[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/adam8-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/adam8-wikipedia\/","headline":"ADAM8 – Wikipedia","name":"ADAM8 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens A Disintegrin and metalloproteinase domain-containing protein 8 is","datePublished":"2020-06-02","dateModified":"2020-06-02","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/adam8-wikipedia\/","about":["Wiki"],"wordCount":3111,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensA Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.[5][6]Table of ContentsFunction[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Function[edit]This gene encodes a member of the ADAM (a disintegrin and metalloproteinase domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell\u2013cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.[6]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000151651 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025473 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (April 1997). “CD156 (human ADAM8): expression, primary amino acid sequence, and gene location”. Genomics. 41 (1): 56\u201362. doi:10.1006\/geno.1997.4607. PMID\u00a09126482.^ a b “Entrez Gene: ADAM8 ADAM metallopeptidase domain 8”.Further reading[edit]Yamamoto S, Higuchi Y, Yoshiyama K, Shimizu E, Kataoka M, Hijiya N, Matsuura K (June 1999). “ADAM family proteins in the immune system”. Immunology Today. 20 (6): 278\u201384. doi:10.1016\/S0167-5699(99)01464-4. PMID\u00a010354553.Schlomann U, Rathke-Hartlieb S, Yamamoto S, Jockusch H, Bartsch JW (November 2000). “Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration”. The Journal of Neuroscience. 20 (21): 7964\u201371. doi:10.1523\/JNEUROSCI.20-21-07964.2000. PMC\u00a06772711. PMID\u00a011050116.Amour A, Knight CG, English WR, Webster A, Slocombe PM, Kn\u00e4uper V, Docherty AJ, Becherer JD, Blobel CP, Murphy G (July 2002). “The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs”. FEBS Letters. 524 (1\u20133): 154\u20138. doi:10.1016\/S0014-5793(02)03047-8. PMID\u00a012135759. S2CID\u00a037423323.Ishikawa N, Daigo Y, Yasui W, Inai K, Nishimura H, Tsuchiya E, Kohno N, Nakamura Y (December 2004). “ADAM8 as a novel serological and histochemical marker for lung cancer”. Clinical Cancer Research. 10 (24): 8363\u201370. doi:10.1158\/1078-0432.CCR-04-1436. PMID\u00a015623614.Foley SC, Mogas AK, Olivenstein R, Fiset PO, Chakir J, Bourbeau J, Ernst P, Lemi\u00e8re C, Martin JG, Hamid Q (April 2007). “Increased expression of ADAM33 and ADAM8 with disease progression in asthma”. The Journal of Allergy and Clinical Immunology. 119 (4): 863\u201371. doi:10.1016\/j.jaci.2006.12.665. PMID\u00a017339047.G\u00f3mez-Gaviro M, Dom\u00ednguez-Luis M, Canchado J, Calafat J, Janssen H, Lara-Pezzi E, Fourie A, Tugores A, Valenzuela-Fern\u00e1ndez A, Mollinedo F, S\u00e1nchez-Madrid F, D\u00edaz-Gonz\u00e1lez F (June 2007). “Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding”. Journal of Immunology. 178 (12): 8053\u201363. doi:10.4049\/jimmunol.178.12.8053. PMID\u00a017548643.Valkovskaya N, Kayed H, Felix K, Hartmann D, Giese NA, Osinsky SP, Friess H, Kleeff J (2008). “ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer”. Journal of Cellular and Molecular Medicine. 11 (5): 1162\u201374. doi:10.1111\/j.1582-4934.2007.00082.x. PMC\u00a04401277. PMID\u00a017979891.External links[edit]The MEROPS online database for peptidases and their inhibitors: M12.208ADAM8 human gene location in the UCSC Genome Browser.ADAM8 human gene details in the UCSC Genome Browser.PDBe-KB provides an overview of all the structure information available in the PDB for Human Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8)This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/adam8-wikipedia\/#breadcrumbitem","name":"ADAM8 – Wikipedia"}}]}]