[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/akap1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/akap1-wikipedia\/","headline":"AKAP1 – Wikipedia","name":"AKAP1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens A kinase anchor protein 1, mitochondrial","datePublished":"2019-12-15","dateModified":"2019-12-15","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/akap1-wikipedia\/","about":["Wiki"],"wordCount":6017,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensA kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Interactions[edit]References[edit]External links[edit]Further reading[edit]Function[edit]The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.[7]Interactions[edit]AKAP1 has been shown to interact with:       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000121057 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018428 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Trendelenburg G, Hummel M, Riecken EO, Hanski C (Sep 1996). “Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain”. Biochem Biophys Res Commun. 225 (1): 313\u20139. doi:10.1006\/bbrc.1996.1172. PMID\u00a08769136.^ Lin RY, Moss SB, Rubin CS (Jan 1996). “Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells”. J Biol Chem. 270 (46): 27804\u201311. doi:10.1074\/jbc.270.46.27804. PMID\u00a07499250.^ a b “Entrez Gene: AKAP1 A kinase (PRKA) anchor protein 1”.^ a b Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). “AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase”. J. Biol. Chem. 277 (47): 45480\u201392. doi:10.1074\/jbc.M206201200. PMID\u00a012223483.^ Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). “AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase”. J. Biol. Chem. 276 (39): 36647\u201351. doi:10.1074\/jbc.M103885200. PMID\u00a011483602.^ a b Carlson CR, Ruppelt A, Task\u00e9n K (Mar 2003). “A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system”. J. Mol. Biol. 327 (3): 609\u201318. doi:10.1016\/S0022-2836(03)00093-7. PMID\u00a012634056.^ a b Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K (April 2000). “Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding”. J. Mol. Biol. 298 (2): 329\u201339. doi:10.1006\/jmbi.2000.3662. PMID\u00a010764601.^ Kapiloff MS, Schillace RV, Westphal AM, Scott JD (Aug 1999). “mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes”. J. Cell Sci. 112 (16): 2725\u201336. doi:10.1242\/jcs.112.16.2725. PMID\u00a010413680.External links[edit]Further reading[edit]Lester LB, Scott JD (1997). “Anchoring and scaffold proteins for kinases and phosphatases”. Recent Prog. Horm. Res. 52: 409\u201329, discussion 429\u201330. PMID\u00a09238861.Michel JJ, Scott JD (2002). “AKAP mediated signal transduction”. Annu. Rev. Pharmacol. Toxicol. 42: 235\u201357. doi:10.1146\/annurev.pharmtox.42.083101.135801. PMID\u00a011807172.Huang LJ, Durick K, Weiner JA,  et\u00a0al. (1997). “Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits”. J. Biol. Chem. 272 (12): 8057\u201364. doi:10.1074\/jbc.272.12.8057. PMID\u00a09065479.Huang LJ, Wang L, Ma Y,  et\u00a0al. (1999). “NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase\u2013anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum”. J. Cell Biol. 145 (5): 951\u20139. doi:10.1083\/jcb.145.5.951. PMC\u00a02133123. PMID\u00a010352013.Herberg FW, Maleszka A, Eide T,  et\u00a0al. (2000). “Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding”. J. Mol. Biol. 298 (2): 329\u201339. doi:10.1006\/jmbi.2000.3662. PMID\u00a010764601.Steen RL, Martins SB, Task\u00e9n K, Collas P (2000). “Recruitment of Protein Phosphatase 1 to the Nuclear Envelope by a-Kinase Anchoring Protein Akap149 Is a Prerequisite for Nuclear Lamina Assembly”. J. Cell Biol. 150 (6): 1251\u201362. doi:10.1083\/jcb.150.6.1251. PMC\u00a02150688. PMID\u00a010995432.Furusawa M, Ohnishi T, Taira T,  et\u00a0al. (2001). “AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase”. J. Biol. Chem. 276 (39): 36647\u201351. doi:10.1074\/jbc.M103885200. PMID\u00a011483602.Razani B, Lisanti MP (2001). “Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A”. Am. J. Physiol., Cell Physiol. 281 (4): C1241\u201350. doi:10.1152\/ajpcell.2001.281.4.C1241. PMID\u00a011546661. S2CID\u00a034190425.Yukitake H, Furusawa M, Taira T,  et\u00a0al. (2003). “AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase”. J. Biol. Chem. 277 (47): 45480\u201392. doi:10.1074\/jbc.M206201200. PMID\u00a012223483.Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (2003). “AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex”. J. Biol. Chem. 277 (52): 50885\u201392. doi:10.1074\/jbc.M206387200. PMID\u00a012414807.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Carlson CR, Ruppelt A, Task\u00e9n K (2003). “A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system”. J. Mol. Biol. 327 (3): 609\u201318. doi:10.1016\/S0022-2836(03)00093-7. PMID\u00a012634056.Steen RL, Beullens M, Landsverk HB,  et\u00a0al. (2004). “AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase”. J. Cell Sci. 116 (Pt 11): 2237\u201346. doi:10.1242\/jcs.00432. PMID\u00a012697839.Hillman RT, Green RE, Brenner SE (2005). “An unappreciated role for RNA surveillance”. Genome Biol. 5 (2): R8. doi:10.1186\/gb-2004-5-2-r8. PMC\u00a0395752. PMID\u00a014759258.Cardone L, Carlucci A, Affaitati A,  et\u00a0al. (2004). “Mitochondrial AKAP121 Binds and Targets Protein Tyrosine Phosphatase D1, a Novel Positive Regulator of src Signaling”. Mol. Cell. Biol. 24 (11): 4613\u201326. doi:10.1128\/MCB.24.11.4613-4626.2004. PMC\u00a0416429. PMID\u00a015143158.Beausoleil SA, Jedrychowski M, Schwartz D,  et\u00a0al. (2004). “Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130\u20135. Bibcode:2004PNAS..10112130B. doi:10.1073\/pnas.0404720101. PMC\u00a0514446. PMID\u00a015302935.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/akap1-wikipedia\/#breadcrumbitem","name":"AKAP1 – Wikipedia"}}]}]