[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2022\/11\/27\/nfkbiz-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/2022\/11\/27\/nfkbiz-wikipedia\/","headline":"NFKBIZ – Wikipedia","name":"NFKBIZ – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens NF-kappa-B inhibitor zeta (I\u03baB\u03b6) is a protein that","datePublished":"2022-11-27","dateModified":"2022-11-27","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/2022\/11\/27\/nfkbiz-wikipedia\/","wordCount":6146,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensNF-kappa-B inhibitor zeta (I\u03baB\u03b6) is a protein that in humans is encoded by the NFKBIZ gene.[5][6][7]  This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.[8]Clinical relevance[edit]NFKBIZ has been implicated as an oncogene in diffuse large B-cell lymphoma (DLBCL). Specifically, genomic locus containing this gene is recurrently amplified in copy number in the activated B-cell (ABC) subgroup of DLBCL.[9] More recently, a recurrence of somatic mutations affecting the 3-prime untranslated region of NFKBIZ were found to promote NFKBIZ expression in ABC DLBCL.[10]I\u03baB\u03b6 is required for expression of the  SASP CCL2 (MCP1) cytokine, which recruits macrophages to remove cancer cells.[7]The flavonoid apigenin has been show to reduce gene expression of I\u03baB\u03b6.[11]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000144802 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035356 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Eto A, Muta T, Yamazaki S, Takeshige K (February 2003). “Essential roles for NF-kappa B and a Toll\/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta”. Biochemical and Biophysical Research Communications. 301 (2): 495\u2013501. doi:10.1016\/S0006-291X(02)03082-6. PMID\u00a012565889.^ Totzke G, Essmann F, Pohlmann S, Lindenblatt C, J\u00e4nicke RU, Schulze-Osthoff K (May 2006). “A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding”. The Journal of Biological Chemistry. 281 (18): 12645\u201354. doi:10.1074\/jbc.M511956200. PMID\u00a016513645.^ a b Alexander E, Hildebrand DG, Schulze-Osthoff K, Essmann F (2013). “I\u03baB\u03b6 is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence”. Journal of Cell Science. 126 (Pt 16): 3738\u20133745. doi:10.1242\/jcs.128835. PMID\u00a023781024.^ “Entrez Gene: NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta”.^ Nogai H, Wenzel SS, Hailfinger S, Grau M, Kaergel E, Seitz V,  et\u00a0al. (September 2013). “I\u03baB-\u03b6 controls the constitutive NF-\u03baB target gene network and survival of ABC DLBCL”. Blood. 122 (13): 2242\u201350. doi:10.1182\/blood-2013-06-508028. PMID\u00a023869088. S2CID\u00a018427175.^ Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK,  et\u00a0al. (October 2018). “Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma”. Nature Communications. 9 (1): 4001. Bibcode:2018NatCo…9.4001A. doi:10.1038\/s41467-018-06354-3. PMC\u00a06167379. PMID\u00a030275490.^ Lim H, Heo MY, Kim HP (2019). “Flavonoids: Broad Spectrum Agents on Chronic Inflammation”. Biomolecules & Therapeutics. 27 (3): 241\u2013253. doi:10.4062\/biomolther.2019.034. PMC\u00a06513185. PMID\u00a031006180.Further reading[edit]Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M (November 2000). “MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production”. FEBS Letters. 485 (1): 53\u20136. doi:10.1016\/S0014-5793(00)02185-2. PMID\u00a011086164. S2CID\u00a085416608.Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B (October 2001). “Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene”. Immunogenetics. 53 (8): 649\u201355. doi:10.1007\/s00251-001-0376-x. PMID\u00a011797098. S2CID\u00a012387932.Haruta H, Kato A, Todokoro K (April 2001). “Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs”. The Journal of Biological Chemistry. 276 (16): 12485\u20138. doi:10.1074\/jbc.C100075200. PMID\u00a011278262.Yamazaki S, Muta T, Takeshige K (July 2001). “A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei”. The Journal of Biological Chemistry. 276 (29): 27657\u201362. doi:10.1074\/jbc.M103426200. PMID\u00a011356851.Kitamura H, Kanehira K, Shiina T, Morimatsu M, Jung BD, Akashi S, Saito M (May 2002). “Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4”. The Journal of Veterinary Medical Science. 64 (5): 419\u201322. doi:10.1292\/jvms.64.419. PMID\u00a012069074.Kitamura H, Matsushita Y, Iwanaga T, Mori K, Kanehira K, Fujikura D, Morimatsu M, Saito M (March 2003). “Bacterial lipopolysaccharide-induced expression of the IkappaB protein MAIL in B-lymphocytes and macrophages”. Archives of Histology and Cytology. 66 (1): 53\u201362. doi:10.1679\/aohc.66.53. PMID\u00a012703554.Shiina T, Konno A, Oonuma T, Kitamura H, Imaoka K, Takeda N, Todokoro K, Morimatsu M (December 2004). “Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease”. The Journal of Biological Chemistry. 279 (53): 55493\u20138. doi:10.1074\/jbc.M409770200. PMID\u00a015491998.Ito T, Morimatsu M, Oonuma T, Shiina T, Kitamura H, Syuto B (November 2004). “Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages”. Gene. 342 (1): 137\u201343. doi:10.1016\/j.gene.2004.07.032. PMID\u00a015527973.Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S (July 2004). “Regulation of Toll\/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta”. Nature. 430 (6996): 218\u201322. Bibcode:2004Natur.430..218Y. doi:10.1038\/nature02738. PMID\u00a015241416. S2CID\u00a04384768.Yamaji D, Kitamura H, Kimura K, Matsushita Y, Okada H, Shiina T, Morimatsu M, Saito M (April 2004). “Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows”. Veterinary Immunology and Immunopathology. 98 (3\u20134): 175\u201384. doi:10.1016\/j.vetimm.2003.12.004. PMID\u00a015010226.Yamazaki S, Muta T, Matsuo S, Takeshige K (January 2005). “Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll\/Interleukin-1 receptor is mediated by mRNA stabilization”. The Journal of Biological Chemistry. 280 (2): 1678\u201387. doi:10.1074\/jbc.M409983200. PMID\u00a015522867.Motoyama M, Yamazaki S, Eto-Kimura A, Takeshige K, Muta T (March 2005). “Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein”. The Journal of Biological Chemistry. 280 (9): 7444\u201351. doi:10.1074\/jbc.M412738200. PMID\u00a015618216.Cowland JB, Muta T, Borregaard N (May 2006). “IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta”. Journal of Immunology. 176 (9): 5559\u201366. doi:10.4049\/jimmunol.176.9.5559. PMID\u00a016622025.Oonuma T, Morimatsu M, Ochiai K, Iwanaga T, Hashizume K (March 2007). “Role of NF-kappaB in constitutive expression of MAIL in epidermal keratinocytes”. The Journal of Veterinary Medical Science. 69 (3): 279\u201384. doi:10.1292\/jvms.69.279. PMID\u00a017409644.Matsuo S, Yamazaki S, Takeshige K, Muta T (August 2007). “Crucial roles of binding sites for NF-kappaB and C\/EBPs in IkappaB-zeta-mediated transcriptional activation”. The Biochemical Journal. 405 (3): 605\u201315. doi:10.1042\/BJ20061797. PMC\u00a02267307. PMID\u00a017447895.  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