[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/agmatinase-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/agmatinase-wikipedia\/","headline":"Agmatinase – Wikipedia","name":"Agmatinase – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens In enzymology, an agmatinase (EC 3.5.3.11)","datePublished":"2019-02-09","dateModified":"2019-02-09","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/wikimedia.org\/api\/rest_v1\/media\/math\/render\/svg\/1c37b981df851b9e54e489e017b1481e37d418f3","url":"https:\/\/wikimedia.org\/api\/rest_v1\/media\/math\/render\/svg\/1c37b981df851b9e54e489e017b1481e37d418f3","height":"","width":""},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/agmatinase-wikipedia\/","about":["Wiki"],"wordCount":4088,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensIn enzymology, an agmatinase (EC 3.5.3.11) is an enzyme that catalyzes the chemical reaction       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4agmatine + H2O \u21cc{displaystyle rightleftharpoons } putrescine + ureaThus, the two substrates of this enzyme are agmatine and H2O, whereas its two products are putrescine and urea.This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is agmatine amidinohydrolase. Other names in common use include agmatine ureohydrolase, and SpeB. This enzyme participates in urea cycle and metabolism of amino groups.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsGenetics[edit]Structural studies[edit]Inhibitors[edit]References[edit]External links[edit]Genetics[edit]In humans, the enzyme is encoded by the AGMAT gene.[5][6][7][8]Structural studies[edit]As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1GQ6, 1GQ7, 1WOG, 1WOH, and 1WOI.Inhibitors[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000116771 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040706 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Mistry SK, Burwell TJ, Chambers RM, Rudolph-Owen L, Spaltmann F, Cook WJ, Morris SM Jr (Jan 2002). “Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus”. Am J Physiol Gastrointest Liver Physiol. 282 (2): G375\u201381. doi:10.1152\/ajpgi.00386.2001. PMID\u00a011804860.^ Dallmann K, Junker H, Balabanov S, Zimmermann U, Giebel J, Walther R (Dec 2003). “Human agmatinase is diminished in the clear cell type of renal cell carcinoma”. Int J Cancer. 108 (3): 342\u20137. doi:10.1002\/ijc.11459. PMID\u00a014648699. S2CID\u00a031927397.^ Iyer RK, Kim HK, Tsoa RW, Grody WW, Cederbaum SD (Mar 2002). “Cloning and characterization of human agmatinase”. Mol Genet Metab. 75 (3): 209\u201318. doi:10.1006\/mgme.2001.3277. PMID\u00a011914032.^ “Entrez Gene: AGMAT agmatine ureohydrolase (agmatinase)”.Morris SM (2004). “Vertebrate agmatinases: what role do they play in agmatine catabolism?”. Ann. N. Y. Acad. Sci. 1009: 30\u20133. doi:10.1196\/annals.1304.003. PMID\u00a015028567. S2CID\u00a024146429.Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K,  et\u00a0al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Chen FW, Davies JP, Ioannou YA (1998). “Differential gene expression in apoptosis: identification of ribosomal protein 23K, a cell proliferation inhibitor”. Mol. Genet. Metab. 64 (4): 271\u201382. doi:10.1006\/mgme.1998.2718. PMID\u00a09758718.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Kim KH, Ahn HJ, Kim DJ,  et\u00a0al. (2006). “Expression, crystallization and preliminary X-ray crystallographic analysis of human agmatinase”. Acta Crystallographica Section F. 61 (Pt 10): 889\u201391. doi:10.1107\/S1744309105027193. PMC\u00a01991308. PMID\u00a016511187.Gregory SG, Barlow KF, McLay KE,  et\u00a0al. (2006). “The DNA sequence and biological annotation of human chromosome 1”. Nature. 441 (7091): 315\u201321. Bibcode:2006Natur.441..315G. doi:10.1038\/nature04727. PMID\u00a016710414.Hirshfield IN, Rosenfeld HJ, Leifer Z, Maas WK (1970). “Isolation and Characterization of a Mutant of Escherichia coli Blocked in the Synthesis of Putrescine”. J. Bacteriol. 101 (3): 725\u201330. doi:10.1128\/JB.101.3.725-730.1970. PMC\u00a0250384. PMID\u00a04908780.Vicente C, Legaz ME (1982). “Preparation and properties of agmatine amidinohydrolase of Evernia prunastri”. Physiol. Plant. 55: 335\u2013339. doi:10.1111\/j.1399-3054.1982.tb00301.x.agmatinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)External links[edit]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/agmatinase-wikipedia\/#breadcrumbitem","name":"Agmatinase – Wikipedia"}}]}]