[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2015\/08\/25\/23s-rrna-guanine2535-n1-methyltransferase-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/2015\/08\/25\/23s-rrna-guanine2535-n1-methyltransferase-wikipedia\/","headline":"23S rRNA (guanine2535-N1)-methyltransferase – Wikipedia","name":"23S rRNA (guanine2535-N1)-methyltransferase – Wikipedia","description":"From Wikipedia, the free encyclopedia 23S rRNA (guanine2535-N1)-methyltransferase (EC 2.1.1.209, AviRa) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine2535-N1)-methyltransferase.[1][2][3]","datePublished":"2015-08-25","dateModified":"2015-08-25","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/wikimedia.org\/api\/rest_v1\/media\/math\/render\/svg\/1c37b981df851b9e54e489e017b1481e37d418f3","url":"https:\/\/wikimedia.org\/api\/rest_v1\/media\/math\/render\/svg\/1c37b981df851b9e54e489e017b1481e37d418f3","height":"","width":""},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/2015\/08\/25\/23s-rrna-guanine2535-n1-methyltransferase-wikipedia\/","wordCount":2892,"articleBody":"From Wikipedia, the free encyclopedia  23S rRNA (guanine2535-N1)-methyltransferase (EC 2.1.1.209, AviRa) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine2535-N1)-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reactionS-adenosyl-L-methionine + guanine2535 in 23S rRNA   \u21cc{displaystyle rightleftharpoons } S-adenosyl-L-homocysteine + N1-methylguanine2535 in 23S rRNAThis is one of the methyltransferases from Streptomyces viridochromogenes . Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis.[4]References[edit]^ Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S (July 2003). “The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose”. Molecular Microbiology. 49 (2): 309\u201318. doi:10.1046\/j.1365-2958.2003.03558.x. PMID\u00a012828631.^ Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A (March 2001). “An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes T\u00fc57”. Antimicrobial Agents and Chemotherapy. 45 (3): 690\u20135. doi:10.1128\/aac.45.3.690-695.2001. PMC\u00a090357. PMID\u00a011181344.^ Mosbacher TG, Bechthold A, Schulz GE (May 2003). “Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes”. Journal of Molecular Biology. 329 (1): 147\u201357. doi:10.1016\/s0022-2836(03)00407-8. PMID\u00a012742024.^ Krupkin M, Wekselman I, Matzov D, Eyal Z, Diskin Posner Y, Rozenberg H, Zimmerman E, Bashan A, Yonath A (November 2016). “Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding”. Proceedings of the National Academy of Sciences of the United States of America. 113 (44): E6796\u2013E6805. doi:10.1073\/pnas.1614297113. PMC\u00a05098648. 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