[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cdk5r1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/cdk5r1-wikipedia\/","headline":"CDK5R1 &#8211; Wikipedia","name":"CDK5R1 &#8211; Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens CDK5R1 Identifiers Aliases CDK5R1, CDK5P35, CDK5R, NCK5A, p23,","datePublished":"2017-08-08","dateModified":"2017-08-08","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/1\/1e\/Protein_CDK5R1_PDB_1h4l.png\/250px-Protein_CDK5R1_PDB_1h4l.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/1\/1e\/Protein_CDK5R1_PDB_1h4l.png\/250px-Protein_CDK5R1_PDB_1h4l.png","height":"202","width":"250"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/cdk5r1-wikipedia\/","about":["Wiki"],"wordCount":9332,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensCDK5R1IdentifiersAliasesCDK5R1, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a, cyclin-dependent kinase 5, regulatory subunit 1 (p35), cyclin dependent kinase 5 regulatory subunit 1External IDsOMIM: 603460 MGI: 101764 HomoloGene: 31200 GeneCards: CDK5R1 RNA expression patternBgeeHumanMouse (ortholog)Top expressed inganglionic eminenceRegion I of hippocampus properBrodmann area 23superior frontal gyrusorbitofrontal cortexBrodmann area 9parietal lobepostcentral gyrusentorhinal cortexprefrontal cortexTop expressed inmedial dorsal nucleusmedial ganglionic eminenceolfactory tuberclenucleus accumbensmedial geniculate nucleusprefrontal cortexlateral geniculate nucleussubiculumhabenuladorsomedial hypothalamic nucleusMore reference expression dataBioGPSWikidataCyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene.[5][6]Function[edit]The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer&#8217;s disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer&#8217;s disease.[6]In melanocytic cells CDK5R1 gene expression may be regulated by MITF.[7]Interactions[edit]CDK5R1 has been shown to interact with:See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000176749 &#8211; Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048895 &#8211; Ensembl, May 2017^ &#8220;Human PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ &#8220;Mouse PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E (October 1994). &#8220;p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5&#8221;. Nature. 371 (6496): 419\u201323. Bibcode:1994Natur.371..419T. doi:10.1038\/371419a0. PMID\u00a08090221. S2CID\u00a04267944.^ a b &#8220;Entrez Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)&#8221;.^ Hoek KS, Schlegel NC, Eichhoff OM,  et\u00a0al. (2008). &#8220;Novel MITF targets identified using a two-step DNA microarray strategy&#8221;. Pigment Cell Melanoma Res. 21 (6): 665\u201376. doi:10.1111\/j.1755-148X.2008.00505.x. PMID\u00a019067971. S2CID\u00a024698373.^ Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (August 2002). &#8220;Pctaire1 interacts with p35 and is a novel substrate for Cdk5\/p35&#8221;. J. Biol. Chem. 277 (35): 31988\u201393. doi:10.1074\/jbc.M201161200. PMID\u00a012084709.^ Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai LH, De Camilli P (March 2001). &#8220;Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2&#8221;. J. Biol. Chem. 276 (11): 8104\u201310. doi:10.1074\/jbc.M008932200. PMID\u00a011113134.^ Kesavapany S, Lau KF, McLoughlin DM, Brownlees J, Ackerley S, Leigh PN, Shaw CE, Miller CC (January 2001). &#8220;p35\/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin\/presenilin-1 interaction&#8221;. Eur. J. Neurosci. 13 (2): 241\u20137. doi:10.1046\/j.1460-9568.2001.01376.x. PMID\u00a011168528.^ Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). &#8220;The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+\/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner&#8221;. J. Neurosci. 22 (18): 7879\u201391. doi:10.1523\/JNEUROSCI.22-18-07879.2002. PMC\u00a06758084. PMID\u00a012223541.^ Wang X, Ching YP, Lam WH, Qi Z, Zhang M, Wang JH (October 2000). &#8220;Identification of a common protein association region in the neuronal Cdk5 activator&#8221;. J. Biol. Chem. 275 (41): 31763\u20139. doi:10.1074\/jbc.M004358200. PMID\u00a010915792.^ Chen F, Studzinski GP (June 2001). &#8220;Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation&#8221;. Blood. 97 (12): 3763\u20137. doi:10.1182\/blood.V97.12.3763. PMID\u00a011389014.^ Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A (September 2001). &#8220;Structure and regulation of the CDK5-p25(nck5a) complex&#8221;. Mol. Cell. 8 (3): 657\u201369. doi:10.1016\/S1097-2765(01)00343-4. PMID\u00a011583627.^ Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (March 2002). &#8220;The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5\/p35nck5a activity&#8221;. J. Biol. Chem. 277 (9): 7324\u201332. doi:10.1074\/jbc.M107270200. PMID\u00a011741927.Further reading[edit]ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}]]>Peruzzi F, Gordon J, Darbinian N, Amini S (2003). &#8220;Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway&#8221;. J. Neurovirol. 8 Suppl 2 (2): 91\u20136. doi:10.1080\/13550280290167885. PMID\u00a012491158.Studzinski GP, Harrison JS (2003). &#8220;The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells&#8221;. Leuk. Lymphoma. 44 (2): 235\u201340. doi:10.1080\/1042819021000030009. PMID\u00a012688339. S2CID\u00a030242995.Takahashi M, Tomizawa K, Sato K,  et\u00a0al. (1995). &#8220;A novel tau-tubulin kinase from bovine brain&#8221;. FEBS Lett. 372 (1): 59\u201364. doi:10.1016\/0014-5793(95)00955-9. PMID\u00a07556643. S2CID\u00a042295269.Tang D, Yeung J, Lee KY,  et\u00a0al. (1995). &#8220;An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator&#8221;. J. Biol. Chem. 270 (45): 26897\u2013903. doi:10.1074\/jbc.270.45.26897. PMID\u00a07592934.Chae T, Kwon YT, Bronson R,  et\u00a0al. (1997). &#8220;Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality&#8221;. Neuron. 18 (1): 29\u201342. doi:10.1016\/S0896-6273(01)80044-1. PMID\u00a09010203. S2CID\u00a018685470.Poon RY, Lew J, Hunter T (1997). &#8220;Identification of functional domains in the neuronal Cdk5 activator protein&#8221;. J. Biol. Chem. 272 (9): 5703\u20138. doi:10.1074\/jbc.272.9.5703. PMID\u00a09038181.Fletcher AI, Shuang R, Giovannucci DR,  et\u00a0al. (1999). &#8220;Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18&#8221;. J. Biol. Chem. 274 (7): 4027\u201335. doi:10.1074\/jbc.274.7.4027. PMID\u00a09933594.Patrick GN, Zukerberg L, Nikolic M,  et\u00a0al. (2000). &#8220;Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration&#8221;. Nature. 402 (6762): 615\u201322. doi:10.1038\/45159. PMID\u00a010604467. S2CID\u00a04414281.Ching YP, Qi Z, Wang JH (2000). &#8220;Cloning of three novel neuronal Cdk5 activator binding proteins&#8221;. Gene. 242 (1\u20132): 285\u201394. doi:10.1016\/S0378-1119(99)00499-0. PMID\u00a010721722.Kwon YT, Gupta A, Zhou Y,  et\u00a0al. (2000). &#8220;Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase&#8221;. Curr. Biol. 10 (7): 363\u201372. doi:10.1016\/S0960-9822(00)00411-5. PMID\u00a010753743. S2CID\u00a016438320.Lee MS, Kwon YT, Li M,  et\u00a0al. (2000). &#8220;Neurotoxicity induces cleavage of p35 to p25 by calpain&#8221;. Nature. 405 (6784): 360\u20134. Bibcode:2000Natur.405..360L. doi:10.1038\/35012636. PMID\u00a010830966. S2CID\u00a0205006589.Wang X, Ching YP, Lam WH,  et\u00a0al. (2000). &#8220;Identification of a common protein association region in the neuronal Cdk5 activator&#8221;. J. Biol. Chem. 275 (41): 31763\u20139. doi:10.1074\/jbc.M004358200. PMID\u00a010915792.Floyd SR, Porro EB, Slepnev VI,  et\u00a0al. (2001). &#8220;Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2&#8221;. J. Biol. Chem. 276 (11): 8104\u201310. doi:10.1074\/jbc.M008932200. PMID\u00a011113134.Kesavapany S, Lau KF, McLoughlin DM,  et\u00a0al. (2001). &#8220;p35\/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin\/presenilin-1 interaction&#8221;. Eur. J. Neurosci. 13 (2): 241\u20137. doi:10.1046\/j.1460-9568.2001.01376.x. PMID\u00a011168528.Chen F, Studzinski GP (2001). &#8220;Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation&#8221;. Blood. 97 (12): 3763\u20137. doi:10.1182\/blood.V97.12.3763. PMID\u00a011389014.Tarricone C, Dhavan R, Peng J,  et\u00a0al. (2001). &#8220;Structure and regulation of the CDK5-p25(nck5a) complex&#8221;. Mol. Cell. 8 (3): 657\u201369. doi:10.1016\/S1097-2765(01)00343-4. PMID\u00a011583627.Rashid T, Banerjee M, Nikolic M (2002). &#8220;Phosphorylation of Pak1 by the p35\/Cdk5 kinase affects neuronal morphology&#8221;. J. Biol. Chem. 276 (52): 49043\u201352. doi:10.1074\/jbc.M105599200. PMID\u00a011604394.Qu D, Li Q, Lim HY,  et\u00a0al. (2002). &#8220;The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5\/p35nck5a activity&#8221;. J. Biol. Chem. 277 (9): 7324\u201332. doi:10.1074\/jbc.M107270200. PMID\u00a011741927.Patzke H, Tsai LH (2002). &#8220;Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29&#8221;. J. Biol. Chem. 277 (10): 8054\u201360. doi:10.1074\/jbc.M109645200. PMID\u00a011784720.External links[edit]li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:\" \"counter(listitem)\"a0 \"}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:\" (\"counter(listitem)\"a0 \"}]]>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}]]>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}]]>PDB gallery1h4l: STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX1ung: STRUCTURAL MECHANISM FOR THE INHIBITION OF CDK5-P25 BY ROSCOVITINE, ALOISINE AND INDIRUBIN.1unh: STRUCTURAL MECHANISM FOR THE INHIBITION OF CDK5-P25 BY ROSCOVITINE, ALOISINE AND INDIRUBIN.1unl: STRUCTURAL MECHANISM FOR THE INHIBITION OF CD5-P25 FROM THE ROSCOVITINE, ALOISINE AND INDIRUBIN.  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