[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2019\/12\/09\/grlf1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/2019\/12\/09\/grlf1-wikipedia\/","headline":"GRLF1 – Wikipedia","name":"GRLF1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Glucocorticoid receptor DNA-binding factor 1 is a protein","datePublished":"2019-12-09","dateModified":"2019-12-09","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/2019\/12\/09\/grlf1-wikipedia\/","wordCount":3142,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensGlucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.[5][6]Function[edit]The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.[6]References[edit]Further reading[edit]Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones”. DNA Research. 9 (3): 99\u2013106. doi:10.1093\/dnares\/9.3.99. PMID\u00a012168954.Warriar N, Pag\u00e9 N, Govindan MV (Aug 1996). “Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element”. The Journal of Biological Chemistry. 271 (31): 18662\u201371. doi:10.1074\/jbc.271.31.18662. PMID\u00a08702520.Tikoo A, Czekay S, Viars C, White S, Heath JK, Arden K, Maruta H (Oct 2000). “p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas”. Gene. 257 (1): 23\u201331. doi:10.1016\/S0378-1119(00)00387-5. PMID\u00a011054565.Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Dec 2000). “Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Research. 7 (6): 347\u201355. doi:10.1093\/dnares\/7.6.347. PMID\u00a011214970.Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Vill\u00e9n J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). “Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130\u20135. Bibcode:2004PNAS..10112130B. doi:10.1073\/pnas.0404720101. PMC\u00a0514446. PMID\u00a015302935.Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (Jan 2005). “Immunoaffinity profiling of tyrosine phosphorylation in cancer cells”. Nature Biotechnology. 23 (1): 94\u2013101. doi:10.1038\/nbt1046. PMID\u00a015592455. S2CID\u00a07200157.Barberis D, Casazza A, Sordella R, Corso S, Artigiani S, Settleman J, Comoglio PM, Tamagnone L (Oct 2005). “p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling” (PDF). Journal of Cell Science. 118 (Pt 20): 4689\u2013700. doi:10.1242\/jcs.02590. PMID\u00a016188938. S2CID\u00a015559113.Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D (Jan 2006). “Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability”. The Journal of Biological Chemistry. 281 (4): 2296\u2013305. doi:10.1074\/jbc.M511248200. PMID\u00a016308318.Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). “Transcriptome analysis of human gastric cancer”. Mammalian Genome. 16 (12): 942\u201354. doi:10.1007\/s00335-005-0075-2. PMID\u00a016341674. S2CID\u00a069278.Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635\u201348. doi:10.1016\/j.cell.2006.09.026. PMID\u00a017081983. S2CID\u00a07827573.Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP (Aug 2007). “Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo”. The Journal of Biological Chemistry. 282 (33): 23910\u20138. doi:10.1074\/jbc.M702169200. PMID\u00a017562701.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2019\/12\/09\/grlf1-wikipedia\/#breadcrumbitem","name":"GRLF1 – Wikipedia"}}]}]