[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/atf6-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/atf6-wikipedia\/","headline":"ATF6 – Wikipedia","name":"ATF6 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Activating transcription factor 6, also known as ATF6,","datePublished":"2021-02-10","dateModified":"2021-02-10","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/atf6-wikipedia\/","about":["Wiki"],"wordCount":6407,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensActivating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6  gene[5][6][7] and is involved in the unfolded protein response.Table of ContentsFunction[edit]See also[edit]Interactions[edit]References[edit]Further reading[edit]External links[edit]Function[edit]ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[8] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6.  The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.See also[edit]Interactions[edit]ATF6 has been shown to interact with YY1[9] and Serum response factor.[6]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000118217 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026663 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Hai TW, Liu F, Coukos WJ, Green MR (December 1989). “Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers”. Genes Dev. 3 (12B): 2083\u201390. doi:10.1101\/gad.3.12b.2083. PMID\u00a02516827.^ a b Zhu C, Johansen FE, Prywes R (September 1997). “Interaction of ATF6 and serum response factor”. Mol. Cell. Biol. 17 (9): 4957\u201366. doi:10.1128\/MCB.17.9.4957. PMC\u00a0232347. PMID\u00a09271374.^ Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VM, Schalkwijk CG, Feskens EJ, Boer JM, Stehouwer CD, van der Kallen CJ, de Bruin TW (July 2007). “Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians”. J. Clin. Endocrinol. Metab. 92 (7): 2720\u20135. doi:10.1210\/jc.2006-2280. PMID\u00a017440018.^ “Entrez Gene: ATF6 activating transcription factor 6”.^ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (2000). “ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1”. Mol. Cell. Biol. 20 (14): 5096\u2013106. doi:10.1128\/MCB.20.14.5096-5106.2000. PMC\u00a085959. PMID\u00a010866666.Further reading[edit]Hai T, Hartman MG (2001). “The molecular biology and nomenclature of the activating transcription factor\/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis”. Gene. 273 (1): 1\u201311. doi:10.1016\/S0378-1119(01)00551-0. PMID\u00a011483355.Hai TW, Liu F, Coukos WJ, Green MR (1990). “Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers”. Genes Dev. 3 (12B): 2083\u201390. doi:10.1101\/gad.3.12b.2083. PMID\u00a02516827.Zhu C, Johansen FE, Prywes R (1997). “Interaction of ATF6 and serum response factor”. Mol. Cell. Biol. 17 (9): 4957\u201366. doi:10.1128\/MCB.17.9.4957. PMC\u00a0232347. PMID\u00a09271374.Yoshida H, Haze K, Yanagi H, Yura T, Mori K (1999). “Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors”. J. Biol. Chem. 273 (50): 33741\u20139. doi:10.1074\/jbc.273.50.33741. PMID\u00a09837962.Haze K, Yoshida H, Yanagi H, Yura T, Mori K (1999). “Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress”. Mol. Biol. Cell. 10 (11): 3787\u201399. doi:10.1091\/mbc.10.11.3787. PMC\u00a025679. PMID\u00a010564271.Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (2000). “ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1”. Mol. Cell. Biol. 20 (14): 5096\u2013106. doi:10.1128\/MCB.20.14.5096-5106.2000. PMC\u00a085959. PMID\u00a010866666.Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K (2001). “Endoplasmic Reticulum Stress-Induced Formation of Transcription Factor Complex ERSF Including NF-Y (CBF) and Activating Transcription Factors 6\u03b1 and 6\u03b2 That Activates the Mammalian Unfolded Protein Response”. Mol. Cell. Biol. 21 (4): 1239\u201348. doi:10.1128\/MCB.21.4.1239-1248.2001. PMC\u00a099577. PMID\u00a011158310.Ye J, Rawson RB, Komuro R, Chen X, Dav\u00e9 UP, Prywes R, Brown MS, Goldstein JL (2001). “ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs”. Mol. Cell. 6 (6): 1355\u201364. doi:10.1016\/S1097-2765(00)00133-7. PMID\u00a011163209.Parker R, Phan T, Baumeister P, Roy B, Cheriyath V, Roy AL, Lee AS (2001). “Identification of TFII-I as the Endoplasmic Reticulum Stress Response Element Binding Factor ERSF: Its Autoregulation by Stress and Interaction with ATF6”. Mol. Cell. Biol. 21 (9): 3220\u201333. doi:10.1128\/MCB.21.9.3220-3233.2001. PMC\u00a086961. PMID\u00a011287625.Gotoh T, Oyadomari S, Mori K, Mori M (2002). “Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP”. J. Biol. Chem. 277 (14): 12343\u201350. doi:10.1074\/jbc.M107988200. PMID\u00a011805088.Chen X, Shen J, Prywes R (2002). “The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi”. J. Biol. Chem. 277 (15): 13045\u201352. doi:10.1074\/jbc.M110636200. PMID\u00a011821395.Thuerauf DJ, Morrison LE, Hoover H, Glembotski CC (2002). “Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16”. J. Biol. Chem. 277 (23): 20734\u20139. doi:10.1074\/jbc.M201749200. PMID\u00a011909875.Okada T, Yoshida H, Akazawa R, Negishi M, Mori K (2002). “Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response”. Biochem. J. 366 (Pt 2): 585\u201394. doi:10.1042\/BJ20020391. PMC\u00a01222788. PMID\u00a012014989.Luo S, Lee AS (2002). “Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein\/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation”. Biochem. J. 366 (Pt 3): 787\u201395. doi:10.1042\/BJ20011802. PMC\u00a01222838. PMID\u00a012076252.Tardif KD, Mori K, Siddiqui A (2002). “Hepatitis C Virus Subgenomic Replicons Induce Endoplasmic Reticulum Stress Activating an Intracellular Signaling Pathway”. J. Virol. 76 (15): 7453\u20139. doi:10.1128\/JVI.76.15.7453-7459.2002. PMC\u00a0136367. PMID\u00a012097557.Shuda M, Kondoh N, Imazeki N, Tanaka K, Okada T, Mori K, Hada A, Arai M, Wakatsuki T, Matsubara O, Yamamoto N, Yamamoto M (2004). “Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis”. J. Hepatol. 38 (5): 605\u201314. doi:10.1016\/S0168-8278(03)00029-1. PMID\u00a012713871.Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M, Mori K (2003). “A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6”. J. Biol. Chem. 278 (33): 31024\u201332. doi:10.1074\/jbc.M300923200. PMID\u00a012782636.Newman JR, Keating AE (2003). “Comprehensive identification of human bZIP interactions with coiled-coil arrays”. Science. 300 (5628): 2097\u2013101. Bibcode:2003Sci…300.2097N. doi:10.1126\/science.1084648. PMID\u00a012805554. S2CID\u00a036715183.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/atf6-wikipedia\/#breadcrumbitem","name":"ATF6 – Wikipedia"}}]}]