[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/abcd4-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/abcd4-wikipedia\/","headline":"ABCD4 – Wikipedia","name":"ABCD4 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens ATP-binding cassette sub-family D member 4","datePublished":"2019-02-11","dateModified":"2019-02-11","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/abcd4-wikipedia\/","about":["Wiki"],"wordCount":2931,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensATP-binding cassette sub-family D member 4 is a protein that in humans is encoded by the ABCD4 gene.[4][5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR\/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and\/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding.[6]References[edit]^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021240 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Holzinger A, Kammerer S, Roscher AA (Sep 1997). “Primary structure of human PMP69, a putative peroxisomal ABC-transporter”. Biochem Biophys Res Commun. 237 (1): 152\u20137. doi:10.1006\/bbrc.1997.7102. PMID\u00a09266848.^ Shani N, Jimenez-Sanchez G, Steel G, Dean M, Valle D (Jan 1998). “Identification of a fourth half ABC transporter in the human peroxisomal membrane”. Hum Mol Genet. 6 (11): 1925\u201331. doi:10.1093\/hmg\/6.11.1925. PMID\u00a09302272.^ a b “Entrez Gene: ABCD4 ATP-binding cassette, sub-family D (ALD), member 4”.Further reading[edit]G\u00e4rtner J, Jimenez-Sanchez G, Roerig P, Valle D (1998). “Genomic organization of the 70-kDa peroxisomal membrane protein gene (PXMP1)”. Genomics. 48 (2): 203\u20138. doi:10.1006\/geno.1997.5177. PMID\u00a09521874.Holzinger A, Roscher AA, Landgraf P,  et\u00a0al. (1998). “Genomic organization and chromosomal localization of the human peroxisomal membrane protein-1-like protein (PXMP1-L) gene encoding a peroxisomal ABC transporter”. FEBS Lett. 426 (2): 238\u201342. doi:10.1016\/S0014-5793(98)00354-8. PMID\u00a09599016.Iida A, Saito S, Sekine A,  et\u00a0al. (2002). “Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8”. J. Hum. Genet. 47 (6): 285\u2013310. doi:10.1007\/s100380200041. PMID\u00a012111378.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Asheuer M, Bieche I, Laurendeau I,  et\u00a0al. (2005). “Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy”. Hum. Mol. Genet. 14 (10): 1293\u2013303. doi:10.1093\/hmg\/ddi140. PMID\u00a015800013.Kuiper H, Sp\u00f6tter A, Williams JL,  et\u00a0al. (2005). “Physical mapping of CHX10, ALDH6A1, and ABCD4 on bovine chromosome 10q34”. Cytogenet. Genome Res. 109 (4): 533. doi:10.1159\/000084217. PMID\u00a015909363.Kimura K, Wakamatsu A, Suzuki Y,  et\u00a0al. (2006). “Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55\u201365. doi:10.1101\/gr.4039406. PMC\u00a01356129. PMID\u00a016344560.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/abcd4-wikipedia\/#breadcrumbitem","name":"ABCD4 – Wikipedia"}}]}]