[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/4-damp-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/4-damp-wikipedia\/","headline":"4-DAMP – Wikipedia","name":"4-DAMP – Wikipedia","description":"From Wikipedia, the free encyclopedia Chemical compound 4-DAMP (1,1-dimethyl-4-diphenylacetoxypiperidinium iodide) is a selective muscarinic acetylcholine receptor (mAChR) M3antagonist.[2] It is","datePublished":"2021-06-27","dateModified":"2021-06-27","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/4-damp-wikipedia\/","about":["Wiki"],"wordCount":1837,"articleBody":"From Wikipedia, the free encyclopediaChemical compound4-DAMP (1,1-dimethyl-4-diphenylacetoxypiperidinium iodide) is a selective muscarinic acetylcholine receptor (mAChR) M3antagonist.[2] It is also able to antagonize M1 receptors but “prefers” M3.[3][4] It competitively binds to the acetylcholine binding site on mAChRs, causing right-ward shift in the dose response curves for mAChR agonists.References[edit]^ “4-DAMP”. Sigma-Aldrich.^ Zhu, MH; Sung, IK; Zheng, H; Sung, TS; Britton, FC; O’Driscoll, K; Koh, SD; Sanders, KM (2011). “Muscarinic activation of Ca2+-activated Cl- current in interstitial cells of Cajal”. J Physiol. 589 (Pt18): 4565\u20134582. doi:10.1113\/jphysiol.2011.211094. PMC\u00a03208225. PMID\u00a021768263.^ Teixeira-Neto, FJ; McDonell, WN; Black, WD; Harris, W and; Grovum, L (2012). “Effects of muscarinic receptor antagonists on acetylcholine-induced contractions of jejunal smooth muscle in horses”. Journal of Veterinary Pharmacology and Therapeutics. 35 (4): 313\u2013318. doi:10.1111\/j.1365-2885.2011.01330.x. PMID\u00a021859432.^ Greenwood, JM and; Dragunow, M (2010). “M3 muscarinic receptors promote cell survival through activation of the extracellular regulated kinase (ERK1\/2) pathway”. Eur J Pharmacol. 640 (1\u20133): 38\u201345. doi:10.1016\/j.ejphar.2010.05.013. PMID\u00a020519144.mAChRsAgonistsAntagonists3-Quinuclidinyl benzilate4-DAMPAclidinium bromide (+formoterol)AbediterolAF-DX 250AF-DX 384Ambutonium bromideAnisodamineAnisodineAntihistamines (first-generation) (e.g., brompheniramine, buclizine, captodiame, chlorphenamine (chlorpheniramine), cinnarizine, clemastine, cyproheptadine, dimenhydrinate, dimetindene, diphenhydramine, doxylamine, meclizine, mequitazine, perlapine, phenindamine, pheniramine, phenyltoloxamine, promethazine, propiomazine, triprolidine)AQ-RA 741AtropineAtropine methonitrateAtypical antipsychotics (e.g., clozapine, fluperlapine, olanzapine (+fluoxetine), rilapine, quetiapine, tenilapine, zotepine)BenactyzineBenzatropine (benztropine)BenziloneBenzilylcholine mustardBenzydamineBIBN 99BiperidenBornaprineCamylofinCAR-226,086CAR-301,060CAR-302,196CAR-302,282CAR-302,368CAR-302,537CAR-302,668CaramiphenCimetropium bromideClidinium bromideCloperastineCS-27349CyclobenzaprineCyclopentolateDarifenacinDAU-5884DesfesoterodineDexetimideDIBDDicycloverine (dicyclomine)DihexyverineDifemerineDiphemanil metilsulfateDitranDrofenineEA-3167EA-3443EA-3580EA-3834Emepronium bromideEtanautineEtybenzatropine (ethybenztropine)FenpiveriniumFentonium bromideFesoterodineFlavoxateGlycopyrronium bromide (+beclometasone\/formoterol, +indacaterol, +neostigmine)HexahydrodifenidolHexahydrosiladifenidolHexbutinolHexocycliumHimbacineHL-031,120HomatropineImidafenacinIpratropium bromide (+salbutamol)IsopropamideJ-104,129HyoscyamineMamba toxin 3Mamba toxin 7MazaticolMebeverineMeladrazineMepenzolateMethanthelineMethoctramineMethylatropineMethylhomatropineMethylscopolamineMetixeneMuscarinic toxin 7N-Ethyl-3-piperidyl benzilateN-Methyl-3-piperidyl benzilateNefopamOctatropine methylbromide (anisotropine methylbromide)OrphenadrineOtenzepad (AF-DX 116)Otilonium bromideOxapium iodideOxitropium bromideOxybutyninOxyphencyclimineOxyphenonium bromidePBIDPD-102,807PD-0298029PenthienatePethidinepFHHSiDPhenglutarimidePhenyltoloxaminePipenzolate bromidePiperidolatePirenzepinePiroheptinePizotifenPoldinePridinolPrifinium bromideProcyclidineProfenamine (ethopropazine)Propantheline bromidePropiverineQuinidine3-Quinuclidinyl thiochromane-4-carboxylateRevefenacinRociverineRU-47,213SCH-57,790SCH-72,788SCH-217,443Scopolamine (hyoscine)Scopolamine butylbromide (hyoscine butylbromide)SilahexacycliumSofpironium bromideSolifenacinSSRIs (e.g., femoxetine, paroxetine)TelenzepineTerodilineTetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin, mirtazapine)Tiemonium iodideTimepidium bromideTiotropium bromideTiquizium bromideTofenacinTolterodineTricyclic antidepressants (e.g., amitriptyline (+perphenazine), amitriptylinoxide, butriptyline, cidoxepin, clomipramine, desipramine, desmethyldesipramine, dibenzepin, dosulepin (dothiepin), doxepin, imipramine, lofepramine, nitroxazepine, northiaden (desmethyldosulepin), nortriptyline, protriptyline, quinupramine, trimipramine)TridihexethylTrihexyphenidylTrimebutineTripitamine (tripitramine)TropacineTropatepineTropicamideTrospium chlorideTypical antipsychotics (e.g., chlorpromazine, chlorprothixene, cyamemazine (cyamepromazine), loxapine, mesoridazine, thioridazine)Umeclidinium bromide (+vilanterol)WIN-2299XanomelineZamifenacinPrecursors(and prodrugs)  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/4-damp-wikipedia\/#breadcrumbitem","name":"4-DAMP – Wikipedia"}}]}]