[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2022\/11\/05\/bombesin-like-receptor-3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/2022\/11\/05\/bombesin-like-receptor-3-wikipedia\/","headline":"Bombesin-like receptor 3 – Wikipedia","name":"Bombesin-like receptor 3 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens The bombesin receptor subtype 3 also known as","datePublished":"2022-11-05","dateModified":"2022-11-05","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/2022\/11\/05\/bombesin-like-receptor-3-wikipedia\/","about":["Wiki"],"wordCount":4130,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensThe bombesin receptor subtype 3 also known as BRS-3 or BB3[5] is a protein which in humans is encoded by the BRS3 gene.[6][7]Function[edit]Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[7][8]BB3 is a G protein-coupled receptor.[6]  BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[6][9][10]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000102239 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031130 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Bombesin Receptors: BB3“. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.^ a b c Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). “BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells”. J. Biol. Chem. 268 (8): 5979\u201384. doi:10.1016\/S0021-9258(18)53415-3. PMID\u00a08383682.^ a b Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). “Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse”. Brain Res. 762 (1\u20132): 165\u201372. doi:10.1016\/S0006-8993(97)00380-6. PMID\u00a09262170. S2CID\u00a01012779.^ “Entrez Gene: BRS3 bombesin-like receptor 3”.^ Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT (1997). “Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors”. J. Biol. Chem. 272 (41): 26062\u201326071. doi:10.1074\/jbc.272.41.26062. PMID\u00a09325344.^ Jensen RT, Battey JF, Spindel ER, Benya RV (2007). “International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states”. Pharmacol. Rev. 60 (1): 1\u201342. doi:10.1124\/pr.107.07108. PMC\u00a02517428. PMID\u00a018055507.Further reading[edit]Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F (1994). “Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus” (PDF). FEBS Lett. 340 (3): 260\u20134. doi:10.1016\/0014-5793(94)80150-9. PMID\u00a08131855. S2CID\u00a099786.Fathi Z, Corjay MH, Shapira H,  et\u00a0al. (1993). “BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells”. J. Biol. Chem. 268 (8): 5979\u201384. doi:10.1016\/S0021-9258(18)53415-3. PMID\u00a08383682.Kane MA, Toi-Scott M, Johnson GL,  et\u00a0al. (1996). “Bombesin-like peptide receptors in human bronchial epithelial cells”. Peptides. 17 (1): 111\u20138. doi:10.1016\/0196-9781(95)02088-8. PMID\u00a08822519. S2CID\u00a030893871.Ohki-Hamazaki H, Watase K, Yamamoto K,  et\u00a0al. (1997). “Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity”. Nature. 390 (6656): 165\u20139. Bibcode:1997Natur.390..165O. doi:10.1038\/36568. PMID\u00a09367152. S2CID\u00a04400418.Ryan RR, Weber HC, Hou W,  et\u00a0al. (1998). “Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3”. J. Biol. Chem. 273 (22): 13613\u201324. doi:10.1074\/jbc.273.22.13613. PMID\u00a09593699.Liu J, Lao ZJ, Zhang J,  et\u00a0al. (2002). “Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)”. Biochemistry. 41 (28): 8954\u201360. doi:10.1021\/bi0202777. PMID\u00a012102638.Ross MT, Grafham DV, Coffey AJ,  et\u00a0al. (2005). “The DNA sequence of the human X chromosome”. Nature. 434 (7031): 325\u201337. Bibcode:2005Natur.434..325R. doi:10.1038\/nature03440. PMC\u00a02665286. PMID\u00a015772651.Hou X, Wei L, Harada A, Tatamoto K (2007). “Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells”. Lung Cancer. 54 (2): 143\u20138. doi:10.1016\/j.lungcan.2006.08.005. PMID\u00a016979789.Tan YR, Qin XQ, Xiang Y,  et\u00a0al. (2007). “PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells”. Biochem. J. 405 (1): 131\u20137. doi:10.1042\/BJ20061754. PMC\u00a01925247. PMID\u00a017355223.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/2022\/11\/05\/bombesin-like-receptor-3-wikipedia\/#breadcrumbitem","name":"Bombesin-like receptor 3 – Wikipedia"}}]}]