[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/a-13-mannosyl-glycoprotein-2-b-n-acetylglucosaminyltransferase-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/a-13-mannosyl-glycoprotein-2-b-n-acetylglucosaminyltransferase-wikipedia\/","headline":"A-1,3-mannosyl-glycoprotein 2-b-N-acetylglucosaminyltransferase – Wikipedia","name":"A-1,3-mannosyl-glycoprotein 2-b-N-acetylglucosaminyltransferase – Wikipedia","description":"From Wikipedia, the free encyclopedia Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101, N-acetylglucosaminyltransferase I, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase, UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-3-D-mannoside","datePublished":"2016-12-09","dateModified":"2016-12-09","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/wikimedia.org\/api\/rest_v1\/media\/math\/render\/svg\/1c37b981df851b9e54e489e017b1481e37d418f3","url":"https:\/\/wikimedia.org\/api\/rest_v1\/media\/math\/render\/svg\/1c37b981df851b9e54e489e017b1481e37d418f3","height":"","width":""},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/a-13-mannosyl-glycoprotein-2-b-n-acetylglucosaminyltransferase-wikipedia\/","wordCount":2022,"articleBody":"From Wikipedia, the free encyclopediaAlpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101, N-acetylglucosaminyltransferase I, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase, UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I, alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, GnTI) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reactionUDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R \u21cc{displaystyle rightleftharpoons } UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-RR represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.References[edit]^ Harpaz N, Schachter H (May 1980). “Control of glycoprotein synthesis. Bovine colostrum UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I. Separation from UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase II, partial purification, and substrate specificity”. The Journal of Biological Chemistry. 255 (10): 4885\u201393. PMID\u00a06445358.^ Mendicino J, Chandrasekaran EV, Anumula KR, Davila M (February 1981). “Isolation and properties of alpha-D-mannose:beta-1,2-N-acetylglucosaminyltransferase from trachea mucosa”. Biochemistry. 20 (4): 967\u201376. doi:10.1021\/bi00507a050. PMID\u00a06452163.^ Miyagi T, Tsuiki S (September 1981). “Studies on UDP-N-acetylglucosamine\u00a0: alpha-mannoside beta-N-acetylglucosaminyltransferase of rat liver and hepatomas”. Biochimica et Biophysica Acta (BBA) – Enzymology. 661 (1): 148\u201357. doi:10.1016\/0005-2744(81)90094-2. PMID\u00a06170335.^ Oppenheimer CL, Eckhardt AE, Hill RL (November 1981). “The nonidentity of porcine N-acetylglucosaminyltransferases I and II”. The Journal of Biological Chemistry. 256 (22): 11477\u201382. PMID\u00a06457827.^ Oppenheimer CL, Hill RL (January 1981). “Purification and characterization of a rabbit liver alpha 1 goes to 3 mannoside beta 1 goes to 2 N-acetylglucosaminyltransferase”. The Journal of Biological Chemistry. 256 (2): 799\u2013804. PMID\u00a06450208.^ Schachter H, Narasimhan S, Gleeson P, Vella G (1983). “Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type”. Methods in Enzymology. 98: 98\u2013134. doi:10.1016\/0076-6879(83)98143-0. PMID\u00a06366476.^ Vella GJ, Paulsen H, Schachter H (June 1984). “Control of glycoprotein synthesis. IX. A terminal Man alpha l-3Man beta 1- sequence in the substrate is the minimum requirement for UDP-N-acetyl-D-glucosamine: alpha-D-mannoside (GlcNAc to Man alpha 1-3) beta 2-N-acetylglucosaminyltransferase I”. Canadian Journal of Biochemistry and Cell Biology. 62 (6): 409\u201317. doi:10.1139\/o84-056. PMID\u00a06235906.^ Unligil UM, Zhou S, Yuwaraj S, Sarkar M, Schachter H, Rini JM (October 2000). “X-ray crystal structure of rabbit N-acetylglucosaminyltransferase I: catalytic mechanism and a new protein superfamily”. The EMBO Journal. 19 (20): 5269\u201380. doi:10.1093\/emboj\/19.20.5269. PMC\u00a0314010. PMID\u00a011032794.External links[edit]  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/a-13-mannosyl-glycoprotein-2-b-n-acetylglucosaminyltransferase-wikipedia\/#breadcrumbitem","name":"A-1,3-mannosyl-glycoprotein 2-b-N-acetylglucosaminyltransferase – Wikipedia"}}]}]