[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/atp1b3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/atp1b3-wikipedia\/","headline":"ATP1B3 – Wikipedia","name":"ATP1B3 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Sodium\/potassium-transporting ATPase subunit beta-3 is an","datePublished":"2016-10-02","dateModified":"2016-10-02","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/atp1b3-wikipedia\/","wordCount":3745,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensSodium\/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene.[5][6][7] ATP1B3 has also been designated as CD298 (cluster of differentiation 298).       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The protein encoded by this gene belongs to the family of Na+\/K+ and H+\/K+ ATPases beta chain proteins, and to the subfamily of Na+\/K+ -ATPases. Na+\/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha\/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+\/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000069849 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032412 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Malik N, Canfield VA, Beckers MC, Gros P, Levenson R (Nov 1996). “Identification of the mammalian Na,K-ATPase 3 subunit”. J Biol Chem. 271 (37): 22754\u20138. doi:10.1074\/jbc.271.37.22754. PMID\u00a08798450.^ Malik N, Canfield V, Sanchez-Watts G, Watts AG, Scherer S, Beatty BG, Gros P, Levenson R (Mar 1998). “Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene”. Mamm Genome. 9 (2): 136\u201343. doi:10.1007\/s003359900704. PMID\u00a09457675. S2CID\u00a031228553.^ a b “Entrez Gene: ATP1B3 ATPase, Na+\/K+ transporting, beta 3 polypeptide”.Further reading[edit]Lingrel JB, Orlowski J, Shull MM, Price EM (1990). “Molecular genetics of Na,K-ATPase”. Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 38: 37\u201389. doi:10.1016\/S0079-6603(08)60708-4. ISBN\u00a0978-0-12-540038-1. PMID\u00a02158121.J\u00f8rgensen PL (1982). “Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+ +K+)-ATPase”. Biochim. Biophys. Acta. 694 (1): 27\u201368. doi:10.1016\/0304-4157(82)90013-2. PMID\u00a06289898.Chiampanichayakul S, Szekeres A, Khunkaewla P,  et\u00a0al. (2003). “Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation”. Int. Immunol. 14 (12): 1407\u201314. doi:10.1093\/intimm\/dxf112. PMID\u00a012456588.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Zhang H, Li XJ, Martin DB, Aebersold R (2003). “Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry”. Nat. Biotechnol. 21 (6): 660\u20136. doi:10.1038\/nbt827. PMID\u00a012754519. S2CID\u00a0581283.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Chi A, Valencia JC, Hu ZZ,  et\u00a0al. (2007). “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes”. J. Proteome Res. 5 (11): 3135\u201344. doi:10.1021\/pr060363j. PMID\u00a017081065.Chiampanichayakul S, Khunkaewla P, Pata S, Kasinrerk W (2007). “Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells”. Tissue Antigens. 68 (6): 509\u201317. doi:10.1111\/j.1399-0039.2006.00726.x. PMID\u00a017176442.Ewing RM, Chu P, Elisma F,  et\u00a0al. (2007). “Large-scale mapping of human protein\u2013protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. doi:10.1038\/msb4100134. PMC\u00a01847948. PMID\u00a017353931.Aughey RJ, Murphy KT, Clark SA,  et\u00a0al. (2007). “Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes”. J. Appl. Physiol. 103 (1): 39\u201347. doi:10.1152\/japplphysiol.00236.2006. PMID\u00a017446412. S2CID\u00a07370462.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/atp1b3-wikipedia\/#breadcrumbitem","name":"ATP1B3 – Wikipedia"}}]}]