[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/ccdc144a-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/ccdc144a-wikipedia\/","headline":"CCDC144A – Wikipedia","name":"CCDC144A – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Coiled-coil domain-containing protein 144A is a protein that","datePublished":"2022-07-03","dateModified":"2022-07-03","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/0\/0e\/Unrooted_Phylogenetic_Tree_of_KIAA0565_and_Orthologous_Proteins.png\/220px-Unrooted_Phylogenetic_Tree_of_KIAA0565_and_Orthologous_Proteins.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/0\/0e\/Unrooted_Phylogenetic_Tree_of_KIAA0565_and_Orthologous_Proteins.png\/220px-Unrooted_Phylogenetic_Tree_of_KIAA0565_and_Orthologous_Proteins.png","height":"168","width":"220"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/ccdc144a-wikipedia\/","about":["Wiki"],"wordCount":1991,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensCoiled-coil domain-containing protein 144A is a protein that in humans is encoded by the CCDC144A gene.[3] An alias of this gene is called KIAA0565. There are four members of the CCDC family: CCDC 144A, 144B, 144C and putative CCDC 144 N-terminal like proteins.[4]This gene has a nucleotide sequence that is 5140 bp long, and it encodes 641 amino acids.[5]  It is found on the short arm, plus (forward) strand of chromosome 17 at p11.2.[6][7]  The mRNA for the CCDC144A gene has 3 alternative splicing isoforms named A2RUR9-1, A2RUR9-2, AND A2RUR9-3, but there is no experimental confirmation available yet.[8]Table of ContentsProtein[edit]Structure[edit]Evolution[edit]Potential Orthologs[edit]Clinical significance[edit]Interacting proteins[edit]Expression[edit]References[edit]External links[edit]Protein[edit]This protein for this gene is also known as coiled coil domain containing 144A (CCDC144A) protein. It consists of 641 amino acids.[9]   This protein weighs 75.8 kDa and has an isoelectric point of 6.357.[10] This protein localizes near the nucleus,[11] and is a soluble protein with a hydrophobicity of -1.021842.[12] This protein is also non-secretory[13] and has 10 potential serine and 3 potential threonine phosphorylation sites.[14] There are no tyrosine sulfation sites,[15] but there are a few potential sumoylation sites on this protein.[16][17] Also, this protein is predicted to be non-myristoylated[18] and does not contain a signal peptide.[13][19]Structure[edit]This protein has a domain of unknown function (DUF) 3496, which has been conserved in eukaryotes.[20]  The DUF3496 domain is found from amino acids 547-622.[9]CCDC144A, an alias of this gene, indicates that there should be a coiled coil domain within the protein. Coiled coils are structural motifs in proteins in which 2 more alpha helices are coiled together, and they usually contain a heptad repeat, hxxhcxc, or hydrophobic (h) and charge (c) amino acid residues.[7] The 5′ and 3′ untranslated regions of the nucleotide sequence of this gene are rich in stem-loop structures.[21] In place of a coiled coil, a leucine zipper was found.[11] Residues from 478-499, “LHNTRDALGRESLILERVQRDL”, are the residues that form the leucine zipper pattern.[11] The structure of this protein consists of mostly alpha helices, with some random coils.[22]Evolution[edit]  NumberSpecies1Nine-banded armadillo2Cow3Flying fox4Mouse eared bat5Chimpanzee6Treeshrew7House mouse8Chinese hamster9Naked mole rat10Rhesus monkey11Crab-eating macaque12Human KIAA056513Platypus14Western clawed frog15Pufferfish16Carolina anole17Zebra finchOrthologs of KIAA0565 protein have been identified mostly in mammals, but some birds, reptiles, amphibians, and fish as well.[23]Potential Orthologs[edit]Protein nameGenus and speciesCommon nameOrtholog spaceQuery cover (%)Max identity (%)Accession numberCCDC 144AMacaca fasicularisCrab-eating macaque09786EHH57800.1[9]CCDC 144A, PartialMacaca mulattaRhesus monkey09786EHH24608.1[9]ANKRD 26Pan troglodytesCommon chimpanzee2e-1609667JAA07196.1[9]ANKRD 26, PredictedDasypus novemcinctusNine-banded armadillo1e-1589665XP_004470808.1[9]ANKRD 26Myotis davidiiMouse eared bat2e-1549664ELK35935.1[9]ANKRD 26Bos taurusCow2e-1579663NP_001107239.1[9]ANKRD 26Tupaia chinensisTreeshrew3e-1479662ELW73004.1[9]ANKRD 26Cricetulus griseusChinese hamster1e-1459660EGW08323.1[9]ANKRD 26Heterocephalus glaberNaked mole rat2e-1389659EHB01988.1[9]ANKRD 26Mus musculusHouse mouse4e-1419657NP_001074581.1[9]ANKRD 26, PartialPteropus alectoBlack flying fox2e-1719751ELK03279.1[9]ANKRD 26-Like, PredictedOrnithorhynchus anatinusPlatypus2e-1089651XP_001509663.2[9]ANKRD 26-Like, PredictedTaeniopygia guttataZebra finch3e-889245XP_004177264.1[9]ANKRD 26-Like, PredictedAnolis carolinensisCarolina anole2e-759744XP_003221333.1[9]ANKRD 26, PredictedXenopus tropicalisWestern clawed frog2e-789844XP_002935004.1[9]Unnamed Protein ProductTetraodon nigroviridisPufferfish1e-289834CAF98417.1[9][23]Clinical significance[edit]This gene has been linked to Smith-Magenis Syndrome (SMS), which is also known as chromosome 17p11.2 deletion syndrome,[24] chromosome 17p deletion syndrome,[25] deletion 17p syndrome,[25] partial monosomy 17p,[25] and deletion abnormality.[26][27]Interacting proteins[edit]There may potentially be two proteins that interact with KIAA0565, and they are ubiquitin specific peptidase 32 (USP32) and ubiquitin specific peptidase 25 (USP25).[28]Expression[edit]This protein has been shown to have relatively low expression in all tissues.[29]References[edit]External links[edit]  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/ccdc144a-wikipedia\/#breadcrumbitem","name":"CCDC144A – Wikipedia"}}]}]