[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/akt1s1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/akt1s1-wikipedia\/","headline":"AKT1S1 – Wikipedia","name":"AKT1S1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Proline-rich AKT1 substrate 1 (PRAS) is a protein","datePublished":"2017-05-19","dateModified":"2017-05-19","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/akt1s1-wikipedia\/","about":["Wiki"],"wordCount":4043,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensProline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene.[5][6]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000204673 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011096 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA (Mar 2003). “Identification of a proline-rich Akt substrate as a 14-3-3 binding partner”. The Journal of Biological Chemistry. 278 (12): 10189\u201394. doi:10.1074\/jbc.M210837200. PMID\u00a012524439.^ “Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich)”.Further reading[edit]Maruyama K, Sugano S (Jan 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH (Feb 2004). “Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor”. The Journal of Neuroscience. 24 (7): 1584\u201393. doi:10.1523\/JNEUROSCI.5209-03.2004. PMC\u00a06730448. PMID\u00a014973226.Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Vill\u00e9n J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). “Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130\u20135. Bibcode:2004PNAS..10112130B. doi:10.1073\/pnas.0404720101. PMC\u00a0514446. PMID\u00a015302935.Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O’Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). “Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization”. Current Biology. 14 (16): 1436\u201350. doi:10.1016\/j.cub.2004.07.051. PMID\u00a015324660.Huang B, Porter G (Oct 2005). “Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis”. Acta Pharmacologica Sinica. 26 (10): 1253\u20138. doi:10.1111\/j.1745-7254.2005.00184.x. PMID\u00a016174443.Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Research. 16 (1): 55\u201365. doi:10.1101\/gr.4039406. PMC\u00a01356129. PMID\u00a016344560.Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635\u201348. doi:10.1016\/j.cell.2006.09.026. PMID\u00a017081983.Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH (Mar 2007). “Insulin signalling to mTOR mediated by the Akt\/PKB substrate PRAS40”. Nature Cell Biology. 9 (3): 316\u201323. doi:10.1038\/ncb1547. PMID\u00a017277771. S2CID\u00a012827916.Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM (Mar 2007). “PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase”. Molecular Cell. 25 (6): 903\u201315. doi:10.1016\/j.molcel.2007.03.003. PMID\u00a017386266.Wang L, Harris TE, Roth RA, Lawrence JC (Jul 2007). “PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding”. The Journal of Biological Chemistry. 282 (27): 20036\u201344. doi:10.1074\/jbc.M702376200. PMID\u00a017510057.Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG (Aug 2007). “PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex”. The Journal of Biological Chemistry. 282 (34): 24514\u201324. doi:10.1074\/jbc.M704406200. PMID\u00a017604271.External links[edit]  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/akt1s1-wikipedia\/#breadcrumbitem","name":"AKT1S1 – Wikipedia"}}]}]