PRDX6 – Wikipedia

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Protein-coding gene in the species Homo sapiens

Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene.[5][6] It is a member of the peroxiredoxin family of antioxidant enzymes.

Function[edit]

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.[6]

= Model organisms[edit]

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Model organisms have been used in the study of PRDX6 function. A conditional knockout mouse line, called Prdx6tm1a(EUCOMM)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117592 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026701 – Ensembl, May 2017
  3. ^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Phelan SA (Mar 2001). “AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant”. Antioxidants & Redox Signaling. 1 (4): 571–584. doi:10.1089/ars.1999.1.4-571. PMID 11233154.
  6. ^ a b “Entrez Gene: PRDX6 peroxiredoxin 6”.
  7. ^ “Salmonella infection data for Prdx6″. Wellcome Trust Sanger Institute.
  8. ^ “Citrobacter infection data for Prdx6″. Wellcome Trust Sanger Institute.
  9. ^ a b c Gerdin AK (2010). “The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice”. Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. ^ “International Knockout Mouse Consortium”.
  12. ^ “Mouse Genome Informatics”.
  13. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, et al. (June 2011). “A conditional knockout resource for the genome-wide study of mouse gene function”. Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. ^ Dolgin E (June 2011). “Mouse library set to be knockout”. Nature. 474 (7351): 262–263. doi:10.1038/474262a. PMID 21677718.
  15. ^ Collins FS, Rossant J, Wurst W (January 2007). “A mouse for all reasons”. Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  16. ^ van der Weyden L, White JK, Adams DJ, Logan DW (June 2011). “The mouse genetics toolkit: revealing function and mechanism”. Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading[edit]



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