u201382. doi:10.1074\/jbc.M301106200. PMID\u00a012719432.^ a b Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). “The Heteromeric Organic Solute Transporter \u03b1-\u03b2, Ost\u03b1-Ost\u03b2, Is an Ileal Basolateral Bile Acid Transporter”. J. Biol. Chem. 280 (8): 6960\u20138. doi:10.1074\/jbc.M412752200. PMC\u00a01224727. PMID\u00a015563450.^ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). “The organic solute transporter \u03b1-\u03b2, Ost\u03b1-Ost\u03b2, is essential for intestinal bile acid transport and homeostasis”. Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891\u20136. Bibcode:2008PNAS..105.3891R. doi:10.1073\/pnas.0712328105. PMC\u00a02268840. PMID\u00a018292224.Further reading[edit]Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Seward DJ, Koh AS, Boyer JL, Ballatori N (2003). “Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta”. J. Biol. Chem. 278 (30): 27473\u201382. doi:10.1074\/jbc.M301106200. PMID\u00a012719432.Dawson PA, Hubbert M, Haywood J,  et\u00a0al. (2005). “The Heteromeric Organic Solute Transporter \u03b1-\u03b2, Ost\u03b1-Ost\u03b2, Is an Ileal Basolateral Bile Acid Transporter”. J. Biol. Chem. 280 (8): 6960\u20138. doi:10.1074\/jbc.M412752200. PMC\u00a01224727. PMID\u00a015563450.Lee H, Zhang Y, Lee FY,  et\u00a0al. (2006). “FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine”. J. Lipid Res. 47 (1): 201\u201314. doi:10.1194\/jlr.M500417-JLR200. PMID\u00a016251721.Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA (2006). “The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes”. Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G476\u201385. doi:10.1152\/ajpgi.00430.2005. PMID\u00a016269519. S2CID\u00a08687386.Ballatori N, Christian WV, Lee JY,  et\u00a0al. (2005). “OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia”. Hepatology. 42 (6): 1270\u20139. doi:10.1002\/hep.20961. PMID\u00a016317684. S2CID\u00a055829915.Boyer JL, Trauner M, Mennone A,  et\u00a0al. (2006). “Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents”. Am. J. Physiol. Gastrointest. Liver Physiol. 290 (6): G1124\u201330. doi:10.1152\/ajpgi.00539.2005. PMID\u00a016423920. S2CID\u00a086156271.Lim J, Hao T, Shaw C,  et\u00a0al. (2006). “A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”. Cell. 125 (4): 801\u201314. doi:10.1016\/j.cell.2006.03.032. PMID\u00a016713569. S2CID\u00a013709685.Sun AQ, Balasubramaniyan N, Xu K,  et\u00a0al. (2007). “Protein-protein interactions and membrane localization of the human organic solute transporter”. Am. J. Physiol. Gastrointest. Liver Physiol. 292 (6): G1586\u201393. doi:10.1152\/ajpgi.00457.2006. PMID\u00a017332473.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2015\/03\/04\/ostalpha-wikipedia\/#breadcrumbitem","name":"OSTalpha – Wikipedia"}}]}]