[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/acrv1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/acrv1-wikipedia\/","headline":"ACRV1 – Wikipedia","name":"ACRV1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Acrosomal protein SP-10 is a protein","datePublished":"2021-10-25","dateModified":"2021-10-25","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/acrv1-wikipedia\/","wordCount":3417,"articleBody":" (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensAcrosomal protein SP-10 is a protein that in humans is encoded by the ACRV1 gene.[5][6][7] (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. This gene consists of 4 exons and its alternative splicing generates multiple distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000134940 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032110 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Wright RM, John E, Klotz K, Flickinger CJ, Herr JC (Jul 1990). “Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10”. Biol Reprod. 42 (4): 693\u2013701. doi:10.1095\/biolreprod42.4.693. PMID\u00a01693291.^ Golden WL, von Kap-Herr C, Kurth B, Wright RM, Flickinger CJ, Eddy R, Shows T, Herr JC (Feb 1994). “Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23\u2192q24 of chromosome 11 by nonisotopic in situ hybridization”. Genomics. 18 (2): 446\u20139. doi:10.1006\/geno.1993.1496. PMID\u00a08288254.^ a b “Entrez Gene: ACRV1 acrosomal vesicle protein 1”.External links[edit]Further reading[edit]Herr JC, Klotz K, Shannon J, et\u00a0al. (1992). “Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes”. Biol. Reprod. 47 (1): 11\u201320. doi:10.1095\/biolreprod47.1.11. PMID\u00a01637938.Homyk M, Anderson DJ, Wolff H, Herr JC (1990). “Differential diagnosis of immature germ cells in semen utilizing monoclonal antibody MHS-10 to the intra-acrosomal antigen SP-10”. Fertil. Steril. 53 (2): 323\u201330. doi:10.1016\/s0015-0282(16)53289-0. PMID\u00a02298314.Freemerman AJ, Flickinger CJ, Herr JC (1995). “Characterization of alternatively spliced human SP-10 mRNAs”. Mol. Reprod. Dev. 41 (1): 100\u20138. doi:10.1002\/mrd.1080410115. PMID\u00a07619499. S2CID\u00a022411156.Foster JA, Klotz KL, Flickinger CJ, et\u00a0al. (1995). “Human SP-10: acrosomal distribution, processing, and fate after the acrosome reaction”. Biol. Reprod. 51 (6): 1222\u201331. doi:10.1095\/biolreprod51.6.1222. PMID\u00a07888499.Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.Wright RM, Suri AK, Kornreich B, et\u00a0al. (1993). “Cloning and characterization of the gene coding for the human acrosomal protein SP-10”. Biol. Reprod. 49 (2): 316\u201325. doi:10.1095\/biolreprod49.2.316. PMID\u00a08373955.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et\u00a0al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Reddi PP, Shore AN, Acharya KK, Herr JC (2002). “Transcriptional regulation of spermiogenesis: insights from the study of the gene encoding the acrosomal protein SP-10”. J. Reprod. Immunol. 53 (1\u20132): 25\u201336. doi:10.1016\/S0165-0378(01)00104-8. PMID\u00a011730901.Strausberg RL, Feingold EA, Grouse LH, et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Gerhard DS, Wagner L, Feingold EA, et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334. 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