[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2022\/11\/27\/trpc5-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/2022\/11\/27\/trpc5-wikipedia\/","headline":"TRPC5 – Wikipedia","name":"TRPC5 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Short transient receptor potential channel 5 (TrpC5) also","datePublished":"2022-11-27","dateModified":"2022-11-27","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/2022\/11\/27\/trpc5-wikipedia\/","about":["Wiki"],"wordCount":4825,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensShort transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene.[5][6][7] TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.Table of ContentsFunction[edit]Activation[edit]Interactions[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Function[edit]TrpC5 is one of the seven mammalian TRPC (transient receptor potential canonical) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na+\u2013H+ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).[5]TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity[8] and neurological behavior.[9] It was established in 2021 that TRPC5 is a component of the dental cold sensing system.[10]Activation[edit]Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin.[11] This channel has also been found to be involved in the action of anaesthetics such as chloroform, halothane and propofol.[12]Interactions[edit]TRPC5 has been shown to interact with STMN3,[13]TRPC1,[14][15] and TRPC4.[15]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000072315 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041710 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b “Entrez Gene: transient receptor potential cation channel”.^ Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK (September 1999). “Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel”. Genomics. 60 (3): 330\u201340. doi:10.1006\/geno.1999.5924. PMID\u00a010493832.^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). “International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels”. Pharmacol. Rev. 57 (4): 427\u201350. doi:10.1124\/pr.57.4.6. PMID\u00a016382100. S2CID\u00a017936350.^ Xu SZ, Zeng B, Daskoulidou N, Chen GL, Atkin SL, Lukhele B (January 2012). “Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure”. Toxicol. Sci. 125 (1): 56\u201368. doi:10.1093\/toxsci\/kfr268. PMID\u00a021984481.^ Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van’t Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE (May 15, 2009). “Essential role for TRPC5 in amygdala function and fear-related behavior”. Cell. 137 (4): 761\u201372. doi:10.1016\/j.cell.2009.03.039. PMC\u00a02719954. PMID\u00a019450521.^ Bernal, Laura; Sotelo-Hitschfeld, Pamela; K\u00f6nig, Christine; Sinica, Viktor; Wyatt, Amanda; Winter, Zoltan; Hein, Alexander; Touska, Filip; Reinhardt, Susanne; Tragl, Aaron; Kusuda, Ricardo; Wartenberg, Philipp; Sclaroff, Allen; Pfeifer, John D.; Ectors, Fabien; Dahl, Andreas; Freichel, Marc; Vlachova, Viktorie; Brauchi, Sebastian; Roza, Carolina; Boehm, Ulrich; Clapham, David E.; Lennerz, Jochen K.; Zimmermann, Katharina (2021). “Odontoblast TRPC5 channels signal cold pain in teeth”. Science Advances. 7 (13): eabf5567. doi:10.1126\/sciadv.abf5567. PMC\u00a07997515. PMID\u00a033771873.^ Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, Al-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ (January 2008). “TRPC channel activation by extracellular thioredoxin”. Nature. 451 (7174): 69\u201372. doi:10.1038\/nature06414. PMC\u00a02645077. PMID\u00a018172497.^ Bahnasi YM, Wright HM, Milligan CJ, Dedman AM, Zeng F, Hopkins PM, Bateson AN, Beech DJ (April 2008). “Modulation of TRPC5 cation channels by halothane, chloroform and propofol”. Br. J. Pharmacol. 153 (7): 1505\u201312. doi:10.1038\/sj.bjp.0707689. PMC\u00a02437913. PMID\u00a018204473.^ Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (August 2003). “TRPC5 is a regulator of hippocampal neurite length and growth cone morphology”. Nat. Neurosci. 6 (8): 837\u201345. doi:10.1038\/nn1092. PMID\u00a012858178. S2CID\u00a07523946.^ Str\u00fcbing C, Krapivinsky G, Krapivinsky L, Clapham DE (October 2003). “Formation of novel TRPC channels by complex subunit interactions in embryonic brain”. J. Biol. Chem. 278 (40): 39014\u20139. doi:10.1074\/jbc.M306705200. PMID\u00a012857742.^ a b Hofmann T, Schaefer M, Schultz G, Gudermann T (May 2002). “Subunit composition of mammalian transient receptor potential channels in living cells”. Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7461\u20136. doi:10.1073\/pnas.102596199. PMC\u00a0124253. PMID\u00a012032305.Further reading[edit]External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.TRPAActivators4-Hydroxynonenal4-Oxo-2-nonenal4,5-EET12S-HpETE15-Deoxy-\u039412,14-prostaglandin J2\u03b1-Sanshool (ginger, Sichuan and melegueta peppers)AcroleinAllicin (garlic)Allyl isothiocyanate (mustard, radish, horseradish, wasabi)AM404ASP-7663BradykininCannabichromene (cannabis)Cannabidiol (cannabis)Cannabigerol (cannabis)Cinnamaldehyde (cinnamon)CR gas (dibenzoxazepine; DBO)CS gas (2-chlorobenzal malononitrile)Cuminaldehyde (cumin)Curcumin (turmeric)Dehydroligustilide (celery)Diallyl disulfideDicentrine (Lindera spp.)Farnesyl thiosalicylic acidFormalinGingerols (ginger)Hepoxilin A3Hepoxilin B3Hydrogen peroxideIcilinIsothiocyanateJT-010Ligustilide (celery, Angelica acutiloba)Linalool (Sichuan pepper, thyme)MethylglyoxalMethyl salicylate (wintergreen)N-MethylmaleimideNicotine (tobacco)Oleocanthal (olive oil)Paclitaxel (Pacific yew)Paracetamol (acetaminophen)PF-4840154Phenacyl chloridePolygodial (Dorrigo pepper)Shogaols (ginger, Sichuan and melegueta peppers)Tear gasesTetrahydrocannabinol (cannabis)TetrahydrocannabiorcolThiopropanal S-oxide (onion)Umbellulone (Umbellularia californica)WIN 55,212-2BlockersTRPCTRPMTRPMLTRPPTRPVActivators2-APB5′,6′-EET9-HODE9-oxoODE12S-HETE12S-HpETE13-HODE13-oxoODE20-HETE\u03b1-Sanshool (ginger, Sichuan and melegueta peppers)Allicin (garlic)AM404AnandamideBisandrographolide (Andrographis paniculata)Camphor (camphor laurel, rosemary, camphorweed, African blue basil, camphor basil)Cannabidiol (cannabis)Cannabidivarin (cannabis)Capsaicin (chili pepper)Carvacrol (oregano, thyme, pepperwort, wild bergamot, others)DHEADiacyl glycerolDihydrocapsaicin (chili pepper)EstradiolEugenol (basil, clove)Evodiamine (Euodia ruticarpa)Gingerols (ginger)GSK1016790AHeatHepoxilin A3Hepoxilin B3Homocapsaicin (chili pepper)Homodihydrocapsaicin (chili pepper)Incensole (incense)Lysophosphatidic acidLow pH (acidic conditions)Menthol (mint)N-Arachidonoyl dopamineN-OleoyldopamineN-OleoylethanolamideNonivamide (PAVA) (PAVA spray)Nordihydrocapsaicin (chili pepper)Paclitaxel (Pacific yew)Paracetamol (acetaminophen)PhenylacetylrinvanilPhorbol esters (e.g., 4\u03b1-PDD)Piperine (black pepper, long pepper)Polygodial (Dorrigo pepper)ProbenecidProtonsRhTxRutamarin (Ruta graveolens)Resiniferatoxin (RTX) (Euphorbia resinifera\/pooissonii)Shogaols (ginger, Sichuan and melegueta peppers)Tetrahydrocannabivarin (cannabis)Thymol (thyme, oregano)Tinyatoxin (Euphorbia resinifera\/pooissonii)TramadolVanillin (vanilla)ZucapsaicinBlockers  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2022\/11\/27\/trpc5-wikipedia\/#breadcrumbitem","name":"TRPC5 – Wikipedia"}}]}]