[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cadps2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/cadps2-wikipedia\/","headline":"CADPS2 &#8211; Wikipedia","name":"CADPS2 &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Calcium-dependent secretion activator 2 is a","datePublished":"2017-07-12","dateModified":"2017-07-12","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/cadps2-wikipedia\/","about":["Wiki"],"wordCount":4423,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensCalcium-dependent secretion activator 2 is a protein that in humans is encoded by the CADPS2 gene.[5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Interactions[edit]Clinical significance[edit]References[edit]External links[edit]Further reading[edit]Function[edit]This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium-binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells.[5]Interactions[edit]This gene interacts with brain-derived neurotrophic factor.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Clinical significance[edit]Cadps2 has been linked to autism[6] and is in the 7q autism susceptibility locus (AUTS1). However, the finding of aberrant CADPS2 splicing was not found to be significant in another study.[7]A knockout mouse model was found to have autistic-like characteristics.[6]CADPS2 has been linked to human and mouse brain structure in two large genomic studies.[8][9]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000081803 &#8211; Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017978 &#8211; Ensembl, May 2017^ &#8220;Human PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ &#8220;Mouse PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b &#8220;Entrez Gene: CADPS2 Ca2+-dependent activator protein for secretion 2&#8221;. National Center for Biotechnology Information.^ a b Sadakata, T; Washida, M; Iwayama, Y;  et\u00a0al. (2007). &#8220;Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients&#8221;. Journal of Clinical Investigation. 117 (4): 931\u201343. doi:10.1172\/JCI29031. PMC\u00a01821065. PMID\u00a017380209.^ Eran, Alal; Graham, Kaitlin R.; Vatalaro, Kayla;  et\u00a0al. (April 2009). &#8220;Comment on &#8220;Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients&#8221;&#8220;. Journal of Clinical Investigation. 119 (4): 679\u201380. doi:10.1172\/JCI38620. PMC\u00a02662571. PMID\u00a019339759.^ French, L.; Pavlidis, P. (6 January 2011). &#8220;Relationships between gene expression and brain wiring in the adult rodent brain&#8221;. PLOS Computational Biology. 7 (1): e1001049. Bibcode:2011PLSCB&#8230;7E1049F. doi:10.1371\/journal.pcbi.1001049. PMC\u00a03017102. PMID\u00a021253556.^ Stein, JL; Hua, X; Lee, S;  et\u00a0al. (15 November 2010). &#8220;Voxelwise genome-wide association study (vGWAS)&#8221;. NeuroImage. 53 (3): 1160\u201374. doi:10.1016\/j.neuroimage.2010.02.032. PMC\u00a02900429. PMID\u00a020171287.External links[edit]Further reading[edit]Nagase T, Kikuno R, Nakayama M,  et\u00a0al. (2001). &#8220;Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro&#8221;. DNA Res. 7 (4): 273\u201381. doi:10.1093\/dnares\/7.4.271. PMID\u00a010997877.Nakayama M, Kikuno R, Ohara O (2003). &#8220;Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs&#8221;. Genome Res. 12 (11): 1773\u201384. doi:10.1101\/gr.406902. PMC\u00a0187542. PMID\u00a012421765.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). &#8220;Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences&#8221;. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS&#8230;9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Cisternas FA, Vincent JB, Scherer SW, Ray PN (2003). &#8220;Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family&#8221;. Genomics. 81 (3): 279\u201391. doi:10.1016\/S0888-7543(02)00040-X. PMID\u00a012659812.Speidel D, Varoqueaux F, Enk C,  et\u00a0al. (2004). &#8220;A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function&#8221;. J. Biol. Chem. 278 (52): 52802\u20139. doi:10.1074\/jbc.M304727200. PMID\u00a014530279.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). &#8220;Complete sequencing and characterization of 21,243 full-length human cDNAs&#8221;. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). &#8220;The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)&#8221;. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Binda AV, Kabbani N, Levenson R (2005). &#8220;Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)&#8221;. Biochem. Pharmacol. 69 (10): 1451\u201361. doi:10.1016\/j.bcp.2005.02.015. PMID\u00a015857609.Kimura K, Wakamatsu A, Suzuki Y,  et\u00a0al. (2006). &#8220;Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes&#8221;. Genome Res. 16 (1): 55\u201365. doi:10.1101\/gr.4039406. PMC\u00a01356129. PMID\u00a016344560.This article incorporates text from the United States National Library of Medicine, which is in the public domain.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/cadps2-wikipedia\/#breadcrumbitem","name":"CADPS2 &#8211; Wikipedia"}}]}]