[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/asymmetric-counteranion-directed-catalysis-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/asymmetric-counteranion-directed-catalysis-wikipedia\/","headline":"Asymmetric counteranion directed catalysis – Wikipedia","name":"Asymmetric counteranion directed catalysis – Wikipedia","description":"From Wikipedia, the free encyclopedia Catalysis in enantioselective synthesis Asymmetric counteranion directed catalysis (ACDC)[1] or chiral anion catalysis [2] in","datePublished":"2016-11-25","dateModified":"2016-11-25","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/7\/79\/Arndtsen_2000.png\/500px-Arndtsen_2000.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/7\/79\/Arndtsen_2000.png\/500px-Arndtsen_2000.png","height":"149","width":"500"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/asymmetric-counteranion-directed-catalysis-wikipedia\/","wordCount":1591,"articleBody":"From Wikipedia, the free encyclopediaCatalysis in enantioselective synthesisAsymmetric counteranion directed catalysis (ACDC)[1] or chiral anion catalysis [2] in enantioselective synthesis is the “induction of enantioselectivity in a reaction proceeding through a cationic intermediate by means of ion pairing with a chiral, enantiomerically pure anion provided by the catalyst”.[1] Although chiral Br\u00f8nsted acid catalyzed reactions may well fall into this category of catalysis under the definition given here (e.g., protonation of an imine by a chiral phosphoric acid), the extent of proton transfer and the demarcation between hydrogen bonding and full proton transfer is often ambiguous.  Hence, some authors may exclude ion pair formation by proton transfer as a type of chiral counteranion catalysis.  The discussion below will focus on chiral ion pairs generated through means other than proton transfer. (For a discussion about chiral Br\u00f8nsted acid catalyzed reactions, see the article on hydrogen bond catalysis.)The concept of utilizing the counteranion as the source of chirality in catalysis was first proposed by Arndtsen and coworkers in 2000, who applied chiral borate anions to copper-catalyzed olefin aziridination and cyclopropanation.[3] The enantioselectivities observed were low:   "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/asymmetric-counteranion-directed-catalysis-wikipedia\/#breadcrumbitem","name":"Asymmetric counteranion directed catalysis – Wikipedia"}}]}]