[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/60s-ribosomal-protein-l7-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/60s-ribosomal-protein-l7-wikipedia\/","headline":"60S ribosomal protein L7 – Wikipedia","name":"60S ribosomal protein L7 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens 60S ribosomal protein L7 is a protein that","datePublished":"2019-05-08","dateModified":"2019-05-08","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/60s-ribosomal-protein-l7-wikipedia\/","about":["Wiki"],"wordCount":5493,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiens60S ribosomal protein L7 is a protein that in humans is encoded by the RPL7 gene.[5][6][7]Table of ContentsFunction[edit]Interactions[edit]References[edit]Further reading[edit]Function[edit]Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus sub-motif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]Interactions[edit]RPL7 has been shown to interact with ZNF7.[8] It interacts with HIV-1 Gag protein through Zinc Finger of HIV-1 Gag.[9]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000147604 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043716 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Seshadri T, Uzman JA, Oshima J, Campisi J (September 1993). “Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene”. The Journal of Biological Chemistry. 268 (25): 18474\u201380. doi:10.1016\/S0021-9258(17)46650-6. PMID\u00a08360149.^ Hemmerich P, von Mikecz A, Neumann F, S\u00f6zeri O, Wolff-Vorbeck G, Zoebelein R, Krawinkel U (January 1993). “Structural and functional properties of ribosomal protein L7 from humans and rodents”. Nucleic Acids Research. 21 (2): 223\u201331. doi:10.1093\/nar\/21.2.223. PMC\u00a0309096. PMID\u00a08441630.^ a b “Entrez Gene: RPL7 ribosomal protein L7”.^ Witte S, Krawinkel U (August 1997). “Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7”. The Journal of Biological Chemistry. 272 (35): 22243\u20137. doi:10.1074\/jbc.272.35.22243. PMID\u00a09268371.^ Mekdad HE, Boutant E, Karnib H, Biedma ME, Sharma KK, Malytska I,  et\u00a0al. (August 2016). “Characterization of the interaction between the HIV-1 Gag structural polyprotein and the cellular ribosomal protein L7 and its implication in viral nucleic acid remodeling”. Retrovirology. 13 (1): 54. doi:10.1186\/s12977-016-0287-4. PMC\u00a04982112. PMID\u00a027515235.Further reading[edit]Wool IG, Chan YL, Gl\u00fcck A (1996). “Structure and evolution of mammalian ribosomal proteins”. Biochemistry and Cell Biology. 73 (11\u201312): 933\u201347. doi:10.1139\/o95-101. PMID\u00a08722009.von Mikecz A, Hemmerich P, Peter HH, Krawinkel U (December 1994). “Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune disease”. Immunobiology. 192 (1\u20132): 137\u201354. doi:10.1016\/S0171-2985(11)80413-4. PMID\u00a07750987.Neumann F, Hemmerich P, von Mikecz A, Peter HH, Krawinkel U (January 1995). “Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells”. Nucleic Acids Research. 23 (2): 195\u2013202. doi:10.1093\/nar\/23.2.195. PMC\u00a0306654. PMID\u00a07862521.Maruyama K, Sugano S (January 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.Witte S, Krawinkel U (August 1997). “Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7”. The Journal of Biological Chemistry. 272 (35): 22243\u20137. doi:10.1074\/jbc.272.35.22243. PMID\u00a09268371.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (May 1998). “A map of 75 human ribosomal protein genes”. Genome Research. 8 (5): 509\u201323. doi:10.1101\/gr.8.5.509. PMID\u00a09582194.Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). “Directed proteomic analysis of the human nucleolus”. Current Biology. 12 (1): 1\u201311. doi:10.1016\/S0960-9822(01)00650-9. PMID\u00a011790298. S2CID\u00a014132033.Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M (January 2003). “Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8”. The Journal of Biological Chemistry. 278 (2): 776\u201383. doi:10.1074\/jbc.M206396200. PMID\u00a012401809.Kasai H, Nadano D, Hidaka E, Higuchi K, Kawakubo M, Sato TA, Nakayama J (May 2003). “Differential expression of ribosomal proteins in human normal and neoplastic colorectum”. The Journal of Histochemistry and Cytochemistry. 51 (5): 567\u201374. doi:10.1177\/002215540305100502. PMID\u00a012704204.Odintsova TI, M\u00fcller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN, Kostka S, Otto A, Wittmann-Liebold B, Karpova GG (April 2003). “Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing”. Journal of Protein Chemistry. 22 (3): 249\u201358. doi:10.1023\/A:1025068419698. PMID\u00a012962325. S2CID\u00a010710245.Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). “Immunoaffinity profiling of tyrosine phosphorylation in cancer cells”. Nature Biotechnology. 23 (1): 94\u2013101. doi:10.1038\/nbt1046. PMID\u00a015592455. S2CID\u00a07200157.Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). “Nucleolar proteome dynamics”. Nature. 433 (7021): 77\u201383. Bibcode:2005Natur.433…77A. doi:10.1038\/nature03207. PMID\u00a015635413. S2CID\u00a04344740.Ko JR, Wu JY, Kirby R, Li IF, Lin A (July 2006). “Mapping the essential structures of human ribosomal protein L7 for nuclear entry, ribosome assembly and function”. FEBS Letters. 580 (16): 3804\u201310. doi:10.1016\/j.febslet.2006.05.073. PMID\u00a016797011. S2CID\u00a025168455.Wu WC, Liu HW, Lin A (February 2007). “Human ribosomal protein L7 displays an ER binding property and is involved in ribosome-ER association”. FEBS Letters. 581 (4): 651\u20137. doi:10.1016\/j.febslet.2007.01.023. PMID\u00a017258209. S2CID\u00a030461645.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/60s-ribosomal-protein-l7-wikipedia\/#breadcrumbitem","name":"60S ribosomal protein L7 – Wikipedia"}}]}]