GPR6 – Wikipedia

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Protein-coding gene in the species Homo sapiens

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[5][6]

Function[edit]

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[7]

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[8]

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Inverse Agonist[edit]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146360 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046922 – Ensembl, May 2017
  3. ^

    “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

  4. ^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ “Entrez Gene: GPR6 G protein-coupled receptor 6”.
  6. ^ Song ZH, Modi W, Bonner TI (July 1995). “Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors”. Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.
  7. ^ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). “Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors”. Cellular Signalling. 14 (11): 941–953. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.
  8. ^ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). “Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth”. The Journal of Biological Chemistry. 282 (14): 10506–10515. doi:10.1074/jbc.M700911200. PMID 17284443.
  9. ^ Laun AS, Shrader SH, Brown KJ, Song ZH (March 2019). “GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol”. Acta Pharmacologica Sinica. 40 (3): 300–308. doi:10.1038/s41401-018-0031-9. PMC 6460361. PMID 29941868.

Further reading[edit]

External links[edit]

  • “GPR6”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.


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