[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/a4galt-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/a4galt-wikipedia\/","headline":"A4GALT – Wikipedia","name":"A4GALT – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens A4GALT Identifiers Aliases A4GALT, A14GALT, A4GALT1, Gb3S, P(k),","datePublished":"2015-02-22","dateModified":"2015-02-22","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/a4galt-wikipedia\/","about":["Wiki"],"wordCount":3733,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensA4GALTIdentifiersAliasesA4GALT, A14GALT, A4GALT1, Gb3S, P(k), P1, P1PK, PK, alpha 1,4-galactosyltransferase, alpha 1,4-galactosyltransferase (P blood group)External IDsOMIM: 607922 MGI: 3512453 HomoloGene: 9690 GeneCards: A4GALT EC number2.4.1.228WikidataLactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.[5][6]The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.[6]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000128274 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047878 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU (Sep 2000). “Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals”. J Biol Chem. 275 (33): 25315\u201321. doi:10.1074\/jbc.M002630200. PMID\u00a010854428.^ a b “Entrez Gene: A4GALT alpha 1,4-galactosyltransferase (globotriaosylceramide synthase)”.Further reading[edit]Dunham I, Shimizu N, Roe BA,  et\u00a0al. (1999). “The DNA sequence of human chromosome 22”. Nature. 402 (6761): 489\u201395. Bibcode:1999Natur.402..489D. doi:10.1038\/990031. PMID\u00a010591208.Steffensen R, Carlier K, Wiels J,  et\u00a0al. (2000). “Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype”. J. Biol. Chem. 275 (22): 16723\u20139. doi:10.1074\/jbc.M000728200. PMID\u00a010747952.Kojima Y, Fukumoto S, Furukawa K,  et\u00a0al. (2000). “Molecular cloning of globotriaosylceramide\/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids”. J. Biol. Chem. 275 (20): 15152\u20136. doi:10.1074\/jbc.M909620199. PMID\u00a010748143.Furukawa K, Iwamura K, Uchikawa M,  et\u00a0al. (2001). “Molecular basis for the p phenotype. Identification of distinct and multiple mutations in the alpha 1,4-galactosyltransferase gene in Swedish and Japanese individuals”. J. Biol. Chem. 275 (48): 37752\u20136. doi:10.1074\/jbc.C000625200. PMID\u00a010993874.Furukawa K, Yokoyama K, Sato T,  et\u00a0al. (2002). “Expression of the Gb3\/CD77 synthase gene in megakaryoblastic leukemia cells: implication in the sensitivity to verotoxins”. J. Biol. Chem. 277 (13): 11247\u201354. doi:10.1074\/jbc.M109519200. PMID\u00a011782470.Koda Y, Soejima M, Sato H,  et\u00a0al. (2002). “Three-base deletion and one-base insertion of the alpha(1,4)galactosyltransferase gene responsible for the P phenotype”. Transfusion. 42 (1): 48\u201351. doi:10.1046\/j.1537-2995.2002.00014.x. PMID\u00a011896312. S2CID\u00a036675818.Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.;  et\u00a0al. (2002). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proceedings of the National Academy of Sciences. 99 (26): 16899\u201316903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Iwamura K, Furukawa K, Uchikawa M,  et\u00a0al. (2004). “The blood group P1 synthase gene is identical to the Gb3\/CD77 synthase gene. A clue to the solution of the P1\/P2\/p puzzle”. J. Biol. Chem. 278 (45): 44429\u201338. doi:10.1074\/jbc.M301609200. PMID\u00a012888565.Hellberg A, Ringressi A, Yahalom V,  et\u00a0al. (2004). “Genetic heterogeneity at the glycosyltransferase loci underlying the GLOB blood group system and collection”. Br. J. Haematol. 125 (4): 528\u201336. doi:10.1111\/j.1365-2141.2004.04930.x. PMID\u00a015142124.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.External links[edit]  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/a4galt-wikipedia\/#breadcrumbitem","name":"A4GALT – Wikipedia"}}]}]