[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/atp6v0b-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/atp6v0b-wikipedia\/","headline":"ATP6V0B – Wikipedia","name":"ATP6V0B – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in Homo sapiens V-type proton ATPase 21 kDa proteolipid subunit is an enzyme","datePublished":"2022-06-07","dateModified":"2022-06-07","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/atp6v0b-wikipedia\/","about":["Wiki"],"wordCount":3280,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in Homo sapiensV-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.[5][6]This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits, plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c’, c”, and d.Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes, or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain, and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.[6]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000117410 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033379 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Nishigori H, Yamada S, Tomura H, Fernald AA, Le Beau MM, Takeuchi T, Takeda J (Oct 1998). “Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F)”. Genomics. 50 (2): 222\u20138. doi:10.1006\/geno.1998.5310. PMID\u00a09653649.^ a b “Entrez Gene: ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b”.External links[edit]Further reading[edit]Finbow ME, Harrison MA (1997). “The vacuolar H+-ATPase: a universal proton pump of eukaryotes”. Biochem. J. 324 (3): 697\u2013712. doi:10.1042\/bj3240697. PMC\u00a01218484. PMID\u00a09210392.Stevens TH, Forgac M (1998). “Structure, function and regulation of the vacuolar (H+)-ATPase”. Annu. Rev. Cell Dev. Biol. 13: 779\u2013808. doi:10.1146\/annurev.cellbio.13.1.779. PMID\u00a09442887.Nelson N, Harvey WR (1999). “Vacuolar and plasma membrane proton-adenosinetriphosphatases”. Physiol. Rev. 79 (2): 361\u201385. doi:10.1152\/physrev.1999.79.2.361. PMID\u00a010221984. S2CID\u00a01477911.Forgac M (1999). “Structure and properties of the vacuolar (H+)-ATPases”. J. Biol. Chem. 274 (19): 12951\u20134. doi:10.1074\/jbc.274.19.12951. PMID\u00a010224039.Kane PM (1999). “Introduction: V-ATPases 1992-1998”. J. Bioenerg. Biomembr. 31 (1): 3\u20135. doi:10.1023\/A:1001884227654. PMID\u00a010340843.Wieczorek H, Brown D, Grinstein S,  et\u00a0al. (1999). “Animal plasma membrane energization by proton-motive V-ATPases”. BioEssays. 21 (8): 637\u201348. doi:10.1002\/(SICI)1521-1878(199908)21:83.0.CO;2-W. PMID\u00a010440860. S2CID\u00a023505139.Nishi T, Forgac M (2002). “The vacuolar (H+)-ATPases–nature’s most versatile proton pumps”. Nat. Rev. Mol. Cell Biol. 3 (2): 94\u2013103. doi:10.1038\/nrm729. PMID\u00a011836511. S2CID\u00a021122465.Kawasaki-Nishi S, Nishi T, Forgac M (2003). “Proton translocation driven by ATP hydrolysis in V-ATPases”. FEBS Lett. 545 (1): 76\u201385. doi:10.1016\/S0014-5793(03)00396-X. PMID\u00a012788495. S2CID\u00a010507213.Morel N (2004). “Neurotransmitter release: the dark side of the vacuolar-H+ATPase”. Biol. Cell. 95 (7): 453\u20137. doi:10.1016\/S0248-4900(03)00075-3. PMID\u00a014597263.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Izumi H, Ise T, Murakami T,  et\u00a0al. (2003). “Structural and functional characterization of two human V-ATPase subunit gene promoters”. Biochim. Biophys. Acta. 1628 (2): 97\u2013104. doi:10.1016\/S0167-4781(03)00119-2. PMID\u00a012890556.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/atp6v0b-wikipedia\/#breadcrumbitem","name":"ATP6V0B – Wikipedia"}}]}]